Dr Deborah Mason - PhD
Telephone:+44 (0)29 208 74561
Fax:+44 (0)29 208 74116
Location:Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
My research elucidates new signalling mechanisms that regulate bone and cartilage turnover, to provide therapeutic and diagnostic targets for osteoporosis, rheumatoid arthritis and osteoarthritis. This has led to the discovery of functional glutamatergic signalling in bone and synovium, and revealed new pathways that mediate cytokine- and mechanically- induced cartilage degradation. Modulation of glutamatergic signalling to enhance bone formation and inhibit pathological changes in arthritis, and delineating the role of PKR in arthritis, are current research priorities.