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Dr Emma Blain 

Link to ScopusTM Database

Selected Publications

Gilbert SJ, Blain EJ, Al-Sabah A, Zhang Y, Duance VC, Mason DJ. (2012) Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. Eur Cell Mater. 23:41-57.

Thomas RS, Clarke AR, Duance VC, Blain EJ. (2011) Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis. Arthritis Res Ther. 13(6):R203

Khan IM, Evans SL, Young RD, Blain EJ, Quantock AJ, Avery N, Archer CW. (2011) Fibroblast growth factor 2 and transforming growth factor β1 induce precocious maturation of articular cartilage. Arthritis Rheum. 63(11):3417-27.

Li S, Jia X, Duance VC, Blain EJ. (2011) The effects of cyclic tensile strain on the organisation and expression of cytoskeletal elements in bovine intervertebral disc cells: an in vitro study. Eur Cell Mater. 21:508-22


Wann AK, Mistry J, Blain EJ, Michael-Titus AT, Knight MM. (2010) Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation. Arthritis Res Ther. 12(6):R207. [Epub ahead of print]

Blain EJ, Ali AY, Duance VC. (2010) Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytother Res. 24(6):905-12


Blain EJ. (2009) Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology. Int J Exp Pathol 90(1): 1-15


Li S, Duance VC, Blain EJ (2008) Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc. J Anat 213(6): 725-32

Davies LC, Blain EJ*, Gilbert SJ, Caterson B, Duance VC. (2008) The potential of IGF-1 and TGFbeta1 for promoting "adult" articular cartilage repair: an in vitro study. Tissue Eng Part A 14(7): 1251-61  (* joint 1st authorship)

Davies LC, Blain EJ, Caterson B, Duance VC. (2008) Chondroitin sulphate impedes the migration of a sub-population of articular cartilage chondrocytes. Osteoarthritis Cartilage 16(8): 855-64

Bazou D, Blain EJ, Coakley TW. (2008) NCAM and PSA-NCAM dependent membrane spreading and F-actin reorganization in suspended adhering neural cells. Mol Memb Biol 25(2): 102-14

Gilbert SJ, Blain EJ, Duance VC, Mason DJ. (2008) Sphingomyelinase decreases type II collagen expression in bovine articular cartilage chondrocytes via the ERK signalling pathway. Arthritis Rheum. 58(1):209-220


Li S, Duance VC, Blain EJ. (2007) F-actin cytoskeletal organisation in intervertebral disc health and disease. Biochem Soc Trans 35(4): 683-5

Blain EJ. (2007) Invited Review: Mechanical regulation of matrix metalloproteinases. Front Biosci 12: 507-27

Campbell JJ, Blain EJ, Chowdhury TT, Knight MM. (2007) Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. Biochem Biophys Res Commun 361(2):329-34


Blain EJ, Gilbert SJ, Hayes AJ, Duance VC. (2006) Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis. Matrix Biol 25(7): 398-408


Gilbert SJ, Blain EJ, Jones P, Duance VC, Mason DJ. (2004) Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis Res Ther 8(4): R89-100

Stephens P, Grenard P, Aeschlimann P, Langley M, Blain E, Kippling D, Thomas D, Aeschlimann D. (2004) Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. J. Cell Sci. 117: 3389-3403


Blain EJ, Mason DJ, Duance VC. (2003) Effect of mechanical stimulation on MMP expression in chondrocytes.  Biorheology  40(1-3): 111-117


Blain EJ, Mason DJ, Duance VC. (2002) The effect of thymosin b4 on articular cartilage chondrocyte MMP expression. Biochem Soc Trans 30(6): 879-882


Blain EJ, Gilbert SJ, Wardale RJ, Capper SJ, Mason DJ, Duance VC. (2001) Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro.  Arch Biochem Biophys 396: 49-55

Book Chapters

Blain EJ. (2010) Chapter 4: Involvement of the cytoskeletal elements in articular cartilage mechanotransduction. Mechanosensitivity and Mechanotransduction, Mechanosensitivity in Cells and Tissues 4, Kamkin, A, Kiseleva, I. (Eds.), 77-106

Blain EJ, Duance VC Chapter 1_4: Tissue Injury and repair – meniscus. Oxford Textbook of Sports Injuries. Editors – Hutson M, Speed C.  (Eds.)(in press).