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The Plasmepsins
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Plasmodium falciparum is now known to encode at least 9 aspartic proteinases (plasmepsins) along with a further Histo-aspartic proteinase (HAP) which is very closely related to plasmepsins I, II and IV. Their nucleotide and protein sequences can be downloaded via the link below. Links to further plasmepsins in the database from other Plasmodium parasites are also provided. Crystal structures have been determined for plasmepsin sequences and are available from Brookhaven Protein Data Bank (PDB) mirror sites. Theoretical models of further plasmepsins are also available at these sites. Links below are only to those structures determined crystallographically. |
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Plasmepsin Sequences Downloadable lists of P. falciparum plasmepsin Protein and DNA sequences (rtf documents) P. vivax plasmepsin (Acc No. AF001208) P. ovale plasmepsin (Acc No. AF001209) P. malariae plasmepsin (Acc No. AF001210) P. berghei plasmepsin (Acc No. AJ223308) P. chabaudi plasmepsin (Acc No. AF427013) |
| Plasmepsin Structures See also: ICS Database Plasmepsin II Structure 1SME (2.70Å) With Isovaleryl pepstatin Plasmepsin II Structure 1M43 (2.40Å) With Isovaleryl pepstatin Plasmepsin II Structure 1LEE (1.90Å) With inhibitor Rs367 Plasmepsin II Structure 1LF2 (1.80Å) With inhibitor Rs370 Plasmepsin II Structure 1LF3 (2.70Å) With inhibitor Eh58 Plasmepsin II Structure 1LF4 (1.90Å) Pro-plasmepsin II Structure 1PFZ (1.85Å) Plasmepsin IV Structure 1LS5 (2.80Å) With Isovaleryl pepstatin P. vivax Plasmepsin Structure 1QS8 (2.50Å) With Isovaleryl pepstatin P. vivax Pro-plasmepsin Structure 1MIQ (2.50Å) |
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CB HomePage | Toxins | Proteinases | FA Synthesis |Publications |
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Updated October '05 |
