Prof Daniela Riccardi - PhD
Telephone:+44 (0)29 208 79132
Fax:+44 (0)29 208 74116
Location:Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
Molecular mechanisms of cation sensing
The ability of cells to sense and respond to changes in the environment is vital to life. Crucial to this process is the extracellular calcium/(cation)-sensing receptor, CaSR. My laboratory is interested in understanding the stimuli serving as signaling molecules at the CaSR in both calciotropic and non-calciotropic tissues in physiology and disease, at the molecular, cellular and whole organism level.
1. To repurpose CaSR antagonists (calcilytics) as novel therapeutics for inflammatory lung disease;
2. To define the role of the CaSR in blood pressure control and in the prevention of vascular calcification;
3. To determine the role of the CaSR in human fetal lung development;
4. To develop an in vitro human primary kidney cell model for studies of drug-induced kidney injury and mineral ion metabolism.