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Prof Trevor Dale  -  PhD


Position:Professor / Deputy Research Division Leader (Molecular Biosciences)

Telephone:+44 (0)29 208 74652
Fax:+44 (0)29 208 74116
Extension:74652
Location:Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX

Research Overview

The primary focus of research in the group is the regulation of the Wnt signal transduction pathway. Wnts together with other peptide ligands including the FGF, EGF, TGF-β and hedgehog families orchestrate cell-cell interactions throughout development. Much of the specificity of each ligand’s function is controlled by intracellular pathways that are activated at the cell surface. Components of the Wnt/β-catenin pathway are frequently mutated in human cancer. This laboratory studies normal and oncogenic Wnt signalling using approaches ranging from biochemistry/structural biology, through cell and organoid based assays to murine models.

Specific projects include:

  1. The biochemistry of Wnt pathway components such as the kinase GSK-3
  2. The identification of novel Wnt regulators through high throughput cDNA, siRNA and drug screening.
  3. The analysis of normal and oncogenic Wnt signalling using murine models and 3D organoid culture systems

Research in the group has led to the recent establishment of a spin out company to commercialise a novel technology for high throughput quantitative protein-interaction assays. (see www.nanotether.co.uk).

Group Members

Dr Kenneth Ewan 

Ms Elizabeth Fraser 

Dr Andrew Hollins 

 

Postgraduate Research Students 

Miss Luned Badder

Mr Mateusz Legut

Miss Anika Offergeld 

Ms Mairian Thomas 

 

Research Division

Molecular Biosciences