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Dr Matt Smalley 


Telephone:+44(0)29 208 75862
Location:European Cancer Stem Cell Research Institute, Cardiff School of Biosciences Hadyn Ellis Building, Maindy Road, Cardiff CF24 4HQ

Research Overview

My group is trying to understand how the combination of different tumour-initiating genetic lesions occurring in different normal stem and progenitor cells in the breast drives breast cancer heterogeneity. We are interested both in inter-tumour heterogeneity – the clinical differences between tumours – as well as intra-tumour heterogeneity and the formation of cells with ‘cancer stem cell’ properties within a neoplasia. We are also trying to understand how the biological processes occurring in normal stem cells can be re-activated in tumours to drive de novo production of tumour cells with stem cell-like properties.