Combating biofilm antimicrobial resistance
A group of multidisciplinary researchers, we have the common research goal of preventing biofilm mediated infections that may arise following the use of an implanted medical device.
Antimicrobial resistance (AMR) occurs when administered antibiotics do not result in eradication of infection. Elevated tolerance to antimicrobials is a property of microorganisms when growing as biofilms and this frequently occurs on the surfaces of implanted medical devices.
Our approach is to present novel anti-biofilm chemistries on the surfaces of biomaterials to generate colonisation resistant materials (CRMs). CRMs will inhibit the attachment or kill adherent microorganisms, thereby preventing viable biofilms formation. A range of antimicrobials, tailored by flexible syntheses can also be incorporated into the bulk matrix of biomaterials to facilitate controlled and stimulated release.
A further aspect of our research explores electromagnetic radiation to disrupt established biofilms and stimulate release of our antimicrobial actives.
Biofilms can be defined as microbial communities that are mostly attached to solid substrates with the microorganisms being embedded in a self-produced extracellular polymeric substance (EPS). Biofilms are highly resistant to external threats and unsurprisingly are the preferred form of microbial growth in the natural environment.
Our researchers are from three Universities (Cardiff, Swansea and Greenwich), the NHS and industry (MBi Wales Ltd) and encompass microbiologists, immunologists, chemists, engineers, clinicians and bioinformaticians.
|Dr Ian Fallis||Inorganic Chemistry||Cardiff University|
|Dr Nancy Dervisi||Inorganic Chemistry||Cardiff University|
|Professor Alastair J Sloan||Bone Biology and Tissue Engineering||Cardiff University|
|Dr Melanie Wilson||Oral Microbiology||Cardiff University|
|Dr Jonathan Lees||Microwave Engineering||Cardiff University|
|Professor Adrian Porch||Electromagnetics, Biomaterials and Mechanical Testing||Cardiff University|
|Professor Sam Evans||Microwave Sensing/Disruption||Cardiff University|
|Dr Ann Smith||Bioinformatics and Data Analysis||Cardiff University|
|Dr Thomas S. Wilkinson||Microbiology and Infectious Disease||Swansea University|
|Mr Paul Milward||Dental Technology and Biomaterial Sciences||Cardiff University|
|Dr Matt Wise||Critical Care||University Hospital of Wales|
|Dr Xiao-Qing Wei||Immunology||Cardiff University|
|Dr Joel Loveridge||NMR Spectroscopy||Cardiff University|
|Professor Peter Griffiths||Drug Delivery||University of Greenwich|
|Dr Stephen Jones||Hip Implant Development and Evaluation||Cardiff University|
|Professor Julian R Marchesi||Human Microbiome||Cardiff University|
|Professor Oliver Williams||Diamond Nanoparticles||Cardiff University|
|Mr Shibendra Nath Datta||Urology||University Hospital of Wales|
|Dr Angelo Amoroso||Inorganic Chemistry||Cardiff University|
|Dr Alison Paul||Physical Chemistry||Cardiff University|
|Dr Simon Pope||Inorganic Chemistry||Cardiff University|
|Professor Mark Waters||Biomaterials||MBi Wales|
|Dr Wayne Ayre||Medical Devices||Cardiff Universtiy|
- Nishio Ayre, W. et al. 2016. A novel liposomal drug delivery system for PMMA bone cements. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104 (8), pp.1510-1524. (10.1002/jbm.b.33488)
- Imtiaz, A. et al. 2015. An integrated continuous class-F-1 mode power amplifier design approach for microwave enhanced portable diagnostic applications. IEEE Transactions on Microwave Theory and Techniques 63 (10), pp.3007-3015. (10.1109/TMTT.2015.2472417)
- Jordan, R. P. C. et al. 2015. Development of an antimicrobial urinary catheter to inhibit urinary catheter encrustation. Microbiology Discovery 3 (1) 1. (10.7243/2052-6180-3-1)
- Almalioti, F. et al. 2013. Convenient syntheses of cyanuric chloride-derived NHC ligands, their Ag(i) and Au(i) complexes and antimicrobial activity. Dalton Transactions 42 (34), pp.12370-12380. (10.1039/c3dt51400e)
Al-Ishaq R, Armstrong J, Gregory M, O'Hara M, Phiri K, Harris LG, Rohde H, Siemssen N, Frommelt L, Mack D, Wilkinson TS. 2015. Effects of polysaccharide intercellular adhesin (PIA) in an ex vivo model of whole blood killing and in prosthetic joint infection (PJI): A role for C5a. International Journal of Medical Microbiology. pii: S1438-4221(15)30004-7. (10.1016/j.ijmm.2015.08.005)