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Prof Paul Kemp  -  DPhil (Oxon)


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Link to ScopusTM Database

Selected Publications

Rushton, D.J., Mattis, V.B., Svendsen, Allen, N.D., and Kemp, P.J. Stimulation of GABA-induced Ca2+ influx enhances maturation of human iPS cell-derived neurons. PloS One. In press, 2013

Lembrechts, R., Brouns, I., Schnorbusch, K., Pintelon, I., Kemp, P.J., Timmermans, J-P, Riccardi, D. and Dirk Adriaensen (2013) Functional expression of the multimodal extracellular calcium-sensing receptor in pulmonary neuroendocrine cells. J Cell Sci. 126(Pt 19):4490-501

Brennan, S.C, Finney, B.A., Lazarou, M., Rosser, A.E., Scherf, C. Adriaensen, D, Kemp, P.J. and Riccardi, D. Fetal Calcium Regulates Branching Morphogenesis in the Developing Human and Mouse Lung: Involvement of Voltage-gated Calcium Channels. PLoS One. In press, 2013

Kemp, P.J. & Telezhkin, V. Oxygen sensing by the carotid body: is it all just rotten eggs? Antioxidants and Redox Signaling. Epub ahead of print, 2013. PMID: 236828652013

Elena Matsa, E., Dixon, J.E., Medway, C., Georgiou, O., Patel, M.J., Kevin Morgan, K., Kemp, P.J., Staniforth, A., Mellor, I. & Denning, C. (2013) Allele-specific RNA interference rescues LQTS phenotype in hiPSC cardiomyocytes European Heart Journal Epub ahead of print. PMID: 23470493. 

NINDS Parkinson's Disease iPSC Consortium; NINDS Huntington's Disease iPSC Consortium; NINDS ALS iPSC Consortium (2012) Creation of an open-access, mutation-defined fibroblast resource for neurological disease research PLoS One 7(8): e43099

The HD iPS Consortium (2012) Induced Pluripotent Stem Cells from Patients with Huntington’s Disease: CAG Expansion-Dependent Phenotypes Cell Stem Cell. 11(2):264-78

Kemp, P.J. & Riccardi, D. (2012) Calcium sensing in development, function and disease Ann. Rev Physiol. 74:271-97

Wilkinson, W.J. & Kemp, P. J. (2011) Carbon Monoxide: an emerging regulator of ion channels by multiple mechanisms J.Physiol. 589:3055-62

Benjamin, A.R., Wilkinson, W.J. De Proost, I, Orogo-Wenn, M.C., Yamazaki, Y., Staub, O., Morita, T., Adriaensen, D., Riccardi, D., Walters, D.V. & Kemp, P.J. (2011) Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive lung liquid absorption Pflügers Archiv. 462(2):267-79 

Telezhkin, V., Brazier, S.P.,  Mears, R., Müller, C.T., Riccardi, D & Kemp, P.J. (2011) Cysteine residue 911 in C-terminal tail of human BKCaα channel subunit is crucial of its activation by carbon monoxide Pflügers Archiv. 461(6): 665-75 

Wilkinson, W.J. and Kemp, P. J. (2011) The CO-releasing molecule, CORM-2, is a potent and selective antagonist of recombinant human P2X4 receptors Purinergic Signal. 7(1): 57-64

Finney, B.A., Wilkinson, W.J., Kemp, P.J. & Riccardi. (2011) An exon 5-less splice variant of the extracellular calcium-sensing receptor rescues absence of the full-length receptor in the developing mouse lung  Exp. Lung Res. 37(5): 269-78

Kelly, C.M., Precious, S.V. , Torres E.M., Harrison A. W., Williams, D., Scherf, C., Weyrauch, U.M., Lane E.L., Allen N.D., Penketh, R., Amso, N.N., Kemp, P. J., Dunnett, S.B. , Rosser, A.E. (2011) Medical terminations of pregnancy: a viable source of tissue for cell replacement therapy for neurodegenerative disorders Cell Transplantation. 20(4):503-13

Cayzac, S.H., Rocher, A., Obeso, A., Gonzalez, C., Riccardi, D. and Kemp, P.J. (2011) Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting L-type Ca2+ channels Respir. Physiol. Neurobiol. 175: 80-9 

Warburton D, El-Hashash A, Carraro G, Tiozzo C, Sala F, Rogers O, De Langhe S, Kemp PJ, Riccardi D, Torday J, Bellusci S, Shi W, Lubkin SR, Jesudason E. (2010) Lung organogenesis. Curr. Top. Dev. Biol. 90:73-158 

Telezhkin, V., Brazier, S.P., Cayzac, S., Riccardi, D. & Kemp P.J. (2010) Hydrogen sulphide inhibits recombinant and natively expressed BKCa channels Respir. Physiol. Neurobiol. Neurobiol. 31: 172(3): 169-78

Kemp, P.J., Telezhkin, V., Wilkinson, W.J., Mears, R., Hanmer S.B., Gadeberg, H.C., Muller, C. T., Riccardi, D. & Brazier, S.P. (2009) Enzyme-linked oxygen sensing by potassium channels Anal. NY Acad Sci. 1177:112-8

Riccardi, D., Finney, B.,Wilkinson, W. J. and Kemp, P. J. (2009) Novel aspects of calcium-sensing receptor biology Pflügers Archiv 458: 1007-1022

Wilkinson, W.J., Gadeberg, H.C., Harrisson, A., Allen, N.D., Riccardi, D and Kemp, P.J. (2009) Carbon monoxide is a rapid modulator of recombinant and native P2X2 ligand-gated ion channels Brit. J. Pharmacol. 158(3):862-71

Kemp, P.J. & Peers, C. (2009) Enzyme-linked oxygen sensing in airways and arterial chemoreceptors Adv. Exp. Med. Biol. 648: 39-48

Telezhkin, V., Brazier, S.P., Cayzac, S., Muller, C. T., Riccardi, D. & Kemp P.J. (2009) Hydrogen sulfide inhibits human BKCa channels Adv. Exp. Med. Biol. 648: 65-72

Brazier, S.P., Telezhkin, V., Mears, R., Muller, C. T., Riccardi, D. & Kemp P.J. (2009) Cysteine residues in the C-terminal tail of the human BKCa a-subunit are important for channel sensitivity to carbon monoxide Adv. Exp. Med. Biol. 648: 49-56 

Cayzac, S., Rocher, A., Obeso, A., Gonzalez, C., Kemp, P.J. & Riccardi, D. (2009) Effects of the polyamine spermine on arterial chemoeception Adv. Exp. Med. Biol. 648: 97-104 

De Proost, I, Pintelon. I, Wilkinson, W.J, Goethals, S, Brouns, I, Van Nassauw, L, Riccardi, D, Timmermans, J-P, Kemp, P.J, Adriaensen, D. (2009) Purinergic paracrine signaling in the airway neuroepithelial microenvironment is revealed by live cell imaging in lung slices FASEB J. 23:1153-1160 

Finney, B., Del Moral, P., Wilkinson, W. J., Cayzac, S., Cole, M., Warburton, D., Kemp, P. J. and Riccardi, D. (2008) Role of calcium-sensing receptor in lung development J. Physiol. 586: 6007-6019 

De Proost, I., Pintelon, I., Brouns, I., Kroese A., B., A., Riccardi, D., Kemp, P. J., Timmermanns, J-P., Adriaensen, D. (2008) Functional live cell imaging of the pulmonary neuroepithelial body microenvironment Am. J. Resp. Cell Mol. Biol. 39:180-9

Williams, S. E., Brazier, S. P., Baban, Telezhkin, V., N, Müller, C. T., Riccardi, D and Kemp, P. J. (2008) A structural motif in the C-terminal tail of slo1 confers carbon monoxide sensitivity to human BKCa channels Pflugers Archiv. Eur. J. Physiol. 456, 561-572

Dvorak, M. M., De Joussineau, C., Carter, H. D., Pisitkim, T. Knepper, M. A., Gamba, G., Kemp, P. J. and Riccardi, D. (2007) Thiazide diuretics directly induce osteoblast differentiation and mineralised nodule formation by targeting a sodium chloride cotransporter in bone J. Amer. Soc. Nephrol. 18, 2509-16

Joannides, A.J., Webber, D., Raineteau, O., Kelly, C., Watts, C., Rosser, A., Caldwell, M., Kemp, P. J., Blakemore, W., Compston, A., Allen, N., and Chandran, S. (2007) Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human ES cells Brain 130, 1263-1275 

Kemp, P. J. and Peers, C. (2007) Oxygen sensing by ion channels. Essays in Biochemistry. 43:77-90

Joannides, A. J., Firoe-Heriche, C., Battersby, A. A., Athauda-Arachichi, P., Bouhom, I. A. Williams, L., Westmore, K., Kemp, P. J., Compston, A., Allen, N. D. and Chandran, S. (2007) A scaleable sand defined system for generating neural stem cells from human embryonic stem cells Stem Cells 25, 731-737

Williams, S.E., Wootton P., Mason H. S., Bould, J., Iles, D. E., Peers, C., Riccardi, D. & Kemp, P.J. (2004) Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel Science, 306, 2993-2997