Dr Deborah Mason - PhD
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Link to ScopusTM Database
Key Publications
Flood S, Parri R, Williams A, Duance V and Mason D (2007) Modulation of interleukin-6 and matrix metalloproteinase 2 expression in human fibroblast-like synoviocytes by functional ionotropic glutamate receptors. Arthritis and Rheumatism 56(8): 2523-2534.
Gilbert SJ, Blain EJ, Duance VC and Mason DJ (2007) Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism in press
S.J. Gilbert, E.J. Blain, P. Jones, V.C. Duance, D.J. Mason (2006) Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arth Res and Ther 8(4):R89
Gilbert SJ, Duance VC and Mason DJ (2005) Protein Kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2(1):9-21.
Mason DJ (2004) Glutamate Signalling and its Potential Application to Tissue Engineering of bone. Eur Cell Mat 7:12-26.
SJ Gilbert, VC Duance, DJ Mason (2003) Does PKR mediate TNF alpha and ceramide induced increases in expression and activation of MMPs in articular cartilage by a novel mechanism? Arth Res Ther 6:46-55.
Gilbert SJ, Duance VC and Mason DJ (2002) TNF-a upregulates PACT and increases phophorylation of PKR and eIF-2a in articular chondrocytes.Biochem Soc Trans 30:886-9
Mason DJ and Huggett JF (2002) Glutamate Transporters in Bone Journal of Musculoskel and Neuronal Interactions 2 (5):406-414.
Huggett JF, Mustafa A, O’Neal L and Mason DJ (2002) The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration. Biochem Soc Trans 30:890-893.
Blain EJ, Gilbert SJ, Wardale RJ, Capper SJ, Mason DJ, Duance VC (2001) Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Arch Biochem Biophys 396:49-55.
Huggett J, Vaughan-Thomas A, Mason DJ (2000) The open reading frame of the Na(+)-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain.FEBS Lett 485(1):13-18.
Mason DJ, Suva LJ, Genever PG, Patton AJ, Steuckle S, Hillam RA, and Skerry TM (1997) Mechanically-regulated expression of a neural glutamate transporter in bone. A role for excitatory amino acids as osteotropic agents? Bone 20 (3):199-20.