Prof Trevor Dale - PhD
Telephone:+44 (0)29 208 74652
Fax:+44 (0)29 208 74116
Extension:74652
Location:Cardiff School of Biosciences, Biomedical Sciences Building, Museum Avenue, Cardiff, CF10 3AX
Research Overview
The primary focus of research in the group is the regulation of the Wnt signal transduction pathway. Wnts together with other peptide ligands including the FGF, EGF, TGFbeta and hedgehog families orchestrate cell-cell interactions throughout development. Much of the specificity of each ligand’s function is controlled by the intracellular pathways that are activated following binding at the cell surface. Components of the Wnt/beta-catenin pathway are frequently mutated in human cancer. This laboratory studies normal and oncogenic Wnt signalling using approaches ranging from biochemistry / structural biology, through cell based assays to murine models.
Specific projects in the group include the biochemistry and structure of the beta-catenin turnover complex, anti-cancer drug screening and altered Wnt signalling in breast cancer.
Group Members
Dr. Thierry Jarde
Dr. Richard Perrins
PhD Students
Felicity Rudge
Research Group
Joint Group Seminars with Adrian Harwood's Lab
Date | Speaker |
| 7/1/2010 | Kenneth Ewan |
| 21/1/2010 | No Meeting |
| 4/2/2010 | Jonathan Ryves |
| 18/2/2010 | Gui-Jie Feng |
| 4/3/2010 | Karin Weening |
| 18/3/2010 | Emma Dalton |
| 1/4/2010 | Bethan Lloyd-Lewis |
| 15/4/2010 | Jon Reddy |
| 29/4/2010 | Bozena Pajak |
| 13/5/2010 | Sebastian Braun |
| 27/5/2010 | Richard Perrins |
| 10/6/2010 | Thierry Jarde |
| 24/6/2010 | Sara Rey |
| 8/7/2010 | Felicity Rudge |
| 22/7/2010 | James Platt |
THIS YEAR'S MEETING
WNT 2010 Meeting, 27-30 October, Stockholm, Sweden
