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Exercise rehabilitation trial in Huntington’s disease.

This study aimed to evaluate the feasibility and benefit of a structured exercise intervention in people with Huntington’s Disease (HD). Participants were randomized into either exercise or control (usual care) groups at 6 sites in the UK, Netherlands, Norway and Germany.

They were assessed at baseline, 13 and 26 weeks. The intervention was 12 weeks, three times per week progressive exercise program, including aerobic (stationary cycling) and upper and lower body strengthening exercise with tapered 1:1 support for 20 of 36 sessions.

At the end of the study, those in the exercise group had better fitness and improved motor function. This study demonstrates that a short-term exercise intervention is safe and feasible.

Individuals with HD may benefit from structured exercise, and intensity, monitoring and support may be key factors in optimising response. Larger scale trials are now required.

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Chief Investigator(s)
Funder(s) Gossweiler Foundation
Sponsor Cardiff University
ISRCTN 11392629

Key facts

Start date 1 Dec 2013
End date 30 Sep 2016
Grant value £178,410
  • Published

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