Dr Catherine Boulter
Telephone:+44 (0)29 208 74311
Fax:+44 (0)29 208 74116
Location:Cardiff School of Biosciences, The Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
The regulation of stem/progenitor cell proliferation, survival and differentiation is of central importance to the formation of organs during embryogenesis and to regeneration and repair following injury. Moreover, defects in these processes underlie many diseases, including cancer. The overall aim of my work is to elucidate the function of specific genes involved in regulating stem/progenitor cells in mammalian organogenesis during development, and to determine how these developmental mechanisms are involved in regeneration and disease. We study the consequences that deregulating expression of specific genes in mesodermal and embryonic stem (ES) cells has on their proliferation, survival and differentiation in cell culture and use transgenic and knockout technologies to investigate the role of these genes in organ development, homeostasis, regeneration and disease.