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PRINCESS

To answer the question of whether a probiotic supplement can reduce the number of infections in care home residents, to reduce antibiotic use in this vulnerable group and help curb antiobiotic drug resistance.

Brief Description

The PRINCESS trial will assess the efficacy and mechanisms of a nutritional intervention (daily probiotics) to enhance immune function and reduce infection in care home residents. This is anticipated to reduce antibiotic prescribing for common infectious diseases in a high-risk population.

Background

Care home residents (CHR) are particularly vulnerable to common infectious diseases which are the commonest cause of hospitalisation in this group, and often result in lasting health decline. Frailty, atypical presentation and bacterial colonisation patterns lead to high antibiotic use. Reducing antibiotic prescribing in the expanding care home sector is central to the challenge of containing antimicrobial resistance (AMR) in the UK.

The PRINCESS trial will assess the efficacy and mechanisms of a nutritional intervention (daily probiotics) to enhance immune function and reduce infection in care home residents. This is anticipated to reduce antibiotic prescribing for common infectious diseases in a high-risk population. Antibiotic prescribing directly correlates with resistance. Fewer antibiotics will reduce the driving influence on AMR and is expected to reduce the likelihood of subsequent resistant infection.

Information

Key facts

Start date 1 Sep 2015
End date 30 Nov 2018
Grant value £2,223,889
Status
  • Follow up

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