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Dr Oleg Gerasimenko

Dr Oleg Gerasimenko

Reader

School of Biosciences

Email
gerasimenkoov@cardiff.ac.uk
Telephone
+44 (0)29 2087 0864
Campuses
Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
Users
Available for postgraduate supervision

Overview

Current projects:

1. Investigation of pathologies of immune cells in exocrine pancreas using in situ preparations and two-photon microscopy. 

2. Studies of pathologies leading to induction of acute pancreatitis. Main approaches have been described in recently published in Physiological Reviews (Petersen et al 2021 The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas). 

3. Improvement of therapeutic treatments for ALL (funded by Children with Cancer UK).

Roles

Module Leader: BI3355 Advances in Physiology and Pathophysiology

Assessment Co-ordinator: BI3253 Advanced Cell Biology and Imaging.

Interested in joining my lab as a self-funded post-graduate student or a postdoc/fellow?  Please contact me by email.

Biography

Reader at Cardiff School of Biosciences, Cardiff University, UK from 2010. 

Lecturer from 2000 and then Reader from 2005 at The University of Liverpool, UK

Received PhD from Bogomoletz Institute of Physiology Ukrainian Academy of Science in 1991.

Published 93 papers in reputed journals (8474 citations by Google Scholar, h-index 47).

Fellow of The Physiological Society, UK.

Editorial board member of journals: Scientific Reports, Cells and Pflügers Archiv - European Journal of Physiology.        

Publications

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

2005

2004

2003

2002

2001

2000

Teaching

Module Leader: BI3355 Advances in Physiology and Pathophysiology

Assessment Co-ordinator: BI3253 Advanced Cell Biology and Imaging.

Current projects: 

  1. Investigation of pathologies of immune cells in exocrine pancreas using in situ preparations and two-photon microscopy. 
  1. Studies of pathologies leading to induction of acute pancreatitis. Main approaches have been described in recently published in Physiological Reviews (Petersen et al 2021). 
  1. Improvement of therapeutic treatments for ALL (funded by Children with Cancer UK). 

Past projects: 

Role of Ca2+ Release and Ca2+ Entry in the Development of Acute Pancreatitis (David Evans et al unpublished). 

Investigation of physiology of exocrine pancreas, using in situ preparations of pancreatic tissue and two-photon microscopy (Gryshchenko et al 2020 “Calcium signalling in pancreatic immune cells in situ”). 

Energy supplements as a potential treatment for acute pancreatitis (Shuang Peng et al 2018) 

Mechanism of asparaginase-induced pancreatitis (Shuang Peng et al 2016) 

NAADP-induced calcium signalling in pancreatic acinar cells (Gerasimenko et al 2015) 

Inhibition of calcium entry as a potential treatment for acute pancreatitis (Gerasimenko et al 2013) 

Calmodulin regulation in pancreatic acinar cells (Gerasimenko et al 2011) 

Role of Bcl-2 in calcium signalling in pancreatic acinar cells (Pawel Ferdek et al 2012)

Postgraduate Research Students

Research data

Asparaginase-induced necrosis of pancreatic acinar cells

Nitric oxide signals in pancreatic stellate cells

Supervision

Several areas of research are available for a potential project:

1. Investigation of physiology and pathology of exocrine pancreas, including investigations in situ using two-photon microscopy (Gryshchenko et al 2020 Calcium signaling in pancreatic immune cells in situ).

2. Studies of pathologies leading to induction of acute pancreatitis. Different approaches have been recently published in  Physiological Reviews (Petersen et al 2021 The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas).

3. Improvement of therapeutic treatments for ALL (funded by Children with Cancer UK). (Peng et al 2018 Galactose protects against cell damage in mouse models of acute pancreatitis). 

Past projects

Supervisor for David Evans - Role of Ca2+ Release and Ca2+ Entry in the Development of Acute Pancreatitis (viva  planned in October 2021).

Supervisor for Shuang Peng - Mechanism of asparaginase-induced pancreatitis (awarded 2017)

Co-Supervisor (33%) for Richard Charlesworth - NAADP-induced calcium signalling in pancreatic acinar cells (awarded 2016)

Supervisor for Eloise Stapleton - Calmodulin regulation in pancreratic acinar cells (awarded 2015)

Supervisor for Pawel Ferdek - Role of Bcl-2 in calcium signalling in pancreatic acinar cells (awarded 2011)