Yr Athro Simon Jones

2022

• Millrine, D., Jenkins, R. H., Hughes, S. T. O. and Jones, S. A. 2022. Making sense of IL-6 signalling cues in pathophysiology. FEBS Letters 596(5), pp. 567-588. (10.1002/1873-3468.14201)
• Misheva, M. et al. 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13(1), article number: 139. (10.1038/s41467-021-27766-8)

2021

• Jenkins, R. H., Hughes, S. T., Cardus Figueras, A. and Jones, S. A. 2021. Unravelling the broader complexity of IL-6 involvement in health and disease. Cytokine 148, article number: 155684. (10.1016/j.cyto.2021.155684)
• Heise, D. et al. 2021. Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits TH17 cell expansion. Science Signaling 14(696), article number: eabc3480. (10.1126/scisignal.abc3480)
• Jones, S. A. and Hunter, C. A. 2021. Is IL-6 a key cytokine target for therapy in COVID-19?. Nature Reviews Immunology 21(6), pp. 337–339. (10.1038/s41577-021-00553-8)

2020

• Jones, S. A., Bryant, C., Lloyd, C. M., McInnes, I. and O'Neill, L. 2020. A vision for cytokine biology with 20/20 clarity. Function 2(1), article number: zqaa042. (10.1093/function/zqaa042)
• Ponsford, M. J. et al. 2020. Cardiometabolic traits, sepsis, and severe COVID-19. Circulation 142(18), pp. 1791–1793. (10.1161/CIRCULATIONAHA.120.050753)
• Lucchesi, D. et al. 2020. Impaired IL‐27 mediated control of CD4+ T cell function impacts on ectopic lymphoid structure formation in patients with Sjögren's Syndrome. Arthritis and Rheumatology 72(9), pp. 1559-1570., article number: Volume72, Issue9 September 2020 Pages 1559-1570. (10.1002/art.41289)
• Harbour, S. N. et al. 2020. Th17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity. Science Immunology 5(49), article number: eaaw2262. (10.1126/sciimmunol.aaw2262)
• O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1(1), article number: zqaa002. (10.1093/function/zqaa002)

2019

• Jones, H. J., Hubbard, L., Mitchell, R. E., Jones, S. A., Williams, N. M., Zammit, S. and Hall, J. 2019. Association of genetic risk for rheumatoid arthritis with cognitive and psychiatric phenotypes across childhood and adolescence. JAMA Network Open 2(6), pp. -., article number: e196118. (10.1001/jamanetworkopen.2019.6118)
• Twohig, J. P. et al. 2019. Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. Nature Immunology 20, pp. 458-470. (10.1038/s41590-019-0350-0)
• Jones, S. A., Takeuchi, T., Aletaha, D., Smolen, J., Choy, E. H. and McInnes, I. 2019. Interleukin 6: the biology behind the therapy. Considerations in Medicine 2 (10.1136/conmed-2018-000005)
• Takeuchi, T., Smolen, J. S., Choy, E., Aletaha, D., McInnes, I. and Jones, S. 2019. Considering new lessons about the use of IL-6 inhibitors in arthritis. BMJ Considerations in Medicine 2(1), pp. 7-11. (10.1136/conmed-2018-000002)
• Smolen, J. S., Aletaha, D., Choy, E., Jones, S., Takeuchi, T. and McInnes, I. 2019. Targeting IL-6: a review of data. BMJ Considerations in Medicine 2(1), pp. 12-18. (10.1136/conmed-2018-000003)
• Choy, E., Jones, S., Aletaha, D., Takeuchi, T., McInnes, I. and Smolen, J. S. 2019. IL-6: To immunity and beyond. BMJ Considerations in Medicine 2(1), pp. 19-23. (10.1136/conmed-2018-000004)

2018

• Rivellese, F. et al. 2018. Mast cells in early rheumatoid arthritis associate with disease severity and support B-cell autoantibody production. Annals of the Rheumatic Diseases 77(12), pp. 1773-1781. (10.1136/annrheumdis-2018-213418)
• Jones, S. A. and Jenkins, B. J. 2018. Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nature Reviews Immunology 18, pp. 773-789. (10.1038/s41577-018-0066-7)
• Jones, G., Hill, D., Cardus Figueras, A. and Jones, S. 2018. IL-27 - a double agent in the IL-6 family. Clinical and Experimental Immunology 193(1), pp. 37-46. (10.1111/cei.13116)
• Fernandez, J. U., Millrine, D. and Jones, S. 2018. Tracking competent host defence to chronic inflammation: An In Vivo model of peritonitis. In: Jenkins, B. J. ed. Inflammation and Cancer., Vol. 1725. Methods in Molecular Biology New York, NY: Springer, pp. 65-75., (10.1007/978-1-4939-7568-6_6)

2017

• Lauder, S. N. et al. 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10(507), article number: eaan2787. (10.1126/scisignal.aan2787)
• Stacey, M. A. et al. 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127(4), pp. 1463-1474. (10.1172/JCI84889)
• Catar, R. et al. 2017. IL-6 trans-signaling links inflammation with angiogenesis in the peritoneal membrane. Journal of the American Society of Nephrology 28(4), pp. 1188-1199. (10.1681/ASN.2015101169)
• Dutzan, N. et al. 2017. On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier. Immunity 46(1), pp. 133-147. (10.1016/j.immuni.2016.12.010)
• Lauder, S. N. et al. 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2(1) (10.12688/wellcomeopenres.10308.1)

2016

• Clement, M. et al. 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12(12), article number: e1006050. (10.1371/journal.ppat.1006050)
• Jones, G., Hill, D. and Jones, S. 2016. Understanding immune cells in tertiary lymphoid organ development: it is all starting to come together. Frontiers in Immunology 7, pp. 1-13., article number: 401. (10.3389/fimmu.2016.00401)
• Liao, C. et al. 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46(9), pp. 2222-2232. (10.1002/eji.201646528)
• Davies, R. et al. 2016. Serum Vascular Cell Adhesion Molecule 1 levels are associated with vascular Dysfunction and increased cardiovascular risk in an animal model and patients with Rheumatoid Arthritis. Rheumatology 55(Supp 1), pp. 54-54., article number: O41. (10.1093/rheumatology/kew102.004)
• Harvey, A. K. et al. 2016. Novel application of behavioral assays allows dissociation of joint pathology from systemic extra-articular alterations induced by inflammatory arthritis. Journal of Rheumatic Diseases and Treatment 2(2), article number: 33. (10.23937/2469-5726/1510033)
• Liu, X., Jones, G. W., Choy, E. H. and Jones, S. A. 2016. The biology behind interleukin-6 targeted interventions. Current Opinion in Rheumatology 28(2), pp. 152-160. (10.1097/BOR.0000000000000255)
• Jones, G. W. and Jones, S. A. 2016. Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues. Immunology 147(2), pp. 141-151. (10.1111/imm.12554)

2015

• Lacroix, M. et al. 2015. Novel insights into IL-6 cis- and trans-signaling pathways by differentially manipulating the assembly of the IL-6 signaling complex. Journal of Biological Chemistry 290, pp. 26943-26953. (10.1074/jbc.M115.682138)
• Jones, G. W. et al. 2015. Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis. Journal of Experimental Medicine 212(11), pp. 1793-1802. (10.1084/jem.20132307)
• Beyer, C. et al. 2015. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages. Annals of the Rheumatic Diseases 74(6), pp. 1317-1324. (10.1136/annrheumdis-2013-204401)
• Hunter, C. A. and Jones, S. A. 2015. IL-6 as a keystone cytokine in health and disease. Nature Immunology 16(5), pp. 448-457. (10.1038/ni.3153)

2014

• Rosser, E. C. et al. 2014. Regulatory B cells are induced by gut microbiota- driven interleukin-1β and interleukin-6 production. Nature Medicine 20, pp. 1334-1339. (10.1038/nm.3680)
• Garbers, C. et al. 2014. The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. Biochimica et Biophysica Acta - Molecular Basis of Disease 1842(9), pp. 1485-1494. (10.1016/j.bbadis.2014.05.018)
• Greenhill, C. J. et al. 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16(4), article number: 419. (10.1186/s13075-014-0419-y)
• Pitzalis, C., Jones, G. W., Bombardieri, M. and Jones, S. A. 2014. Ectopic lymphoid-like structures in infection, cancer and autoimmunity. Nature Reviews Immunology 14(7), pp. 447-462. (10.1038/nri3700)
• Rosas, M. et al. 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344(6184), pp. 645-648. (10.1126/science.1251414)
• Jones, S. A., Fraser, D. J., Fielding, C. A. and Jones, G. W. 2014. Interleukin-6 in renal disease and therapy. Nephrology Dialysis Transplantation 30(4), pp. 564-574. (10.1093/ndt/gfu233)
• Fielding, C. A. et al. 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40(1), pp. 40-50. (10.1016/j.immuni.2013.10.022)

2013

• Lauder, S. N. et al. 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43(10), pp. 2613-2625. (10.1002/eji.201243018)
• Greenhill, C. J. et al. 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63(3), pp. 267. (10.1016/j.cyto.2013.06.105)
• Fielding, C. A., Jones, G. W., Taylor, P. R., Jenkins, B. J., Topley, N. and Jones, S. A. 2013. IL-6 regulation of Th1 responses drives fibrosis in unresolved inflammation [Abstract]. Cytokine 63(3), pp. 262. (10.1016/j.cyto.2013.06.082)
• Davies, L. C. et al. 2013. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications 4, article number: 1886. (10.1038/ncomms2877)
• Orr, S. J. et al. 2013. LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells. PLoS Pathogens 9(5), article number: e1003357. (10.1371/journal.ppat.1003357)
• Moideen, A. N. et al. 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52(s1), pp. 138-139.
• Choy, E. H. S., Kavanaugh, A. and Jones, S. A. 2013. The problem of choice: current biologic agents and future prospects in RA [review]. Nature Reviews Rheumatology 9(3), pp. 154-163. (10.1038/nrrheum.2013.8)
• Chakraborty, M., McGreal, E. P., Davies, P. L., Nowell, M. A., Jones, S. A. and Kotecha, S. 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104(3), pp. 161-167. (10.1159/000351015)

2012

• McDonald, J. U., Rosas, M., Brown, G. D., Jones, S. A. and Taylor, P. R. 2012. Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. PLoS ONE 7(9), article number: e45781. (10.1371/journal.pone.0045781)
• Greenhill, C. J. et al. 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137, pp. 43-44.
• O'Connor, R. A., Floess, S., Huehn, J., Jones, S. A. and Anderton, S. M. 2012. Foxp3+Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production. European Journal of Immunology 42(5), pp. 1174-1179. (10.1002/eji.201142216)
• Moideen, A. N., Evans, L., Osgood, L. E., Williams, A., Jones, S. A. and Nowell, M. A. 2012. Nicotinamide adenine dinucleotide (NAD plus) biosynthesis enzymes in rheumatoid arthritis [Abstract]. Rhuematology 51(s3), pp. 142-142. (10.1093/rheumatology/kes108)
• Greenhill, C. et al. 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51, pp. 48-48. (10.1093/rheumatology/kes117)
• Jones, G. W., Greenhill, C. J., Williams, A. S., Nowell, M. A., Jenkins, B. J. and Jones, S. A. 2012. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Rhuematology 51(s3), pp. 43-44. (10.1093/rheumatology/kes117)

2011

• Jones, G. W., Greenhill, C. J., Williams, A. S., Nowell, M. A., Jenkins, B. J. and Jones, S. A. 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Immunology 135(S1), pp. 158. (10.1111/j.1365-2567.2011.03534.x)
• Greenhill, C. J. et al. 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135(s1), pp. 158-158. (10.1111/j.1365-2567.2011.03534.x)
• Jones, G. W., Williams, A. S., Nowell, M. A., Jenkins, B. J. and Jones, S. A. 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B- cell responses [Abstract]. Arthritis and Rheumatism 63(s10), pp. S978-S978. (10.1002/art.33310)
• Smale, S., Carty, S. M., Goodfellow, R. M., Choy, E. H., Rose-John, S., Jones, S. A. and Williams, A. S. 2011. Inhibiting IL-6 trans-signalling with soluble gp130Fc potently reduces the incidence and severity of collagen-induced experimental arthritis [Abstract]. Arthritis and Rheumatism 63(s10), pp. S446-S447.
• Evans, L. C., Williams, A. S., Hayes, A. J., Jones, S. A. and Nowell, M. A. 2011. Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthritis. Arthritis and Rheumatism 63(7), pp. 1866-1877. (10.1002/art.30338)
• Colmont, C. S. et al. 2011. Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors. Nephrology Dialysis Transplantation 26(12), pp. 4079-4090. (10.1093/ndt/gfr217)
• McDonald, J. U. et al. 2011. In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. The FASEB Journal 25(6), pp. 1972-1982. (10.1096/fj.10-178517)
• Lauder, S. N. et al. 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66(5), pp. 368-374. (10.1136/thx.2010.150318)
• Jones, G. W. et al. 2011. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The FASEB Journal 25(1), pp. 409-419. (10.1096/fj.10-166843)
• Rosas, M. et al. 2011. Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells. European Journal of Immunology 41(2), pp. 356-365. (10.1002/eji.201040962)
• Liddiard, K., Rosas, M., Davies, L. C., Jones, S. A. and Taylor, P. R. 2011. Macrophage heterogeneity and acute inflammation. European Journal of Immunology 41(9), pp. 2503-2508. (10.1002/eji.201141743)
• Davies, L. C., Rosas, M., Smith, P. J., Fraser, D. J., Jones, S. A. and Taylor, P. R. 2011. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology 41(8), pp. 2155-2164. (10.1002/eji.201141817)
• Kennedy, C. L. et al. 2011. The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17. The Journal of Pathology 225(2), pp. 255-264. (10.1002/path.2933)
• Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
• Jones, S. A., Scheller, J. and Rose-John, S. 2011. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Journal of Clinical Investigation 121(9), pp. 3375-3383. (10.1172/JCI57158)
• McGreal, E. P., Chakraborty, M., Winter, V. T., Jones, S. A., Coalson, J. J. and Kotecha, S. 2011. Dynamic expression of IL-6 trans-signalling molecules in the lungs of preterm baboons undergoing mechanical ventilation. Neonatology 100(2), pp. 130-138. (10.1159/000322148)

2010

• Stumhofer, J. S. et al. 2010. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nature Immunology 11(12), pp. 1119-1126. (10.1038/ni.1957)
• Jones, G. W. et al. 2010. Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract]. Immunology 131(s1), pp. 102-102. (10.1111/j.1365-2567.2010.03390.x)
• Lauder, S. N., Smart, K., Ondondo, B., Fielding, C. A., Godkin, A. J., Jones, S. A. and Gallimore, A. M. 2010. A critical role for interleukin-6 in limiting influenza-induced pathology and generating heterosubtypic immunity [Abstract]. Immunology 131(S1), pp. 186. (10.1111/j.1365-2567.2010.03390.x)
• Lissilaa, R. et al. 2010. Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity. The Journal of Immunology 185(9), pp. 5512-5521. (10.4049/jimmunol.1002015)
• Coles, B., Colmont, C. S., Fielding, C. A., Kift-Morgan, A., Hams, E., Topley, N. and Jones, S. A. 2010. Local manipulation of IL-6 trans-signaling therapeutically enhances anti-microbial host defense [Abstract]. Cytokine 52(1-2), pp. 80-81. (10.1016/j.cyto.2010.07.335)
• Jones, G. W. et al. 2010. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. The Journal of Immunology 184(4), pp. 2130-2139. (10.4049/jimmunol.0901528)
• Jones, G. W. et al. 2010. Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 184(4), pp. 2130-2139.
• Page, C. E. et al. 2010. Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis. Arthritis Research & Therapy 12(2), article number: R49. (10.1186/ar2960)
• Leggate, M., Nowell, M. A., Jones, S. A. and Nimmo, M. N. 2010. The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones 15(6), pp. 827-833. (10.1007/s12192-010-0192-z)
• McGreal, E. P. et al. 2010. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802(7-8), pp. 649-658. (10.1016/j.bbadis.2010.04.005)
• Page, C. E. et al. 2010. Interferon-gamma inhibits interleukin-1 beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis. Arthritis Research and Therapy 12(2), article number: R49.

2009

• Cash, H. et al. 2009. Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. The Journal of Rheumatology 37(1), pp. 60-70. (10.3899/jrheum.090194)
• Nowell, M. A. et al. 2009. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 182(1), pp. 613-622.
• Morgan, A. H. et al. 2009. Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. Journal of Biological Chemistry 284(32), pp. 21185-21191. (10.1074/jbc.M109.021634)
• Raby, A. et al. 2009. Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering. The Journal of Immunology 183(1), pp. 506-517. (10.4049/jimmunol.0802909)

2008

• Jones, G. W. et al. 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125(s1), pp. 62-62. (10.1111/j.1365-2567.2008.02974.x)
• Rabe, B. et al. 2008. The role of IL6-transsignaling in acute and chronic inflammation [Abstract]. Cytokine 43(3), pp. 244-244. (10.1016/j.cyto.2008.07.073)
• Jenkins, B. J. et al. 2008. Differential roles of IL-6 and IL-11 in inflammation and tumorigenesis [Abstract]. Cytokine 43(3), pp. 243-243. (10.1016/j.cyto.2008.07.069)
• Hams, E. et al. 2008. Oncostatin M receptor-β signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181(3), pp. 2174-2180.
• Fielding, C. A. et al. 2008. IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. Journal of Immunology 181(3), pp. 2189-2195.
• Hams, E. et al. 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181(3), pp. 2174-2180.
• Morton, J. et al. 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN -dependent iNOS expression in the vasculature of healthy mice. Blood 111(10), pp. 5187-5194. (10.1182/blood-2007-10-117283)
• Jones, G. W. et al. 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47(S2), pp. II20-II20. (10.1093/rheumatology/kem509)
• Page, C. E. et al. 2008. Ifn gamma protects articular cartilage against IL-1 induced tissue injury in arthritis. C Page, S Smale, S Lauder, S Carty, R Goodfellow, S Jones, N Topley & A Williams. School of medicine, Cardiff University, Cardiff, CF14 4XN [Poster Abstract]. Rhuematology 47(s2), pp. II177-II177. (10.1093/rheumatology/kem534)
• Smale, S., Amos, N., Jones, S. A. and Williams, A. S. 2008. Local activation of STAT3 but not STAT1 during collagen induced arthritis. Correlation with local and systemic cytokine activity [Poster Abstract]. Rheumatology 47(s2), pp. II53-II53. (10.1093/rheumatology/kem514)
• Longhi, M. P. et al. 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4(2), article number: e1000006. (10.1371/journal.ppat.1000006)
• Rabe, B. et al. 2008. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 111(3), pp. 1021-1028. (10.1182/blood-2007-07-102137)
• Jones, S. A., Jones, G. W., Williams, A. S. and Nowell, M. A. 2008. Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression. Immunology Endocrine & Metabolic Agents in Medicinal Chemistry 8(3), pp. 235-246.
• Dioszeghy, V. et al. 2008. 12/15-lipoxygenase regulates the inflammatory response to bacterial products in vivo. The Journal of Immunology 181(9), pp. 6514-6524.

2007

• Rabe, B. et al. 2007. IL6/sIL6R-transsignaling controls innate and aquired immunity [Abstract]. Cytokine 39(1), pp. 34-34. (10.1016/j.cyto.2007.07.129)
• Jones, G. W. et al. 2007. TL1A counteracts the IL-6 control of the STAT3-mediated development of T helper 17 cells [Abstract]. Cytokine 39(1), pp. 18-19.
• Hams, E. et al. 2007. Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract]. Cytokine 39(1), pp. 14-14. (10.1016/j.cyto.2007.07.053)
• Williams, A. S. et al. 2007. Interferon-γ protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints. Arthritis & Rheumatism 56(7), pp. 2244-2254. (10.1002/art.22732)
• Carty, S. M., Nowell, M. A., Lauder, S. N., Goodfellow, R. M., Jones, S. A., Williams, B. D. and Williams, A. S. 2007. Combination therapy with etanercept and sgp130 for rheumatoid arthritis is more effective than monotherapy [Abstract]. Rheumatology 46(s1), pp. I18-I18. (10.1093/rheumatology/kem1007)

2006

• Dimitrov, S. et al. 2006. Sleep enhances IL-6 trans-signaling in humans. The FASEB Journal 20(12), pp. 2174-2176. (10.1096/fj.06-5754fje)
• Carty, S. M., Nowell, M. A., Goodfellow, R. M., Jones, S. A., Williams, B. D. and Williams, A. S. 2006. TINFa and IL-6/slL-6R interactions regulate the magnitude and the phenotype of synovial Leucocyte infiltration in rheumatoid arthritis [Abstract]. Arthritis and Rheumatism 54(9), pp. S597-S597.
• Nowell, M. A. et al. 2006. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Arthritis & Rheumatism 54(7), pp. 2084-2095. (10.1002/art.21942)
• Monslow, J. et al. 2006. Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 281(26), pp. 18043-18050. (10.1074/jbc.M510467200)
• Peake, N. J. et al. 2006. Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor. Rheumatology 45(12), pp. 1485-1489. (10.1093/rheumatology/kel154)
• Richards, P. J. et al. 2006. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis & Rheumatism 54(5), pp. 1662-1672. (10.1002/art.21818)
• Grau, S. et al. 2006. The role of human HtrA1 in arthritic disease. The Journal of Biological Chemistry 281(10), pp. 6124-6129. (10.1074/jbc.M500361200)

2005

• Fielding, C. A. et al. 2005. Viral IL-6 blocks neutrophil infiltration during acute inflammation. The Journal of Immunology 175(6), pp. 4024-4029.
• McLoughlin, R. M. et al. 2005. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 102(27), pp. 9589-9594. (10.1073/pnas.0501794102)
• Carty, S. M., Nowell, M. A., Goodfellow, R. M., Topley, N., Jones, S. A., Williams, B. D. and Williams, A. S. 2005. Interleukin 6 (IL-6) signalling in rheumatoid arthritis. Rheumatology 44, pp. I38-I38.

2004

• McLoughlin, R. M. et al. 2004. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. The Journal of Immunology 172, pp. 5676-83.

2003

• Nowell, M. A. et al. 2003. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. The Journal of Immunology 171(6), pp. 3202-3209.
• McLoughlin, R. M. et al. 2003. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. The Journal of Clinical Investigation 112(4), pp. 598-607. (10.1172/JCI200317129)

2001

• Robson, R. L., McLoughlin, R. M., Witowski, J., Loetscher, P., Wilkinson, T. S., Jones, S. A. and Topley, N. 2001. Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo. The Journal of Immunology 167(2), pp. 1028-1038.
• Hurst, S. M. et al. 2001. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14(6), pp. 705-714. (10.1016/S1074-7613(01)00151-0)