Skip to content
Skip to navigation menu


Dr Neil Hardingham 

Dachtler, J.*, Hardingham, N.R.*, & Fox, K.D. The role of Nitric Oxide Synthase in cortical plasticity is sex specific J.Neurosci 32, 14994-14999. [* Joint First Author] (2012).

Dachtler, J.*, Hardingham, N.R.* , Wright, N.F., Glazewski, S.,Blain, E. and Fox, K. Experience-dependent plasticity acts via GluR1 and a novel neuronal nitric oxide synthase-dependent synaptic mechanism in adult cortex. J. Neurosci. 31, 11220-30     [ * Joint First Author] (2011). 

Hardingham, N.R., Gould, T.M & Fox, K.D Anatomical and Sensory Experiential Determinants of Synaptic Plasticity in Layer 2/3 Pyramidal Neurons from Mouse Barrel Cortex. J.Comp.Neurol. 519,  2090-2124 (2011).

Hardingham, N.R., Read, J.C., Trevelyan, A.J., Nelson, J.C, Jack, J.J.B. & Bannister, N.J. Quantal analysis reveals a functional correlation between pre- and postsynaptic efficacy from excitatory synapses in rat neocortex. J. Neurosci. 30, 1441-1451 (2010).                         

Hardingham, N., Wright, N, Dachtler, J. & Fox, K. Sensory deprivation unmasks a PKA dependent mechanism of potentiation in the barrel cortex. Neuron. 60, 861-874 (2008).

Philips, K., Hardingham, N. & Fox, K. Postsynaptic action potentials are required for nitric-oxide-dependent long term potentiation in CA1 neurons of adult GluR1 knock-out and wild-type mice. J Neurosci. 28, 14031-14041. (2008).

Wright N, Glazewski S, Hardingham N, Phillips K, Pervolaraki E, Fox K. Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex. Nat Neurosci. 11(10):1140-2 (2008).

Hardingham NR, Hardingham GE, Fox KD, Jack JJ. Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity. J Neurophysiol. 97(4):2965-75 (2007).

Hardingham N, Fox K. The role of nitric oxide and GluR1 in presynaptic and postsynaptic components of neocortical potentiation. J Neurosci. 12; 26(28):7395-404 (2006).

Hardingham NR, Bannister NJ, Read JC, Fox KD, Hardingham GE, Jack JJ. Extracellular calcium regulates postsynaptic efficacy through group 1 metabotropic glutamate receptors. J Neurosci. 26(23):6337-45 (2006).

Soriano FX, Papadia S, Hofmann F, Hardingham NR, Bading H, Hardingham GE. Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. J Neurosci. 26(17):4509-18 (2006).

Papadia S, Stevenson P, Hardingham NR, Bading H, Hardingham GE. Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection. J Neurosci. 25(17):4279-87 (2005).

Hardingham N, Glazewski S, Pakhotin P, Mizuno K, Chapman PF, Giese KP, Fox K. Neocortical long-term potentiation and experience-dependent synaptic plasticity require alpha-calcium/calmodulin-dependent protein kinase II autophosphorylation. J Neurosci. 23(11):4428-36 (2003).

Hardingham NR, Larkman AU. Rapid report: the reliability of excitatory synaptic transmission in slices of rat visual cortex in vitro is temperature dependent. J Physiol. 507(1):249-56 (1998).