Biomedicine lies at the interface of basic and preclinical research and investigates the fundamental mechanisms of the normal and disease processes that influence life-long health - spanning from conception into old age, and from the single cell to the whole organism in its environment.
Our biomedical research encompasses three main areas of focus:
- Developmental origins of disease - elucidating the prenatal and epigenetic influences that impact on later-life risk of disease.
- Mechanisms of health and disease - understanding the physiological, connective tissue, neurological and cancer-based mechanisms of disease.
- Disease intervention - the development of therapeutic strategies to prevent and treat disease.
This division has direct links with two University Research Institutes - the European Cancer Stem Cell Research Institute and the Neuroscience and Mental Health Research Institute. Our Biomedicine division also plays a central role in the Arthritis Research UK Centre and Wales Gene Park Genome Editing Facility.
Fellowship and PhD applications
We welcome approaches by potential fellowship applicants whose interests map onto the divisional research areas.
We also welcome applications from PhD students with research interests that fit our strategic research areas.
Please contact BIOSI-Research@cardiff.ac.uk for more information.
|Name||Area of interest|
|Professor Rosalind John - Head of Division||How Epigenetic Marks direct Mammalian Development and drive Human Disease.|
|Professor Dipak Ramji - Joint Deputy Head of Division (Postgraduate Divisional Tutor)||Inflammation, atherosclerosis and regulation of gene expression.|
|Professor Matt Smalley - Joint Deputy Head of Division||The role of normal mammary stem and progenitor cells in the generation of breast cancer phenotypic heterogeneity and cancer stem cells.|
|Dr Fernando Anjos-Afonso||Biology of Haematopoietic stem/progenitor cells and their niche|
|Dr Emma Blain||Connective tissue mechanobiology.|
|Dr Raquel Boque Sastre|
|Professor Vladimir Buchman||Functional significance of synuclein proteins in the normal and degenerating nervous system.|
|Dr Vikesh Chhabria||Synthesis of biomimetic nanomaterial formulations for biomedical purposes and development of novel screening technologies for protein aggregation screening of advanced therapeutic medicinal products.|
|Dr Richard Clarkson||Apoptosis in normal mammary tissues and in models of breast cancer.|
|Professor Vic Duance (Emeritus)||Structure and function of the minor collagens of cartilage, cell signalling pathways associated with mechanical and cytokine mediated cartilage degeneration.|
|Dr Julia Gerasimenko||Molecular mechanisms of pathological processes in exocrine pancreas.|
|Dr Oleg Gerasimenko||Investigation of cell death mechanisms.|
|Dr Sarah Hall||Design, development and evaluation of physiology-related teaching and learning activities; authentic learning opportunities in the undergraduate curriculum.|
|Dr Tim Higgins|
|Dr Catherine Hogan||Epithelial cell-cell communication and pancreatic cancer.|
|Professor Clare Hughes||Cartilage proteoglycan metabolism in osteoarthritis.|
|Dr Helen Jones||Signalling mechanisms involved in cancer biology.|
|Dr Renata Jurkowska||Epigenetic regulation of cell renewal and differentiation in the healthy and diseased human lung|
|Dr Branko Latinkic||Cardiac differentiation|
|Professor Stan Marée|
|Dr Deborah Mason||Signalling mechanisms regulating bone and cartilage turnover, in osteoporosis, rheumatoid arthritis and osteoarthritis.|
|Dr Helen McCarthy||Biology of both the articular cartilage progenitor cell and a meniscus-specific progenitor cell in human and equine tissue and their potential role in tissue repair and osteoarthritis.|
|Dr Jittima Muensoongnoen|
|Dr Larissa Nelson|
|Dr Natalia Ninkina|
|Dr Lee Parry||Understanding the interaction between diet, microbiota, immunity and cancer.|
|Dr Girish Patel (Honorary)||Skin cancer stem cells.|
|Dr Helen Pearson||Prostate cancer translational research, preclinical trials, and PI3K/DNA damage repair signalling|
|MRC Professor Ole Petersen CBE FRS||Calcium signalling: physiology & pathophysiology.|
|Dr David Petrik||Adult neurogenesis and adult neural stem cells in hippocampus and hypothalamus|
|Dr Toby Phesse||Cell signalling and stem cell function during homeostasis, regeneration and cancer in the gastrointestinal tract.|
|Dr Helen Quasnichka|
|Dr Jim Ralphs||The synthesis, deposition and organisation of collagenous matrices in highly ordered connective tissues.|
|Professor Daniela Riccardi||Molecular mechanisms of nutrient sensing.|
|Dr Kirsty Richardson|
|Dr Neil Rodrigues||Haematopoietic stem/progenitor cell biology and its dysregulation in myelodysplasia and myeloid leukaemia.|
|Dr Hannah Shaw|
|Dr Paul Shaw (Honorary)||Clinician with basic-science translational research interests in lung and GI cancers.|
|Dr Florian Siebzehnrubl||Regulation of tumour progression and therapy resistance in brain cancer.|
|Dr Katherine Smith|
|Dr Shiby Stephens||Clinical anatomist with research interest in human musculoskeletal pathologies.|
|Professor Karl Swann||The physiology of eggs at fertilisation and embryos during early development.|