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Mineralised Tissue Biology Repair and Regeneration in Orofacial Biology

Mesenchymal stem cells isolated from human dental pulp

Mesenchymal stem cells isolated from human dental pulp

Head of Theme: Prof Alastair J Sloan

Key findings, achievements and areas of work

  • Harnessing Dental Pulp Stem Cells to Enhance Tissue Regeneration (MRC, £274K)
  • Probing the mechanical control of stem cell fate through the development of novel, non-invasive imaging technologies (with Prof P Stephens and colleagues EPSRC, £1.5M)
  • An ex vivo Rodent Mandible Culture Model for Bone Repair, Smith EL, Locke M, Waddington RJ and Sloan RJ (2010) Tissue Engineering Part C EPub.
  • Colombo JS, Balani D, Sloan AJ, Crean StJ, Okazaki J, Waddington RJ (2010) Delayed osteoblast differentiation and altered inflammatory response around implants placed in incisor sockets of type 2 diabetic rats.  Clinical Oral Implants Research.  In press.
  • Identification of novel antimicrobials and development of new techniques to promote vital pulp therapy modulating host-microbial interaction (£61K Cross-School Richard Whipp Cardiff University Studentship, School of Pharmacy)
  • Hunter-Schreger Bands and their implications for clinical dentistry. (2010) Lynch CD, O’Sullivan VR, McGillycuddy CT, Dockery P, Rees JS, Sloan AJ. Journal of Oral Rehabilitation (In-press)
  • Ex vivo models to further understanding of inflammatory cell bone diseases (£194K MRC/NC3R)
  • Dilemmas in operative dentistry: to bond or to base? Effects of adhesive restorative agents on solubilising dentine matrix proteins (L Sadaghiani, ASM Gilmour, RJ Waddington, AJ Sloan, CD Lynch) - Awarded poster prize at the joint meeting with the Academy of Operative Dentistry European Section 2010.
  • Molecular and functional study of novel cytokine IL-35 (11K; China Scholarship Council; MAO Lewis, XQ Wei Cardiff; FY Liew, Glasgow)

Group Members

  • Prof Alastair J Sloan - Reader in Bone Biology & Tissue Engineering, Head of Tissue Engineering & Reparative Dentistry
  • Prof Rachel J Waddington - Professor in Oral Biochemistry, Director of Postgraduate Research Studies
  • Dr Chris Lynch - Senior Clinical Lecturer / Honorary Consultant in Restorative Dentistry, Clinical lead Mineralised Tissue Group
  • Dr Xiao-Qing Wei - Lecturer
  • Mrs Leili Sadaghiani - Clinical Lecturer / Specialist Registrar in Restorative Dentistry
  • Dr John Colombo - Postdoctoral Research Assistant
  • Mr Chi P Lee - Postgraduate Research Student
  • Mrs Bindhu Koshy - Clinical Research Fellow
  • Mr Madhan Natarajan - Clinical Lecturer
  • Gurcharn Bhamra - Clinical Lecturer
  • Mr Amr Alraies - Postgraduate Research Student
  • Miss Jodie Harrington - Postgraduate Research Student
  • Norhayati Yusop - Postgraduate Research Student

Clinical Staff Directly Associated with the Mineralised Tissue Group

  • Dr Alan Gilmour - Reader / Consultant in Restorative Dentistry
  • Prof Jeremy Rees - Professor of Restorative Dentistry
  • Dr Helen Rogers - Walport Clinical Lecturer

Staff Associated with the Mineralised Tissue Group