Professor Ole Petersen

CBE FRS

Director of the Cardiff University - Academia Europaea Knowledge Hub

: petersenoh@cardiff.ac.uk
: +44 (0)29 2068 8249
: Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX

Director of a research programme investigating the role of Ca2+ in the pathophysiology of pancreatitis and Scientific Director of the Cardiff University – Academia Europaea Knowledge Hub’s SAPEA (Science Advice for Policy by European Academies) Project, supported by a grant from the European Commission’s Horizon 2020 Programme (1^st October 2016 - 30^th September 2020).

Education/Degrees

Medical student, University of Copenhagen 1961 – 1969

Cand. Med. (Laudabilis) (MB ChB) University of Copenhagen, 1969

Authorized Medical Practitioner (Danish State Health Authority) 1969

Dr. med. (MD) University of Copenhagen, 1972, for thesis “Acetylcholine-induced ion transports involved in the formation of saliva” (Thesis published as Supplement 381 in Acta physiol scand [now Acta Physiologica] 1972)

Posts held

Lecturer, Institute of Medical Physiology, University of Copenhagen, 1969-73

Wellcome-Carlsberg Travelling Research Fellow, Department of Pharmacology, University of Cambridge, UK, 1971-72 (on leave of absence from University of Copenhagen)

Senior Lecturer, Institute of Medical Physiology, University of Copenhagen, Denmark, 1973-78

Symers Professor of Physiology and Head of the Department of Physiology, University

of Dundee, Scotland, 1975-81 (on leave of absence from University of Copenhagen

1975-78).

Head of the Department of Physiology, University of Liverpool, 1981-1998

George Holt Professor of Physiology, University of Liverpool, England, 1981- 2009

Director (Head) of Cardiff University’s School of Biosciences, 2010 - 2015

Professor at Cardiff School of Biosciences, 2010 –

Honours and awards

2018	The American Physiological Society's Walter B Cannon Memorial Award Lecturer. The Plenary Award Lecture to be delivered at Experimental Biology in San Diego, USA on 22nd April 2018
2017	Elected Honorary Member of the German Society for Gastroenterology, Digestive and Metabolic Diseases. Award Lecture at the 72nd Annual Meeting of the Society in Dresden, September 2017
2015	Appointed Vice-President of Academia Europaea
2015	Elected Honorary Member of The Physiological Society
2014	Elected Vice-President (Science, Technology and Medicine) of The Learned Society of Wales for 3 years, beginning at The Society's AGM on 14th May 2014
2013	Opening Plenary Lecture at the 2013 Annual Congress of the Brazilian Society of Physiology in Sao Paulo
2013	Keynote Lecture at the 37th International Congress of Physiological Sciences (IUPS2013), Birmingham, UK http://www.voicesfromoxford.org/video/the-role-of-calcium-in-pancreatic-disease/397
2013	The American Physiological Society's Horace W Davenport Distinguished Lectureship, Experimental Biology 2013, Boston, Massachusetts, USA
2012	MRC Professorship and MRC Programme Grant renewed (2012 – 2017)
2012	Public (Inaugural) Lecture as Member of the German National Academy of Sciences, Leopoldina, Halle, Germany
2011	Honorary Professor at College of Medicine, Jinan National University, Guangzhou, China
2011	Elected Fellow of the Learned Society of Wales
2010	Elected Member of the German National Academy of Sciences Leopoldina
2010	Appointed Chair of HEFCE's Biological Sciences Sub-panel, REF2014
2010	Appointed Member of the Welsh Government's Science Advisory Council for Wales
2010	Lifetime Achievement Award, European Pancreatic Club
2009	American Gastroenterological Association's State-of-the-Art Lecture, Digestive Diseases Week 2009, Chicago, USA
2008	Appointed Commander of the Order of the British Empire (CBE) in The Queen's New Year Honours list for 'Services to Science'
2008	Appointed Chair of the European Research Council's Starting Grant Panel LS4 (2009-2011)
2008	Keynote Lecture at 4th Covian Symposium, University of Sao Paulo, Brazil
2008	MRC Professorship and MRC Programme Grant renewed (2008 - 2012)
2006	President of The Physiological Society, UK (2006 – 2008)
2005	Vice-President of The Royal Society (2005 – 2006)
2005	Plenary Keynote Lecture, 82nd Annual Meeting of the Physiological Society of Japan, Sendai
2005	JA Young Memorial Lecture, Gordon Research Conference on Salivary Glands, California, USA
2004	Elected Honorary Member of the Hungarian Academy of Sciences
2003	Purkyne Medal from the Academy of Sciences of the Czech Republic
2003	The Keynote Lecture, Gordon Research Conference on Calcium Signaling, Mass., USA
2003	Chair of Physiological Review's European Editorial Committee (2003 – 2011)
2003	MRC Professorship and MRC Programme Grant renewed (2003 – 2008)
2001	Secretary General of the International Union of Physiological Sciences (IUPS) (2001 – 2009)
2000	Elected Fellow of The Royal Society (FRS)

2013

Gerasimenko, J. V.et al. 2013. Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proceedings of the National Academy of Sciences of the United States of America 110(32), pp. 13186-13191. (10.1073/pnas.1300910110)
Heygi, P. and Petersen, O. 2013. The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. In: Nilius, B. et al. eds. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 165. Cham, Switzerland: Springer Verlag, pp. 1-30., (10.1007/112_2013_14)

2012

Ferdek, P.et al. 2012. A novel role for Bcl-2 in regulation of cellular calcium extrusion. Current Biology 22(13), pp. 1241-1246. (10.1016/j.cub.2012.05.002)
Gerasimenko, O. V., Petersen, O. H. and Gerasimenko, J. V. 2012. Role of intracellular acid Ca2+ stores in pathological pancreatic protease activation [Editorial]. Expert Review of Gastroenterology & Hepatology 6(2), pp. 129-131. (10.1586/EGH.12.5)
Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2012. The war within - unraveling the molecular causes of acute pancreatitis - a potentially deadly disease in which the pancreas essentially digests itself - is yielding clues to how it might be treated. The Scientist 26(2), pp. 40-44.
Spät, A. and Petersen, O. H. 2012. A special issue on the cell-specific roles of mitochondrial Ca2+ handling [Editorial]. Pflugers Archiv European Journal of Physiology 464(1), pp. 1-2. (10.1007/s00424-012-1123-x)
Petersen, O. H. 2012. Specific mitochondrial functions in separate sub-cellular domains of pancreatic acinar cells. Pflugers Archiv European Journal of Physiology 464(1), pp. 77-87. (10.1007/s00424-012-1099-6)

2011

Petersen, O. H.et al. 2011. Aberrant Ca2+ signalling through acidic calcium stores in pancreatic acinar cells. Cell Calcium 50(2), pp. 193-199. (10.1016/j.ceca.2011.02.010)
Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2011. Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000 Medicine Reports(3), article number: 15. (10.3410/M3-15)
Booth, D.et al. 2011. Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140(7), pp. 2116-2125. (10.1053/j.gastro.2011.02.054)
Gerasimenko, J. V.et al. 2011. Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 108(14), pp. 5873-5878. (10.1073/pnas.1016534108)
Lur, G.et al. 2011. InsP3 receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. Biochemical Journal 436(2), pp. 231-239. (10.1042/BJ20110083)

2010

Verkhratsky, A. and Petersen, O. H. 2010. Bernd Nilius: The Bard of ion channels. Congratulations on 65th birthday. Pflügers Archiv European Journal of Physiology 460(4), pp. 691-694. (10.1007/s00424-010-0857-6)
Voronina, S. G.et al. 2010. Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138(5), pp. 1976-1987. (10.1053/j.gastro.2010.01.037)
Petersen, O. H. 2010. Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology. Brazilian Journal of Medical and Biological Research 42(1), pp. 9-16.
Chvanov, M., Petersen, O. H. and Tepikin, A. V. 2010. Pharmacologically directed cell disposal: labelling damaged cells for phagocytosis as a strategy against acute pancreatitis. Molecular Interventions 10(2), pp. 80-85. (10.1124/mi.10.2.9)
Walsh, C. M.et al. 2010. Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochemical Journal 425(1), pp. 159-168. (10.1042/BJ20090884)
Verkhratsky, A. and Petersen, O. H. 2010. Principles of the Ca2+ homeostatic/signalling system. In: Verkhratsky, A. and Petersen, O. H. eds. Calcium Measurement Methods. Neuromethods, Vol. 43. New York: Humana Press, pp. 1-11., (10.1007/978-1-60761-476-0_1)
Blum, R., Petersen, O. H. and Verkhratsky, A. 2010. Ca2+ imaging of intracellular organelles: endoplasmic reticulum. In: Verkhratsky, A. and Petersen, O. H. eds. Calcium measurement methods. Neuromethods, Vol. 43. New York: Humana Press, pp. 146-167., (10.1007/978-1-60761-476-0_8)
Verkhratsky, A. N. and Petersen, O. H. 2010. Preface. In: Verkhratsky, A. N. and Petersen, O. H. eds. Calcium Measurement Methods. Neuromethods, Vol. 43. New York, NY; London: Humana Press, pp. vii-vii.

2009

Petersen, O. H. 2009. The International Union of Physiological Sciences IUPS Editorial VIII [Editorial]. Physiology 24(6), pp. 320-321. (10.1152/physiol.00035.2009)
Lur, G.et al. 2009. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology 19(19), pp. 1648-1653. (10.1016/j.cub.2009.07.072)
Baumgartner, H. K.et al. 2009. Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. Journal of Biological Chemistry 284(31), pp. 20796-20803. (10.1074/jbc.M109.025353)
Petersen, O. H.et al. 2009. Fatty acids, alcohol and fatty acid ethyl esters: Toxic Ca2+ signal generation and pancreatitis. Cell Calcium 45(6), pp. 634-642. (10.1016/j.ceca.2009.02.005)
Gerasimenko, J. V.et al. 2009. Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 106(26), pp. 10758-10763. (10.1073/pnas.0904818106)
Criddle, D. N.et al. 2009. Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 297(6), pp. G1085-G1092. (10.1152/ajpgi.00119.2009)
Walsh, C.et al. 2009. Modulation of calcium signalling by mitochondria. Biochimica et Biophysica Acta-Bioenergetics 1787(11), pp. 1374-1382. (10.1016/j.bbabio.2009.01.007)

2008

Kaneko, A. and Petersen, O. H. 2008. The International Union of Physiological Sciences IUPS Editorial VI [Editorial]. Physiology 23(6), pp. 308-309. (10.1152/physiol.00027.2008)
Mukherjee, R.et al. 2008. Corrigendum to “Mitochondrial injury in pancreatitis” [Cell Calcium 44 (1) (2008) 14–23]. Cell Calcium 44(5), pp. 520. (10.1016/j.ceca.2008.07.001)
Kaneko, A. and Petersen, O. H. 2008. The International Union of Physiological Sciences IUPS Editorial V [Editorial]. Physiology 23(3), pp. 126-127. (10.1152/physiol.00012.2008)
Sutton, R. D., Petersen, O. H. and Pandol, S. J. 2008. Pancreatitis and Calcium Signalling: Report of an International Workshop. Pancreas 36(4), pp. e1-e14. (10.1097/MPA.0b013e3181675010)
Barrow, S. L.et al. 2008. ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Archiv - European Journal of Physiology 455(6), pp. 1025-1039. (10.1007/s00424-007-0360-x)
Chvanov, M.et al. 2008. ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflugers Archiv-European Journal of Physiology 457(2), pp. 505-517. (10.1007/s00424-008-0529-y)
Petersen, O. H. 2008. Ca2+-induced pancreatic cell death: Roles of the endoplasmic reticulum, zymogen granules, lysosomes and endosomes. Journal of Gastroenterology and Hepatology 23(S1), pp. S31-S36. (10.1111/j.1440-1746.2007.05281.x)
Murphy, J. A.et al. 2008. Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135(2), pp. 632-641. (10.1053/j.gastro.2008.05.026)
Park, M. K.et al. 2008. The endoplasmic reticulum as an integrator of multiple dendritic events. Neuroscientist 14(1), pp. 68-77. (10.1177/1073858407305691)
Mukheriee, R.et al. 2008. Mitochondrial injury in pancreatitis. Cell Calcium 44(1), pp. 14-23. (10.1016/j.ceca.2007.11.013)
Petersen, O. H. and Tepikin, A. V. 2008. Polarized calcium signaling in exocrine gland cells. Annual Review of Physiology 70, pp. 273-299. (10.1146/annurev.physiol.70.113006.100618)

2007

Kaneko, A. and Petersen, O. H. 2007. The International Union of Physiological Sciences IUPS Editorial IV [Editorial]. Physiology 22(6), pp. 354. (10.1152/physiol.00038.2007)
Criddle, D. N.et al. 2007. The pancreas misled: signals to pancreatitis. Pancreatology 7(5-6), pp. 436-446. (10.1159/000108960)
Kaneko, A. and Petersen, O. H. 2007. The International Union of Physiological Sciences IUPS Editorial III [Editorial]. Physiology 22(3), pp. 156-157. (10.1152/physiol.00013.2007)
Voronina, S. G.et al. 2007. Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran-bound indicator: endocytic and nonendocytic vacuoles. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(6), pp. G1333-G1338. (10.1152/ajpgi.00275.2007)
Petersen, O. H. and Verkhratsky, A. 2007. Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells. Cell Calcium 42(4-5), pp. 373-378. (10.1016/j.ceca.2007.05.012)
Baumgartner, H. K.et al. 2007. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(1), pp. G296-G307. (10.1152/ajpgi.00103.2007)
Criddle, D. N.et al. 2007. Calcium signalling and pancreatic cell death: apoptosis or necrosis?. Cell Death and Differentiation 14(7), pp. 1285-1294. (10.1038/sj.cdd.4402150)
Nicotera, P.et al. 2007. Janus a god with two faces: death and survival utilise same mechanisms conserved by evolution. Cell Death and Differentiation 14(7), pp. 1235-1236. (10.1038/sj.cdd.4402161)
Sherwood, M. W.et al. 2007. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 104(13), pp. 5674-5679. (10.1073/pnas.0700951104)
Barrow, S. L.et al. 2007. ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflugers Archiv-European Journal of Physiology 455(6), pp. 1025-1039. (10.1007/s00424-007-0360-x)

2006

Criddle, D. N.et al. 2006. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. Journal of Biological Chemistry 281(52), pp. 40485-40492. (10.1074/jbc.M607704200)
Criddle, D. N., Sutton, R. and Petersen, O. H. 2006. Role of Ca2+ in pancreatic cell death induced by alcohol metabolites. Journal of Gastroenterology and Hepatology 21(Sup.s3), pp. S14-S17. (10.1111/j.1440-1746.2006.04577.x)
Petersen, O. H. 2006. The FEPS Inaugural Lecture – Bristol 2005 [Editorial]. Acta Physiologica 187(3), pp. 353. (10.1111/j.1748-1716.2006.01572.x)
Criddle, D. N.et al. 2006. Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis. Gastroenterology 130(3), pp. 781-793. (10.1053/j.gastro.2005.12.031)
Kaneko, A. and Petersen, O. H. 2006. The International Union of Physiological Sciences: IUPS Editorial [Editorial]. Physiology 21(1), pp. 2. (10.1152/physiol.00061.2005)
Petersen, O. H. and Sutton, R. 2006. Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee. Trends in Pharmacological Sciences 27(2), pp. 113-120. (10.1016/j.tips.2005.12.006)
Gerasimenko, J. V.et al. 2006. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. Journal of Biological Chemistry 281(52), pp. 40154-40163. (10.1074/jbc.M606402200)
Verkhratsky, A., Krishtal, O. A. and Petersen, O. H. 2006. From Galvani to patch clamp: the development of electrophysiology. Pflugers Archiv European Journal of Physiology 453(3), pp. 233-247. (10.1007/s00424-006-0169-z)
Petersen, O. H., Sutton, R. and Criddle, D. N. 2006. Failure of calcium microdomain generation and pathological consequences. Cell Calcium 40(5-6), pp. 593-600. (10.1016/j.ceca.2006.08.020)
Menteyne, A.et al. 2006. Generation of Specific Ca2+ Signals from Ca2+ Stores and Endocytosis by Differential Coupling to Messengers. Current Biology 16(19), pp. 1931-1937. (10.1016/j.cub.2006.07.070)
Chvanov, M.et al. 2006. Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO Journal 25(13), pp. 3024. (10.1038/sj.emboj.7601207)
Gerasimenko, J. V.et al. 2006. NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. Journal of Cell Science 119(2), pp. 226-238. (10.1242/jcs.02721)

2005

Chvanov, M., Petersen, O. H. and Tepikin, A. 2005. Free radicals and the pancreatic acinar cells: role in physiology and pathology. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360(1464), pp. 2273-2284. (10.1098/rstb.2005.1757)
Petersen, O. H., Spat, A. and Verkhratsky, A. 2005. Introduction: reactive oxygen species in health and disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360(1464), pp. 2197-2199. (10.1098/rstb.2005.1776)
Dolman, N. J.et al. 2005. Stable Golgi-mitochondria complexes and formation of Golgi Ca2+ gradients in pancreatic acinar cells. Journal of Biological Chemistry 280(16), pp. 15794-15799. (10.1074/jbc.M412694200)
Knot, H. J.et al. 2005. Twenty years of calcium imaging: cell physiology to dye for. Molecular Interventions 5(2), pp. 112-127. (10.1124/mi.5.2.8)
Voronina, S. G.et al. 2005. Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration. Journal of Biological Chemistry 280(3), pp. 1764-1770. (10.1074/jbc.M410230200)
Burdakov, D., Petersen, O. H. and Verkhratsky, A. 2005. Intraluminal calcium as a primary regulator of endoplasmic reticulum function. Cell Calcium 38(3-4), pp. 303-310. (10.1016/j.ceca.2005.06.010)
Petersen, O. H., Michalak, M. and Verkhratsky, A. 2005. Calcium signalling: past, present and future. Cell Calcium 38(3-4), pp. 161-169. (10.1016/j.ceca.2005.06.023)
Petersen, O. H. 2005. Ca2+ signalling and Ca2+-activated ion channels in exocrine acinar cells. Cell Calcium 38(3-4), pp. 171-200. (10.1016/j.ceca.2005.06.024)
Galione, A. and Petersen, O. H. 2005. The NAADP receptor: new receptors or new regulation?. Molecular Interventions 5(2), pp. 73-79. (10.1124/mi.5.2.4)

2004

Criddle, D. N.et al. 2004. Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites. Proceedings of the National Academy of Sciences of the United States of America 101(29), pp. 10738-10743. (10.1073/pnas.0403431101)
Voronina, S. G.et al. 2004. Effects of secretagogues and gile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating ΔΨm. Journal of Biological Chemistry 279(26), pp. 27327-27338. (10.1074/jbc.M311698200)
Park, M. K., Lee, M. and Petersen, O. H. 2004. Morphological and functional changes of dissociated single pancreatic acinar cells: testing the suitability of the single cell as a model for exocytosis and calcium signaling. Cell Calcium 35(4), pp. 367-379. (10.1016/j.ceca.2003.10.003)
Petersen, O. H. 2004. Local and global Ca2+ signals: physiology and pathophysiology. Biological Research 37(4), pp. 661-664.
Yano, K., Petersen, O. H. and Tepikin, A. V. 2004. Dual sensitivity of sarcoplasmic/endoplasmic Ca2+-ATPase to cytosolic and endoplasmic reticulum Ca2+ as a mechanism of modulating cytosolic Ca2+ oscillations. Biochemical Journal 383(2), pp. 353-360. (10.1042/BJ20040629)

2003

Dolman, N. J., Tepikin, A. and Petersen, O. H. 2003. Generation and modulation of cytosolic Ca2+ signals in pancreatic acinar cells: Techniques and mechanisms. Biochemical Society Transactions 31(5), pp. 947-949.
Gerasimenko, J. V.et al. 2003. NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. Journal of Cell Biology 163(2), pp. 271-282. (10.1083/jcb.200306134)
Johnson, P. R.et al. 2003. Non-uniform distribution of mitochondria in pancreatic acinar cells. Cell and Tissue Research 313(1), pp. 37-45. (10.1007/s00441-003-0741-1)
Ashby, M. C.et al. 2003. Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. Journal of Biological Chemistry 278(23), pp. 20860-20864. (10.1074/jbc.M302599200)
Mogami, H.et al. 2003. Decoding of short-lived Ca2+ influx signals into long term substrate phosphorylation through activation of two distinct classes of protein kinase C. Journal of Biological Chemistry 278(11), pp. 9896-9904. (10.1074/jbc.M210653200)
Gerasimenko, O. V.et al. 2003. Calcium signalling in and around the nuclear envelope. Biochemical Society Transactions 31(1), pp. 76-78.
Cancela, J. M., Charpentier, G. and Petersen, O. H. 2003. Co-ordination of Ca2+ signalling in mammalian cells by the new Ca2+-releasing messenger NAADP. Pflugers Archiv: European Journal of Physiology 446(3), pp. 322-327. (10.1007/s00424-003-1035-x)
Petersen, O. H. 2003. FEPS in Nice: a date with the best of European Physiology. Pflugers Archiv European Journal of Physiology 446(2), pp. 285-286. (10.1007/s00424-003-1047-6)
Gerasimenko, J. V.et al. 2003. Calcium signalling in and around the nuclear envelope. Biochemical Society Transactions 31(1), pp. 76-78.
Sutton, R.et al. 2003. Signal transduction, calcium and acute pancreatitis. Pancreatology 3(6), pp. 497-505. (10.1159/000075581)
Petersen, O. H. 2003. Localization and regulation of Ca2+ entry and exit pathways in exocrine gland cells. Cell Calcium 33(5-6), pp. 337-344. (10.1016/S0143-4160(03)00047-2)
Ashby, M. C., Petersen, O. H. and Tepikin, A. V. 2003. Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells. Biochemical Journal 369(3), pp. 441-445. (10.1042/BJ20021039)

2002

Cancela, J. M. and Petersen, O. H. 2002. Regulation of intracellular Ca2+ stores by multiple Ca2+-releasing messengerS. Diabetes 51(Supp 3), pp. S349-S357. (10.2337/diabetes.51.2007.S349)
Petersen, O. H. 2002. Cation channels: homing in on the elusive CAN channels. Current Biology 12(15), pp. R520-R522. (10.1016/S0960-9822(02)01027-8)
Lomax, R. B.et al. 2002. Basal and physiological Ca2+ leak from the endoplasmic reticulum of pancreatic acinar cells: second messenger-activated channels and translocons. Journal of Biological Chemistry 277(29), pp. 26479-26485. (10.1074/jbc.M201845200)
Verkhratsky, A. and Petersen, O. H. 2002. The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death. European Journal of Pharmacology 447(2-3), pp. 141-154. (10.1016/S0014-2999(02)01838-1)
Yu, L.et al. 2002. An N-terminal truncated form of Orp150 Is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import. Journal of Biological Chemistry 277(27), pp. 24538-24545. (10.1074/jbc.M203550200)
Park, M., Tepikin, A. V. and Petersen, O. H. 2002. What can we learn about cell signalling by combining optical imaging and patch clamp techniques?. Pflugers Archiv: European Journal of Physiology 444(3), pp. 305-316. (10.1007/s00424-002-0832-y)
Voronina, S.et al. 2002. Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. The Journal of Physiology 540(1), pp. 49-55. (10.1113/jphysiol.2002.017525)
Cancela, J. M.et al. 2002. Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers. EMBO Journal 21(5), pp. 909-919. (10.1093/emboj/21.5.909)
Gerasimenko, J. V.et al. 2002. Menadione-induced apoptosis: Roles of cytosolic Ca2+ elevations and the mitochondrial permeability transition pore. Journal of Cell Science 115, pp. 485-497.
Voronina, S.et al. 2002. Correlation of NADH and Ca2+ signals in mouse pancreatic acinar cells. The Journal of Physiology 539(1), pp. 41-52. (10.1113/jphysiol.2001.013134)
Ashby, M. C.et al. 2002. Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves. Journal of cell biology 158(2), pp. 283-292.
Petersen, O. H. and Burdakova, N. 2002. The specificity of Ca 2+ signalling.. Acta Physiologica Hungarica 89(4), pp. 439-450. (10.1556/APhysiol.89.2002.4.4)
Gerasimenko, O. V.et al. 2002. The distribution of the endoplasmic reticulum in living pancreatic acinar cells. Cell Calcium 32(5-6), pp. 261-268. (10.1016/S0143416002001938)
Bootman, M. D., Petersen, O. H. and Verkhratsky, A. 2002. The endoplasmic reticulum is a focal point for co-ordination of cellular activity. Cell Calcium 32(5-6), pp. 231-234. (10.1016/S0143416002002002)
Camello, C.et al. 2002. Calcium leak from intracellular stores - the enigma of calcium signalling. Cell Calcium 32(5-6), pp. 355-361. (10.1016/S0143416002001926)

2001

Petersen, O. H. 2001. Letter from The President. Pflugers Archiv: European Journal of Physiology 443(2), pp. 331-332. (10.1007/s004240100692)
Park, M. K.et al. 2001. Local uncaging of caged Ca2+ reveals distribution of Ca2+-activated Cl- channels in pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 98(19), pp. 10948-10953. (10.1073/pnas.181353798)
Petersen, O. H. and Fedirko, N. V. 2001. Calcium signalling: store-operated channel found at last. Current Biology 11(13), pp. R520-R523. (10.1016/S0960-9822(01)00309-8)
Petersen, O. H., Tepikin, A. and Park, M. K. 2001. The endoplasmic reticulum: one continuous or several separate Ca2+ stores?. Trends in Neurosciences 24(5), pp. 271-276. (10.1016/S0166-2236(00)01787-2)
Burdakov, D., Cancela, J. M. and Petersen, O. H. 2001. Bombesin-induced cytosolic Ca2+spiking in pancreatic acinar cells depends on cyclic ADP-ribose and ryanodine receptors. Cell Calcium 29(3), pp. 211-216. (10.1054/ceca.2000.0188)
Petersen, O. H. 2001. Physiologists, physiology departments and universities: discipline and interdisciplinarity. Pflugers Archiv: European Journal of Physiology 441(5), pp. 725-727. (10.1007/s004240000477)
Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2001. Membrane repair: Ca2+-elicited lysosomal exocytosis. Current Biology 11(23), pp. R971-R974. (10.1016/S0960-9822(01)00577-2)
Park, M. K.et al. 2001. Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport. EMBO Journal 20(8), pp. 1863-1874. (10.1093/emboj/20.8.1863)

2000

Raraty, M.et al. 2000. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 97(24), pp. 13126-13131. (10.1073/pnas.97.24.13126)
Cansela, J. M.et al. 2000. Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate. Embo Journal 19(11), pp. 2549-2557. (10.1093/emboj/19.11.2549)
Petersen, O. H. and Cancela, J. M. 2000. Nerve guidance: Attraction or repulsion by local Ca2+ signals. Current Biology 10(8), pp. R311-R314. (10.1016/S0960-9822(00)00438-3)
Park, M. K., Petersen, O. H. and Tepikin, A. V. 2000. The endoplasmic reticulum as one continuous Ca2+ pool: Visualization of rapid Ca2+ movements and equilibration. Embo Journal 19(21), pp. 5587-5941. (10.1093/emboj/19.21.5729)
Petersen, O. H. 2000. The functional organisation of calcium signalling in exocrine acinar cells. Journal of Korean Medical Science 15, pp. S44-S45. (10.3346/jkms.2000.15.S.S44)

I pioneered, with Yoshio Maruyama, patch clamp single channel and whole-cell current recordings in epithelial cells. We discovered hormone-evoked, messenger-mediated ion channel activation (Maruyama & Petersen Nature 1982a,b), voltage-activation of epithelial ion channels (Maruyama et al Nature 1983a,b) and integrated these data into the first model of how ion channels control exocrine fluid secretion (Petersen & Maruyama Nature 1984 [ISI [WoS] Citation Classic]; Petersen J Physiol 1992). I discovered sub-cellular Ca²⁺ spiking in epithelial cells (Wakui et al Nature 1989, Cell 1990; Thorn et al Cell 1993), messenger-mediated Ca²⁺ release from the nuclear envelope (Gerasimenko et al Cell 1995) as well as the secretory granules (Gerasimenko et al Cell 1996) and intracellular Ca²⁺ tunnels (Mogami et al Cell1997). Together with Oleg and Julia Gerasimenko, we demonstrated the crucial role of Ca²⁺ release channels and store-operated Ca²⁺ entry in Acute Pancreatitis (Raraty et al PNAS 2000; Gerasimenko et al PNAS 2009; 2011), provided proof-of-principle for Ca²⁺ release-activated Ca²⁺ (CRAC) channel blockade as a treatment of severe Acute Pancreatitis (Gerasimenko et al PNAS 2013; J Physiol 2014) and discovered a critical role for pancreatic stellate cells in this disease (Ferdek et al J Physiol 2016; Gryshchenko et al J Physiol 2016,2018).

We continue our work to define the precise intra- and inter-cellular mechanisms driving the important human disease Acute Pancreatitis and to identify the optimal pharmacological intervention points that could prevent and/or cure this disease.

In addition to my primary research work, I am also heavily involved in the European Union’s Scientific Advice Mechanism. As Vice-President of Academia Europaea, I am a member of the Board of SAPEA (Science Advice for Policy by European Academies), a Horizon 2020 funded (Euro 6 million) project. The purpose is to provide and publish Evidence Review Reports to inform and underpin the Scientific Opinions of the European Commission’s High Level Group of Science Advisors in response to questions from the Commissioners. Academia Europaea is one of the 5 European networks comprising SAPEA and the work of Academia Europaea in this respect is largely conducted by Cardiff University’s Academia Europaea Knowledge Hub. I am the Director of the Knowledge Hub (located in the Hadyn Ellis Building), which currently employs 3 full time staff funded partly by the European Commission and partly by Cardiff University. In 2017 the Cardiff Hub co-ordinated and led the work on the very first SAPEA Evidence Review Report on ‘Food from the Oceans’ which was formally presented to the Commission and published at the end of 2017.

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Professor Ole Petersen

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Professor Ole Petersen

Education/Degrees

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A Cardiff University Professor has been rewarded for his ground-breaking research, which has contributed significantly to the field of physiology and pathophysiology.

Report led by University-based Academia Europaea hub handed to European Commission

Professor Ole Petersen from Cardiff University has been recognised for his groundbreaking work.