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Peer reviewed research articles

Langdon-Jones, E. et al. 2014. Fluorescent Rhenium-Naphthalimide conjugates as cellular imaging agents. Inorganic Chemistry 53(7), pp. 3788-3797. (10.1021/ic500142z)

Sivan, S. et al. 2014. Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc. European Spine Journal 23(3), pp. 344-353. (10.1007/s00586-013-2767-8)

Hayes, A. et al. 2014. Confocal microscopy demonstrates association of LTBP-2 in fibrillin-1 microfibrils and colocalisation with perlecan in the disc cell pericellular matrix. Tissue and Cell 46(3), pp. 185-197. (10.1016/j.tice.2014.04.002)

Boros-Majewska, J. et al. 2014. Novel Nystatin A1 derivatives exhibiting low host cell toxicity and antifungal activity in an in vitro model of oral candidosis. Medical Microbiology and Immunology  (10.1007/s00430-014-0343-4)

Shu, C. et al. 2013. The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal 30(7), pp. 717-725. (10.1007/s10719-013-9475-9)

Millet, C. et al. 2013. Mitochondria-derived organelles in the diplomonad fish parasite Spironucleus vortens. Experimental Parasitology 135(2), pp. 262-273. (10.1016/j.exppara.2013.07.003)

Hayes, A. et al. 2013. Spinal deformity in aged zebrafish Is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis. PLoS ONE 8(9), pp. e75787. (10.1371/journal.pone.0075787)  

Williams, C. et al. 2013. Diversity in mitochondrion-derived organelles of the parasitic diplomonads Spironucleus and Giardia. Trends in Parasitology 29(7), pp. 311-312. (10.1016/

Hayes, A. et al. 2013. Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis. Developmental Dynamics 242(6), pp. 778-789. (10.1002/dvdy.23970)

Li, S. et al. 2013. The effect of beta-xylosides on the chondrogenic differentiation of mesenchymal stem cells. Histochemistry and Cell Biology 139(1), pp. 59-74. (10.1007/s00418-012-1017-1)

Hayes, A. J., Smith, S. M. and Melrose, J. 2013. Comparative immunolocalisation of fibrillin-1 and perlecan in the human foetal, and HS-deficient hspg2 exon 3 null mutant mouse intervertebral disc. Histochemistry and Cell Biology 139(1), pp. 1-11. (10.1007/s00418-012-1041-1)

Lloyd, D. et al. 2013. Intracellular oxygen: similar results from two methods of measurement using Phosphorescent nanoparticles. Journal of Innovative Optical Health Sciences 7(2), article number: 1350041. (10.1142/S1793545813500417)

Melrose, J., Isaacs, M.D., Smith, S.M., Hughes, C.E., Little, C.B., Caterson, B., Hayes, A.J. (2012) Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochemistry and Cell Biology. Web link

Taylor, D.W., Ahmed, N., Hayes, A.J., Ferguson, P., Gross, A.E., Caterson, B., Kandel, R.A. (2012) Hyaline Cartilage Tissue Is Formed through the Co-culture of Passaged Human Chondrocytes and Primary Bovine Chondrocytes. Journal of Histochemistry and Cytochemistry. Web link

Hooper, S., Percival, S., Hill, K., Thomas, D., Hayes, A.J., Williams, D. (2012) The visualisation and speed of kill of wound isolates on a silver alginate dressing. International Wound Journal. Web link.

Li, S., Hughes, C., Melrose, J., Smith, S.M., Little, C.B., Caterson, B., Hayes, A.J. (2011) Chondroitin sulphate sulphation motifs as biomarkers for identifying the development of musculoskeletal tissues in human foetal bone. Journal of Bone and Joint Surgery, 93-B Web link

Hayes, A.J., Isaacs, M.D., Hughes, C., Caterson, B. & Ralphs, J.R. (2011) Collagen fibrillogenesis in the development of the annulus fibrosus of the intervertebral disc. eCM 22: 226-241.Web link

Hayes, A.J., Lord, M.S., Smith, M.M., Whitelock, J.M., Weiss, A.S. & Melrose, J. (2011) Colocalization in vivo and association in vitro of perlecan and elastin. Histochem Cell Biol 136: 537-454.Web link

Hayes, A.J. & Ralphs, J.R. (2011) The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-1 and IGF-1. Histochem Cell Biol 136: 163-175. Web link

Hayes A.J., Smith, S.M., Gibson, M.A. & Melrose, J. (2011) Comparative immunolocalisation of the elastin fibre associated proteins fibrillin-1, LTBP2 and MAGP-1 with components of the collagenous and proteoglycan matrix of the foetal human intervertebral disc. Spine [Epub ahead of print] PMID: 21540769. Web link

Parsons, P., Gilbert, S.J., Vaughan-Thomas, A., Sorrel, D.A., Notman, R., Bishop, M., Hayes, A.J., Mason, D.J. & Duance, V.C. (2011) Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. J Biol Chem 286: 34986-34997. Web link

Thorp-Greenwood, F.L., Fernandez-Moreira, V., Millet, C.O., Williams, C.F., Cable, J., Court, J.B., Hayes, A.J., Lloyd, D. & Coogan, M.P. (2011) A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging. Chem Commun 47: 3096-3098. Web link

Evans, L., Williams, A.S., Hayes, A.J., Jones, S.A. & Nowell, M. (2011) Selective inhibition of pre-B-cell enhancing factor suppresses leukocyte infiltration and cartilage degradation. Arthritis & Rheumatism. Accepted for publication.

Hayes, A.J., Hughes, C., Ralphs, J. & Caterson, B. (2011) Chondroitin sulphate sulphation motif expression in the ontogeny of the intervertebral disc. Eur. Cells &  Mat. 21: 1-14 Web link

Silva, S., Henriques, M., Hayes, A., Oliveira, R., Azeredo, J. & Williams, D.W. (2010) Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium. Pending minor corrections for publication in J. Oral Pathology & Medicine. JOPM-07-10-OA-1286. Web link

Akhtar, S., Bron, A.J., Hayes, A.J., Meek, K.M. & Caterson (2010) Role of keratan sulphate (sulphated poly-N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis. Accepted for publication in Graefes Arch. Clin. Exp. Ophthalmol. DOI 10.1007/s00417-010-1512-9 Web link

Fernandez-Moreira, V., Thorp-Greenwood, F.J., Amoroso, A.J., Cable, J., Court, J.B., Gray, V., Hayes, A.J., Jenkins, R.L., Kariuki, B.M., Lloyd, D., Millet, C.O., Williams, C.F., Coogan, M.P. (2010) Uptake and localisation of rhenium fac-tricarbonyl polypyridyls in fluorescent cell imaging experiments. Org. Biomol. Chem. 8(17):3888-901 Web link

Coogan, M.P., Court, J.B., Gray, V.L., Hayes, A.J., Lloyd, S.H., Millet, C.O., Pope, S.J.A. & Lloyd, D. (2010) Probing intracellular oxygen by quenched phosphorescence lifetimes of nanoparticles containing polyacrylamide-embedded [Ru(dpp(SO3Na)2)3]Cl2. Photochem. Photobiol. Sci. 9: 103-109 Web link

Li, S., Hughes, C., Melrose, J., Smith, S.M., Little, C.B., Caterson, B., Hayes, A.J. (June 2009) Chondroitin sulphate sulphation motifs as biomarkers for identifying the development of musculoskeletal tissues in human foetal bone. Annual Meeting of the British Orthopaedic Research Society, Newcastle, England..

Malic S.M., Hill, K.E., Hayes, A., Percival S.L., Thomas, D., Williams, D.W. (2009) Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid (PNA) fluorescent in situ hybridisation (FISH) Microbiol. 155, 2603-2611 Web link

Nowell, M.A., Williams, A.S., Carty, S.A., Scheller, J., Hayes, A.J., Jones, G.W., Richards, P.J., Slinn, S., Ernst, M., Jenkins, B.J., Topley, N., Rose-John, S., Jones, S.A. (2009) Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. J Immunol. 2009 Jan 1;182(1): 613-22 Web link

Gealy, C.C., Hayes, A.J., Buckwell, R.E, Young, R.D, Caterson, B., Quantock, A.J., Ralphs, J.R. (2008) Actin and type I Collagen Propeptide Distribution in the Developing Chick Cornea. Invest Ophthalmol Vis Sci .Web link

Akhtar, S., Kerr, B.C., Hayes A.J., Hughes, C.E., Meek, K.M. & Caterson, B. (2008) Immunochemical localisation of keratan sulphate proteoglycans in cornea, sclera and limbus using a keratanase generated neoepitope monoclonal antibody. Invest Ophthalmol Vis Sci. 49: 2424-2431. Web link

Bazou, D., Coakley, W.T., Hayes, A.J., Jackson, S.K. (2008) Long-term viability and proliferation of alginate-encapsulated 3-D HepG2 aggregates formed in an ultrasound trap. Toxicol. In Vitro (in press)

Amoroso A.J., Arthur, R.J., Coogan, M.P., Court, J.B., Fernandez-Moreira, V., Hayes, A.J., Lloyd, D., Millet, C., Pope, S.J.A. (2008) 3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria. New J. Chem.(in press) Web link

Melrose, J., Hayes, A.J., Whitelock, J.M., Little, C.B. (2008) Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues. BioEssays 30: 457-469. pdf

Hayes, A.J., Hughes, C., Caterson, B (2008) Antibodies and immunohistochemistry in extracellular matrix research. Methods. 45: 10-21.

Hayes, A.J., Tudor, D, Nowell, M.A., Caterson, B., Hughes, C.E. (2008) Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. J. Histochem. Cytochem. 56: 125-138.  pdf

Hayes, A.J., Hall, A., Brown, L., Tubo, R, Caterson, B. (2007) Macromolecular organization and in vitro growth characteristics of scaffold-free neocartilage grafts. J. Histochem. Cytochem. 55: 853-866. pdf

Gealy, E.C., Kerr, B.C., Young, R.D., Tudor, D., Hayes, A.J., Hughes, C.E., Caterson, B., Quantock, A.J., Ralphs, J.R. (2007) Differential expression of the keratan sulphate proteoglycan, keratocan, during chick corneal embryogenesis. Histochem Cell Biol. 128: 551-555. Web link

Amoroso, A.J., Coogan, M.P., Dunne, J.E., Fernandez-Moreira, V., Hess, J.B., Hayes, A.J., Lloyd, D., Millet, C., Pope, S.J., Williams, C. (2007) Rhenium fac tricarbonyl bisimine complexes: biologically useful fluorochromes for cell imaging applications. Chem. Commun. (Camb). 2007: 3066-3068. pdf

Workman, V.L., Dunnett, S.B., Kille, P., Palmer, D.D. (2007) On-chip alginate microencapsulation of functional cells. Macromolecular Rapid Communications. 28 DOI: 10.1002/marc.200700641.  pdf

Workman, V. L., Dunnett, S. B., Kille, P, Palmer, D. D. (2007) Microfluidic chip-based synthesis of alginate microspheres for encapsulation of immortalized human cells. Biomicrofluidics 1, 014105. pdf

Blain, E.J., Gilbert, S.J., Hayes, A.J., Duance, V.C. (2006) Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis. Matrix Biol. 25: 398-408.

Aon, M.A., Cortassa S., Lemar K.M., Hayes, A.J., Lloyd D. (2006) Single and cell population respiratory oscillations in yeast: a 2 photon scanning laser microscopy study. FEBS Lett. 581: 8-14.

Malic, S., Hill, H.E., Ralphs, J.R., Hayes, A.J., Thomas D.W., Potts A.J., Williams D.W. (2006) Characterisation of Candida albicans infection of an in vitro oral epithelial model using confocal laser scanning microscopy. Oral Microbiol  Immunol. 22: 188-194. pdf

Reed, K.R., Sansom, O.J., Hayes, A.J., Gescher, A.J., Peters, J.M., Clarke, A.R. (2006) PPAR Delta Status and mismatch repair mediated neoplasia in the mouse intestine. BMC cancer. 6: 113.  pdf

Thomas, R.S., Liddell, J.E., Murphy, L.S., Pache, D.M., Kidd, E.J. (2006) An antibody to the beta-secretase cleavage site on amyloid-beta-protein precursor inhibits amyloid-beta production. J. Alzheimers Dis. 10: 379-390. pdf

Young, R.D., Tudor, D., Hayes, A.J., Kerr, B., Hayashida, Y., Nishida, K., Meek, K.M., Caterson, B., Quantock, A.J. (2005) Atypical composition and ultrastructure of proteoglycans in the mouse corneal stroma. Invest. Opthalmol. Vis. Sci. 46: 1973-1978. pdf

Reed, K.R., Sansom, O.J, Hayes, A.J., Gescher, A.J., Winton, D.J., Peters, J.M., Clarke, A.R. (2004) PPAR delta status and Apc-mediated tumourigenesis in the mouse intestine.  Oncogene. 23:8992-6. pdf

Sansom, O.J., Reed, K.R., Hayes, A.J., Ireland, H., Brinkmann, H., Newton, I.P., Batlle, E., Simon-Assmann, P., Clevers, H., Nathke, I.S., Clarke, A.R., Winton, D.J. (2004) Loss of Apc in vivo immediately perturbs Wnt signalling, differentiation, and migration. Genes & Development. 18: 1385-1390. pdf

Hayes, A.J., Dowthwaite, G.P., Webster, S.V., Archer, C.W. (2003) The distribution of Notch receptors and their ligands during articular cartilage development. J. Anat. 202: 495-502. pdf

Hayes, A.J., MacPherson, S., Morrison, H., Dowthwaite, G., Ferguson, M.W.J., Archer, C.W. (2001) The development of articular cartilage: Evidence for an appositional growth mechanism. Anat. & Embryol. 203: 469-479. Web link

Hayes, A.J., Benjamin, M., Ralphs, J.R. (2001) Extracellular matrix in development of the intervertebral disc. Matrix Biol. 20: 107-121.

Hayes, A.J., Benjamin, M., Ralphs, J.R. (1999) Roles of actin stress fibres in the development of the intervertebral disc: Cytoskeletal control of extracellular matrix assembly. Dev. Dyn. 215: 179-189. pdf

Lloyd D., Hayes A.J., Ralphs, J.R. (1999) Confocal laser scanning of environmental samples. In: Methods in Biotechnology. Volume 12: Environmental Monitoring of Bacteria (ed. Clive Edwards). Human Press Inc., Totowa, NJ.  Web link

Williams I., Paul F., Lloyd D., Jepras R., Critchley I., Newman M., Warrack J., Giokarini T., Hayes A.J., Randerson P.F., Venables W.A. (1999) Flow cytometry and other techniques show that Staphylococcus aureus undergoes significant physiological changes in the early stages of surface attached culture. Microbiol. U.K. 145: 1325-1333. pdf

Shnyder S.D., Hayes A.J., Pringle J., Archer C.W. (1998) P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. British Journal of Cancer 78: 757-759. Web link

Lloyd D., Thomas K.L., Hayes A.J., Hill B., Hales B.A., Edwards C., Saunders J.R., Ritchie D.A., Upton M. (1998) Micro-ecology of peat: Minimally invasive analysis using confocal laser scanning microscopy, membrane inlet mass spectrometry and PCR amplification of methanogen-specific gene sequences. FEMS Microbiol. Ecol. 25: 179-188. pdf

Hayes A.J., Benjamin M., Ralphs, J.R. (1997) The involvement of actin in annulus formation in the rat lumbar intervertebral disc. J. Anat. 191:125. Web link

Biagini, G.A., Hayes, A.J., Suller, M.T., Winters, C.W., Finlay, B.J., Lloyd, D.97) Hydrogenosomes of Metopus contortus physiologically resemble mitochondria. Microbiology. 143: 1623-1629. Web link

Lloyd, D., Moran, A.., Suller, M.T.E., Dinsdale, M.G., Hayes, A.J. (1996) Flow cytometric monitoring of rhodamine 123 and a cyanine dye uptake by yeast during cider fermentation. J. Inst. Brew. 102: 251-259. Web link

Lloyd D., Williams A.G., Amann R., Hayes, A.J., Durrant L., Ralphs J.R. (1996) Intracellular prokaryotes in rumen ciliate protozoa: Detection by confocal laser scanning microscopy after in situ hybridisation with fluorescent 16s rRNA probes. Europ. J. Protistol. 32: 523-531. Web link

Lloyd, D., Hayes, A.J. (1995) Vigour, vitality and viability of micro-organisms. FEMS Microbiol. Lett. 133: 1-7. Web link


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