Our response to Coronavirus (COVID-19)
Systems Immunity University Research Institute (SIURI) researchers have mobilized in response to coronavirus (COVID-19).
We have been working with colleagues in NHS Wales, Public Health Wales and Welsh Government and have played important roles in UK-wide initiatives in virus sequencing and understanding the role of the immune system during coronavirus (COVID-19), amongst a wide range of research activities.
Understanding the immune system during COVID-19
SIURI scientists made major contributions to coronavirus COVID19 immunology-related research, gaining new insight into how the immune system functions during SARS-CoV-2 infection, investigating new therapeutic strategies to modulate the immune response in severe COVID patients, and developing diagnostics designs to detect whether individuals have mounted immune responses to SARS-CoV-2.
- Professor Paul Morgan
- Dr Richard Stanton
- Dr Eddie Wang
- Professor David Price
- Professor Ian Humphreys
- Professor Awen Gallimore
- Professor Peter Ghazal
- Professor Andy Sewell
- Covid patients at 'death's door' recovering with immune system drugs, scientists say - The Telegraph
- Coronavirus: Immunity may be more widespread than tests suggest - BBC News
- Welsh scientists join UK effort to understand how the immune system responds during Covid-19.
Examining immune responses in asymptomatic individuals
We are performing a national Core Study (in collaboration with Nottingham and Cambridge), coordinating COVID-19 asymptomatic testing programmes in university settings nationally, including the Cardiff University qPCR pipeline, providing insight on acquired immunity across the student population.
Studying COVID vaccinations
Protecting the most vulnerable individuals is a key priority for the SARS-CoV-2 vaccination strategy. We are examining the effect of vaccination on both SARS-CoV-2-specific T cell and antibody responses in cancer patients, in collaboration with the Velindre University NHS Trust and the Wales Cancer Bank
With the Wales Kidney Research Unit, we are studying vaccine-induced immune responses in renal dialysis patients.
Tracking and attacking SARS-CoV-2
We have made major contributions to national efforts, as part of the COVID-19 Genomics UK (COG-UK) Consortium, tracking SARS-CoV-2.
We have participated in local efforts in establishing the Cardiff University PCR pipeline for asymptomatic testing of our staff and students, to help detect SARS-CoV-2 infections. We have also developed strategies for controlling SARS-CoV-2 infection, investigating whether mouthwash can be exploited to control SARS-CoV-2 infection.
Multi-morbidity and predicting outcome
Beyond immunology, SIURI researchers have made significant impact in understanding how other diseases and conditions, termed multi-morbidity, impacts on COVID-19 severity. We have investigated whether we can predict clinical outcome of COVID-19 by early biomarkers.
Dealing with the information pandemic
Working with researchers in Oxford University, we have established a literature review system for immunology-related COVID-19 scientific literature.
The initiative, driven by PhD students and postdocs has led to the development of ‘Living Reviews’, which enable constant updating to keep up with the ever-changing research topic of COVID-19.
The reviews are available in the new open access journal of the Oxford University Press (OUP), Oxford Open Immunology.