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Solid cancers

Solid Cancers

Our aim is to improve the outcome of patients with cancer with a primary focus on clinical trials and linked laboratory research.

We are a highly collaborative unit with local, national and international links. We are formed of several clinical academics, three basics science groups and the Wales Cancer Bank. We are particularly interested in the effects of multiple therapies on the cancer and the patient, and have current strengths in novel combination trials and radiotherapy trials.

We have funding from various sources including Cancer Research UK, Prostate Cancer UK, Medical Research Council and, within Wales, by Cancer Research Wales, Tenovus, the Life Sciences Research Network Wales and Health and Care Research Wales.

We have strong links to College Infrastructure units, such as the Centre for Trials Research (WCTU), The Wales Research and Diagnostic PET Imaging Centre and European Cancer Stem Cell Research Institute (ECSCRI), and the NHS, particularly Velindre NHS Trust and Cardiff and Vale University Health Board.

Theme lead

Dr John Staffurth

Dr John Staffurth

Director of Radiotherapy Trials and Clinical Reader in Oncology

Email
staffurthjn@cardiff.ac.uk
Telephone
+44 (0)29 2031 6964

Area of interest

John is a Clinical Reader and Consultant Clinical Oncologist at Cardiff University and Velindre Cancer Centre, Director for Radiotherapy Trials for the Centre for Trials Research and Chair of the Radiotherapy Research Group in Velindre. His clinical practice and research is focussed on urological cancers and radiotherapy.

He is a member of the National Cancer Research Institute (NCRI) prostate cancer study group and of its localised subgroup. He is a member of the NCRI Radiotherapy Research group (CTRad) and chaired its Technology, Physics and Radiotherapy Trials Quality Assurance (RTTQA) work stream for five years. He is on the management group of the NCRI's RTTQA group. He is actively in clinical trial design and delivery across the disease spectrum of prostate and bladder cancer, with a particular interest in radiotherapy trials.

John chairs the translational research group of the PIVOTAL boost trial and leads the pelvic nodal protocol development group. He is the clinical lead for the Cardiff RTTQA group and is involved in researching educational opportunities linked to this.

John has been involved in national groups implementing advanced radiotherapy into the UK, and is a member of the Clinical Oncology Subcommittee of the Welsh Scientific Advisory Committee. He oversees the Late Phase Trials work package of the Wales Cancer Research Centre. John has a long standing collaboration with Dr Emilino Spezi, Senior Lecturer in the School of Engineering, covering imaging and technology within radiotherapy.

Principal members of staff

NameArea of interest
Dr John StaffurthProfessor Richard Adams, Professor Malcolm Mason, Professor Howard Kynaston, Professor Peter Barrett-Lee and Mererid Evans

Designing and delivering multi-centre late-phase clinical trials and associated translational research in various solid (prostate, bladder, breast, colorectal and head and neck) cancers in collaboration with local, national and international collaborators.

Professor John Chester and Dr Robert Jones

Designing and delivering multi-centre early-phase clinical trials and associated translational research in various solid (including bladder, breast, and head and neck) cancers in collaboration with local, national and international collaborators.

Professor Richard AdamsProfessor Malcolm Mason and Alison Parry-Jones

Collecting and curating tissue samples with a focus on breast, prostate, colorectal and lung cancer; supporting the generation of novel research groups in these tumours.

Dr Aled Clayton

Investigating the complex cell-communication roles of tumour exosomes in the microenvironment, and their utility as cancer biomarkers.

Dr Zsuzsanna Tabi

Research group with an interest T-cell immunology in cancer and changes with different therapies, with a particular strength in prostate cancer and mesothelioma.

Dr Alan Parker

Research within the Parker group focuses on development of refined, tumour selective virotherapies based on adenoviral vectors for both local and systemic applications in chemotherapy resistant cancers.

Research groups