Peritoneal Immunity Group
The focus of our research is the understanding of the mechanisms controlling inflammation-driven membrane damage in peritoneal dialysis patients.
Research
The main focus of research remains the mechanisms controlling leukocyte recruitment and clearance during inflammation. The initial focus has been on acute inflammation and defining those factors that govern resolution of inflammation.
Over the next years the focus of our work will be in examining the mechanisms by which resolving acute inflammation becomes manifested as chronic inflammation characterized by deregulated leukocyte trafficking and activation.
With this latter aim in mind we have recently developed a flare model of peritoneal inflammation that has provided clear evidence of a chronic inflammatory phenotype being developed as a result of repeated inflammatory hits.
These data parallel our clinical observations of deregulated IL-6 signalling in PD patients with a history of infection. Given the presumed importance of IL-6 signalling in many of these processes these studies will use both IL-6 deficient mice as well as conditional mutants of the JAK-STAT signaling cascade to dissect these events.
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Staff academaidd
Cyhoeddiadau
- Rhodes, D. A. et al., 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194 (5), pp.2390-2398. (10.4049/jimmunol.1401064)
- Stack, G. et al. 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11 (2) e1004641. (10.1371/journal.ppat.1004641)
- Rosser, E. C. et al., 2014. Regulatory B cells are induced by gut microbiota- driven interleukin-1β and interleukin-6 production. Nature Medicine 20 , pp.1334-1339. (10.1038/nm.3680)
- Davey, M. S. et al., 2014. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. Journal of Immunology 193 (7), pp.3704-3716. (10.4049/jimmunol.1401018)
- Pitzalis, C. et al., 2014. Ectopic lymphoid-like structures in infection, cancer and autoimmunity. Nature Reviews Immunology 14 (7), pp.447-462. (10.1038/nri3700)