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Dr Tomasz Jurkowski

Dr Tomasz Jurkowski

Senior Lecturer

School of Biosciences

Email
jurkowskit@cardiff.ac.uk
Telephone
+44 (0)29 2087 6291
Campuses
Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
Users
Available for postgraduate supervision

Overview

Research overview

I want to understand how a cell’s differentiation state is established and how it is maintained over the whole lifetime of an organism. Because the cell’s differentiation state is encoded in the epigenetic blueprint, the stability of the cellular differentiation state depends on the stability of the underlying epigenetic profile. However, as the enzymes maintaining the epigenetic states are responsive to various parameters, epigenetic signatures are also dynamic in nature, thus providing transcriptional plasticity in response to environmental stimuli and intrinsic and extrinsic cellular stress. My group employs an interdisciplinary, modular approach to dissect the chromatin networks responsible for establishing and maintaining the epigenetic signals.

Current research within the group splits across three interdisciplinary themes:

  • Understanding the biochemistry and specificity of epigenetic machinery (with a focus on DNA methyltransferases and demethylases)
  • Synthetic epigenetics - developing tools and applying them to study and control cell epigenetic system
  • Single-cell multi-omics - developing novel technology to study epigenetic and transcriptional profiles of single cells

Biography

Tomasz Jurkowski studied Molecular Biology at Warsaw University (PL) (1999-2004). He did his MSc thesis in the laboratory of Dr Janusz Bujnicki (IIMCB, PL) and Dr Monika Radlinska (Warsaw University, PL). Afterwards, he joined the group of Dr Albert Jeltsch at Jacobs University Bremen for his doctoral training, which he completed in 2008. After 4 years of post-doctoral training at Jacobs University in 2012, he joined the Faculty of Chemistry at the University of Stuttgart as a Junior Professor in Biochemistry and Molecular Epigenetics. In 2019 he joined Cardiff University as Senior Lecturer in Mammalian Systems.

Academic positions

  • 2019 – present: Senior Lecturer for Mammalian Systems, Cardiff University
  • 2012 – 2019: Junior Professor for Molecular Epigenetics and Biochemistry, Stuttgart University (Germany)
  • 2009 – 2012: 50% Postdoctoral Researcher, 50% Teaching Lecturer, Jacobs University Bremen (Germany)

Publications

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2009

2008

2007

2006

Supervision

I am interested in supervising students in:

  • Molecular epigenetics: Biochemistry of epigenetic machinery
  • Synthetic epigenetics: Developing and applying innovative tools to study and manipulate epigenetic systems in the cells
  • Biochemistry of nucleic acid modifying enzymes: from polymerases to oxidases
  • Single-cell multiomics: New methods to study single cells using cutting edge new omics tools
  • High-throughput assays and automation