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Dr Emyr Lloyd-Evans 

Link to ScopusTM Database

Selected Publications

Morgan AJ, Platt FM, Lloyd-Evans E and Galione A (2011) Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease. Biochemistry Journal, 439(3):349-374.

Lloyd-Evans E and Platt FM (2011) Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases. Cell Calcium, 50(2):200-205.

Lloyd-Evans E, Waller-Evans H, Peterneva K and Platt FM (2010) Endolysosomal calcium regulation and disease. Biochemical Society Transactions, 38(6):1458-1464.

Ruas M, Rietdorf K, Arredouani A, Davis LC, Lloyd-Evans E, Koegel H, Funnell TM, Morgan AJ, Ward JA, Watanabe K, Cheng X, Churchill GC, Zhu MX, Platt FM, Wessel GM, Parrington J and Galione A (2010) Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca(2+) Signaling and Endolysosomal Trafficking. Current Biology, 20(8):703-709.

Lloyd-Evans E and Platt FM (2010) Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease. Traffic,11(4):419-428.

Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A and Platt FM (2008) Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nature Medicine, 14(11):1247-1255.

Elliot-Smith E, Speak AO, Lloyd-Evans E, Smith DA, van der Spoel AC, Jeyakumar M, Butters TD, Dwek RA, d'Azzo and Platt FM (2008) Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis. Molecular Genetics and Metabolism, 94(2):204-211.

Pelled D, Trajkovic-Bodennec S, Lloyd-Evans E, Sidransky E, Schiffmann R and Futerman AH (2005) Enhanced calcium release in the acute neuronopathic form of Gaucher disease. Neurobiology of Disease,18(1):83-88.

Lachmann RH, te Vruchte D, Lloyd-Evans E, Reinkensmeier G, Sillence DJ, Fernandez-Guillen L, Dwek RA, Butters TD, Cox TM and Platt FM (2004) Treatment with miglustat reverses the lipid-trafficking defect in Niemann-Pick disease type C. Neurobiology of Disease,16(3):654-658.

te Vruchte D, Lloyd-Evans E, Veldman RJ, Neville DC, Dwek RA, Platt FM, van Blitterswijk WJ and Sillence DJ (2004) Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. Journal of Biological Chemistry, 279(25):26167-26175.

Lloyd-Evans E, Pelled D, Riebeling C and Futerman AH (2003) Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms. Biochemical Journal, 375(Pt 3):561-565.

Pelled D*, Lloyd-Evans E*, Riebeling C, Jeyakumar M, Platt FM and Futerman AH (2003) Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin. Journal of Biological Chemistry, 278(32): 29496-29501.

Lloyd-Evans E, Pelled D, Riebeling C, Bodennec J, de-Morgan A, Waller H, Schiffmann R and Futerman AH (2003) Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms. Journal of Biological Chemistry, 278(26):23594-23599.

*Joint 1st author