Mae'r cynnwys hwn ar gael yn Saesneg yn unig.
Our basic science and clinical research is focused around three themes: neuroscience and ageing; stem cells, regeneration and repair; and visual and ocular development.
Neuroscience and ageing
Age-related eye disease accounts for more than 70% of all vision loss in the UK, with macular disease being the leading cause.
Our research provides an ideal platform for the development of new and improved methods for the detection and management of visual problems relating to the nervous system and ageing.
Our research is enhanced by strong links with the Neuroscience and Mental Health Research Institute, the Dementia Research Institute (DRI), and the Cardiff University Brain Imaging Research Centre (CUBRIC).
Our neuro-degeneration and ageing theme is pursued within six collaborative groups:
Stem cells, regeneration and repair
Our research is aimed at understanding the causes of ocular degeneration and the development of novel eye care treatments and products for improved ocular health.
To address the world-wide shortage of corneal donor tissue for the treatment of corneal disorders and pathologies, we have joined forces with Linkoping University, the University of Montreal and LV Prasad Eye Institute, in an international collaborative effort to develop a suitable artificial corneal replacement.
We also continue to collaborate closely with clinician-scientists in Osaka University to harness the power of human induced pluripotent stem (iPS) cells to generate transplantable eye tissue capable of restoring visual function.
In the field of glaucoma and inherited optic neuropathy, our research investigates novel therapeutic agents, which include adult stem cells, as well as their secreted constituents (e.g. exosomes). We test these novel neuroprotective therapeutic strategies in state-of-the-art in vitro and in vivo models, and human embryonic stem cell-derived retinal cultures.
Our stem cells, regeneration and repair research is pursued within three collaborative groups:
Visual and ocular development
Our visual and ocular development research uses patient centred and basic science approaches to investigate normal and aberrant visual and ocular development.
Our research combines basic science investigations with patient centred studies into normal and abnormal visual function. Key areas of activity focus on developmental biology, the genetics of myopia and the understanding of visual function in children with Down's syndrome.
In 2017, our Down’s Syndrome Vision Research was awarded the UK’s most prestigious academic award – a Queen’s Anniversary Prize – for its pioneering research and treatment of vision problems in children with Down’s syndrome.
Our visual and ocular-development theme is pursued within four collaborative groups: