Dr Neil Rodrigues
Reader, Postgraduate Divisional Tutor
- rodriguesn@cardiff.ac.uk
- +44 (0)29 2068 8507
- European Cancer Stem Cell Research Institute, Cardiff School of Biosciences, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ
- Available for postgraduate supervision
Overview
Research overview
My laboratory is interested in haematopoietic stem/progenitor cell biology and their dysregulation in bone marrow failure and haematologic cancer. We are investigating the transcriptional and post-transcriptional mechanisms regulating haematopoietic stem/progenitor cells, myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML) with the ultimate purpose of identifying more specific and less toxic treatment strategies for MDS and AML.
Lab members
- Amani Alsayari
- Hamed Ahmad A Alzahrani
- Sarab Taha
- Hind Alqahtani
Current grant support
- Leukaemia Cancer Society
- Royal Embassy of Saudi Arabia
Biography
Dr. Rodrigues has a longstanding interest in stem cell biology, with a particular interest in the haematopoietic system. He initially trained in Professor David Scadden's laboratory at Harvard Medical School and went on to obtain a D.Phil in Clinical Medicine from Green College, University of Oxford under the joint supervision of Professors Scadden, Paresh Vyas and Tariq Enver. Following several years of teaching at Oxford and post-doctoral research training in the Enver laboratory, he established his NIH funded laboratory at Boston University School of Medicine where he also held an Assistant Professor appointment. In September 2013, Dr. Rodrigues was recruited to re-establish his laboratory at the European Cancer Stem Cell Institute. He holds a Readership at Cardiff University.
Publications
2022
- Menendez-Gonzalez, J. B., Strange, K. E., Bassetto, M., Brancale, A., Rodrigues, N. P. and Ferla, S. 2022. Ligand-based discovery of a novel GATA2 inhibitor targeting acute myeloid leukemia cells. Frontiers In Drug Discovery 2, article number: 1013229. (10.3389/fddsv.2022.1013229)
- Menendez-Gonzalez, J. B. and Rodrigues, N. P. 2022. Exploring the associations between clonal hematopoiesis of indeterminate potential, myeloid malignancy, and atherosclerosis. In: Ramji, D. ed. Atherosclerosis., Vol. 2419. Methods in Molecular Biology Springer, pp. 73-88., (10.1007/978-1-0716-1924-7_5)
- Almotiri, A., Abdelfattah, A. and Rodrigues, N. P. 2022. Flow cytometry analysis of hematopoietic stem/progenitor cells and mature blood cell subsets in atherosclerosis. In: Ramji, D. ed. Atherosclerosis., Vol. 2419. Methods in Molecular Biology Springer, pp. 583-595., (10.1007/978-1-0716-1924-7_36)
2021
- Lawson, H. et al. 2021. CITED2 coordinates key haematopoietic regulatory pathways to maintain the HSC pool in both steady-state haematopoiesis and transplantation. Stem Cell Reports 16(11), pp. 2784-2797. (10.1016/j.stemcr.2021.10.001)
- Abdelfattah, A. M. et al. 2021. Gata2 haploinsufficiency promotes proliferation and functional decline of HSCs with myeloid bias during aging. Blood Advances 5(20), pp. 4285-4290. (10.1182/bloodadvances.2021004726)
- O'Morain, V. L. et al. 2021. The Lab4P consortium of probiotics attenuates atherosclerosis in LDL receptor deficient mice fed a high fat diet and causes plaque stabilization by inhibiting inflammation and several pro-atherogenic processes. Molecular Nutrition & Food Research 65(17), article number: 2100214. (10.1002/mnfr.202100214)
- Moss, J. W. E. et al. 2021. Protective effects of a unique combination of nutritionally active ingredients on risk factors and gene expression associated with atherosclerosis in C57BL/6J mice fed a high fat diet. Food and Function 12(8), pp. 3657-3671. (10.1039/D0FO02867C)
- Lawson, H. et al. 2021. JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells. Blood Advances 5(3), pp. 889-899. (10.1182/bloodadvances.2020002702)
- Almotiri, A. et al. 2021. Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. Journal of Clinical Investigation 131(1), article number: e129115. (10.1172/JCI129115)
2019
- Menendez Gonzalez, J. B. et al. 2019. Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells. Scientific Reports 9, article number: 12212. (10.1038/s41598-019-48589-0)
- Menendez Gonzalez, J. B. et al. 2019. Gata2 as a crucial regulator of stem cells in adult hematopoiesis and acute myeloid leukemia. Stem Cell Reports 13(2), pp. 291-306. (10.1016/j.stemcr.2019.07.005)
- Menendez-Gonzalez, J. B., Saleh, L., Feng, G. J. and Rodrigues, N. P. 2019. Isolation of murine hematopoietic stem cells. In: Boyd, A. S. ed. Immunological Tolerance: Methods and Protocols., Vol. 1899. Methods in Molecular Biology New York: Humana Press, pp. 15-23., (10.1007/978-1-4939-8938-6_2)
2018
- Boyd, A. S. and Rodrigues, N. P. 2018. Stem cells cycle toward immune surveillance. Immunity 48(2), pp. 187-190. (10.1016/j.immuni.2018.02.006)
2017
- Portero Migueles, R. et al. 2017. Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny. Developmental Biology 424(2), pp. 236-245. (10.1016/j.ydbio.2016.12.021)
- Guitart, A. V. et al. 2017. Fumarate hydratase is a critical regulator of hematopoietic stem cell functions. Journal of Experimental Medicine 214(3), pp. -., article number: 719. (10.1084/jem.20161087)
2013
- Rodrigues, N. and Tipping, A. J. 2013. Transcription factor GATA-2 regulates quiescence of hematopoietic stem and progenitor cells. In: Hayat, M. A. ed. Tumor Dormancy, Quiescence, and Senescence, Volume 2., Vol. 2. Springer, pp. 277-288., (10.1007/978-94-007-7726-2_26)
- Guha, P., Morgan, J. W., Mostoslavsky, G., Rodrigues, N. and Boyd, A. S. 2013. Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells. Cell Stem Cell 12(4), pp. 407-412. (10.1016/j.stem.2013.01.006)
2012
- Boyd, A. S., Rodrigues, N., Lui, K. O., Fu, X. and Xu, Y. 2012. Concise review: Immune recognition of induced pluripotent stem cells. Stem Cells 30(5), pp. 797-803. (10.1002/stem.1066)
- Rodrigues, N., Tipping, A. J., Wang, Z. and Enver, T. 2012. GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia. The International Journal of Biochemistry & Cell Biology 44(3), pp. 457-460. (10.1016/j.biocel.2011.12.004)
2009
- Kranc, K. R. et al. 2009. Cited2 is an essential regulator of adult hematopoietic stem cells. Cell Stem Cell 5(6), pp. 659-665. (10.1016/j.stem.2009.11.001)
- Tipping, A. J. et al. 2009. High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood 113(12), pp. 2661-2672. (10.1182/blood-2008-06-161117)
2008
- Rodrigues, N. et al. 2008. GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood 112(13), pp. 4862-4873. (10.1182/blood-2008-01-136564)
2007
- Nijnik, A. et al. 2007. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447(7145), pp. 686-690. (10.1038/nature05875)
2005
- Rodrigues, N. et al. 2005. Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood 106(2), pp. 477-484. (10.1182/blood-2004-08-2989)
- Craiu, A. et al. 2005. Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function. Blood 105(5), pp. 2235-2238. (10.1182/blood-2003-12-4399)
2004
- Qiu, J., Takagi, Y., Harada, J., Rodrigues, N., Moskowitz, M. A., Scadden, D. T. and Cheng, T. 2004. Regenerative response in ischemic brain restricted by p21cip1/waf1. Journal of Experimental Medicine 199(7), pp. 937-945. (10.1084/jem.20031385)
2002
- Adams, G. B. et al. 2002. Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood 101(1), pp. 45-51. (10.1182/blood-2002-02-0486)
2001
- Cheng, T., Shen, H., Rodrigues, N., Stier, S. and Scadden, D. T. 2001. Transforming growth factor β1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21Cip1/Waf1or p27Kip1. Blood 98(13), pp. 3643-3649. (10.1182/blood.V98.13.3643)
2000
- Cheng, T., Rodrigues, N., Shen, H., Yang, Y., Dombkowski, D., Sykes, M. and Scadden, D. T. 2000. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287(5459), pp. 1804-1808. (10.1126/science.287.5459.1804)
- Cheng, T., Rodrigues, N., Dombkowski, D., Stier, S. and Scadden, D. T. 2000. Stem cell repopulation efficiency but not pool size is governed by p27 (kip1). Nature Medicine 6, pp. 1235-1240. (10.1038/81335)