Dr Vera Knauper
Selected Publications
Amour,A., Hutton,M., Knauper,V., Slocombe,P.M., Webster,A., Butler,M., Knight,C.G., Smith,B.J., Docherty,A.J., and Murphy,G. (1999). Inhibition of the metalloproteinase domain of mouse TACE. Ann. N. Y. Acad. Sci. 878, 728-731.
Balbin,M., Fueyo,A., Knauper,V., Lopez,J.M., Alvarez,J., Sanchez,L.M., Quesada,V., Bordallo,J., Murphy,G., and Lopez-Otin,C. (2001). Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J. Biol. Chem. 276, 10253-10262.
Cowell,S., Knauper,V., Stewart,M.L., D'Ortho,M.P., Stanton,H., Hembry,R.M., Lopez-Otin,C., Reynolds,J.J., and Murphy,G. (1998). Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3. Biochem. J. 331 ( Pt 2), 453-458.
Gomis-Ruth,F.X., Gohlke,U., Betz,M., Knauper,V., Murphy,G., Lopez-Otin,C., and Bode,W. (1996). The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain. J. Mol. Biol. 264, 556-566.
Knauper,V., Wilhelm,S.M., Seperack,P.K., DeClerck,Y.A., Langley,K.E., Osthues,A., and Tschesche,H. (1993). Direct activation of human neutrophil procollagenase by recombinant stromelysin. Biochem. J. 295 ( Pt 2), 581-586.
Knauper,V., Lopez-Otin,C., Smith,B., Knight,G., and Murphy,G. (1996). Biochemical characterization of human collagenase-3. J. Biol. Chem. 271, 1544-1550.
Knauper,V., Murphy,G., and Tschesche,H. (1996). Activation of human neutrophil procollagenase by stromelysin 2. Eur. J. Biochem. 235, 187-191.
Knauper,V., Will,H., Lopez-Otin,C., Smith,B., Atkinson,S.J., Stanton,H., Hembry,R.M., and Murphy,G. (1996). Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme. J. Biol. Chem. 271, 17124-17131.
Knauper,V., Docherty,A.J., Smith,B., Tschesche,H., and Murphy,G. (1997). Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis. FEBS Lett. 405, 60-64.
Knauper,V., Smith,B., Lopez-Otin,C., and Murphy,G. (1997). Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13). Eur. J. Biochem. 248, 369-373.
Knauper,V., Cowell,S., Smith,B., Lopez-Otin,C., O'Shea,M., Morris,H., Zardi,L., and Murphy,G. (1997). The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. J. Biol. Chem. 272, 7608-7616.
Knauper,V., Patterson,M.L., Gomis-Ruth,F.X., Smith,B., Lyons,A., Docherty,A.J., and Murphy,G. (2001). The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity. Eur. J. Biochem. 268, 1888-1896.
Knauper,V., Bailey,L., Worley,J.R., Soloway,P., Patterson,M.L., and Murphy,G. (2002). Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13. FEBS Lett. 532, 127-130. Lee,M.H., Knauper,V., Becherer,J.D., and Murphy,G. (2001). Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-alpha convertase. Biochem. Biophys. Res. Commun. 280, 945-950.
Stracke,J.O., Hutton,M., Stewart,M., Pendas,A.M., Smith,B., Lopez-Otin,C., Murphy,G., and Knauper,V. (2000). Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. J. Biol. Chem. 275, 14809-14816.
Worley,J.R., Thompkins,P.B., Lee,M.H., Hutton,M., Soloway,P., Edwards,D.R., Murphy,G., and Knauper,V. (2003). Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP). Biochem. J. 372, 799-809.