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Dr Oleg Gerasimenko 


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Link to ScopusTM Database

Selected Publications (from 2006)

Gerasimenko, J.V., Gerasimenko, O.V. and Petersen, O.H. (2014) The role of Ca2+ in the pathophysiology of pancreatitis. J. Physiol.  Doi: 10.1113/jphysiol.2013.261784

Gerasimenko, J.V., Gryshchenko, O., Ferdek, P.E., Stapleton, E., Hebert, T.O.G., Bychkova, S., Peng, S., Begg, M., Gerasimenko, O.V. & Petersen, O.H. (2013) Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy Proc. Natl. Acad. Sci. USA (PNAS) 110, 13186-13191

Ferdek, P.E., Gerasimenko, J.V., Peng, S., Tepikin, A.V., Petersen, O.H. and Gerasimenko, O.V. (2012) A novel role for Bcl-2 in regulation of cellular calcium extrusion. Curr. Biol. 22:1241-1246

Petersen, O.H., Gerasimenko, O.V. and Gerasimenko, J.V. (2012) The war within - Unraveling the molecular causes of acute pancreatitis—a potentially deadly disease in which the pancreas essentially digests itself—is yielding clues to how it might be treated. The Scientist February 2012 26(2) 40-44

(Open Access: http://the-scientist.com/2012/02/01/the-war-within/)

Gerasimenko, OV. Gerasimenko, JV. Mitochondrial function and malfunction in the pathophysiology of pancreatitis. (2012) Pflugers Archiv-European Journal of Physiology 464 (1) Pages: 89-99.

Petersen, O.H., Gerasimenko, O.V. and Gerasimenko, J.V. (2011) Pathobiology of acute pancreatitis: focus on intracellular calcium and calmodulin. F1000 Reports Medicine 3: 15.

(Open Access: http://f1000.com/reports/m/3/15/pdf)

Gerasimenko, J.V., Lur, G., Ferdek, P., Sherwood, M.W., Ebisui, E., Tepikin, A.V., Mikoshiba, K., Petersen, O.H. and Gerasimenko, O.V. (2011) Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through inositol trisphosphate receptors. Proc. Natl. Acad. Sci. USA (PNAS) 108, 5873-5878.

(Open Access: http://www.pnas.org/content/108/14/5873.full.pdf+html)

Petersen, O.H., Gerasimenko, O.V., Tepikin, A.V. and Gerasimenko, J.V. (2011) Aberrant Ca2+ signalling through acidic Ca2+ stores in pancreatic acinar cells. Cell Calcium 50, 193-199.

Booth, D.M., Murphy, J.A., Mukherjee, R., Awais, M., Neoptolemos, J.P., Gerasimenko, O.V., Tepikin, A.V., Petersen, O.H., Sutton, R. and Criddle, D.N. (2011) Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells. Gastroenterology 140, 2116-2125.

Voronina, S.G., Barrow, S.L., Simpson, A.W.M., Gerasimenko, O.V., Da Silva Xavier, G., Rutter, G.A., Petersen, O.H. & Tepikin, A.V. (2010) Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology 138, 1976-1987.

Gerasimenko, J.V., Lur, G., Sherwood, M.W., Ebisui, E., Tepikin, A.V., Mikoshiba, K., Gerasimenko, O.V. & Petersen, O.H. (2009) Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc. Natl. Acad. Sci. USA (PNAS) 106, 10758-10763.

Lur, G., Haynes, L.P., Prior, I.A., Gerasimenko, O.V., Feske, S., Petersen, O.H., Burgoyne, R.D. & Tepikin, A.V. (2009) Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology 19, 1648-1653.

Baumgartner, H.K., Gerasimenko, J.V., Thorne, C., Ferdek, P., Pozzan, T., Tepikin, A.V., Petersen, O.H., Sutton, R., Watson, A.J.M. & Gerasimenko, O.V. (2009) Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J. Biol. Chem. 284, 20796-20803.

Petersen, O.H., Tepikin, A.V., Gerasimenko, J.V., Gerasimenko, O.V., Sutton, R. & Criddle, D.N. (2009) Fatty acids, alcohol and fatty acid ethyl esters: toxic Ca2+ signal generation and acute pancreatitis. Cell Calcium 45, 634-642.

Chvanov, M., Walsh, C.M., Haynes, L.P., Voronina, S.G., Lur, G., Gerasimenko, O.V., Barraclough, R., Rudland, P.S., Petersen, O.H., Burgoyne, R.D. & Tepikin, A.V. (2008) ATP depletion induces translocation to puncta and formation of STIM1 - ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP. Pflügers Arch.- Eur. J. Physiol. 457, 505-517.

Murphy, J.A., Criddle, D.N., Sherwood, M., Chvanov, M., Mukherjee, R.,  McLaughlin, E.,  Booth, D., Gerasimenko, J.V., Raraty, M.G.T., Ghaneh, P., Neoptolemos, J.P., Gerasimenko, O.V., Tepikin, A.V., Green, G.M., Reeve, J.R. Jr., Petersen, O.H. & Sutton, R. (2008) Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells. Gastroenterology 135, 632-641. (See also Editorial: Gastroenterology 135, 357-360, 2008)

Barrow, S.L., Voronina, S.G., Da Silva Xavier, G, Chvanov, M.A., Longbottom, R.E., Gerasimenko, O.V., Petersen, O.H., Rutter, G.A., Tepikin, A.V. (2008) ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflügers Arch.- Eur. J. Physiol. 455, 1025-1029.

Sherwood, M., Prior, I.A., Voronina, S.G., Barrow, S.L., Woodsmith, J.D., Gerasimenko, O.V., Petersen, O.H. & Tepikin, A.V. (2007) Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. Proc. Natl. Acad. Sci. USA (PNAS) 104, 5674-5679.

Voronina, S.G., Sherwood, M., Gerasimenko, O.V.,  Petersen, O.H., Tepikin, A.V. (2007) Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran – bound indicator: endocytic and non-endocytic vacuoles. Am. J. Physiol. (G.I. & Liver) 293, G1333-G1338.

Criddle D.N., Gerasimenko, J., Baumgartner, H.K., Jaffar, M., Voronina, S.G., Sutton, R., Petersen, O.H. & Gerasimenko, O.V. (2007) Calcium signalling and pancreatic cell death: apoptosis or necrosis? Cell Death Differ. 14, 1285-1294.

Baumgartner, H.K., Gerasimenko, J.V., Thorne, C., Ashurst, L.H., Barrow, S.L., Chvanov, M.A., Gillies, S., Criddle, D.N., Tepikin, A.V., Petersen, O.H., Sutton, R., Watson, A.J.M. & Gerasimenko, O.V. (2007) Caspase-8 – mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins. Am. J. Physiol. (G-I & Liver) 293, G296-G307.

Criddle, D.N., Gillies, S., Baumgartner-Wilson, H.K., Jaffar, M., Chinje, E.C., Passmore, S., Chvanov, M., Barrow, S., Gerasimenko, O.V., Tepikin, A.V., Sutton, R. & Petersen, O.H. (2006) Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. J. Biol. Chem. 281, 40485-40492.

Chvanov, M., Gerasimenko O.V., Petersen, O.H. & Tepikin, A.V. (2006) Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO J. 25, 3024-3032.

Gerasimenko, J.V., Flowerdew, S.E., Voronina, S.G., Sukhomlin, T.K., Tepikin, A.V., Petersen, O.H. & Gerasimenko, O.V. (2006) Bile acids induce Ca2+ release from both the ER and acidic intracellular calcium stores through activation of IP3Rs and RyRs. J. Biol. Chem. 281, 40154-40163.

Gerasimenko, J.V., Sherwood, M., Tepikin, A.V., Petersen, O.H. & Gerasimenko, O.V. (2006) NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area. J. Cell Sci.  119, 226-238.

Burdakov, D; Jensen, LT; Alexopoulos, H; Williams, RH; Fearon, IM; O'Kelly, I; Gerasimenko, O; Fugger, L; Verkhratsky, A (2006) Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose NEURON  50(5)   Pages: 711-722.