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Dr Deborah Mason  -  PhD

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Link to ScopusTM Database

Glutamatergic Signalling

  1. Cleo S Bonnet, Anwen S Williams, Sophie J Gilbert, Ann K Harvey, Bronwen A Evans, and Deborah J Mason  AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis. Annals of Rheumatic Diseases - under review.
  2. Brakspear KS and Mason DJ (2012) Glutamate signaling in bone. Front. Endocrin. 3:97.
  3. Flood S, Parri R, Williams A, Duance V and Mason DJ (2007) Modulation of interleukin-6 and matrix metalloproteinase 2 expression in human fibroblast-like synoviocytes by functional ionotropic glutamate receptors. Arthritis and Rheumatism 56(8): 2523-2534.
  4. Mason DJ (2004) The role of glutamate transporters in bone cell signalling. Journal of Musculoskeletal and Neuronal Interactions 4:128-131.            
  5. Mason DJ (2004) Glutamate Signalling and its Potential Application to Tissue  Engineering of bone. European Cells and Materials 7:12-26
  6. Mason DJ and Huggett JF (2002) Glutamate Transporters in Bone Journal of Musculoskeletal and Neuronal Interactions 2 (5): 406-414
  7. Huggett JF, Mustafa A, O’Neal L and Mason DJ (2002) The glutamate transporter GLAST-1 (EAAT-1) is expressed in the plasma membrane of osteocytes and is responsive to extracellular glutamate concentration. Biochem Soc Trans 30:890-893.
  8. Skerry T, Genever P, Taylor A, Dobson K, Mason D , Suva L. (2001) Letters to the Editor: Absence of Evidence is not evidence of absence. The shortcomings of the GLAST knockout mouse. JBMR 16 (9):1729-1730.
  9. Huggett J, Vaughan-Thomas A, Mason DJ (2000) The open reading frame of the Na(+)-dependent glutamate transporter GLAST-1 is expressed in bone and a splice variant of this molecule is expressed in bone and brain. FEBS Lett 485(1):13-18.
  10. Mason DJ, Suva LJ, Genever PG, Patton AJ, Steuckle S, Hillam RA, and Skerry TM (1997). Mechanically-regulated expression of a neural glutamate transporter in bone.  A role for excitatory amino acids as osteotropic agents? Bone 20 (3):199-20.


  1.  Gilbert SJ, Meakin LB, Nowell MA, Bonnet CS, Ladiges WC, Morton J, Duance VC and Mason DJ. Deletion of P58IPK, the cellular inhibitor of the protein kinases PKR and PERK, causes bone changes and joint degeneration in mice. Osteoarthritis and Cartilage – under review.
  2. Gilbert SJ, Blain EJ, Vaughan-Thomas A, Duance VC and Mason DJ (2012) Protein kinase R plays a pivotal role in the oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European Cells and Materials, 23:41-57.
  3. Gilbert SJ, Blain EJ, Duance VC and Mason DJ (2008) Sphingomyelinase decreases type II collagen expression in bovine articular chondrocytes via the ERK signalling pathway. Arthritis and Rheumatism 58:209-220.
  4. Gilbert SJ, Blain EJ, Jones P, Duance VC, Mason DJ (2006) Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis Research and Therapy 8(4):R89
  5. Gilbert SJ, Duance VC and Mason DJ (2006) Protein Kinase R: A novel mediator of articular cartilage degradation in arthritis. Current Rheumatology Reviews 2(1):9-21.     
  6. Gilbert SJ, Duance VC, Mason DJ (2004) Does PKR mediate TNF alpha and ceramide induced increases in expression and activation of MMPs in articular cartilage by a novel mechanism? Arthritis Res Ther 6:46-55.
  7. Gilbert SJ, Duance VC and Mason DJ (2002) Tumour necrosis factor a up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-a in articular chondrocytes. Biochem Soc Trans 30:886-9.


  1. JB Catterall, S Dewitt, DJ Mason, Wilson C, K Fagerlund, JM Halleen, B Caterson. CTx-II is a marker of cartilage destruction and reflects cartilage metabolism. Osteoarthritis and Cartilage - under review
  2. DJ Mason, K Brakspear, C Wilson, R Williams, R S Kotwal (2010). Glutamate, a signal that links mechanical loading, pain and pathology in human arthritis. Invited paper, Computer Methods in Biomechanics and Biomedical Engineering, Porto. ISBN: 978-9562121-0-8.