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Dr Dipak Ramji 


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Link to ScopusTM Database

Selected Publications

Ashlin, T. G., Buckley, M. L., Salter, R. C., Johnson, J. L., Kwan, A. P. L. and Ramji, D.P. (2014) The anti-atherogenic cytokine interleukin-33 inhibits the expression of a disintegrin and metalloproteinase with thrombospondin motifs-1, -4 and -5 in human macrophages: Requirement of extracellular signal-regulated kinase, c-Jun N-terminal kinase and phosphoinositide 3-kinase signaling pathways. International Journal of Biochemistry and Cell Biology 46:113-123.

Michael, D. R., Salter, R. C. and Ramji, D. P. (2012) TGF-β inhibits the uptake of modified low density lipoprotein by human macrophages through a Smad-dependent pathway: A dominant role for Smad-2. Biochimica et Biophysica Acta-Molecular Basis of Disease 1822:1608-1616.

Michael, D. R., Ashlin, T. G., Buckley, M. L. and Ramji, D. P. (2012). Liver X receptors, atherosclerosis and inflammation. Current Atherosclerosis Reports 14:284-293.

McLaren, J. E., Michael, D. R., Ashlin, T. G. and Ramji, D. P. (2011) Cytokines, macrophage lipid metabolism and foam cells: Implications for cardiovascular disease therapy. Progress in Lipid Research 50:331-337.

Salter, R. C., Arnaoutakis, K., Michael, D. R., Singh, N. N., Ashlin, T. G., Buckley, M. L., Kwan, A. P. L. and Ramji, D. P. (2011) The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-β and requires Smads, p38 mitogen-activated protein kinase and c-Jun. International Journal of Biochemistry and Cell Biology 43:805-811.

Huwait, E. A., Greenow, K. R., Singh, N. N. and Ramji, D. P. (2011) A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression. Cellular Signalling 23:542-549.

Li N, McLaren JE, Michael DR, Clement M, Fielding CA and Ramji DP (2010) ERK is integral to the IFN-gamma-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages. Journal of Immunology 185(5):3041-3048. 

McLaren JE, Michael DR, Salter RC, Ashlin TG, Calder CJ, Miller AM, Liew FY and Ramji DP (2010) IL-33 reduces macrophage foam cell formation. Journal of Immunology 185(2):1222-1229. 

McLaren JE, Calder CJ, McSharry BP, Sexton K, Salter RC, Singh NN, Wilkinson GWG, Wang ECY and Ramji DP (2010) The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184(10):5827-5854. 

Salter RC, Ashlin TG, Kwan APL and Ramji DP (2010) ADAMTS proteases: key roles in atherosclerosis. Journal of Molecular Medicine 88(12):1203-1211.  

Ali S, Singh NN, Yildirim H and Ramji DP (2010) Requirement for nuclear factor kappa B signalling in the interleukin-1-induced expression of the CCAAT/enhancer binding protein-delta gene in hepatocytes. International Journal of Biochemistry & Cell Biology 42(1):113-119. 

McLaren JE and Ramji DP (2009) Interferon gamma: A master regulator of atherosclerosis. Cytokine & Growth Factor Reviews 20(2):125-135. 

Singh NN and Ramji DP (2008) Protein kinase CK2, an important regulator of the inflammatory response? Journal of Molecular Medicine-JMM 86(8):887-897. 

Harris SM, Harvey EJ, Hughes TR and Ramji DP (2008) The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2-and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3. Cellular Signalling 20(12):2296-2301. 

Harvey EJ, Li N and Ramji DP (2007) Critical role for casein kinase 2 and phosphoinositide-3-kinase in the interferon-gamma-induced expression of monocyte chemoattractant protein-1 and other key genes implicated in atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology 27(4):806-812. 

Irvine SA, Martin J, Hughes TR and Ramji DP (2006) Lipoprotein lipase is expressed by glomerular mesangial cells. International Journal of Biochemistry & Cell Biology 38(1):12-16. 

Monslow J, Williams JD, Fraser DJ, Michael DR, Foka P, Kift-Morgan AP, Luo DD, Fielding CA, Craig KJ, Topley N, Jones SA, Ramji DP and Bown T  (2006) Sp1 and sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. Journal of Biological Chemistry 281(26):18043-18050. 

Singh NN and Ramji DP (2006) The role of transforming growth factor-beta in atherosclerosis. Cytokine & Growth Factor Reviews 17(6):487-499. 

Singh NN and Ramji DP (2006) Transforming growth factor-beta-induced expression of the apolopoprotein E gene requires c-Jun N-terminal kinase, p38 kinase, and casein kinase 2. Arteriosclerosis Thrombosis and Vascular Biology 26(6):1323-1329. 

Irvine SA, Foka P, Rogers SA, Mead JR and Ramji DP (2005) A critical role for the Sp1-binding sites in the transforming growth factor-beta-mediated inhibition of lipoprotein lipase gene expression in macrophages. Nucleic Acids Research 33(5):1423-1434.