Publications
Peer reviewed research articles (1995-present)
Hooper, S., Percival, S., Hill, K., Thomas, D., Hayes, A.J., Williams, D. (2012) The visualisation and speed of kill of wound isolates on a silver alginate dressing. International Wound Journal (accepted for publication).
Li, S., Hughes, C., Melrose, J., Smith, S.M., Little, C.B., Caterson, B., Hayes, A.J. (2011) Chondroitin sulphate sulphation motifs as biomarkers for identifying the development of musculoskeletal tissues in human foetal bone. Journal of Bone and Joint Surgery, 93-B Web link
Hayes, A.J., Isaacs, M.D., Hughes, C., Caterson, B. & Ralphs, J.R. (2011) Collagen fibrillogenesis in the development of the annulus fibrosus of the intervertebral disc. eCM 22: 226-241.Web link
Hayes, A.J., Lord, M.S., Smith, M.M., Whitelock, J.M., Weiss, A.S. & Melrose, J. (2011) Colocalization in vivo and association in vitro of perlecan and elastin. Histochem Cell Biol 136: 537-454.Web link
Hayes, A.J. & Ralphs, J.R. (2011) The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-1 and IGF-1. Histochem Cell Biol 136: 163-175. Web link
Hayes A.J., Smith, S.M., Gibson, M.A. & Melrose, J. (2011) Comparative immunolocalisation of the elastin fibre associated proteins fibrillin-1, LTBP2 and MAGP-1 with components of the collagenous and proteoglycan matrix of the foetal human intervertebral disc. Spine [Epub ahead of print] PMID: 21540769. Web link
Parsons, P., Gilbert, S.J., Vaughan-Thomas, A., Sorrel, D.A., Notman, R., Bishop, M., Hayes, A.J., Mason, D.J. & Duance, V.C. (2011) Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. J Biol Chem 286: 34986-34997. Web link
Thorp-Greenwood, F.L., Fernandez-Moreira, V., Millet, C.O., Williams, C.F., Cable, J., Court, J.B., Hayes, A.J., Lloyd, D. & Coogan, M.P. (2011) A ‘Sleeping Trojan Horse’ which transports metal ions into cells, localises in nucleoli, and has potential for bimodal fluorescence/PET imaging. Chem Commun 47: 3096-3098. Web link
Evans, L., Williams, A.S., Hayes, A.J., Jones, S.A. & Nowell, M. (2011) Selective inhibition of pre-B-cell enhancing factor suppresses leukocyte infiltration and cartilage degradation. Arthritis & Rheumatism. Accepted for publication.
Hayes, A.J., Hughes, C., Ralphs, J. & Caterson, B. (2011) Chondroitin sulphate sulphation motif expression in the ontogeny of the intervertebral disc. Eur. Cells & Mat. 21: 1-14 Web link
Silva, S., Henriques, M., Hayes, A., Oliveira, R., Azeredo, J. & Williams, D.W. (2010) Candida glabrata and Candida albicans co-infection of an in vitro oral epithelium. Pending minor corrections for publication in J. Oral Pathology & Medicine. JOPM-07-10-OA-1286. Web link
Akhtar, S., Bron, A.J., Hayes, A.J., Meek, K.M. & Caterson (2010) Role of keratan sulphate (sulphated poly-N-acetyllactosamine repeats) in keratoconic cornea, histochemical, and ultrastructural analysis. Accepted for publication in Graefes Arch. Clin. Exp. Ophthalmol. DOI 10.1007/s00417-010-1512-9 Web link
Fernandez-Moreira, V., Thorp-Greenwood, F.J., Amoroso, A.J., Cable, J., Court, J.B., Gray, V., Hayes, A.J., Jenkins, R.L., Kariuki, B.M., Lloyd, D., Millet, C.O., Williams, C.F., Coogan, M.P. (2010) Uptake and localisation of rhenium fac-tricarbonyl polypyridyls in fluorescent cell imaging experiments. Org. Biomol. Chem. 8(17):3888-901 Web link
Coogan, M.P., Court, J.B., Gray, V.L., Hayes, A.J., Lloyd, S.H., Millet, C.O., Pope, S.J.A. & Lloyd, D. (2010) Probing intracellular oxygen by quenched phosphorescence lifetimes of nanoparticles containing polyacrylamide-embedded [Ru(dpp(SO3Na)2)3]Cl2. Photochem. Photobiol. Sci. 9: 103-109 Web link
Li, S., Hughes, C., Melrose, J., Smith, S.M., Little, C.B., Caterson, B., Hayes, A.J. (June 2009) Chondroitin sulphate sulphation motifs as biomarkers for identifying the development of musculoskeletal tissues in human foetal bone. Annual Meeting of the British Orthopaedic Research Society, Newcastle, England..
Malic S.M., Hill, K.E., Hayes, A., Percival S.L., Thomas, D., Williams, D.W. (2009) Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid (PNA) fluorescent in situ hybridisation (FISH) Microbiol. 155, 2603-2611 Web link
Nowell, M.A., Williams, A.S., Carty, S.A., Scheller, J., Hayes, A.J., Jones, G.W., Richards, P.J., Slinn, S., Ernst, M., Jenkins, B.J., Topley, N., Rose-John, S., Jones, S.A. (2009) Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. J Immunol. 2009 Jan 1;182(1): 613-22 Web link
Gealy, C.C., Hayes, A.J., Buckwell, R.E, Young, R.D, Caterson, B., Quantock, A.J., Ralphs, J.R. (2008) Actin and type I Collagen Propeptide Distribution in the Developing Chick Cornea. Invest Ophthalmol Vis Sci .Web link
Akhtar, S., Kerr, B.C., Hayes A.J., Hughes, C.E., Meek, K.M. & Caterson, B. (2008) Immunochemical localisation of keratan sulphate proteoglycans in cornea, sclera and limbus using a keratanase generated neoepitope monoclonal antibody. Invest Ophthalmol Vis Sci. 49: 2424-2431. Web link
Bazou, D., Coakley, W.T., Hayes, A.J., Jackson, S.K. (2008) Long-term viability and proliferation of alginate-encapsulated 3-D HepG2 aggregates formed in an ultrasound trap. Toxicol. In Vitro (in press)
Amoroso A.J., Arthur, R.J., Coogan, M.P., Court, J.B., Fernandez-Moreira, V., Hayes, A.J., Lloyd, D., Millet, C., Pope, S.J.A. (2008) 3-Chloromethylpyridyl bipyridine fac-tricarbonyl rhenium: a thiol-reactive luminophore for fluorescence microscopy accumulates in mitochondria. New J. Chem.(in press) Web link
Melrose, J., Hayes, A.J., Whitelock, J.M., Little, C.B. (2008) Perlecan, the "jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues. BioEssays 30: 457-469. pdf
Hayes, A.J., Hughes, C., Caterson, B (2008) Antibodies and immunohistochemistry in extracellular matrix research. Methods. 45: 10-21.
Hayes, A.J., Tudor, D, Nowell, M.A., Caterson, B., Hughes, C.E. (2008) Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells. J. Histochem. Cytochem. 56: 125-138. pdf
Hayes, A.J., Hall, A., Brown, L., Tubo, R, Caterson, B. (2007) Macromolecular organization and in vitro growth characteristics of scaffold-free neocartilage grafts. J. Histochem. Cytochem. 55: 853-866. pdf
Gealy, E.C., Kerr, B.C., Young, R.D., Tudor, D., Hayes, A.J., Hughes, C.E., Caterson, B., Quantock, A.J., Ralphs, J.R. (2007) Differential expression of the keratan sulphate proteoglycan, keratocan, during chick corneal embryogenesis. Histochem Cell Biol. 128: 551-555. Web link
Amoroso, A.J., Coogan, M.P., Dunne, J.E., Fernandez-Moreira, V., Hess, J.B., Hayes, A.J., Lloyd, D., Millet, C., Pope, S.J., Williams, C. (2007) Rhenium fac tricarbonyl bisimine complexes: biologically useful fluorochromes for cell imaging applications. Chem. Commun. (Camb). 2007: 3066-3068. pdf
Workman, V.L., Dunnett, S.B., Kille, P., Palmer, D.D. (2007) On-chip alginate microencapsulation of functional cells. Macromolecular Rapid Communications. 28 DOI: 10.1002/marc.200700641. pdf
Workman, V. L., Dunnett, S. B., Kille, P, Palmer, D. D. (2007) Microfluidic chip-based synthesis of alginate microspheres for encapsulation of immortalized human cells. Biomicrofluidics 1, 014105. pdf
Blain, E.J., Gilbert, S.J., Hayes, A.J., Duance, V.C. (2006) Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis. Matrix Biol. 25: 398-408.
Aon, M.A., Cortassa S., Lemar K.M., Hayes, A.J., Lloyd D. (2006) Single and cell population respiratory oscillations in yeast: a 2 photon scanning laser microscopy study. FEBS Lett. 581: 8-14.
Malic, S., Hill, H.E., Ralphs, J.R., Hayes, A.J., Thomas D.W., Potts A.J., Williams D.W. (2006) Characterisation of Candida albicans infection of an in vitro oral epithelial model using confocal laser scanning microscopy. Oral Microbiol Immunol. 22: 188-194. pdf
Reed, K.R., Sansom, O.J., Hayes, A.J., Gescher, A.J., Peters, J.M., Clarke, A.R. (2006) PPAR Delta Status and mismatch repair mediated neoplasia in the mouse intestine. BMC cancer. 6: 113. pdf
Thomas, R.S., Liddell, J.E., Murphy, L.S., Pache, D.M., Kidd, E.J. (2006) An antibody to the beta-secretase cleavage site on amyloid-beta-protein precursor inhibits amyloid-beta production. J. Alzheimers Dis. 10: 379-390. pdf
Young, R.D., Tudor, D., Hayes, A.J., Kerr, B., Hayashida, Y., Nishida, K., Meek, K.M., Caterson, B., Quantock, A.J. (2005) Atypical composition and ultrastructure of proteoglycans in the mouse corneal stroma. Invest. Opthalmol. Vis. Sci. 46: 1973-1978. pdf
Reed, K.R., Sansom, O.J, Hayes, A.J., Gescher, A.J., Winton, D.J., Peters, J.M., Clarke, A.R. (2004) PPAR delta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene. 23:8992-6. pdf
Sansom, O.J., Reed, K.R., Hayes, A.J., Ireland, H., Brinkmann, H., Newton, I.P., Batlle, E., Simon-Assmann, P., Clevers, H., Nathke, I.S., Clarke, A.R., Winton, D.J. (2004) Loss of Apc in vivo immediately perturbs Wnt signalling, differentiation, and migration. Genes & Development. 18: 1385-1390. pdf
Hayes, A.J., Dowthwaite, G.P., Webster, S.V., Archer, C.W. (2003) The distribution of Notch receptors and their ligands during articular cartilage development. J. Anat. 202: 495-502. pdf
Hayes, A.J., MacPherson, S., Morrison, H., Dowthwaite, G., Ferguson, M.W.J., Archer, C.W. (2001) The development of articular cartilage: Evidence for an appositional growth mechanism. Anat. & Embryol. 203: 469-479. Web link
Hayes, A.J., Benjamin, M., Ralphs, J.R. (2001) Extracellular matrix in development of the intervertebral disc. Matrix Biol. 20: 107-121.
Hayes, A.J., Benjamin, M., Ralphs, J.R. (1999) Roles of actin stress fibres in the development of the intervertebral disc: Cytoskeletal control of extracellular matrix assembly. Dev. Dyn. 215: 179-189. pdf
Lloyd D., Hayes A.J., Ralphs, J.R. (1999) Confocal laser scanning of environmental samples. In: Methods in Biotechnology. Volume 12: Environmental Monitoring of Bacteria (ed. Clive Edwards). Human Press Inc., Totowa, NJ. Web link
Williams I., Paul F., Lloyd D., Jepras R., Critchley I., Newman M., Warrack J., Giokarini T., Hayes A.J., Randerson P.F., Venables W.A. (1999) Flow cytometry and other techniques show that Staphylococcus aureus undergoes significant physiological changes in the early stages of surface attached culture. Microbiol. U.K. 145: 1325-1333. pdf
Shnyder S.D., Hayes A.J., Pringle J., Archer C.W. (1998) P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma. British Journal of Cancer 78: 757-759. Web link
Lloyd D., Thomas K.L., Hayes A.J., Hill B., Hales B.A., Edwards C., Saunders J.R., Ritchie D.A., Upton M. (1998) Micro-ecology of peat: Minimally invasive analysis using confocal laser scanning microscopy, membrane inlet mass spectrometry and PCR amplification of methanogen-specific gene sequences. FEMS Microbiol. Ecol. 25: 179-188. pdf
Hayes A.J., Benjamin M., Ralphs, J.R. (1997) The involvement of actin in annulus formation in the rat lumbar intervertebral disc. J. Anat. 191:125. Web link
Biagini, G.A., Hayes, A.J., Suller, M.T., Winters, C.W., Finlay, B.J., Lloyd, D.97) Hydrogenosomes of Metopus contortus physiologically resemble mitochondria. Microbiology. 143: 1623-1629. Web link
Lloyd, D., Moran, A.., Suller, M.T.E., Dinsdale, M.G., Hayes, A.J. (1996) Flow cytometric monitoring of rhodamine 123 and a cyanine dye uptake by yeast during cider fermentation. J. Inst. Brew. 102: 251-259. Web link
Lloyd D., Williams A.G., Amann R., Hayes, A.J., Durrant L., Ralphs J.R. (1996) Intracellular prokaryotes in rumen ciliate protozoa: Detection by confocal laser scanning microscopy after in situ hybridisation with fluorescent 16s rRNA probes. Europ. J. Protistol. 32: 523-531. Web link
Lloyd, D., Hayes, A.J. (1995) Vigour, vitality and viability of micro-organisms. FEMS Microbiol. Lett. 133: 1-7. Web link
Page content written and maintained by Dr. A.J. Hayes and Mr. M. Isaacs