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Prof Michael Ehrmann 


The Periplasm 2006 M. Ehrmann (ed). ASM Press ISBN: 1-55581-398-4

The Periplasm 2006 M. Ehrmann (ed). ASM Press ISBN: 1-55581-398-4

Link to ScopusTM Database

Selected Publications 

Thompson, N.J., Merdanovic, M., Ehrmann, M., van Duijn, E., and  Heck, A.J.R. 2014. Substrate Occupancy at the Onset of Oligomeric Transitions of DegP. Structure 22: 281–290

Mastny, M., Heuck, A., Kurzbauer, R., Heiduk, A., Boisguerin, P., Volkmer, R.,  Ehrmann, M.,  Rodriguez, C.D.A., Rudner, D.Z., and Clausen, T. 2013. CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. Cell 155:647–658

Malet, M., Canellas, F., Sawa, J., Yan, J., Thalassinos, K., Ehrmann, M., Clausen, T., and H. Saibil. 2012. Binding of substrate proteins inside the molecular cage of the chaperone-protease DegQ. Nat. Struct. Mol. Biol. 19:152-157

Sinha, S., Lopes, D.H.J., Du, C., Pang, E., Shanmugam, A., Lomakin, A., Talbiersky, P., Tennstädt, A, McDaniel, K., Bakshi, R., Kuo, P-Y., Ehrmann, M., Benedek, G., Loo, J.A., Klärner, F.-G., Schrader, T., Wang, C.,  and G. Bitan. 2011. Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins. JACS 133:16958-16969

Merdanovic M, Clausen T, Kaiser M, Huber R and M. Ehrmann. 2011. Protein quality control in the bacterial periplasm. Annu. Rev. Microbiol. 65:149-168.

Kley, J., Schmidt, B., Boyanov, B., Stolt-Bergner, P., Kirk, R., Ehrmann, M., Knopf, R.R., Naveh, L., Adam, Z. and T. Clausen. 2011. Structural adaptation of the plant protease Deg1 to repair photosystem II at intense light. Nat. Struct. Mol. Biol. 18:728-731

Clausen T, Kaiser M, Huber R and M. Ehrmann. 2011. HtrA proteases: Regulated proteolysis in protein quality control. Nat. Rev. Mol. Cell Biol. , 12:152-62.

Trübestein L, Tennstaedt A, Mönig T, Krojer T, Canellas F, Kaiser M, Clausen T, and M. Ehrmann. 2011. Substrate induced remodeling of the active site regulates human HtrA1 activity. Nat. Struct. Mol. Biol., 18:386-388.

Merdanovic M, Mamant N, Meltzer M, Poepsel S, Auckenthaler A, Melgaard R, Hauske P, Nagel-Steger L, Clarke AR, Kaiser M, Huber R, and M. Ehrmann. 2010. Determinants of structural and functional plasticity of a widely conserved protease chaperone complex. Nat. Struct. Mol. Biol., 17:837-43.

Sawa J, Alexander Heuck P, Ehrmann M, and T. Clausen. 2010. Molecular transformers in the cell: Lessons learned from the DegP protease-chaperone. Curr. Opin. Struct. Biol., 20:253-258.

Krojer, T., Sawa, J., Schäfer, E., Saibil, H. R., Ehrmann, M. and T. Clausen. 2008 Structural basis for the regulated protease and chaperone function of DegP. Nature, 453:885-890 Highlighted in 2008 Structure 16: 989-90

Krojer, T., Pangerl, K., Kurt, J., Sawa, J., Stingl, C., Mechtler, K., Huber, R., Ehrmann, M., and T. Clausen 2008 The interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proc. Natl. Acad. Sci. USA, 105:7702-7707

Meltzer, M, Hasenbein, S., Hauske, P., Kucz, N., Merdanovic, M., Grau, S., Beil, A., Jones, D., Krojer, T., Clausen, T., Ehrmann, M.* and M. Kaiser* 2007. Allosteric activation of HtrA protease DegP by stress signals in bacterial protein quality control. Angew Chem. Int. Ed. Engl., 47:1332-1334 * corresponding authors

Hasselblatt, H., Kurzbauer, R., Wilken, C., Krojer, T., Sawa, J., Kurt, J., Kirk, R., Hasenbein, S., Ehrmann, M., and T. Clausen 2007 Regulation of the sE stress response by DegS: How the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress. Genes Dev. 21:2659-2670

Eser, M., Henrichs, T., Boyd, D. and M. Ehrmann. 2007. Target directed proteolysis in vivo. Methods Enzymol. 421:68-83

Hasenbein, S., Merdanovic, M. and M. Ehrmann 2007 Determinants of regulated proteolysis in signal transduction. Genes Dev. 21: 6-10

Chien, J., Aletti, G., Baldi, A., Catalano, V., Muretto, P., Keeney, G.L., Kalli, K.R., Staub, J., Ehrmann, M., Cliby, W.A., Lee, Y.K., Bible, K.C., Hartmann, L.C., Kaufmann, S.H. and V. Shridhar 2006 Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. J. Clin. Invest. 116: 1994-2004

Grau S, Richards PJ, Kerr B, Hughes C, Caterson B, Williams AS, Junker U, Jones SA, Clausen T, Ehrmann M. 2006. The Role of Human HtrA1 in Arthritic Disease. J. Biol. Chem. 281:6124- 6129.

Grau, S. Baldi, A., Bussani, R., Tian, X., Stefanescu, R., Przybylski, M., Shridhar, V., Clausen, T. and M. Ehrmann. 2005. Implications of human HtrA1 in amyloid precursor protein processing. Proc. Natl. Acad. Sci. USA, 102:6021-6026.

Henrichs, T., Mikhaleva, N., Conz, C., Deuerling, Boyd, D., E., Zelasny, A., Bibi, E., Ban, N. and M. Ehrmann. 2005. Target-directed proteolysis at the ribosome. Proc. Natl. Acad. Sci. USA, 102:4246-4251.

Ehrmann, M and T. Clausen. Proteolysis as a regulatory mechanism. 2004 Annu. Rev. Genet. 38: 709-724

Wilken, C., Kitzing, K., Kurzbauer, R., Ehrmann, M. and T. Clausen 2004. Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease domain. Cell 117:483-494

Eser, M., and M. Ehrmann. 2003. SecA-dependent quality control of intracellular protein localisation. Proc. Natl. Acad. Sci. USA 100:
13231-13234 Highlighted in Science 203:1296 & J. Cell Biol. 163:691

Clausen, T, Southan, C. and Ehrmann, M 2002. The HtrA family of proteases, implications for protein composition and cell fate. Mol. Cell 10:443-455

Krojer, T, Garrido-Franco, M, Huber, R., Ehrmann, M and Clausen, T. 2002. Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature 416: 455-459

Uhland, K., Mondigler, M., Spiess, C., Prinz, W. and M. Ehrmann 2000. The determinants of translocation and folding of TreF, a trehalase of E. coli. J. Biol. Chem. 275: 23439-23445

Spiess, C., Beil, A., and M. Ehrmann 1999. A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein. Cell 97: 339-34