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Leading Cardiff Chemistry research in the spotlight

22 May 2014

A recent communication in the Journal of the American Chemical Society, by Professor Rudolf Allemann and co-workers, is the subject of a prestigious Spotlight article by the journal. The work investigated the role of protein motions in& catalysis by dihydrofolate reductase from Thermotoga maritima,a bacterium which grows in extremely hot environments such as hot springs and hydrothermal vents. By labelling the entire enzyme with& heavy isotopes of hydrogen, carbon and nitrogen, and investigating the effect on the catalysed chemistry, the study found no evidence of the coupling of motions to the chemistry. Previous studies on other enzymes have found a link between motions and chemistry. The new work therefore suggests that proteins motions are not universally coupled to reaction kinetics, and offers clues into the types of evolutionary trade-offs that may occur in enzymes to gain thermal stability.

Spotlights, is a new feature introduced to the Journal of the American Chemical Society in 2012, and is intended to make published research more accessible to the broader community. To find out more details the link to the Spotlight article is:

http://pubs.acs.org/doi/pdf/10.1021/ja504884p

 

Leading Cardiff Chemistry research in the spotlight

Original image copyright MARUM, University of Bremen, Germany