
Yr Athro Matthias Eberl
Reader, Division of Infection and Immunity. Engagement Lead, Systems Immunity Research Institute.
- eberlm@cardiff.ac.uk
- +44 (0)29 2068 7011
- 3F08, Adeilad Henry Wellcome ar gyfer Ymchwil Biofeddygol, Ysbyty Athrofaol Cymru, Parc y Mynydd Bychan, Caerdydd, CF14 4XN
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwg
I have always been interested in the molecular and cellular basis of host-pathogen relationships and the underlying modulation of complex immune responses.
During my PhD I established a screening method to identify CD4+ T cell antigens from cDNA libraries of the parasite Schistosoma mansoni. I then extended these studies during a two-year postdoc, and investigated the cellular and humoral immune response to schistosomes upon infection and vaccination.
My research since 2000 has concentrated on defining the role of human γδ T cells in bridging innate and adaptive immune responses.
γδ T cells are the prototype of 'unconventional' lymphocytes in that they are not restricted by classical MHC and display characteristics of 'conventional' T cells, NK cells and myeloid cells. Normally only constituting a minor population in human blood, they occupy a unique niche in microbial recognition and contribute to tumour surveillance.
More recently we have started to characterise early immune responses in acutely infected patients and define pathogen-specific signatures of cellular and soluble biomarkers ('immune fingerprints').
My research is placed at the interface of basic, translational and clinical research and benefits greatly from interdisciplinary collaborations with immunologists, microbiologists, biochemists, epidemiologists and clinicians.
Besides implications for diagnosis and treatment of microbial infections this work has direct consequences for vaccine design and cancer immunotherapy.
Bywgraffiad
Career profile
- since 08/2015
Reader, Division of Infection & Immunity, School of Medicine, Cardiff University
- 2011-2015
Senior Lecturer, Cardiff Institute of Infection & Immunity, School of Medicine, Cardiff University
- 2007-2011
RCUK Fellow in Translational Research, School of Medicine, Cardiff University
- 2005-2006
Postdoc, Institute of Cell Biology, University of Bern (Switzerland)
Lab: Prof Bernhard Moser
- 2000-2005
Postdoc, Institute of Biochemistry, School of Medicine, University of Giessen (Germany)
Lab: Dr Hassan Jomaa
- 1998-2000
Postdoc, Department of Biology, University of York (UK)
Lab: Prof Alan Wilson
- 1995-1998
PhD Student, Institute of Biochemistry, School of Medicine, University of Giessen (Germany)
Lab: Prof Ewald Beck
Anrhydeddau a Dyfarniadau
- 2015: Promotion to Reader, Cardiff University
- 2011: Promotion to Senior Lecturer, Cardiff University
- 2009: Best Free Communications Prize at 9th European Peritoneal Dialysis Meeting, Strasbourg, France
- 2007: RCUK Fellowship in Translational Research in Experimental Medicine
- 2007: Wellcome Trust 'VIP' Award
- 1995: PhD Studentship, "Graduiertenkolleg Molekulare Biologie und Pharmakologie", German Research Foundation (DFG)
Aelodaethau proffesiynol
- British Society for Immunology (BSI):
BSI Board of Trustees since Jan 2017,
BSI Forum 2009-2016,
Chairman of the BSI South Wales Immunology Group 2007-2015
- German Society for Immunology (DGfI)
Ymrwymiadau siarad cyhoeddus
Invited speaker and/or session chair
- Dublin 2017: European Peritoneal Dialysis Meeting (EuroPD)
- Liverpool 2016: British Society for Immunology / Dutch Society for Immunology
- London 2016: International γδ T Cell Conference
- Chicago 2015: FASEB Conference on Autoimmunity
- Newcastle 2014: BSI Immunology North East Annual Symposium
- Chicago 2014: International γδ T Cell Conference
- Maastricht 2013: European Peritoneal Dialysis Meeting (EuroPD)
- Glasgow 2012: European Congress of Immunology
- Amsterdam 2012: EuTRiPD Academy
- Freiburg 2012: International γδ T Cell Conference
- Palermo 2012: International PhD Program in Immunopharmacology
- Birmingham 2011: European Peritoneal Dialysis Meeting (EuroPD)
- Cervo Ligure 2011: 5th Cervo Preclinical Working Conference
- Galway 2011: Irish Society for Immunology
- Vancouver 2010: Society for Leukocyte Biology / International Endotoxin and Innate Immunity Society
- Kiel 2010: International γδ T Cell Conference
- London 2008: Miltenyi T Cell Day
- Marseille 2008: International γδ T Cell Conference
- Cardiff 2008: Wales Cancer Conference
Seminars
- Université Libre de Bruxelles (2017)
- University of Würzburg (2016)
- University of Cambridge (2013)
- Barts and The London (2012)
- CIDR, King's College London (2012)
- University College Cork (2011)
- CMCBI, King's College London (2011)
- Dstl Porton Down, Salisbury (2009)
- University of Würzburg (2008)
- BSI South Wales Immunology Group, Cardiff (2007)
- Institut Pasteur Parise (2005)
- University of Bern (2005)
- University of Freiburg (2005)
- University of Giessen (2005)
- Universitat Pompeu Fabra, Barcelona (2005)
- University of Tübingen (2004)
- University College Cork (2003)
- Bakh Institute of Biochemistry, Moscow (2003)
- Université Montpellier II (2002)
Conference attendance
- Krakow 2015: European Peritoneal Dialysis Meeting (EuroPD)
- Madrid 2014: International Society for Peritoneal Dialysis
- Sheffield 2014: PD Research Day
- Liverpool 2013: British Society for Immunology
- Liverpool 2010: British Society for Immunology
- Strasbourg 2009: European Peritoneal Dialysis Meeting (EuroPD)
- Berlin 2009: European Congress of Immunology
- Glasgow 2008: British Society for Immunology
- Heidelberg 2007: German Society for Immunology
- La Jolla 2006: International γδ T Cell Conference
- Kiel 2005: German Society for Immunology / Scandinavian Society for Immunology
- Uppsala 2004: XV International Symposium on Problems of Listeriosis
- Maastricht 2004: German Society for Immunology / Dutch Society for Immunology
- Harrogate 2003: British Society for Immunology
- Berlin 2003: German Society for Immunology
- Harrogate 2002: British Society for Immunology / British Society for Allergy and Clinical Immunology
- Marburg 2002: German Society for Immunology
- Harrogate 1999: British Society for Immunology / British Society for Allergy and Clinical Immunology
- Woods Hole 1999: 3rd Immunoparasitology Meeting
- Cambridge 1999: WHO/UNDP/World Bank Schistosoma Genome Network Meeting
- Aussois 1998: Conferences Jacques Monod "Parasite Interactions with the Immune System: Protection or Pathology?"
- Dresden 1998: German Society for Parasitology
- Harrogate 1998: British Society for Immunology
- Edinburgh 1997: "Parasitic Helminths - from Genomes to Vaccines"
- Würzburg 1997: German Society for Immunology
- Manchester 1997: British Society for Parasitology
- Munich 1996: German Society for Parasitology
Pwyllgorau ac adolygu
- since 08/2015: Engagement Lead, Systems Immunity Research Institute
- since 04/2014: Chair of PhD Appraisal Panel, Infection & Immunity
- since 05/2011: Founder and Administrator, γδ T Cell Forum
- since 11/2009: Web Editor, Infection & Immunity
Reviewer experience
Funding bodies
- AERES - Evaluation Agency for Research and Higher Education, France
- Barts and The London Charity
- BBSRC - Biotechnology and Biological Sciences Research Council
- Cancer Research UK
- Crohn’s in Childhood Research Association (CICRA)
- Crohn's and Colitis UK
- European Research Council (ERC)
- Fondation pour la Recherche Médicale, France
- German-Israeli Foundation for Scientific Research and Development
- Institut National du Cancer (INCa), France
- Kay Kendall Leukaemia Fund
- Kidney Research UK
- King’s Health Partners R&D Challenge Fund
- MRC - Medical Research Council
- Ministry of Science, Technology and Space, Israel
- Multiple Sclerosis Society, UK
- Research Grants Council, Hong Kong
- Wellcome Trust
- Wilhelm Sander Foundation, Germany
PhD examiner
- Cardiff University
- King's College London
- National University of Ireland, Maynooth
- University of Lisbon, Portugal
- University of Palermo, Italy
- Medical University of Vienna, Austria
- University of Bordeaux, France
International journals
- American Journal of Physiology – Renal Physiology
- Blood
- Bone
- BMC Immunology
- Breast Cancer Research
- Cancer Immunology Immunotherapy
- Cancer Research
- Carcinogenesis
- Cell Biochemistry & Function
- Cellular Immunology
- Chronobiology International
- Clinical Cancer Research
- Clinical and Developmental Immunology
- Clinical and Experimental Immunology
- Clinical and Experimental Medicine
- Current Cancer Drug Targets
- Current Immunology Reviews
- Cytokine
- EMBO Reports
- European Journal of Immunology
- Experimental Parasitology
- FASEB Journal
- FEBS Journal
- Frontiers in Immunology
- Haematologica
- Human Immunology
- Immunology
- Immunology and Cell Biology
- Immunology Letters
- Infection and Immunity
- International Immunology
- International Journal of Artificial Organs
- International Journal of Immunogenetics
- International Urology and Nephrology
- Journal of the American Chemical Society
- Journal of the American Society of Nephrology
- Journal of Biological Chemistry
- Journal of Biological Regulators and Homeostatic Agents
- Journal of Clinical Investigation
- Journal of Immunology
- Journal of Infectious Diseases
- Journal of Leukocyte Biology
- Journal of Medicinal Chemistry
- Journal of Molecular Medicine
- Journal of Translational Medicine
- Kidney International
- Microbes and Infection
- Molecular Immunology
- Mucosal Immunology
- Nephrology, Dialysis, Transplantation
- OncoImmunology
- Oncology Reviews
- Parasite Immunology
- Peritoneal Dialysis International
- PLoS ONE
- PLoS Pathogens
- Science Translational Medicine
- Scientific Reports
- Trends in Immunology
- Trends in Parasitology
Cyhoeddiadau
2022
- Burton, R. J., Cuff, S. M., Morgan, M. P., Artemiou, A. and Eberl, M. 2022. GeoWaVe: Geometric median clustering with weighted voting for ensemble clustering of cytometry data. Bioinformatics 39(1) (10.1093/bioinformatics/btac751)
- Cuff, S. M., Merola, J. P., Eberl, M. and Gray, W. P. 2022. Presence of ventriculoperitoneal and lumbar shunts stimulate long lasting non-inflammatory changes in the cerebrospinal fluid distinct from the response to bacterial infection. [Online]. medRxiv. (10.1101/2022.10.12.22280998) Available at: https://doi.org/10.1101/2022.10.12.22280998
- Cuff, S. M. et al. 2022. Inflammatory biomarker signatures in post-surgical drain fluid may detect anastomotic leaks within 48 hours of colorectal resection. [Online]. MedRxiv. Available at: https://www.medrxiv.org/content/10.1101/2022.08.05.22278403v1
- Fielding, C. A. et al. 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 (10.7554/eLife.74489)
- Ponsford, M. J. et al. 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75(4), pp. 255-262. (10.1136/jclinpath-2020-207157)
- Tyrrell, J. M. et al. 2022. 'Superbugs': raising public awareness of antimicrobial resistance through a pop-up science shop. Research for All 6(1), pp. 1-21. (10.14324/RFA.06.1.06)
2021
- Kaminski, H., Couzi, L. and Eberl, M. 2021. Unconventional T cells and kidney disease. Nature Reviews Nephrology 17, pp. 795-813. (10.1038/s41581-021-00466-8)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Editor's Note: Relates to: 'Immuno-antibiotics: targeting microbial metabolic pathways sensed by unconventional T cells'. Immunotherapy Advances 1(1), article number: ltab023. (10.1093/immadv/ltab023)
- Burton, R. J., Ahmed, R., Cuff, S. M., Baker, S., Artemiou, A. and Eberl, M. 2021. CytoPy: An autonomous cytometry analysis framework. PLoS Computational Biology 17(6), article number: e1009071. (10.1371/journal.pcbi.1009071)
- Eberl, M., Oldfield, E. and Herrmann, T. 2021. Immuno-antibiotics: Targeting microbial metabolic pathways sensed by unconventional T cells. Immunotherapy Advances 1(1), article number: ltab005. (10.1093/immadv/ltab005)
2020
- Cuff, S. M., Merola, J. P., Twohig, J. P., Eberl, M. and Gray, W. P. 2020. Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation. Brain Communications 2(2), article number: fcaa218. (10.1093/braincomms/fcaa218)
- Kouzeli, A. et al. 2020. CXCL14 preferentially synergizes with homeostatic chemokine receptor systems. Frontiers in Immunology 11, article number: 561404. (10.3389/fimmu.2020.561404)
- Goodlad, C. et al. 2020. Measurement of innate immune response biomarkers in peritoneal dialysis effluent using a rapid diagnostic point-of-care device as a diagnostic indicator of peritonitis. Kidney International 97(6), pp. 1253-1259. (10.1016/j.kint.2020.01.044)
- Catar, R. A. et al. 2020. Control of neutrophil influx during peritonitis by transcriptional cross-regulation of chemokine CXCL1 by IL‐17 and IFN‐γ. Journal of Pathology 251(2), pp. 175-186. (10.1002/path.5438)
- Eberl, M. 2020. Antigen recognition by human γδ T cells: one step closer to knowing. Immunology and Cell Biology 98(5), pp. 351-354. (10.1111/imcb.12334)
- Raffray, L., Burton, R. J., Baker, S. E., Morgan, M. P. and Eberl, M. 2020. Zoledronate rescues immunosuppressed monocytes in sepsis patients. Immunology 159(1), pp. 88-95. (10.1111/imm.13132)
2019
- Gadalla, A. A. M. et al. 2019. Identification of clinical and urine biomarkers for uncomplicated urinary tract infection using machine learning algorithms. Scientific Reports 9(1), article number: 19694. (10.1038/s41598-019-55523-x)
- Nguyen, C. T., Maverakis, E., Eberl, M. and Adamopoulos, I. E. 2019. γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity. Seminars in Immunopathology 41(5), pp. 595-605. (10.1007/s00281-019-00752-5)
- Burton, R. J., Albur, M., Eberl, M. and Cuff, S. M. 2019. Using artificial intelligence to reduce diagnostic workload without compromising detection of urinary tract infections. BMC Medical Informatics and Decision Making 19(1), article number: 171. (10.1186/s12911-019-0878-9)
- Brook, A. C. et al. 2019. Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis. Scientific Reports 9, article number: 10136. (10.1038/s41598-019-46585-y)
- Pottanat, N. D. et al. 2019. Analysis of the Ribonuclease a superfamily of antimicrobial peptides in patients undergoing chronic peritoneal dialysis. Scientific Reports 9, pp. -., article number: 7753. (10.1038/s41598-019-44219-x)
2018
- Vermijlen, D., Gatti, D., Kouzeli, A., Rus, T. and Eberl, M. 2018. γδ T cell responses: How many ligands will it take till we know?. Seminars in Cell and Developmental Biology 84, pp. 75-86. (10.1016/j.semcdb.2017.10.009)
- Chakera, A., Mulroney, K., Shak, H., McGuire, A., Eberl, M. and Topley, N. 2018. Peritonitis in Peritoneal Dialysis patients: the case for rapid diagnosis, targeted treatment and monitoring to improve outcomes. European Medical Journal Nephrology 6, pp. 56-64.
- McCarthy, N. E. and Eberl, M. 2018. Human γδ T-cell control of mucosal immunity and inflammation. Frontiers in Immunology 9, article number: 985. (10.3389/fimmu.2018.00985)
- Rhodes, D. A. et al. 2018. Regulation of human γδ T cells by BTN3A1 protein stability and ATP-binding cassette transporters. Frontiers in Immunology 9, article number: 662. (10.3389/fimmu.2018.00662)
2017
- Aufricht, C. et al. 2017. Biomarker research to improve clinical outcomes of peritoneal dialysis: consensus of the European Training and Research in Peritoneal Dialysis (EuTRiPD) network. Kidney International 92(4), pp. 824-835. (10.1016/j.kint.2017.02.037)
- Chen, H. et al. 2017. Synergistic targeting of breast cancer stem-like cells by human γδ T cells and CD8+ T cells. Immunology and Cell Biology 95(7), pp. 620-629. (10.1038/icb.2017.21)
- Zhang, J. et al. 2017. Machine-learning algorithms define pathogen-specific local immune fingerprints in peritoneal dialysis patients with bacterial infections. Kidney International 92(1), pp. 179-191. (10.1016/j.kint.2017.01.017)
- Howard, J. et al. 2017. The antigen presenting potential of Vγ9Vδ2 T-cells during Plasmodium falciparum blood-stage infection.. Journal of Infectious Diseases 215(10), pp. 1569-1579. (10.1093/infdis/jix149)
- Tyler, C. J., McCarthy, N. E., Lindsay, J. O., Stagg, A. J., Moser, B. and Eberl, M. 2017. Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. The Journal of Immunology 198(9), article number: 1700003. (10.4049/jimmunol.1700003)
- Raby, A. et al. 2017. Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. Journal of the American Society of Nephrology 28(2), pp. 461-478. (10.1681/ASN.2015080923)
2016
- Liuzzi, A. R. et al. 2016. Unconventional human T cells accumulate at the site of infection in response to microbial ligands and induce local tissue remodeling. Journal of Immunology 197(6), pp. 2195-2207. (10.4049/jimmunol.1600990)
- Johansson, M. A. et al. 2016. Probiotic lactobacilli modulate staphylococcus aureus-induced activation of conventional and unconventional T cells and NK cells. Frontiers in Immunology 7, article number: 273. (10.3389/fimmu.2016.00273)
- Morgan, M., Szakmany, T., Power, S., Olaniyi, P., Kathy, R., Hall, J. E. and Eberl, M. 2016. Sepsis patients with first and second-hit infections show different outcomes depending on the causative organism. Frontiers in Microbiology 7, article number: 207. (10.3389/fmicb.2016.00207)
2015
- Liuzzi, A. R., McLaren, J. E., Price, D. and Eberl, M. 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36, pp. 31-37. (10.1016/j.coi.2015.06.002)
- Piggott, L., Omidvar, N., Martí Pérez, S., French, R., Eberl, M. and Clarkson, R. W. E. 2015. Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 17(1), pp. 96. (10.1186/s13058-015-0597-9)
- Bonneville, M. et al. 2015. Chicago 2014 – 30 years of γδ T cells. Cellular Immunology 296(1), pp. 3-9. (10.1016/j.cellimm.2014.11.001)
- Tyler, C. J., Doherty, D. G., Moser, B. and Eberl, M. 2015. Human Vγ9/Vδ2 T cells: Innate adaptors of the immune system. Cellular Immunology 296(1), pp. 10-21. (10.1016/j.cellimm.2015.01.008)
- Rhodes, D. A. et al. 2015. Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin. Journal of Immunology 194(5), pp. 2390-2398. (10.4049/jimmunol.1401064)
2014
- Eberl, M., Friberg, I. M., Liuzzi, A. R., Morgan, M. and Topley, N. 2014. Pathogen-specific immune fingerprints during acute infection: The diagnostic potential of human γδ T-cells. Frontiers in Immunology 5, article number: 572. (10.3389/fimmu.2014.00572)
- Khan, M. W. A., Eberl, M. and Moser, B. 2014. Potential use of γδ T cell-based vaccines in cancer immunotherapy. Frontiers in Immunology 5, article number: 512. (10.3389/fimmu.2014.00512)
- Davey, M. S. et al. 2014. Microbe-specific unconventional T cells induce human neutrophil differentiation into antigen cross-presenting cells. Journal of Immunology 193(7), pp. 3704-3716. (10.4049/jimmunol.1401018)
- Khan, M. W. A. et al. 2014. Expanded human blood-derived gamma delta T cells display potent antigen-presentation functions. Frontiers in Immunology 5, article number: 344. (10.3389/fimmu.2014.00344)
2013
- Chen, H., Dieli, F. and Eberl, M. 2013. An unconventional TRAIL to cancer therapy. European Journal of Immunology 43(12), pp. 3159-3162. (10.1002/eji.201344105)
- Lin, C., Roberts, G. W., Kift-Morgan, A. P., Donovan, K., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Lin, C., Roberts, G. W., Kift-Morgan, A., Donovan, K. L., Topley, N. and Eberl, M. 2013. Pathogen-specific local immune fingerprints diagnose bacterial infection in peritoneal dialysis patients. Journal of the American Society of Nephrology 24(12), pp. 2002-2009. (10.1681/ASN.2013040332)
- Welton, J. L., Marti, S., Mahdi, M. H., Boobier, C., Barrett-Lee, P. and Eberl, M. 2013. γδ T cells predict outcome in zoledronate-treated breast cancer patients [Comment]. Oncologist 18(8), pp. E22-E23. (10.1634/theoncologist.2013-0097)
- Lin, C., Kift-Morgan, A. P., Moser, B., Topley, N. and Eberl, M. 2013. Suppression of pro-inflammatory T-cell responses by human mesothelial cells. Nephrology Dialysis Transplantation 28(7), pp. 1743-1750. (10.1093/ndt/gfs612)
- Welton, J. et al. 2013. Monocytes and γδ T cells control the acute phase response to intravenous zoledronate: insights from a phase IV safety trial. Journal of Bone and Mineral Research (JBMR) 28(3), pp. 464-471. (10.1002/jbmr.1797)
2012
- Silva-Santos, B., Schamel, W. W. A., Fisch, P. and Eberl, M. 2012. gamma delta T-cell conference 2012: Close encounters for the fifth time. European Journal of Immunology 42(12), pp. 3101-3105. (10.1002/eji.201270101)
- Riganti, C., Massaia, M., Davey, M. S. and Eberl, M. 2012. Human γδ T-cell responses in infection and immunotherapy: Common mechanisms, common mediators?. European Journal of Immunology 42(7), pp. 1668-1676. (10.1002/eji.201242492)
- Heuston, S., Begley, M., Davey, M., Eberl, M., Casey, P. G., Hill, C. and Gahan, C. G. M. 2012. HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for growth of Listeria monocytogenes EGDe. Microbiology 158(7), pp. 1684-1693. (10.1099/mic.0.056069-0)
- Bansal, R. R., Mackay, C. R., Moser, B. and Eberl, M. 2012. IL-21 enhances the potential of human gamma delta T cells to provide B-cell help. European Journal of Immunology 42(1), pp. 110-119. (10.1002/eji.201142017)
2011
- Piggott, L., Omidvar, N., Marti-Perez, S., Eberl, M. and Clarkson, R. W. E. 2011. Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL. Breast Cancer Research 13(5), article number: R88. (10.1186/bcr2945)
- Davey, M. S. et al. 2011. Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection. Plos Pathogens 7(5), article number: e1002040. (10.1371/journal.ppat.1002040)
- Davey, M. S. et al. 2011. Failure to detect production of IL-10 by activated human neutrophils [Letter]. Nature Immunology 12(11), pp. 1017-1018. (10.1038/ni.2111)
- Moser, B. and Eberl, M. 2011. γδ T-APCs: a novel tool for immunotherapy? [Book Review]. Cellular and Molecular Life Sciences 68(14), pp. 2443-2452. (10.1007/s00018-011-0706-6)
- Clark, S. R. et al. 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117(6), pp. 2033-2043. (10.1182/blood-2010-04-278887)
2010
- Meuter, S., Eberl, M. and Moser, B. 2010. Prolonged antigen survival and cytosolic export in cross-presenting human γδ T cells. Proceedings of the National Academy of Sciences of the United States of America 107(19), pp. 8730-8735. (10.1073/pnas.1002769107)
- Meraviglia, S. et al. 2010. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients. Clinical and Experimental Immunology 161(2), pp. 290-297. (10.1111/j.1365-2249.2010.04167.x)
- Brown, A. C., Eberl, M., Crick, D. C., Jomaa, H. and Parish, T. 2010. The nonmevalonate pathway of isoprenoid biosynthesis in mycobacterium tuberculosis is essential and transcriptionally regulated by dxs. Journal of Bacteriology 192(9), pp. 2424-2433. (10.1128/JB.01402-09)
2009
- Eberl, M. and Moser, B. 2009. Monocytes and γδ T cells: close encounters in microbial infection. Trends in Immunology 30(12), pp. 562-568. (10.1016/j.it.2009.09.001)
- Eberl, M., Roberts, G. W., Meuter, S., Williams, J. D., Topley, N. and Moser, B. 2009. A rapid crosstalk of human gamma delta T cells and monocytes drives the acute inflammation in bacterial infections. Plos Pathogens 5(2), pp. 6-6., article number: e1000308. (10.1371/journal.ppat.1000308)
- Brandes, M. et al. 2009. Cross-presenting human gamma delta T cells induce robust CD8(+) alpha beta T cell responses. Proceedings of the National Academy of Sciences of the United States of America 106(7), pp. 2307-2312. (10.1073/pnas.0810059106)
2007
- Dieli, F. et al. 2007. Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer. Cancer Research 67(15), pp. 7450-7457. (10.1158/0008-5472.can-07-0199)
- Vermijlen, D. et al. 2007. Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropy. The Journal of Immunology 178(7), pp. 4304-4314. (10.4049/jimmunol.178.7.4304)
- Moser, B. and Eberl, M. 2007. gammadelta T cells: novel initiators of adaptive immunity [review]. Immunological Reviews 215(1), pp. 89-102. (10.1111/j.1600-065x.2006.00472.x)
- Zafranskaya, M., Oschamnn, P., Engel, R., Weishaupt, A., van Noort, J. M., Jomaa, H. and Eberl, M. 2007. Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis. Immunology 121(1), pp. 29-39. (10.1111/j.1365-2567.2006.02518.x)
2006
- Eberl, M., Wesch, D., Dieli, F. and Jomaa, H. 2006. Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells. Journal of Leukocyte Biology 79(4), pp. 663-6. (10.1189/jlb.1105640)
2005
- Eberl, M., Jomaa, H., Pircher, H. and Fisch, P. 2005. Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). Journal of leukocyte biology 77, pp. 67-70. (10.1189/jlb.0204096)
2004
- Eberl, M., Beck, E., Christiansen, G. and Jamba, Z. 2004. Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do so. Infection and Immunity 72(8), pp. 4881-3. (10.1128/IAI.72.8.4881-4883.2004)
- Eberl, M., Jomaa, H. and Hayday, A. C. 2004. Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cells. Immunology 112(3), pp. 364-368. (10.1111/j.1365-2567.2004.01921.x)
- Begley, M., Gahan, C. G., Kollas, A. K., Hintz, M., Hill, C., Jomaa, H. and Eberl, M. 2004. The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes. FEBS Letters 561(1-3), pp. 99-104. (10.1016/s0014-5793(04)00131-0)
2003
- Ostrovsky, D. N., Dyomina, G. R., Deryabina, Y. I., Goncharenko, A. ., Eberl, M., Shumaev, A. and Shashkov, S. 2003. Properties of 2-C-Methyl-D-Erythritol 2,4-Cyclopyrophosphate, an intermediate in Nonmevalonate Isoprenoid Biosynthesis. Applied Biochemistry and Microbiology c/c of Prikladnaia Biokhimiia i Mikrobiologiia 39(5), pp. 497-502. (10.1023/A:1025452804046)
- Eberl, M. and Jomaa, H. 2003. A genetic basis for human gammadelta T-cell reactivity towards microbial pathogens [letter]. Trends in Immunology 24(8), pp. 407-409. (10.1016/s1471-4906(03)00170-4)
- Eberl, M., Hintz, M., Reichenberg, A., Kollas, A. K., Wiesner, J. and Jomaa, H. 2003. Microbial isoprenoid biosynthesis and human gammadelta T cell activation [review]. FEBS Letters 544(1-3), pp. 4-10. (10.1016/s0014-5793(03)00483-6)
- Reichenberg, A. et al. 2003. Replacing the pyrophosphate group of HMB-PP by diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism. Biorganic and Medicinal Chemistry Letters 13(7), pp. 1257-1260. (10.1016/s0960-894x(03)00138-0)
2002
- Kollas, A. K. et al. 2002. Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis. FEBS Letters 532(3), pp. 432-436. (10.1016/s0014-5793(02)03725-0)
- Eberl, M., al-Sherbiny, M., Hagan, P., Ljubojevic, S., Thomas, A. W. and Wilson, R. A. 2002. A novel and sensitive method to monitor helminth infections by faecal sampling. Acta Tropica 83(2), pp. 183-187. (10.1016/s0001-706x(02)00089-x)
- Eberl, M., Engel, R., Beck, E. and Jomaa, H. 2002. Differentiation of human gamma-delta T cells towards distinct memory phenotypee. Cellular Immunology 218(1-2), pp. 1-6. (10.1016/s0008-8749(02)00519-1)
- Eberl, M. 2002. Don't count your interleukins before they've hatched [letter]. Trends in Immunology 23(7), pp. 341-342. (10.1016/s1471-4906(02)02239-1)
- Eberl, M. et al. 2002. Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli. Immunology 106(2), pp. 200-211. (10.1046/j.1365-2567.2002.01414.x)
2001
- Hintz, M. et al. 2001. Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli. FEBS Letters 509(2), pp. 317-322. (10.1016/s0014-5793(01)03191-x)
- Eberl, M. et al. 2001. Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees. Infection and Immunity 69(9), pp. 5352-5362. (10.1128/iai.69.9.5352-5362.2001)
- Altincicek, B. et al. 2001. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Letters 499(1-2), pp. 37-40. (10.1016/s0014-5793(01)02516-9)
- Eberl, M. et al. 2001. Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?. Journal of Infectious Diseases 183(8), pp. 1238-1247. (10.1086/319691)
- Atincicek, B. et al. 2001. Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis. The Journal of Immunology 166(6), pp. 3655-3658. (10.4049/jimmunol.166.6.3655)
- Kasper, G. et al. 2001. A calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins. The Journal of Immunology 23(3), pp. 141-152. (10.1046/j.1365-3024.2001.00366.x)
2000
- Eberl, M., Beck, E., Coulson, P., Okamura, H., Wilson, R. A. and Mountford, A. P. 2000. IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigen. Vaccine 18(19), pp. 2002-2008. (10.1016/s0264-410x(99)00532-0)
1999
- Jomaa, H. et al. 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285(5433), pp. 1573-1576. (10.1126/science.285.5433.1573)
- Eberl, M., Mountford, A. P., Jankovic, D. and Beck, E. 1999. Isolation of T-cell antigens by using a recombinant protein library and its application to the identification of novel vaccine candidates against schistosomiasis. Infection and Immunity 67(7), pp. 3383-3389.
Addysgu
Teaching
In order to overcome the awe-inspiring complexity of the immune system and press it into digestible portions, immunology teaching is often in the danger to over-simplify scenarios and/or follow temporary fashions. The main challenges are to keep up abreast with the latest literature and incorporate recent advances into the lessons; to transport one’s own enthusiasm for science to the students; to demonstrate that even the most complex mechanisms can be of enormous clinical relevance in health and disease; and to confront students with standard methods in diagnostic and research labs, but also to make them aware of the possibilities of modern technology. My goal is to educate open-minded and critical students that are provided with all the scientific but also interpersonal tools required for being capable of questioning contemporary points of view and solving new problems.
Undergraduate teaching
I have been participating in the Year 2 SSC module “Interactive Immunology” for eight consecutive years, which comprises lectures, student lab paracticals and an assessment of student presentations. From 2017 on I will be lecturing in a new module on Biomarkers and Diagnostics developments.
I have trained undergraduate summer students as well as internship and Erasmus students.
Since 2010 I have acted as Personal Tutor for Medicine students, since 2013 as Academic Mentor.
Postgraduate teaching
I have supervised or co-supervised more than ten PhD students, all of whom completed, or are on course to complete, their PhD within four years.
I serve as Chair of approx. 20 appraisal panels for PhD and MD students per year, and have been appointed as internal examiner or viva chair of PhD theses at Cardiff University and as external examiner of PhD theses in the UK, Ireland, Italy and Portugal.
Public engagement and involvement
As Engagement Lead and member of the Steering Group of the Systems Immunity Research Institute, I aim to reach out to all stake-holders and engage with patients, health care providers, schools, policy makers, media, funding bodies and industry, and have set up a Lay Faculty of members of the public who help us reach our goals.
Current projects
- Please see details at Moser/Eberl Lab -
External profiles
Present and past group members
- Raya Ahmed, Research Associate
- Simone Cuff, Research Associate
- Loic Raffray, Research Associate
- Ann Kift-Morgan, Research Assistant
- Amy Brook, PhD student
- Ariadni Kouzeli, PhD student (co-supervisor)
- Teja Rus, PhD student (co-supervisor)
- Maximilian Keisker, Erasmus student
- Raj Bansal, PhD student 2007-2012
- Hung-Chang Chen, PhD student 2011-2016
- Chantal Colmont, Research Assistant 2013-2014
- Martin Davey, PhD student/Research Associate 2008-2013
- Ida Jackson (Friberg), Research Associate 2013-2015
- Chan-Yu Lin, PhD student 2009-2012
- Anna Rita Liuzzi, PhD student/Research Associate 2013-2016
- Christophe Macri, internship student 2009
- Salvador Martí Pérez, Research Associate 2009-2010
- Matt Morgan, PhD student 2011-2014 (co-supervisor)
- Luke Piggott, PhD student 2009-2012 (co-supervisor)
- Michele Scotto di Mase, internship student 2015
- Yasmin Shanneik, Erasmus student 2014-2015
- Chris Tyler, PhD student 2012-2016
- Joanne Welton, Research Associate 2011-2013
- Jingjing Zhang, Research Associate 2015-2016
Grant support
2017-2018
EU Horizon 2020, Marie Skłodowska-Curie Individual Fellowship (to Dr. Loic Raffray)
"Innate-like T-cells in sepsis (ILTIS): Implications for early diagnosis and rescue of immune suppression"
Main supervisor (co-supervisor Dr. Matt Morgan)
€ 97,727 (12 months)
Life Sciences Bridging Fund Wales, Pathfinder Grant
"Development of rapid in vitro diagnostic tests for early detection and characterisation of infection"
Co-applicant (Lead applicant: Prof. Ian Weeks; co-applicants: Prof. Nicholas Topley, Dr. Fraser Logue)
£ 74,554 (12 months)
2016-2019
MRC research grant
"Innate pathogen sensing by local unconventional T cells during microbial infections"
Principal Applicant (co-applicants: Prof. Donald Fraser, Prof. David Price, Dr. Kristin Ladell, Prof. Phil Taylor, Prof. Jamie Rossjohn)
£ 660,663 (36 months)
2016-2019
Health and Care Research Wales, Clinical Research Time Award (to Dr. Matt Morgan)
Academic Supervisor
£ 66,535 (36 months)
2016
Wellcome Trust ISSF Seedcorn Award
"γδ T-cell-mediated polarisation of CD4+ T-cell responses: implications for Crohn's disease"
Principal Applicant (co-applicants: Prof. Bernhard Moser, Dr. Andrew Stagg, Dr. James Lindsay)
£ 34,000 (6 months)
2016
Cardiff Incoming Visiting Fellowship (to Prof. Thomas Herrmann)
Principal Applicant
£ 5,500 (3 months)
2015-2018
MRC PhD Studentship (to Amy Brook)
"Pathogen-specific microRNA signatures during acute peritoneal infection"
Principal Applicant (co-applicants: Prof. Donald Fraser, Dr. Timothy Bowen)
£ 60,000 (36 months)
2015-2018
MRC PhD Studentship (to Ariadni Kouzeli)
"Use of human gamma/delta T-APCs in anti-tumour immunity"
Co-applicant (Principal applicant: Prof. Bernhard Moser; co-applicant: Prof. Andrew Godkin)
£ 60,000 (36 months)
2015-2018
Tenovus PhD Studentship (to Teja Rust)
"Human gamma/delta T-APCs: Processing of tumour antigens and induction of anti-tumour immunity"
Co-applicant (Principal applicant: Prof. Bernhard Moser; co-applicant: Prof. Awen Gallimore)
£ 89,780 (36 months)
2015-2018
NISCHR, Wales Cancer Research Centre project grant
"Preclinical models for novel immunotherapies"
Principal Applicant (co-applicants: Prof. Awen Gallimore, Prof. Bernhard Moser, Prof. Andrew Godkin, Dr. Ann Ager)
£ 110,000 (36 months)
2015-2016
Kidney Research UK, Project Grant
"Rapid detection of infection and improving survival in dialysis patients: the role of unconventional T-cell driven inflammatory responses"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Bernhard Moser, Dr. Kieron Donovan, Prof. Donald Fraser)
£ 199,218 (24 months)
2014-2015
MRC-Confidence in Concept Scheme (Biomedical Catalyst)
"Point-of-care diagnosis of acute sepsis"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Paul Davis, Dr. Peter Morgan, Dr. Tamas Szakmany, Dr. Matt Morgan)
£ 44,935 (12 months)
2014
Severnside Alliance for Translational Research (SARTRE), Health Technology Challenge Project Award
"Point-of-care diagnosis of bloodstream infections"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Judith Hall, Prof. Paul Davis)
£ 24,912 (6 months)
2014
British Society for Immunology
BSI Travel Awards to Chris Tyler, Hung-Chang Chen, Matt Morgan and Matthias Eberl
gamma/delta T Cell Conference in Chicago, USA, 16-18 May 2014
£ 4,000
2013-2016
EU FP7 Marie Curie Initial Training Network, ITN 287813
"European Training and Research in Peritoneal Dialysis (EuTRiPD)"
PhD Supervisor (in collaboration with academic centres in Amsterdam, Berlin, Cardiff, Heidelberg, Madrid, Poznan, Strasbourg, Vienna; industrial partners: Zytoprotect, Baxter, Abbott; and Dutch Kidney Foundation, Kidney Research UK, EuroPD)
€ 3,140,988 in total; € 517,568 of which to Cardiff University (48 months)
2013-2016
NIHR Invention for Innovation (i4i) Early Stage Product Development Award
"Rapid, non-invasive tests for acute bacterial infections based on pathogen specific immune fingerprints"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Prof. Ian Weeks, Prof. Chris Butler, Dr. Eryl Cox, Prof. Paul Davis)
£ 421,961 (30 months)
2013-2014
NISCHR/Wellcome Trust ISSF Seedcorn/Feasibility Grant
"Defining pathogen-specific responses in acute infection: development of point-of-care tests for bacterial identification"
Principal Applicant (co-applicants: Prof. Nicholas Topley, Dr. Kieron Donovan, Dr. Julian Marchesi, Dr. James Chess)
£ 49,972 (12 months)
2013
NISCHR Academic Health Science Collaboration Equipment Call
Co-applicant (lead applicant: Dr. Kieron Donovan)
£ 5,000
2013
Cancer Research UK, Cardiff CR-UK Centre Development Fund
"Overcoming the resistance of breast cancer stem cells to novel immunotherapies"
Principal Applicant (co-applicants: Dr. Richard Clarkson, Hung-Chang Chen)
£ 4,950 (12 months)
2012-2015
MRC PhD Studentship (to Chris Tyler)
"Control of alpha/beta T cell responses by human gamma/delta T-APCs"
Principal Applicant (co-applicant: Prof. Bernhard Moser)
£ 60,000 (36 months)
2012
British Society for Immunology
BSI Travel Awards to Martin Davey, Joanne Welton and Chan-Yu Lin
gamma/delta T Cell Conference in Freiburg, Germany, 31 May-2 June 2012
£ 2,100
2011-2015
Tenovus PhD Studentship (to Hung-Chang Chen)
"Human gamma/delta T cells for immunotherapy of breast cancer"
Principal Applicant (co-applicant: Dr. Richard Clarkson)
£ 89,993 (45 months)
2010-2013
Welsh Assembly Government, Health Research Award
"Improving patient outcomes from peritoneal dialysis related infections"
Principal co-applicant (Lead applicant: Dr. Gareth Roberts; co-applicants: Prof. Nicholas Topley, Prof. Aled Phillips)
£ 207,325 (45 months)
2010
Wellcome Trust, Biomedical Vacation Scholarship (to Sarah Rollason)
"gamma/delta T cells for cancer immunotherapy"
Principal applicant
£ 1,080 (6 weeks)
2010
Cancer Research UK, Cardiff CR-UK Centre Development Fund
Principal Applicant (co-applicants: Prof. Malcolm Mason, Prof. Peter Barrett-Lee)
£ 4,940 (9 months)
2010
British Society for Immunology
BSI Travel Awards to Raj Bansal, Martin Davey
gamma/delta T Cell Conference in Kiel , Germany, 19-21 May 2010
£ 1,000
2009-2013
Baxter Healthcare, Renal Discoveries Extramural Grant
"T cells, monocytes and neutrophils: detrimental crosstalk in peritoneal dialysis-related infection"
Principal Applicant (co-applicant: Prof. John D. Williams)
US$ 374,947 (48 months)
2009-2012
Cancer Research UK, Project Grant
"The functional plasticity of gamma/delta T cells and their exploitation in cancer therapy"
Principal Applicant (co-applicants: Prof. Malcolm Mason, Prof. Peter Barrett-Lee)
£ 170,067 (42 months)
2009-2010
Breast Cancer Campaign, Small Pilot Grant
"The role of TRAIL in human gamma/delta T cell-mediated cytotoxicity toward breast cancer cells"
Principal Applicant (co-applicant: Dr. Richard Clarkson)
£ 19,944 (12 months)
2008-2010
Welsh Assembly Government, MRC Health Research Partnership Award
"The role of T cells in peritoneal dialysis-related inflammation and infection"
Principal Applicant (co-applicant: Prof. Nicholas Topley)
£ 209,660 (27 months)
2007-2010
MRC Studentship (to Raj Bansal)
"B cell help provided by human gamma/delta T cells"
Principal Applicant (co-applicant: Prof. Bernhard Moser)
£ 55,050 (36 months)
2007-2011
Research Councils UK
RCUK Fellowship in Translational Research in Experimental Medicine
£ 125,000 (60 months)
2007
Wellcome Trust, 'Value in People' Award
"Cells in bridging innate and adaptive immune responses"
Principal Applicant (co-applicant: Prof. Paul Morgan)
£ 34,786 (12 months)
Supervision
Goruchwyliaeth gyfredol
Past projects
PhD – Chris J Tyler
"Control of CD4+ T cell responses by γδ T-APCs"
Supervisor (Co-supervisor: Prof. Bernhard Moser)
Awarded in 2016
PhD – Anna Rita Liuzzi
"Unconventional T-cell driven inflammatory responses during acute peritonitis: implications for diagnosis and therapy of peritoneal dialysis patients"
Supervisor (Co-supervisor: Dr. Tim Bowen)
Awarded in 2015
PhD – Hung-Chang Chen
"Human γδ T cell-based immune therapy for breast cancer"
Supervisor (Co-supervisor: Dr. Richard Clarkson)
Awarded in 2015
PhD – Matt P Morgan
"Immune fingerprinting in acute severe sepsis"
Co-supervisor (Supervisor: Prof. Judith Hall)
Awarded in 2014
PhD – Luke Piggott
"Investigating the therapeutic potential of cellular FLICE-like inhibitory protein and TRAIL in preclinical models of breast cancer"
Co-supervisor (Supervisor: Dr. Richard Clarkson)
Awarded in 2012
PhD – Chan-Yu Lin
"The role of γδ T cells in peritoneal dialysis-associated bacterial infection"
Supervisor (Co-supervisor: Prof. Nicholas Topley)
Awarded in 2012
PhD – Martin S Davey
"Cellular crosstalk of human Vγ9/Vδ2 T cells, neutrophils and monocytes in response to bacterial infections"
Supervisor (Co-supervisor: Prof. Bernhard Moser)
Awarded in 2012
PhD – Raj R Bansal
"B cell help provided by human γδ T cells"
Supervisor (Co-supervisor: Prof. Bernhard Moser)
Awarded in 2012
Ymgysyllty
I am passionate about engaging and involving the public in my research and disseminate relevant findings to specialist and lay audiences.
As Engagement Lead of the Systems Immunity Research Institute, I conceive, oversee and coordinate a wide range of engagement and involvement activities, and aim to reach out to all stake-holders in our research - patients, health care providers, schools, policy makers, media, funders, industry and the general public.
I established and chair a Lay Faculty for the Systems Immunity Research Institute consisting of members of the public who provide valuable feedback on research proposals, study protocols, consent forms, news items and press releases, and help foster a close dialogue between local scientists and the wider public. This Lay Faculty has developed into a flagship involvement activity at Cardiff University and has received very positive feedback from Health and Care Research Wales and the Wellcome Trust.
In addition to facilitating and promoting engagement activities by colleagues across the Systems Immunity Research Institute and the College of Biomedical and Life Sciences, over the past 3 years I directly developed and contributed to activities such as 1) showcasing Cardiff research twice at Techniquest, the local Science museum; 2) promoting the importance of international research and collaboration for Cardiff University, Wales and the UK at receptions in the National Assembly for Wales and the House of Commons; 3) hosting the MP for Cardiff Central, Jo Stevens, at the Annual Infection & Immunity Meeting 2017; 4) creating educational computer games for primary schools; 5) developing a Welsh-medium philosophy/immunology workshop for primary school children; 6) establishing contacts with Radio Glamorgan, the local hospital radio station; 7) designing a Cardiff-wide bus stop poster campaign; 8) running a university-wide picture/artwork competition; 9) celebrating diversity and equality across Infection & Immunity, the School of Medicine and the University as a whole, and promoting the importance of international collaboration and training for local research and innovation; and 10) collaborating with BBC Wales on a programme about sepsis involving BBC weatherman Derek Brockway, and on sourcing laboratory equipment and props for the Dr Who Christmas Special 2014.
As Web Editor of the Systems Immunity URI (and its predecessors, the i3-IRG and the Institute of Infection & Immunity, since 2009), I have substantially improved the visibility of local research, teaching, innovation and engagement, accompanied by successful social media accounts (>1,600 Twitter followers). I also created an interactive ‘γδ T cell Forum’, which has >1,000 followers from >50 countries and has developed into a key networking resource in the field.
Through my participation in the core activities of the British Society for Immunology (BSI), the largest immunological society in Europe, I directly promote immunology-related research, public engagement and education in Wales, the UK and beyond. I was elected as BSI Trustee in 2017, after serving two terms as Regional Representative for Wales on the BSI Forum (2010-2016), the Society’s ‘think tank’. As one of only 12 Trustees, I am directly responsible for the effective operation of the Society, with regard to finance, governance, strategy and supervision of its CEO. As Chairman of the BSI South Wales regional group (2007-2015), I established Cardiff as one of the most active and visible regional groups in the UK, increased its annual budget eight-fold, and created the prestigious annual Jonathan Boulter Memorial Lecture given by the leading immunologists in the world.