A new approach to target aberrant systolic calcium release and associated cardiac arrhythmias
Understanding the triggers for abnormal calcium release may enable novel anti-arrhythmic therapies to be developed.
The central aim of this project is to understand how pathological changes in calcium regulation in the heart can lead to arrhythmias and sudden death. We are investigating this question using:
- transgenic mouse models of human heart disease
- confocal calcium imaging and electrophysiology in isolated cardiac muscle cells (myocytes)
- whole organ physiology (perfused heart)
- in vivo functional measurements
- in silico approaches
This project has received funding of £748,171 over 5 years from the British Heart Foundation Intermediate Basic Sciences Research Fellowship to Dr Ewan Fowler.
- Dr Spyros Zissimopoulos, Swansea University (co-supervisor)
We offer postgraduate research study with interdisciplinary collaborations and connections with industry, commerce & government.