Professor Ole Petersen

CBE FRS

Director of the Cardiff University - Academia Europaea Knowledge Hub

: petersenoh@cardiff.ac.uk
: +44 (0)29 2068 8249
: Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX

PRIMARY RESEARCH:

I direct a research programme investigating the role of calcium ions in the pathophysiology of Acute Pancreatitis. We have recently published a substantial article summarizing and reviewing our work over the last 20 years on the physiology of the exocrine pancreas and the pathophysiology of Acute Pancreatitis. This article also presents an entirely new concept of the development of this often fatal disease that has important therapeutic implications:

Petersen OH, Gerasimenko JV, Gerasimenko OV, Gryshchenko O, Peng S (2021). The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas. Physiol Rev 101: 1691- 1744.

https://doi.org/10.1152/physrev.00003.2021

Latest news: The International Association of Pancreatology (IAP) will present me with the 2022 IAP Palade Prize (named after the Nobel Laureate George Palade) at the Joint IAP - JPS (Japanese Pancreatic Society) Conference, to be held at the Kyoto International Conference Center, 7-9 July 2022, at which I'll also deliver the State-of-the-Art Award Lecture.

My current (March 2022) h-index is 101 (Google Scholar) or 92 (Web of Science)

SCIENCE ADVICE:

I am also Academic Director of the Cardiff University - Academia Europaea Knowledge Hub

https://aecardiffknowledgehub.wales

and, as Vice-President of Academia Europaea, in charge of the Hub's work in SAPEA (Science Advice for Policy by European Academies), which is an important part of the European Commission's Scientific Advice Mechanism

https://www.sapea.info

EDITORIAL WORK:

I am Editor-in-Chief of the American Physiological Society's new Open Access journal Function, published in partnership with Oxford University Press

https://academic.oup.com/function

Education/Degrees

Medical student, University of Copenhagen 1961 – 1969

Cand. Med. (Laudabilis) (MB ChB) University of Copenhagen, 1969

Authorized Medical Practitioner (Danish State Health Authority) 1969

Dr. med. (MD) University of Copenhagen, 1972, for thesis “Acetylcholine-induced ion transports involved in the formation of saliva” (Thesis published as Supplement 381 in Acta physiol scand [now Acta Physiologica] 1972)

Posts held

Lecturer, Institute of Medical Physiology, University of Copenhagen, 1969-73

Wellcome-Carlsberg Travelling Research Fellow, Department of Pharmacology, University of Cambridge, UK, 1971-72 (on leave of absence from University of Copenhagen)

Senior Lecturer, Institute of Medical Physiology, University of Copenhagen, Denmark, 1973-78

Symers Professor of Physiology and Head of the Department of Physiology, University of Dundee, Scotland, 1975-81 (on leave of absence from University of Copenhagen 1975-78).

Head of the Department of Physiology, University of Liverpool, 1981-1998

George Holt Professor of Physiology, University of Liverpool, England, 1981- 2009

Director (Head) of Cardiff University’s School of Biosciences, 2010 - 2015

Professor at Cardiff School of Biosciences, 2010 –

Elections to Fellow or Member of Academies (Societies) of Science or Medicine

Fellow of the Royal Society (FRS). Elected 2000. Vice-President 2005-2006.

Member of the German National Academy of Sciences Leopoldina (ML). Elected 2010.

Honorary Member of the Hungarian Academy of Sciences. Elected 2004.

Member of the Royal Danish Academy of Sciences and Letters. Elected 1988.

Fellow of the Academy of Medical Sciences (FMedSci). Founding Member 1998.

Member of Academia Europaea (MAE). Founding Member 1988. Vice-President 2015 -

Fellow of the Learned Society of Wales (FLSW). Elected 2011. Vice-President 2014 - 2018.

Fellow of the Royal College of Physicians (FRCP). Elected 2001.

Honorary Member of the German Society for Gastroenterology, Digestive and Metabolic Diseases. Elected 2017.

Honorary Member of The Physiological Society. Elected 2015. President 2006 - 2008.

Honorary Member of the Hungarian Physiological Society. Elected 2002.

Honorary Member of the Polish Physiological Society. Elected 1993.

National Honour

Commander of the Order of the British Empire (CBE) for 'Services to Science'. Award received personally from Queen Elizabeth II, at Buckingham Palace, 7th May 2008.

Awards and Keynote Lectures (Selection)

The International Association of Pancreatology's (IAP) 2022 Palade Prize. Award Lecture to be delivered at the Joint Conference of IAP and the Japanese Pancreatic Society, to be held at the Kyoto International Conference Center, Kyoto, Japan, 7-9 July 2022

Fellow of the International Union of Physiological Sciences (IUPS) and Inaugural Member (one of thirty worldwide) of the IUPS Academy of Physiology, 2021

The Inaugural Sir Michael Berridge Memorial Lecture, FASEB Calcium and Cell Function Conference (virtual), 26th October 2021.

Academia Europaea's 2020 Gold Medal Award. The Gold Medal was received from the President of Academia Europaea, and the Award Lecture ‘Science, scientific publishing and scientific advice for policy: 50 years of personal experiences’ was delivered, in person, at the Academy's 32nd Annual Conference in Barcelona on 20th October 2021. Published in European Review (doi: 10.1017/S1062798722000084)

Honorary Professor at Jinan University, Guangzhou, China. A series of 4 lectures delivered in Guangzhou in March 2019.

The American Physiological Society's 2018 Walter B Cannon Award. Plenary Award Lecture delivered at Experimental Biology (EB), San Diego Convention Center, California, 22nd April 2018. Published in Physiological Reviews 101: 1691-1744, 2021

Opening Plenary Lecture at the 2013 Annual Congress of the Brazilian Society of Physiology. Rebeirao Preto, Sao Paulo, 7th September 2013

The American Physiological Society's Horace W Davenport Distinguished Lecture. Experimental Biology (EB), Boston, Massachusetts, 23rd April 2013.

The 2012 Leopoldina Lecture. Delivered at the German National Academy of Sciences Leopoldina, Halle on 23rd May 2012.

Lifetime Achievement Award. European Pancreatic Club (EPC). Award lecture delivered at the EPC's Annual Meeting, Stockholm, 17th June 2010.

Plenary Keynote Lecture at Annual Meeting of the Korean Physiological Society, Gagneung, South Korea, 30th October 2009.

Opening Plenary Lecture at Beijing Joint Conference of Physiological Sciences 2008. Beijing 20th October 2008.

The Plenary Keynote Lecture at 82nd Annual Conference of the Physiological Society of Japan, Sendai, May 2005.

Purkyne Honorary Medal for 'Merit in the Biological Sciences' from the Academy of Sciences of the Czech Republic. 2003.

The Keynote Lecture at Gordon Research Conference in Calcium Signaling, South Hadley, Massachusetts, July 2003.

2022

Petersen, O. H. and Verkhratsky, A. 2022. The responsibility of scientists in a time of war. Function 3(3), article number: zqac023. (10.1093/function/zqac023)
Petersen, O. H. 2022. Ups and downs of science during a tumultuous period of history: a personal perspective. European Review (10.1017/S1062798722000084)
Ocskay, K. et al. 2022. Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (REAPPEAR): protocol of a randomised controlled trial and a cohort study. BMJ Open 12(1), article number: e050821. (10.1136/bmjopen-2021-050821)
Petersen, O. H. 2022. Is CD38 involved in Ca2+ signalling elicited by activation of T cell receptors?. Cell Calcium 101, article number: 102524. (10.1016/j.ceca.2021.102524)
Gerasimenko, J. V., Petersen, O. H. and Gerasimenko, O. V. 2022. SARS-CoV-2 S Protein Subunit 1 Elicits Ca2+ Influx – Dependent Ca2+ Signals in Pancreatic Stellate Cells and Macrophages In Situ. Function 3(2) (10.1093/function/zqac002)

2021

Petersen, O. H., Gerasimenko, J., Gerasimenko, O. V., Gryshchenko, O. and Peng, S. 2021. The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas. Physiological Reviews 101(4), pp. 1691-1744. (10.1152/physrev.00003.2021)

2020

Gryshchenko, O., Gerasimenko, J., Petersen, O. H. and Gerasimenko, O. V. 2020. Calcium signaling in pancreatic immune cells in situ. Function 2(1), article number: zqaa026. (10.1093/function/zqaa026)
Ferdek, P. E., Jakubowska, M. A., Huang, W. and Petersen, O. H. 2020. Editorial: spotlight on the background actors - physiology and pathophysiology of supporting, accessory and less common cell types in the gastrointestinal tract. Frontiers in Physiology 11, article number: 766. (10.3389/fphys.2020.00766)
Hegyi, P. et al. 2020. Academia Europaea position paper on translational medicine: the cycle model for translating scientific results into community benefits. Journal of Clinical Medicine 9(5), article number: 1532. (10.3390/jcm9051532)
Petersen, O. H. 2020. FUNCTION is now functional. Function 1(1), article number: zqaa001. (10.1093/function/zqaa001)
Zádori, N. et al. 2020. EarLy Elimination of Fatty Acids iN hypertriglyceridemia-induced acuTe pancreatitis (ELEFANT trial): protocol of an open-label, multicenter, adaptive randomized clinical trial. Pancreatology 20(3), pp. 369-376. (10.1016/j.pan.2019.12.018)
Koncz, B. et al. 2020. LIFEStyle, prevention and risk of Acute PaNcreatitis (LIFESPAN): protocol of a multicentre and multinational observational case-control study. BMJ Open 10(1), article number: e029660. (10.1136/bmjopen-2019-029660)
Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2020. Endocytic uptake of SARS-CoV-2: the critical roles of pH, Ca2+ and NAADP. Function 1(1), article number: zqaa003. (10.1093/function/zqaa003)

2019

Jakubowska, M. A. et al. 2019. ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells. British Journal of Pharmacology 176(22), pp. 4402-4415. (10.1111/bph.14505)
Peng, S. and Petersen, O. H. 2019. One or two Ca2+ stores in the neuronal endoplasmic reticulum?. Trends in Neurosciences 42(11), pp. 755-757. (10.1016/j.tins.2019.09.003)
Mikó, A. et al. 2019. Observational longitudinal multicentre investigation of acute pancreatitis (GOULASH PLUS): follow-up of the GOULASH study, protocol. BMJ Open 9(8), article number: e025500. (10.1136/bmjopen-2018-025500)
Levente, K. et al. 2019. Endoscopic sphincterotomy for delaying choLecystectomy in mild acute biliarY pancreatitis (EMILY study): Protocol of a multicentre randomised clinical trial. BMJ Open 9, article number: e025551. (10.1136/bmjopen-2018-025551)
Petersen, O. H. 2019. Reproducibility - again. Journal of Physiology 597(3), pp. 657-658. (10.1113/JP277486)

2018

Peng, S., Gerasimenko, J. V., Tsugorka, T. M., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2018. Galactose protects against cell damage in mouse models of acute pancreatitis. Journal of Clinical Investigation 128(9), pp. 3769-3778. (10.1172/JCI94714)
Gryshchenko, O., Gerasimenko, J., Peng, S., Gerasimenko, O. V. and Petersen, O. H. 2018. Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology. Journal of Physiology 596(14), pp. 2663-2678. (10.1113/JP275395)
Vervliet, T., Gerasimenko, J. V., Ferdek, P. E., Jakubowska, M. A., Petersen, O. H., Gerasimenko, O. V. and Bultynck, G. 2018. BH4 domain peptides derived from Bcl-2/Bcl-XL as novel tools against acute pancreatitis. Cell Death Discovery 4, article number: 58. (10.1038/s41420-018-0054-5)

2017

Márta, K. et al. 2017. High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial. BMJ Open 7(9), pp. e015874. (10.1136/bmjopen-2017-015874)
Petersen, O. H., Courjaret, R. and Machaca, K. 2017. Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites. The Journal of Physiology 595(10), pp. 2999-3014. (10.1113/JP272772)
Petersen, O. 2017. The effects of Ca2+ buffers on cytosolic Ca2+ signalling. The Journal of Physiology 595(10), pp. 3107-3108. (10.1113/JP273852)
Ferdek, P. E., Jakubowska, M. A., Polina, N., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2017. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell Death and Disease 8, article number: e2640. (10.1038/cddis.2017.41)

2016

Ferdek, P. E., Jakubowska, M. A., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Bile acids induce necrosis in pancreatic stellate cells dependent on calcium entry and sodium-driven bile uptake. Journal of Physiology 594(21), pp. 6147-6164. (10.1113/JP272774)
Peng, S., Gerasimenko, J. V., Tsugorka, T., Gryshchenko, O., Samarasinghe, S., Petersen, O. H. and Gerasimenko, O. V. 2016. Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 371(1700), article number: 20150423. (10.1098/rstb.2015.0423)
Jakubowska, M. A., Ferdek, P. E., Gerasimenko, O. V., Gerasimenko, J. V. and Petersen, O. H. 2016. Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation. Open Biology 6(8), article number: 160149. (10.1098/rsob.160149)
Mukherjee, R. et al. 2016. Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP. Gut 65(8), pp. 1333-1346. (10.1136/gutjnl-2014-308553)
Petersen, O. and Verkhratsky, A. 2016. Calcium and ATP control multiple vital functions. Philosophical Transactions of the Royal Society B: Biological Sciences 371(1700), pp. 20150418., article number: 20150418. (10.1098/rstb.2015.0418)
Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Calcium signalling in pancreatic stellate cells: mechanisms and potential roles. Cell Calcium 59(2-3), pp. 140-144. (10.1016/j.ceca.2016.02.003)
Gryshchenko, O., Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2016. Ca2+ signals mediated by bradykinin type 2 receptors in normal pancreatic stellate cells can be inhibited by specific Ca2+ channel blockade. Journal of Physiology 594(2), pp. 281-293. (10.1113/JP271468)

2015

Huang, W. et al. 2015. Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca 2+ release. Gut 66(2), pp. 301-313. (10.1136/gutjnl-2015-309363)
Petersen, O. H. 2015. Ca2+ signalling in the endoplasmic reticulum/secretory granule microdomain. Cell Calcium 58(4), pp. 397-404. (10.1016/j.ceca.2015.01.006)
Gerasimenko, J. et al. 2015. Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release. Cell Calcium 58(3), pp. 237-245. (10.1016/j.ceca.2015.05.005)

2014

Petersen, O. H. 2014. Calcium signalling and secretory epithelia. Cell Calcium 55(6), pp. 282-289. (10.1016/j.ceca.2014.01.003)
Gerasimenko, J. V., Petersen, O. H. and Gerasimenko, O. V. 2014. Monitoring of intra-ER free Ca2+. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 3(3), pp. 63-71. (10.1002/wmts.106)
Petersen, O. H. 2014. Can specific calcium channel blockade be the basis for a drug-based treatment of acute pancreatitis?. Expert Review of Gastroenterology & Hepatology 8(4), pp. 339-341. (10.1586/17474124.2014.896192)
Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2014. The role of Ca2+ in the pathophysiology of pancreatitis. The Journal of Physiology 592(2), pp. 269-280. (10.1113/jphysiol.2013.261784)
Huang, W. et al. 2014. Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis. Gut 63(8), pp. 1313-1324. (10.1136/gutjnl-2012-304058)

2013

Gerasimenko, J. V. et al. 2013. Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proceedings of the National Academy of Sciences of the United States of America 110(32), pp. 13186-13191. (10.1073/pnas.1300910110)
Heygi, P. and Petersen, O. 2013. The exocrine pancreas: the acinar-ductal tango in physiology and pathophysiology. In: Nilius, B. et al. eds. Reviews of Physiology, Biochemistry and Pharmacology., Vol. 165. Cham, Switzerland: Springer Verlag, pp. 1-30., (10.1007/112_2013_14)

2012

Ferdek, P., Gerasimenko, J. V., Peng, S., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2012. A novel role for Bcl-2 in regulation of cellular calcium extrusion. Current Biology 22(13), pp. 1241-1246. (10.1016/j.cub.2012.05.002)
Gerasimenko, O. V., Petersen, O. H. and Gerasimenko, J. V. 2012. Role of intracellular acid Ca2+ stores in pathological pancreatic protease activation [Editorial]. Expert Review of Gastroenterology & Hepatology 6(2), pp. 129-131. (10.1586/EGH.12.5)
Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2012. The war within - unraveling the molecular causes of acute pancreatitis - a potentially deadly disease in which the pancreas essentially digests itself - is yielding clues to how it might be treated. The Scientist 26(2), pp. 40-44.
Spät, A. and Petersen, O. H. 2012. A special issue on the cell-specific roles of mitochondrial Ca2+ handling [Editorial]. Pflugers Archiv European Journal of Physiology 464(1), pp. 1-2. (10.1007/s00424-012-1123-x)
Petersen, O. H. 2012. Specific mitochondrial functions in separate sub-cellular domains of pancreatic acinar cells. Pflugers Archiv European Journal of Physiology 464(1), pp. 77-87. (10.1007/s00424-012-1099-6)

2011

Petersen, O. H., Gerasimenko, O. V., Tepikin, A. and Gerasimenko, J. V. 2011. Aberrant Ca2+ signalling through acidic calcium stores in pancreatic acinar cells. Cell Calcium 50(2), pp. 193-199. (10.1016/j.ceca.2011.02.010)
Petersen, O. H., Gerasimenko, O. V. and Gerasimenko, J. V. 2011. Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000 Medicine Reports(3), article number: 15. (10.3410/M3-15)
Booth, D. et al. 2011. Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140(7), pp. 2116-2125. (10.1053/j.gastro.2011.02.054)
Gerasimenko, J. V. et al. 2011. Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 108(14), pp. 5873-5878. (10.1073/pnas.1016534108)
Lur, G. et al. 2011. InsP3 receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences. Biochemical Journal 436(2), pp. 231-239. (10.1042/BJ20110083)

2010

Verkhratsky, A. and Petersen, O. H. 2010. Bernd Nilius: The Bard of ion channels. Congratulations on 65th birthday. Pflügers Archiv European Journal of Physiology 460(4), pp. 691-694. (10.1007/s00424-010-0857-6)
Voronina, S. G. et al. 2010. Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138(5), pp. 1976-1987. (10.1053/j.gastro.2010.01.037)
Petersen, O. H. 2010. Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology. Brazilian Journal of Medical and Biological Research 42(1), pp. 9-16.
Chvanov, M., Petersen, O. H. and Tepikin, A. V. 2010. Pharmacologically directed cell disposal: labelling damaged cells for phagocytosis as a strategy against acute pancreatitis. Molecular Interventions 10(2), pp. 80-85. (10.1124/mi.10.2.9)
Walsh, C. M., Chvanov, M., Haynes, L. P., Petersen, O. H., Tepikin, A. V. and Burgoyne, R. D. 2010. Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry. Biochemical Journal 425(1), pp. 159-168. (10.1042/BJ20090884)
Verkhratsky, A. and Petersen, O. H. 2010. Principles of the Ca2+ homeostatic/signalling system. In: Verkhratsky, A. and Petersen, O. H. eds. Calcium Measurement Methods. Neuromethods Vol. 43. New York: Humana Press, pp. 1-11., (10.1007/978-1-60761-476-0_1)
Blum, R., Petersen, O. H. and Verkhratsky, A. 2010. Ca2+ imaging of intracellular organelles: endoplasmic reticulum. In: Verkhratsky, A. and Petersen, O. H. eds. Calcium measurement methods. Neuromethods Vol. 43. New York: Humana Press, pp. 146-167., (10.1007/978-1-60761-476-0_8)
Verkhratsky, A. N. and Petersen, O. H. 2010. Preface. In: Verkhratsky, A. N. and Petersen, O. H. eds. Calcium Measurement Methods. Neuromethods Vol. 43. New York, NY; London: Humana Press, pp. vii-vii.

2009

Petersen, O. H. 2009. The International Union of Physiological Sciences IUPS Editorial VIII [Editorial]. Physiology 24(6), pp. 320-321. (10.1152/physiol.00035.2009)
Lur, G. et al. 2009. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology 19(19), pp. 1648-1653. (10.1016/j.cub.2009.07.072)
Baumgartner, H. K. et al. 2009. Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. Journal of Biological Chemistry 284(31), pp. 20796-20803. (10.1074/jbc.M109.025353)
Petersen, O. H., Tepikin, A. V., Gerasimenko, J. V., Gerasimenko, O. V., Sutton, R. and Criddle, D. N. 2009. Fatty acids, alcohol and fatty acid ethyl esters: Toxic Ca2+ signal generation and pancreatitis. Cell Calcium 45(6), pp. 634-642. (10.1016/j.ceca.2009.02.005)
Gerasimenko, J. V. et al. 2009. Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proceedings of the National Academy of Sciences of the United States of America 106(26), pp. 10758-10763. (10.1073/pnas.0904818106)
Criddle, D. N. et al. 2009. Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 297(6), pp. G1085-G1092. (10.1152/ajpgi.00119.2009)
Walsh, C., Barrow, S., Voronina, S., Chvanov, M., Petersen, O. H. and Tepikin, A. V. 2009. Modulation of calcium signalling by mitochondria. Biochimica et Biophysica Acta-Bioenergetics 1787(11), pp. 1374-1382. (10.1016/j.bbabio.2009.01.007)

2008

Kaneko, A. and Petersen, O. H. 2008. The International Union of Physiological Sciences IUPS Editorial VI [Editorial]. Physiology 23(6), pp. 308-309. (10.1152/physiol.00027.2008)
Mukherjee, R., Criddle, D. N., Gukovskaya, A., Pandol, S., Petersen, O. H. and Sutton, R. 2008. Corrigendum to “Mitochondrial injury in pancreatitis” [Cell Calcium 44 (1) (2008) 14–23]. Cell Calcium 44(5), pp. 520. (10.1016/j.ceca.2008.07.001)
Kaneko, A. and Petersen, O. H. 2008. The International Union of Physiological Sciences IUPS Editorial V [Editorial]. Physiology 23(3), pp. 126-127. (10.1152/physiol.00012.2008)
Sutton, R. D., Petersen, O. H. and Pandol, S. J. 2008. Pancreatitis and Calcium Signalling: Report of an International Workshop. Pancreas 36(4), pp. e1-e14. (10.1097/MPA.0b013e3181675010)
Barrow, S. L. et al. 2008. ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Archiv - European Journal of Physiology 455(6), pp. 1025-1039. (10.1007/s00424-007-0360-x)
Chvanov, M. et al. 2008. ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflugers Archiv-European Journal of Physiology 457(2), pp. 505-517. (10.1007/s00424-008-0529-y)
Petersen, O. H. 2008. Ca2+-induced pancreatic cell death: Roles of the endoplasmic reticulum, zymogen granules, lysosomes and endosomes. Journal of Gastroenterology and Hepatology 23(S1), pp. S31-S36. (10.1111/j.1440-1746.2007.05281.x)
Murphy, J. A. et al. 2008. Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135(2), pp. 632-641. (10.1053/j.gastro.2008.05.026)
Park, M. K., Choi, Y. M., Kang, Y. K. and Petersen, O. H. 2008. The endoplasmic reticulum as an integrator of multiple dendritic events. Neuroscientist 14(1), pp. 68-77. (10.1177/1073858407305691)
Mukheriee, R., Criddle, D. N., Gukvoskaya, A., Pandol, S., Petersen, O. H. and Sutton, R. 2008. Mitochondrial injury in pancreatitis. Cell Calcium 44(1), pp. 14-23. (10.1016/j.ceca.2007.11.013)
Petersen, O. H. and Tepikin, A. V. 2008. Polarized calcium signaling in exocrine gland cells. Annual Review of Physiology 70, pp. 273-299. (10.1146/annurev.physiol.70.113006.100618)

2007

Kaneko, A. and Petersen, O. H. 2007. The International Union of Physiological Sciences IUPS Editorial IV [Editorial]. Physiology 22(6), pp. 354. (10.1152/physiol.00038.2007)
Criddle, D. N., McLaughlin, E., Murphy, J. A., Petersen, O. H. and Sutton, R. 2007. The pancreas misled: signals to pancreatitis. Pancreatology 7(5-6), pp. 436-446. (10.1159/000108960)
Baumgartner, H. K. et al. 2007. Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(1), pp. G296-G307. (10.1152/ajpgi.00103.2007)
Kaneko, A. and Petersen, O. H. 2007. The International Union of Physiological Sciences IUPS Editorial III [Editorial]. Physiology 22(3), pp. 156-157. (10.1152/physiol.00013.2007)
Voronina, S. G., Sherwood, M. W., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2007. Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran-bound indicator: endocytic and nonendocytic vacuoles. American Journal of Physiology-Gastrointestinal and Liver Physiology 293(6), pp. G1333-G1338. (10.1152/ajpgi.00275.2007)
Petersen, O. H. and Verkhratsky, A. 2007. Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells. Cell Calcium 42(4-5), pp. 373-378. (10.1016/j.ceca.2007.05.012)
Criddle, D. N. et al. 2007. Calcium signalling and pancreatic cell death: apoptosis or necrosis?. Cell Death and Differentiation 14(7), pp. 1285-1294. (10.1038/sj.cdd.4402150)
Nicotera, P., Petersen, O. H., Melino, G. and Verkhratsky, A. 2007. Janus a god with two faces: death and survival utilise same mechanisms conserved by evolution. Cell Death and Differentiation 14(7), pp. 1235-1236. (10.1038/sj.cdd.4402161)
Sherwood, M. W. et al. 2007. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 104(13), pp. 5674-5679. (10.1073/pnas.0700951104)

2006

Criddle, D. N. et al. 2006. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. Journal of Biological Chemistry 281(52), pp. 40485-40492. (10.1074/jbc.M607704200)
Criddle, D. N., Sutton, R. and Petersen, O. H. 2006. Role of Ca2+ in pancreatic cell death induced by alcohol metabolites. Journal of Gastroenterology and Hepatology 21(Sup.s3), pp. S14-S17. (10.1111/j.1440-1746.2006.04577.x)
Petersen, O. H. 2006. The FEPS Inaugural Lecture – Bristol 2005 [Editorial]. Acta Physiologica 187(3), pp. 353. (10.1111/j.1748-1716.2006.01572.x)
Criddle, D. N. et al. 2006. Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis. Gastroenterology 130(3), pp. 781-793. (10.1053/j.gastro.2005.12.031)
Petersen, O. H. and Sutton, R. 2006. Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee. Trends in Pharmacological Sciences 27(2), pp. 113-120. (10.1016/j.tips.2005.12.006)
Kaneko, A. and Petersen, O. H. 2006. The International Union of Physiological Sciences: IUPS Editorial [Editorial]. Physiology 21(1), pp. 2. (10.1152/physiol.00061.2005)
Gerasimenko, J. V., Flowerdew, S. E., Voronina, S. G., Sukhomlin, T. K., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2006. Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors. Journal of Biological Chemistry 281(52), pp. 40154-40163. (10.1074/jbc.M606402200)
Verkhratsky, A., Krishtal, O. A. and Petersen, O. H. 2006. From Galvani to patch clamp: the development of electrophysiology. Pflugers Archiv European Journal of Physiology 453(3), pp. 233-247. (10.1007/s00424-006-0169-z)
Petersen, O. H., Sutton, R. and Criddle, D. N. 2006. Failure of calcium microdomain generation and pathological consequences. Cell Calcium 40(5-6), pp. 593-600. (10.1016/j.ceca.2006.08.020)
Menteyne, A., Burdakov, A., Charpentier, G., Petersen, O. H. and Cancela, J. 2006. Generation of Specific Ca2+ Signals from Ca2+ Stores and Endocytosis by Differential Coupling to Messengers. Current Biology 16(19), pp. 1931-1937. (10.1016/j.cub.2006.07.070)
Chvanov, M., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2006. Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO Journal 25(13), pp. 3024. (10.1038/sj.emboj.7601207)
Gerasimenko, J. V., Sherwood, M., Tepikin, A., Petersen, O. H. and Gerasimenko, O. V. 2006. NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. Journal of Cell Science 119(2), pp. 226-238. (10.1242/jcs.02721)

2005

Chvanov, M., Petersen, O. H. and Tepikin, A. 2005. Free radicals and the pancreatic acinar cells: role in physiology and pathology. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360(1464), pp. 2273-2284. (10.1098/rstb.2005.1757)
Petersen, O. H., Spat, A. and Verkhratsky, A. 2005. Introduction: reactive oxygen species in health and disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 360(1464), pp. 2197-2199. (10.1098/rstb.2005.1776)
Dolman, N. J., Gerasimenko, J. V., Gerasimenko, O. V., Voronina, S. G., Petersen, O. H. and Tepikin, A. V. 2005. Stable Golgi-mitochondria complexes and formation of Golgi Ca2+ gradients in pancreatic acinar cells. Journal of Biological Chemistry 280(16), pp. 15794-15799. (10.1074/jbc.M412694200)
Knot, H. J. et al. 2005. Twenty years of calcium imaging: cell physiology to dye for. Molecular Interventions 5(2), pp. 112-127. (10.1124/mi.5.2.8)
Voronina, S. G., Gryshchenko, O. V., Gerasimenko, O. V., Green, A. K., Petersen, O. H. and Tepikini, A. V. 2005. Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration. Journal of Biological Chemistry 280(3), pp. 1764-1770. (10.1074/jbc.M410230200)
Petersen, O. H., Michalak, M. and Verkhratsky, A. 2005. Calcium signalling: past, present and future. Cell Calcium 38(3-4), pp. 161-169. (10.1016/j.ceca.2005.06.023)
Burdakov, D., Petersen, O. H. and Verkhratsky, A. 2005. Intraluminal calcium as a primary regulator of endoplasmic reticulum function. Cell Calcium 38(3-4), pp. 303-310. (10.1016/j.ceca.2005.06.010)
Petersen, O. H. 2005. Ca2+ signalling and Ca2+-activated ion channels in exocrine acinar cells. Cell Calcium 38(3-4), pp. 171-200. (10.1016/j.ceca.2005.06.024)
Galione, A. and Petersen, O. H. 2005. The NAADP receptor: new receptors or new regulation?. Molecular Interventions 5(2), pp. 73-79. (10.1124/mi.5.2.4)

2004

Criddle, D. N., Raraty, M. G. T., Neoptolemos, J. P., Tepikin, A. V., Petersen, O. H. and Sutton, R. 2004. Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites. Proceedings of the National Academy of Sciences of the United States of America 101(29), pp. 10738-10743. (10.1073/pnas.0403431101)
Voronina, S. G., Barrow, S. L., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2004. Effects of secretagogues and gile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating ΔΨm. Journal of Biological Chemistry 279(26), pp. 27327-27338. (10.1074/jbc.M311698200)
Park, M. K., Lee, M. and Petersen, O. H. 2004. Morphological and functional changes of dissociated single pancreatic acinar cells: testing the suitability of the single cell as a model for exocytosis and calcium signaling. Cell Calcium 35(4), pp. 367-379. (10.1016/j.ceca.2003.10.003)
Yano, K., Petersen, O. H. and Tepikin, A. V. 2004. Dual sensitivity of sarcoplasmic/endoplasmic Ca2+-ATPase to cytosolic and endoplasmic reticulum Ca2+ as a mechanism of modulating cytosolic Ca2+ oscillations. Biochemical Journal 383(2), pp. 353-360. (10.1042/BJ20040629)
Petersen, O. H. 2004. Local and global Ca2+ signals: physiology and pathophysiology. Biological Research 37(4), pp. 661-664.

2003

Gerasimenko, J. V., Maruyama, Y., Yano, K., Dolman, N. J., Tepikin, A. V., Petersen, O. H. and Gerasimenko, O. V. 2003. NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. Journal of Cell Biology 163(2), pp. 271-282. (10.1083/jcb.200306134)
Dolman, N. J., Tepikin, A. and Petersen, O. H. 2003. Generation and modulation of cytosolic Ca2+ signals in pancreatic acinar cells: Techniques and mechanisms. Biochemical Society Transactions 31(5), pp. 947-949.
Johnson, P. R., Dolman, N. J., Pope, M., Vaillant, C., Petersen, O. H., Tepikin, A. V. and Erdemli, G. 2003. Non-uniform distribution of mitochondria in pancreatic acinar cells. Cell and Tissue Research 313(1), pp. 37-45. (10.1007/s00441-003-0741-1)
Ashby, M. C., Camello-Almaraz, C., Gerasimenko, O. V., Petersen, O. H. and Tepikin, A. V. 2003. Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. Journal of Biological Chemistry 278(23), pp. 20860-20864. (10.1074/jbc.M302599200)
Mogami, H., Zhang, H., Suzuki, Y., Urano, T., Saito, N., Kojima, I. and Petersen, O. H. 2003. Decoding of short-lived Ca2+ influx signals into long term substrate phosphorylation through activation of two distinct classes of protein kinase C. Journal of Biological Chemistry 278(11), pp. 9896-9904. (10.1074/jbc.M210653200)
Gerasimenko, O. V., Maruyama, Y., Tepikin, A., Petersen, O. H. and Gerasimenko, J. V. 2003. Calcium signalling in and around the nuclear envelope. Biochemical Society Transactions 31(1), pp. 76-78.
Sutton, R., Criddle, D., Raraty, M. G. T., Tepikin, A., Neoptolemos, J. P. and Petersen, O. H. 2003. Signal transduction, calcium and acute pancreatitis. Pancreatology 3(6), pp. 497-505. (10.1159/000075581)
Petersen, O. H. 2003. Localization and regulation of Ca2+ entry and exit pathways in exocrine gland cells. Cell Calcium 33(5-6), pp. 337-344. (10.1016/S0143-4160(03)00047-2)
Ashby, M. C., Petersen, O. H. and Tepikin, A. V. 2003. Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells. Biochemical Journal 369(3), pp. 441-445. (10.1042/BJ20021039)
Cancela, J. M., Charpentier, G. and Petersen, O. H. 2003. Co-ordination of Ca2+ signalling in mammalian cells by the new Ca2+-releasing messenger NAADP. Pflugers Archiv: European Journal of Physiology 446(3), pp. 322-327. (10.1007/s00424-003-1035-x)
Petersen, O. H. 2003. FEPS in Nice: a date with the best of European Physiology. Pflugers Archiv European Journal of Physiology 446(2), pp. 285-286. (10.1007/s00424-003-1047-6)

2002

Cancela, J. M. and Petersen, O. H. 2002. Regulation of intracellular Ca2+ stores by multiple Ca2+-releasing messengerS. Diabetes 51(Supp 3), pp. S349-S357. (10.2337/diabetes.51.2007.S349)
Petersen, O. H. 2002. Cation channels: homing in on the elusive CAN channels. Current Biology 12(15), pp. R520-R522. (10.1016/S0960-9822(02)01027-8)
Lomax, R. B., Camello, C., Van Coppenolle, F., Petersen, O. H. and Tepikin, A. V. 2002. Basal and physiological Ca2+ leak from the endoplasmic reticulum of pancreatic acinar cells: second messenger-activated channels and translocons. Journal of Biological Chemistry 277(29), pp. 26479-26485. (10.1074/jbc.M201845200)
Verkhratsky, A. and Petersen, O. H. 2002. The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death. European Journal of Pharmacology 447(2-3), pp. 141-154. (10.1016/S0014-2999(02)01838-1)
Yu, L. et al. 2002. An N-terminal truncated form of Orp150 Is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import. Journal of Biological Chemistry 277(27), pp. 24538-24545. (10.1074/jbc.M203550200)
Park, M., Tepikin, A. V. and Petersen, O. H. 2002. What can we learn about cell signalling by combining optical imaging and patch clamp techniques?. Pflugers Archiv: European Journal of Physiology 444(3), pp. 305-316. (10.1007/s00424-002-0832-y)
Voronina, S., Longbottom, R., Sutton, R., Petersen, O. H. and Tepikin, A. 2002. Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology. The Journal of Physiology 540(1), pp. 49-55. (10.1113/jphysiol.2002.017525)
Cancela, J. M., Van Coppenolle, F., Galione, A., Tepikin, A. V. and Petersen, O. H. 2002. Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers. EMBO Journal 21(5), pp. 909-919. (10.1093/emboj/21.5.909)
Gerasimenko, J. V., Gerasimenko, O. V., Palejwala, A., Tepikin, A., Petersen, O. H. and Watson, A. J. M. 2002. Menadione-induced apoptosis: Roles of cytosolic Ca2+ elevations and the mitochondrial permeability transition pore. Journal of Cell Science 115, pp. 485-497.
Voronina, S., Sukhomlin, T., Johnson, P. R., Erdemli, G., Petersen, O. H. and Tepikin, A. 2002. Correlation of NADH and Ca2+ signals in mouse pancreatic acinar cells. The Journal of Physiology 539(1), pp. 41-52. (10.1113/jphysiol.2001.013134)
Gerasimenko, O. V., Gerasimenko, J. V., Rizzuto, R. R., Treiman, M., Tepikin, A. V. and Petersen, O. H. 2002. The distribution of the endoplasmic reticulum in living pancreatic acinar cells. Cell Calcium 32(5-6), pp. 261-268. (10.1016/S0143416002001938)
Bootman, M. D., Petersen, O. H. and Verkhratsky, A. 2002. The endoplasmic reticulum is a focal point for co-ordination of cellular activity. Cell Calcium 32(5-6), pp. 231-234. (10.1016/S0143416002002002)
Camello, C., Lomax, R., Petersen, O. H. and Tepikin, A. V. 2002. Calcium leak from intracellular stores - the enigma of calcium signalling. Cell Calcium 32(5-6), pp. 355-361. (10.1016/S0143416002001926)
Ashby, M. C., Craske, M., Park, M. K., Gerasimenko, O. V., Burgoyne, R. D., Petersen, O. H. and Tepikin, A. V. 2002. Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves. Journal of cell biology 158(2), pp. 283-292.
Petersen, O. H. and Burdakova, N. 2002. The specificity of Ca 2+ signalling.. Acta Physiologica Hungarica 89(4), pp. 439-450. (10.1556/APhysiol.89.2002.4.4)

2001

Petersen, O. H. 2001. Letter from The President. Pflugers Archiv: European Journal of Physiology 443(2), pp. 331-332. (10.1007/s004240100692)
Park, M. K., Lomax, R. B., Tepikin, A. V. and Petersen, O. H. 2001. Local uncaging of caged Ca2+ reveals distribution of Ca2+-activated Cl- channels in pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 98(19), pp. 10948-10953. (10.1073/pnas.181353798)
Petersen, O. H. and Fedirko, N. V. 2001. Calcium signalling: store-operated channel found at last. Current Biology 11(13), pp. R520-R523. (10.1016/S0960-9822(01)00309-8)
Petersen, O. H., Tepikin, A. and Park, M. K. 2001. The endoplasmic reticulum: one continuous or several separate Ca2+ stores?. Trends in Neurosciences 24(5), pp. 271-276. (10.1016/S0166-2236(00)01787-2)
Burdakov, D., Cancela, J. M. and Petersen, O. H. 2001. Bombesin-induced cytosolic Ca2+spiking in pancreatic acinar cells depends on cyclic ADP-ribose and ryanodine receptors. Cell Calcium 29(3), pp. 211-216. (10.1054/ceca.2000.0188)
Petersen, O. H. 2001. Physiologists, physiology departments and universities: discipline and interdisciplinarity. Pflugers Archiv: European Journal of Physiology 441(5), pp. 725-727. (10.1007/s004240000477)
Gerasimenko, J. V., Gerasimenko, O. V. and Petersen, O. H. 2001. Membrane repair: Ca2+-elicited lysosomal exocytosis. Current Biology 11(23), pp. R971-R974. (10.1016/S0960-9822(01)00577-2)
Park, M. K., Ashby, M. C., Erdemli, G., Petersen, O. H. and Tepikin, A. V. 2001. Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport. EMBO Journal 20(8), pp. 1863-1874. (10.1093/emboj/20.8.1863)

2000

Raraty, M., Ward, J., Erdemli, G., Vaillant, C., Neoptolemos, J. P., Sutton, R. and Petersen, O. H. 2000. Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells. Proceedings of the National Academy of Sciences of the United States of America 97(24), pp. 13126-13131. (10.1073/pnas.97.24.13126)
Cansela, J. M., Gerasimenko, O. V., Gerasimenko, J. V., Tepikin, A. V. and Petersen, O. H. 2000. Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate. Embo Journal 19(11), pp. 2549-2557. (10.1093/emboj/19.11.2549)
Petersen, O. H. and Cancela, J. M. 2000. Nerve guidance: Attraction or repulsion by local Ca2+ signals. Current Biology 10(8), pp. R311-R314. (10.1016/S0960-9822(00)00438-3)
Park, M. K., Petersen, O. H. and Tepikin, A. V. 2000. The endoplasmic reticulum as one continuous Ca2+ pool: Visualization of rapid Ca2+ movements and equilibration. Embo Journal 19(21), pp. 5587-5941. (10.1093/emboj/19.21.5729)
Petersen, O. H. 2000. The functional organisation of calcium signalling in exocrine acinar cells. Journal of Korean Medical Science 15, pp. S44-S45. (10.3346/jkms.2000.15.S.S44)

Main Research Achievements

I pioneered, with Yoshio Maruyama, patch clamp single channel and whole-cell current recordings in epithelial cells. We discovered hormone-evoked, messenger-mediated ion channel activation (Maruyama & Petersen Nature 1982a,b), voltage-activation of epithelial ion channels (Maruyama et al Nature 1983a,b) and integrated these data into the first model of how ion channels control exocrine fluid secretion (Petersen & Maruyama Nature 1984 [ISI [WoS] Citation Classic]; Petersen J Physiol 1992). I discovered sub-cellular Ca²⁺ spiking in epithelial cells (Wakui et al Nature 1989, Cell 1990; Thorn et al Cell 1993), messenger-mediated Ca²⁺ release from the nuclear envelope (Gerasimenko et al Cell 1995) as well as the secretory granules (Gerasimenko et al Cell 1996) and intracellular Ca²⁺ tunnels (Mogami et al Cell 1997). Together with Oleg and Julia Gerasimenko, we demonstrated the crucial role of Ca²⁺ release channels and store-operated Ca²⁺ entry in Acute Pancreatitis (Raraty et al PNAS 2000; Gerasimenko et al PNAS 2009; 2011), provided proof-of-principle for Ca²⁺ release-activated Ca²⁺ (CRAC) channel blockade as a treatment of severe Acute Pancreatitis (Gerasimenko et al PNAS 2013; J Physiol 2014) and discovered a critical role for pancreatic stellate cells in this disease (Ferdek et al J Physiol 2016; Gryshchenko et al J Physiol 2016,2018). More recently, we have discovered Ca2+ signalling events in pancreatic immune cells that are likely to be important for initiating the cytokine storm that is responsible for severe, and often fatal, cases of Acute Pancreatitis (Gryshchenko et al Function 2021).

Current Research work

We continue our work to define the precise intra- and inter-cellular mechanisms driving the important human disease Acute Pancreatitis and to identify the optimal pharmacological intervention points that could prevent and/or cure this disease. We are following up an important paper in J Clin Invest (Peng et al 2018) in which we showed that galactose (a major ingredient in normal human milk) can protect very effectively against Acute Pancreatitis.

Role in the European Science Advice Mechanism

In addition to my primary research work, I am also heavily involved in the European Union’s Scientific Advice Mechanism. As Vice-President of Academia Europaea, I am a member of the Board of SAPEA (Science Advice for Policy by European Academies), a Horizon 2020 funded (Euro 6 million) project. The purpose is to provide and publish Evidence Review Reports to inform and underpin the Scientific Opinions of the European Commission’s Group of Chief Science Advisors in response to questions from the Commissioners. Academia Europaea is one of the 5 European networks comprising SAPEA and the work of Academia Europaea in this respect is largely conducted by Cardiff University’s Academia Europaea Knowledge Hub. I am the Director of the Knowledge Hub, which currently employs 3 staff members, funded partly by the European Commission and partly by Cardiff University. In 2017 the Cardiff Hub co-ordinated and led the work on the very first SAPEA Evidence Review Report on ‘Food from the Oceans’ which was formally presented to the Commission and published at the end of 2017. In 2019, we published the Evidence Review Report on 'Making sense of science under conditions of complexity and uncertainty'. At the very end of 2020, we published our latest Evidence Review Report on 'Biodegradabiliy of plastics in the open environment' and delivered it to the European Commission. All our Evidence Review Reports can be viewed via the SAPEA website (www.sapea.info) and are Open Access.

Affiliated staff

Primary Research

Dr Oleksiy Gryschenko (Regular Visiting Senior Scientist from the Bogomoletz Institute of Physiology, National Academy of Sciences Ukraine)
Dr Shuang Peng (Regular Visiting Associate Professor from Jinan University, Guangzhou, China

European Science Advice Mechanism

* Ms Louise Edwards (Hub Manager, Academia Europaea - Cardiff University Knowledge Hub)

* Mrs Juliet Davies (Executive Officer, Academia Europaea - Cardiff University Knowledge Hub)