Genetic and genomic medicine
Cell and molecular biologists, genomic scientists, bioinformaticians and clinical geneticists are working to better understand the mechanisms of cancer and inherited disorders and to translate this knowledge to the diagnosis, treatment and prevention of cancer and inherited conditions.
Funded by the Medical Research Council (MRC), Cancer Research UK, BloodWise, Health and Care Research Wales, as well many other research charities, the work undertaken in the sub-division aims to build on our existing areas strengths.
Area of interest
Understanding how telomere-driven genome instability and DNA repair deficiencies can drive the evolution of the cancer genome and the clinical applications of telomere length analysis.
Principal members of staff
|Name||Area of interest|
|Professor Rachel Errington|
Using fundamental biophotonics and imaging principles to determine cellular phenotypes in complex 2D/3D systems.
|Professor Simon Reed|
Using novel genomic methods for measuring DNA damage and repair in chromatin to identify signatures that predict response to therapies.
|Dr Andrew Tee|
Using rare cancer predisposition syndromes to elucidate the underlying mechanisms of tumourigenesis.
|Professor David Cooper|
Cataloging gene lesions responsible for human inherited disease.
|Professor Julian Sampson|
Investigating the molecular and cellular mechanisms and opportunities for targeted therapy in tuberous sclerosis and familial colorectal cancer.
|Professor Angus Clarke|
Clinical and molecular genetics research into Rett syndrome and related disorders.