Dr D. Dafydd Jones - PhD
Telephone:+44 (0)29 208 74290
Location:Cardiff School of Biosciences, Main Building, Museum Avenue, Cardiff, CF10 3AT
The main focus of my research group is exploring the structural and functional plasticity of proteins. Our research involves the study and engineering of specific protein systems, construction of artificial protein scaffolds and utilisation of expanded genetic code for non-natural amino acid incorporation. Much of the group’s work has a basis in synthetic biology whereby we construct new protein components or modify existing proteins for new applications, including single molecule electron transfer. Both rational protein engineering and directed evolution are used to create new proteins and structural biology, single molecule analysis, molecular dynamics, biophysics and biochemistry are used to investigate the properties of these novel proteins. We have also recently developed several transposon-based methods for the directed evolution of proteins using non-homologous recombination.