
Professor Julian R Marchesi
Honorary Professor
- marchesijr@cardiff.ac.uk
- +44 (0)29 2087 4188
- Fax:
- +44 (0)29 2087 4116
- Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
- Available for postgraduate supervision
Overview
The human microbiome has recently been found to be an integral part of human biology. For many years it was viewed as a source of infection, but now we know it is an essential component of the host and needed for normal development and function. My research since 2001 has focused on understanding the roles that the bacterial component of the microbiome plays in maintaining health and promoting diseases.
Research overview
- Microbiology of the gut, skin, lung and female reproductive system
- Host-microbes interactions in the gut, lungs, skin and female reproductive system
- Impact of bacterial produced metabolites and proteins in the gut and female reproductive system
- Bioactive and biocatalytic agents from the human microbiome using functional metagenomics
- Using metataxonomics (16S rRNA gene profiles) and metagenomics to explore the human microbiome in health and disease
- The role of the microbiome in cancer, inflammatory bowel disease, obesity, liver disease, pre-term labour and autoimmune diseases
- How the microbiome interacts with the diet to drive health.
- Understanding the role of the gut microbiota in controlling infections in the gut and providing colonization resistance.
Microbiomes, Microbes and Informatics
The Marchesi group is part of the recently formed Microbiomes, Microbes and Informatics (MMI) group (webpage underdevelopment). The MMI group currently comprises the research groups of Thomas Connor, Esh Mahenthiralingam, Julian Marchesi and Andrew Weightman, and has over 25 active research staff and postgraduate students.
The MMI group are highly research active generating over £3.5 million in grant income between 2010 and 2017, and publishing extensively in top journals (cumulative h index > 150, > 400 publications, and > 25,000; source Scopus.com).
The four current MMI staff recently moved (June 2017) to a single shared location within a new £1.6 million refurbished area of the Sir Martin Evans Building. This comprises a large class II certified research laboratory, equipment and tissue culture rooms, a group office area and academic offices. The MMI group welcomes approaches by potential fellowship applicants and funded PhD students to host their research and expand our strategic research on Microbiomes, Microbes and Informatics.
Interested in joining my lab as a self-funded post-graduate student or a postdoc/fellow? Please contact me by email.
Biography
After graduating from Cardiff University I started work on looking at the impact of genetically modified microbes on natural ecosystems. At this point I developed an interest in the contribution of uncultured microbes to the maintenance and function of "natural" ecosystems i.e. molecular microbial ecology. After this research position I continued to use molecular biological methods to investigate microbes in the deep biosphere ecosystem which exists below the sea-floor and developed molecular methods to investigate methane producing bacteria in this ecosystem.
I followed this work with a Wellcome Trust Fellowship and extended my molecular microbial ecology interest to investigate, using culture independent methods, the diversity and distribution of genes involved in biodegradation of priority pollutants. It was during this period that I started turning my attention to using these molecular methods to explore the unculturable bacteria and their involvement in the human ecosystem.
I obtained a Lectureship in the Department of Microbiology, University College Cork (UCC) and this provided me with the opportunity to investigate the contribution microbes make to gastrointestinal tract function. In UCC my group investigated the human gut ecosystem in health and disease and used molecular methods to understand how bacteria contribute to the key functions which are found in human GI tracts.
My current research interest is to continue this work in Cardiff and to further shed light on the contributions and role the human microbiome plays in health and disease. The human microbiome consists of all the microbial genomes which are found in the human ecosystem. The main fraction resides in the gastrointestinal tract and this collection of genetic information contains many functions which are able to influence the host's own metabolism. In fact the combined metabolic functions of these microbes are equivalent to that of the liver and we are now considering the gut microbiome as a virtual organ. But unlike any conventional organ the range of functions are very dynamic and can be perturbed easily. The gut microbiome has been implicated in many health and disease processes including obesity, non-alcoholic fatty liver disease and several atopic diseases. Since this collection of microbes varies from one individual to another there exists the possibility that different individuals are being affected differently by their microbiome.
Publications
2022
- Whelan, E. et al. 2022. Risk factors for ovarian cancer: An umbrella review of the literature. Cancers 14(11), article number: e2708. (10.3390/cancers14112708)
- Webberley, T. S. et al. 2022. The impact of probiotic supplementation on cognitive, pathological and metabolic markers in a transgenic mouse model of Alzheimer’s Disease. Frontiers in Neuroscience 16, article number: 843105. (10.3389/fnins.2022.843105)
2021
- Allegretti, J. R. et al. 2021. Inflammatory bowel disease outcomes following fecal microbiota transplantation for recurrent C. difficile infection. Inflammatory Bowel Diseases 27(9), article number: 1371–1378. (10.1093/ibd/izaa283)
- Garaiova, I. et al. 2021. Probiotics with vitamin C for the prevention of upper respiratory tract symptoms in children aged 3-10 years: randomised controlled trial. Beneficial Microbes 12(5), pp. 431-440. (10.3920/BM2020.0185)
- Li, J. V. et al. 2021. Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype. Microbiome 9(1), article number: 139. (10.1186/s40168-021-01086-x)
- O'Sullivan, D. M. et al. 2021. An inter-laboratory study to investigate the impact of the bioinformatics component on microbiome analysis using mock communities. Scientific Reports 11, article number: 10590. (10.1038/s41598-021-89881-2)
- Ghani, R. et al. 2021. Disease prevention not decolonization: a model for fecal microbiota transplantation in patients colonized with multidrug-resistant organisms. Clinical Infectious Diseases 72(8), pp. 1444-1447. (10.1093/cid/ciaa948)
- Mullish, B. H. et al. 2021. Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?. Gut Microbes 13(1), pp. 1-9. (10.1080/19490976.2021.1900997)
- Moshkelgosha, S. et al. 2021. Modulating gut microbiota in a mouse model of Graves' orbitopathy and its impact on induced disease. Microbiome 9(1), article number: 45. (10.1186/s40168-020-00952-4)
- Short, C. S. et al. 2021. Lactobacillus-depleted vaginal microbiota in pregnant women living with HIV-1 infection are associated with increased local inflammation and preterm birth. Frontiers in Cellular and Infection Microbiology 10, article number: 596917. (10.3389/fcimb.2020.596917)
- Seyfried, F. et al. 2021. Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss. Gut Microbes 13(1), pp. 1-20. (10.1080/19490976.2021.1875108)
- Michael, D. R. et al. 2021. Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults. Scientific Reports 11(1), article number: 5. (10.1038/s41598-020-78285-3)
- Huus, K. E. et al. 2021. Changes in IgA-targeted microbiota following fecal transplantation for recurrent Clostridioides difficile infection. Gut Microbes 13(1), pp. 1-12. (10.1080/19490976.2020.1862027)
2020
- Baunwall, S. M. D., Lee, M. M., Eriksen, M. K., Mullish, B. H., Marchesi, J. R., Dahlerup, J. F. and Hvas, C. L. 2020. Faecal microbiota transplantation for recurrent Clostridioides difficile infection: An updated systematic review and meta-analysis. EClinicalMedicine 29, article number: 100642. (10.1016/j.eclinm.2020.100642)
- Taylor, H. et al. 2020. Multiomic features associated with mucosal healing and inflammation in paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics 52(9), pp. 1491-1502. (10.1111/apt.16086)
- Lowe, J. et al. 2020. Study protocol: azithromycin therapy for chronic lung disease of prematurity (AZTEC) - a randomised, placebo-controlled trial of azithromycin for the prevention of chronic lung disease of prematurity in preterm infants. BMJ Open 10(10), article number: e041528. (10.1136/bmjopen-2020-041528)
- Skinner, C., Thompson, A. J., Thursz, M. R., Marchesi, J. R. and Vergis, N. 2020. Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention. Therapeutic Advances in Gastroenterology 13, pp. 1-16. (10.1177/1756284820942616)
- Martinez-Gili, L. et al. 2020. Understanding the mechanisms of efficacy of fecal microbiota transplant in treating recurrent Clostridioides difficile infection and beyond: the contribution of gut microbial-derived metabolites. Gut Microbes 12(1), article number: 1810531. (10.1080/19490976.2020.1810531)
- Pataia, V. et al. 2020. Obeticholic acid improves fetal bile acid profile in a mouse model of gestational hypercholanemia. AJP - Gastrointestinal and Liver Physiology 319(2), pp. G197-G211. (10.1152/ajpgi.00126.2020)
- Gallacher, D., Mitchell, E., Alber, D., Wach, R., Klein, N., Marchesi, J. R. and Kotecha, S. 2020. Dissimilarity of the gut-lung axis and dysbiosis of the lower airways in ventilated preterm infants. European Respiratory Journal 55(5), article number: 1901909. (10.1183/13993003.01909-2019)
- Mitra, A. et al. 2020. The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nature Communications 11(1), article number: 1999. (10.1038/s41467-020-15856-y)
- May, S., McDermott, G., Marchesi, J. and Parry, L. 2020. Impact of black raspberries on the normal and malignant Apc deficient murine gut microbiome. Journal of Berry Research 10(1), pp. 61-76. (10.3233/JBR-180372)
- Michael, D. R. et al. 2020. A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being. Scientific Reports 10(1), pp. -., article number: 4183. (10.1038/s41598-020-60991-7)
- Ovadia, C. et al. 2020. Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy. Scientific Reports 10(1), article number: 3895. (10.1038/s41598-020-60821-w)
- Sequeira, R. P., McDonald, J. A. K., Marchesi, J. R. and Clarke, T. B. 2020. Commensal Bacteroidetes protect against Klebsiella pneumoniae colonization and transmission through IL-36 signalling. Nature Microbiology 5(2), pp. 304-313. (10.1038/s41564-019-0640-1)
- Al-Memar, M. et al. 2020. The association between vaginal bacterial composition and miscarriage: a nested case-control study. BJOG: An International Journal of Obstetrics and Gynaecology 127(2), pp. 264-274. (10.1111/1471-0528.15972)
- Walters, J. R. and Marchesi, J. R. 2020. Chronic diarrhea, bile acids, and Clostridia. Journal of Clinical Investigation 130(1), pp. 77-79. (10.1172/JCI133117)
- Segal, J. P., Mullish, B. H., Quraishi, M. N., Iqbal, T., Marchesi, J. R. and Sokol, H. 2020. Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease. Therapeutic Advances in Gastroenterology 13, pp. 1-14. (10.1177/1756284820946904)
- Segal, J. P., Mak, J. W. Y., Mullish, B. H., Alexander, J. L., Ng, S. C. and Marchesi, J. R. 2020. The gut microbiome: an under-recognised contributor to the COVID-19 pandemic?. Therapeutic Advances in Gastroenterology 13, article number: 175628482097491. (10.1177/1756284820974914)
- Jukes, C. A. et al. 2020. Bile salt metabolism is not the only factor contributing to Clostridioides (Clostridium) difficile disease severity in the murine model of disease. Gut Microbes 11(3), pp. 481-496. (10.1080/19490976.2019.1678996)
2019
- Yalchin, M., Segal, J. P., Mullish, B. H., Nabil Quraishi, M., Iqbal, T. H., Marchesi, J. R. and Hart, A. L. 2019. Gaps in knowledge and future directions for the use of faecal microbiota transplant in the treatment of inflammatory bowel disease. Therapeutic Advances in Gastroenterology 12, pp. 1-18. (10.1177/1756284819891038)
- Pinato, D. J., Gramenitskaya, D., Altmann, D. M., Boyton, R. J., Mullish, B. H., Marchesi, J. R. and Bower, M. 2019. Antibiotic therapy and outcome from immune-checkpoint inhibitors. Journal for ImmunoTherapy of Cancer 7(1), article number: 287. (10.1186/s40425-019-0775-x)
- Salem, F. et al. 2019. Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences. United European Gastroenterology Journal 7(8), pp. 1008-1032. (10.1177/2050640619867555)
- Mullish, B. H. et al. 2019. Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection. Gut 68(10), pp. 1791-1800. (10.1136/gutjnl-2018-317842)
- Scott, A. J. et al. 2019. International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis. Gut 68, pp. 1624-1632. (10.1136/gutjnl-2019-318556)
- McIlvride, S. et al. 2019. Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in mouse model of gestational diabetes. AJP - Endocrinology and Metabolism 317(2), pp. E399-E410. (10.1152/ajpendo.00407.2018)
- Chambers, E. S. et al. 2019. Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial. Gut 68(8), pp. 1430-1438. (10.1136/gutjnl-2019-318424)
- Ovadia, C. et al. 2019. Enhanced microbial bile acid deconjugation and impaired ileal uptake in pregnancy repress intestinal regulation of bile acid synthesis. Hepatology 70(1), pp. 276-293. (10.1002/hep.30661)
- Mullish, B., Ghani, R., McDonald, J. and Marchesi, J. 2019. Faecal microbiota transplant for eradication of multidrug-resistant Enterobacteriaceae: a lesson in applying best practice? Re: 'a five-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: a randomized clinical trial'. Clinical Microbiology and Infection 25(7), pp. 912-913. (10.1016/j.cmi.2019.01.010)
- Brown, R. et al. 2019. Prospective observational study of vaginal microbiota pre- and post-rescue cervical cerclage. BJOG: An International Journal of Obstetrics and Gynaecology 126(7), pp. 916-925. (10.1111/1471-0528.15600)
- Brown, R. G. et al. 2019. Establishment of vaginal microbiota composition in early pregnancy and its association with subsequent preterm prelabor rupture of the fetal membranes. Translational Research, The Journal of Laboratory and Clinical Medicine 207, pp. 30-43. (10.1016/j.trsl.2018.12.005)
- Hegade, V. S. et al. 2019. Autotaxin, bile acid profile and effect of ileal bile acid transporter inhibition in primary biliary cholangitis patients with pruritus. Liver International 39(5), pp. 967-975. (10.1111/liv.14069)
- Maurice, J. B. et al. 2019. Monocyte-macrophage activation is associated with nonalcoholic fatty liver disease and liver fibrosis in HIV monoinfection independently of the gut microbiome and bacterial translocation. AIDS 33(5), pp. 805-814. (10.1097/QAD.0000000000002133)
- Segal, J. P. et al. 2019. The application of omics techniques to understand the role of the gut microbiota in inflammatory bowel disease. Therapeutic Advances in Gastroenterology 12, pp. 1-13. (10.1177/1756284818822250)
- Simon, J., Marchesi, J. R., Mougel, C. and Selosse, M. 2019. Host-microbiota interactions: from holobiont theory to analysis. Microbiome 7(1), pp. -., article number: 5. (10.1186/s40168-019-0619-4)
- Monaghan, T. et al. 2019. Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in the bile acid-farnesoid X receptor-fibroblast growth factor pathway. Gut Microbes 10(2), pp. 142-148. (10.1080/19490976.2018.1506667)
2018
- Moshkelgosha, S. et al. 2018. Gut microbiome in BALB/c and C57BL/6J mice undergoing experimental thyroid autoimmunity associate with differences in immunological responses and thyroid function. Hormone and Metabolic Research 50(12), pp. 932-941. (10.1055/a-0653-3766)
- McDonald, J. A. et al. 2018. Inhibiting growth of Clostridioides difficile by restoring valerate, produced by the intestinal microbiota. Gastroenterology 155(5), pp. 1495-1507. (10.1053/j.gastro.2018.07.014)
- Naz, I. et al. 2018. Investigation of the active biofilm communities on polypropylene filter media in a fixed biofilm reactor for wastewater treatment. Journal of Chemical Technology and Biotechnology 93(11), pp. 3264-3275. (10.1002/jctb.5686)
- Mullish, B. H., Pechlivanis, A., Barker, G. F., Thursz, M. R., Marchesi, J. R. and McDonald, J. A. 2018. Functional microbiomics: Evaluation of gut microbiota-bile acid metabolism interactions in health and disease. Methods 149, pp. 49-58. (10.1016/j.ymeth.2018.04.028)
- Pruski, P., Lewis, H. V., Lee, Y. S., Marchesi, J. R., Bennett, P. R., Takats, Z. and MacIntyre, D. A. 2018. Assessment of microbiota:host interactions at the vaginal mucosa interface. Methods 149, pp. 74-84. (10.1016/j.ymeth.2018.04.022)
- Pouncey, A. L., Scott, A. J., Alexander, J. L., Marchesi, J. and Kinross, J. 2018. Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment. ecancermedicalscience 12, article number: 868. (10.3332/ecancer.2018.868)
- Alexander, J. L., Scott, A. J., Pouncey, A. L., Marchesi, J., Kinross, J. and Teare, J. 2018. Colorectal carcinogenesis: an archetype of gut microbiota-host interaction. ecancermedicalscience 12, article number: 865. (10.3332/ecancer.2018.865)
- Mullish, B. H., Osborne, L. S., Marchesi, J. R. and McDonald, J. A. 2018. The implementation of omics technologies in cancer microbiome research. ecancermedicalscience 12, article number: 864. (10.3332/ecancer.2018.864)
- Mullish, B. H., McDonald, J. A., Thursz, M. R. and Marchesi, J. R. 2018. Antibiotic-associated disruption of microbiota composition and function in cirrhosis is restored by fecal transplant. Hepatology 68(3), pp. 1205-1205. (10.1002/hep.30090)
- Marchesi, J. R. 2018. Advancing microbiome research. Microbiology 164(8), pp. 1005-1006. (10.1099/mic.0.000688)
- Martin, G., Kolida, S., Marchesi, J., Want, E., Sidaway, J. E. and Swann, J. R. 2018. In vitro modeling of bile acid processing by the human fecal microbiota. Frontiers in Microbiology 9, article number: 1153. (10.3389/fmicb.2018.01153)
- Masetti, G. et al. 2018. Gut microbiota in experimental murine model of Graves' orbitopathy established in different environments may modulate clinical presentation of disease. Microbiome 6, article number: 97. (10.1186/s40168-018-0478-4)
- Brown, R. G. et al. 2018. Vaginal dysbiosis increases risk of preterm fetal membrane rupture, neonatal sepsis and is exacerbated by erythromycin. BMC Medicine 16, article number: 9. (10.1186/s12916-017-0999-x)
- Cobbold, J. F. et al. 2018. Rifaximin in non-alcoholic steatohepatitis: an open-label pilot study. Hepatology Research 48(1), pp. 69-77. (10.1111/hepr.12904)
- Ding, N. S., Mullish, B. H., McLaughlin, J., Hart, A. and Marchesi, J. R. 2018. Meeting update: faecal microbiota transplantation-bench, bedside, courtroom?. Frontline Gastroenterology 9(1), pp. 45-48. (10.1136/flgastro-2016-100752)
2017
- Pascoe, E. L., Hauffe, H. C., Marchesi, J. R. and Perkins, S. E. 2017. Network analysis of gut microbiota literature: an overview of the research landscape in non-human animal studies. ISME Journal 11(12), pp. 2644-2651. (10.1038/ismej.2017.133)
- Scott, A., Merrifield, C., Alexander, J., Marchesi, J. and Kinross, J. 2017. Highlights from the Inaugural International Cancer Microbiome Consortium Meeting (ICMC), 5-6 September 2017, London, UK. ecancermedicalscience 11 (10.3332/ecancer.2017.791)
- O'Hagan, C., Li, J. V., Marchesi, J. R., Plummer, S., Garaiova, I. and Good, M. A. 2017. Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats. Neurobiology of Learning and Memory 144, pp. 36-47. (10.1016/j.nlm.2017.05.015)
- Köhling, H. L., Plummer, S. F., Marchesi, J. R., Davidge, K. S. and Ludgate, M. 2017. The microbiota and autoimmunity: their role in thyroid autoimmune diseases. Clinical Immunology 183, pp. 63-74. (10.1016/j.clim.2017.07.001)
- Mullish, B. H., McDonald, J. A. K., Thursz, M. R. and Marchesi, J. R. 2017. Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: a randomized clinical trial. Hepatology 66(4), pp. 1354-1355. (10.1002/hep.29369)
- Mitra, A. et al. 2017. Comparison of vaginal microbiota sampling techniques: cytobrush versus swab. Scientific Reports 7(1), article number: 9802. (10.1038/s41598-017-09844-4)
- Kinross, J. et al. 2017. A prospective analysis of mucosal microbiome-metabonome interactions in colorectal cancer using a combined MAS 1HNMR and metataxonomic strategy. Scientific Reports 7(1), article number: 8979. (10.1038/s41598-017-08150-3)
- Marino, P. J., Wise, M. P., Smith, A., Marchesi, J. R., Riggio, M. P., Lewis, M. A. O. and Williams, D. W. 2017. Community analysis of dental plaque and endotracheal tube biofilms from mechanically ventilated patients. Journal of Critical Care 39, pp. 149-155. (10.1016/j.jcrc.2017.02.020)
- Michael, D. R. et al. 2017. The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice. Scientific Reports 7, article number: 2883. (10.1038/s41598-017-02889-5)
- Drake, M. J., Morris, N., Apostolidis, A., Rahnama'i, M. S. and Marchesi, J. R. 2017. The urinary microbiome and its contribution to lower urinary tract symptoms; ICI-RS 2015. Neurourology and Urodynamics 36(4), pp. 850-853. (10.1002/nau.23006)
- O'Toole, P. W., Marchesi, J. R. and Hill, C. 2017. Next-generation probiotics: the spectrum from probiotics to live biotherapeutics. Nature Microbiology 2(5), article number: 17057. (10.1038/nmicrobiol.2017.57)
- Alexander, J. L., Wilson, I. D., Teare, J., Marchesi, J. R., Nicholson, J. K. and Kinross, J. M. 2017. Gut microbiota modulation of chemotherapy efficacy and toxicity. Nature Reviews Gastroenterology & Hepatology 14(6), pp. 356-365. (10.1038/nrgastro.2017.20)
- Li, J. V., Swann, J. and Marchesi, J. R. 2017. Biology of the microbiome 2: metabolic role. Gastroenterology Clinics of North America 46(1), pp. 37-47. (10.1016/j.gtc.2016.09.006)
- Kindinger, L. M. et al. 2017. The interaction between vaginal microbiota, cervical length, and vaginal progesterone treatment for preterm birth risk. Microbiome 5, article number: 6. (10.1186/s40168-016-0223-9)
- Lynch, A. et al. 2017. The Bacteroidales produce an N-acylated derivative of glycine with both cholesterol-solubilising and hemolytic activity. Scientific Reports 7(1), article number: 13270. (10.1038/s41598-017-13774-6)
- Innes, A. J. et al. 2017. Faecal microbiota transplant: a novel biological approach to extensively drug-resistant organism-related non-relapse mortality [Letter to the Editor]. Bone Marrow Transplantation 52(10), pp. 1452-1454. (10.1038/bmt.2017.151)
2016
- Mitra, A., MacIntyre, D. A., Marchesi, J. R., Lee, Y. S., Bennett, P. R. and Kyrgiou, M. 2016. The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia: what do we know and where are we going next?. Microbiome 4, article number: 58. (10.1186/s40168-016-0203-0)
- Kindinger, L. M. et al. 2016. Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage. Science Translational Medicine 8(350), article number: 350ra102. (10.1126/scitranslmed.aag1026)
- Hodgson, D. M. et al. 2016. Segregation of the anodic microbial communities in a microbial fuel cell cascade. Frontiers in Microbiology 7, article number: 699. (10.3389/fmicb.2016.00699)
- Gratton, J. et al. 2016. Optimized sample handling strategy for metabolic profiling of human feces. Analytical Chemistry 88(9), pp. 4661-4668. (10.1021/acs.analchem.5b04159)
- Phetcharaburanin, J., Lees, H., Marchesi, J. R., Nicholson, J. K., Holmes, E., Seyfried, F. and Li, J. V. 2016. Systemic characterization of an obese phenotype in the Zucker rat model defining metabolic axes of energy metabolism and host-microbial interactions. Journal of Proteome Research 15(6), pp. 1897-1906. (10.1021/acs.jproteome.6b00090)
- Morris, L. S. and Marchesi, J. R. 2016. Assessing the impact of long term frozen storage of faecal samples on protein concentration and protease activity. Journal of Microbiological Methods 123, pp. 31-38. (10.1016/j.mimet.2016.02.001)
- Broaders, E., O'Brien, C., Gahan, C. G. M. and Marchesi, J. R. 2016. Evidence for plasmid mediated salt tolerance in the human gut microbiome and potential mechanisms. FEMS Microbiology Ecology 92(3), article number: fiw019. (10.1093/femsec/fiw019)
- Holmes, E., MacIntyre, D., Modi, N. and Marchesi, J. R. 2016. Handing on health to the next generation. In: Holmes, E. et al. eds. Metabolic Phenotyping in Personalized and Public Healthcare. Academic Press, pp. 213-264., (10.1016/B978-0-12-800344-2.00008-2)
- Kinross, J. and Marchesi, J. R. 2016. The aging superorganism. In: Holmes, E. et al. eds. Metabolic Phenotyping in Personalized and Public Healthcare. Academic Press, pp. 265-290., (10.1016/B978-0-12-800344-2.00009-4)
- Sands, K. M. et al. 2016. Microbial profiling of dental plaque from mechanically ventilated patients. Journal of Medical Microbiology 65(2), pp. 147-159. (10.1099/jmm.0.000212)
- Naz, I., Hodgson, D., Smith, A., Marchesi, J. R., Ahmed, S., Avignone-Rossa, C. and Saroj, D. P. 2016. Effect of the chemical composition of filter media on the microbial community in wastewater biofilms at different temperatures. RSC Advances 6(106), pp. 104345-104353. (10.1039/C6RA21040F)
2015
- Mitra, A. et al. 2015. Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity. Scientific Reports 5, article number: 16865. (10.1038/srep16865)
- Marchesi, J. R. et al. 2015. The gut microbiota and host health: a new clinical frontier. Gut 65(2), pp. 330-339. (10.1136/gutjnl-2015-309990)
- Kreisinger, J., Bastien, G., Hauffe, H. C., Marchesi, J. and Perkins, S. E. 2015. Interactions between multiple helminths and the gut microbiota in wild rodents. Philosophical Transactions B: Biological Sciences 370(1675), article number: 20140295. (10.1098/rstb.2014.0295)
- Flight, W. G. et al. 2015. Rapid detection of emerging pathogens and loss of microbial diversity associated with severe lung disease in cystic fibrosis. Journal of Clinical Microbiology 53(7), pp. 2022-2029. (10.1128/JCM.00432-15)
- Mullish, B. H., Marchesi, J. R., Thursz, M. R. and Williams, H. R. T. 2015. Microbiome manipulation with faecal microbiome transplantation as a therapeutic strategy in Clostridium difficile infection. QJM: An International Journal of Medicine 108(5), pp. 355-359. (10.1093/qjmed/hcu182)
- MacIntyre, D. A. et al. 2015. The vaginal microbiome during pregnancy and the postpartum period in a European population. Scientific Reports 5, article number: 8988. (10.1038/srep08988)
- O'Mahony, M. M., Henneberger, R., Selvin, J., Kennedy, J., Doohan, F., Marchesi, J. R. and Dobson, A. D. W. 2015. Inhibition of the growth of Bacillus subtilis DSM10 by a newly discovered antibacterial protein from the soil metagenome. Bioengineered 6(2), pp. 89-98. (10.1080/21655979.2015.1018493)
- Morris, L. S. and Marchesi, J. R. 2015. Current functional metagenomic approaches only expand the existing protease sequence space, but does not presently add any novelty to it. Current Microbiology 70(1), pp. 19-26. (10.1007/s00284-014-0677-6)
- Lamour, S. D. et al. 2015. Metabolic, immune, and gut microbial signals mount a systems response to Leishmania major infection. Journal of Proteome Research 14(1), pp. 318-329. (10.1021/pr5008202)
2014
- Progatzky, F. et al. 2014. Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation. Nature Communications 5, article number: 5864. (10.1038/ncomms6864)
- Bull, M. J. et al. 2014. The domestication of the probiotic bacterium Lactobacillus acidophilus. Scientific Reports 4, article number: 7202. (10.1038/srep07202)
- O'Mahony, S. M. et al. 2014. Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats. Neuroscience 277, pp. 885-901. (10.1016/j.neuroscience.2014.07.054)
- Lees, H., Swann, J., Poucher, S. M., Nicholson, J. K., Holmes, E., Wilson, I. D. and Marchesi, J. R. 2014. Age and microenvironment outweigh genetic influence on the zucker rat microbiome. PLoS ONE 9(9), article number: e100916. (10.1371/journal.pone.0100916)
- Peng, J., Narasimhan, S., Marchesi, J. R., Benson, A., Wong, F. S. and Wen, L. 2014. Long term effect of gut microbiota transfer on diabetes development. Journal of Autoimmunity 53, pp. 85-94. (10.1016/j.jaut.2014.03.005)
- Culligan, E. P., Sleator, R. D., Marchesi, J. R. and Hill, C. 2014. Metagenomic identification of a novel salt tolerance gene from the human gut microbiome which encodes a membrane protein with homology to a brp/blh-family β-Carotene 15,15′-Monooxygenase. PLoS ONE 9(7), article number: e103318. (10.1371/journal.pone.0103318)
- Culligan, E. P., Marchesi, J. R., Hill, C. and Sleator, R. D. 2014. Combined metagenomic and phenomic approaches identify a novel salt tolerance gene from the human gut microbiome. Frontiers in Microbiology 5, article number: 189. (10.3389/fmicb.2014.00189)
- Culligan, E. P., Sleator, R. D., Marchesi, J. R. and Hill, C. 2014. Metagenomics and novel gene discovery: promise and potential for novel therapeutics. Virulence 5(3), pp. 1-14. (10.4161/viru.27208)
2013
- Bull, M. J., Plummer, S., Marchesi, J. R. and Mahenthiralingam, E. 2013. The life history of 'Lactobacillus acidophilus' as a probiotic: a tale of revisionary taxonomy, misidentification and commercial success. FEMS Microbiology Letters 349(2), pp. 77-87. (10.1111/1574-6968.12293)
- Lewis, D. A., Brown, R. C., Williams, J., White, P., Jacobsen, S. K., Marchesi, J. R. and Drake, M. J. 2013. The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults. Frontiers in Cellular and Infection Microbiology 3, pp. 41. (10.3389/fcimb.2013.00041)
- Broaders, E., Gahan, C. and Marchesi, J. R. 2013. Mobile genetic elements of the human gastrointestinal tract: Potential for spread of antibiotic resistance genes. Gut Microbes 4(4), pp. 271-280. (10.4161/gmic.24627)
- Van Woerden, H. C., Gregory, C. J., Brown, R. C., Marchesi, J. R., Hoogendoorn, B. and Matthews, I. P. 2013. Differences in fungi present in induced sputum samples from asthma patients and non-atopic controls: a community based case control study. BMC Infectious Diseases 13, article number: 69. (10.1186/1471-2334-13-69)
- Moreno-Hagelsieb, G., Culligan, E. P., Sleator, R. D., Marchesi, J. R. and Hill, C. 2013. Functional environmental screening of a metagenomic library identifies stlA; a unique salt tolerance locus from the human gut microbiome. PLoS ONE 8(12), pp. e82985. (10.1371/journal.pone.0082985)
- Prorok-Hamon, M. et al. 2013. Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer. Gut 63(5), pp. 761-770. (10.1136/gutjnl-2013-304739)
2012
- Culligan, E. P., Sleator, R. D., Marchesi, J. R. and Hill, C. 2012. Functional metagenomics reveals novel salt tolerance loci from the human gut microbiome. ISME Journal 6(10), pp. 1916-1925. (10.1038/ismej.2012.38)
- Tjalsma, H., Boleij, A., Marchesi, J. R. and Dutilh, B. E. 2012. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nature Reviews. Microbiology 10(8), pp. 575-582. (10.1038/nrmicro2819)
- Tilg, H. and Marchesi, J. R. 2012. Too much fat for the gut's microbiota. Gut 61(4), pp. 474-475. (10.1136/gutjnl-2011-301918)
- Bull, M. J., Marchesi, J. R., Vandamme, P., Plummer, S. and Mahenthiralingam, E. 2012. Minimum taxonomic criteria for bacterial genome sequence depositions and announcements. Journal of Microbiological Methods 89(1), pp. 18-21. (10.1016/j.mimet.2012.02.008)
- Turroni, F. et al. 2012. Diversity of bifidobacteria within the infant gut microbiota. PLoS ONE 7(5), article number: e36957. (10.1371/journal.pone.0036957)
- Marchesi, J. R., Li, J., Holmes, E., Ashrafian, H., Athanasiou, T., Darzi, A. and Nicholson, J. K. 2012. Reply [to Eileen F. Murphy, Eamonn M.M. Quigley: The Microbiota and Bariatric Surgery: It's a Bug's Life. Gastroenterology, Volume 142, Issue 2, February 2012, Pages 399-401]. Gastroenterology 142(2), pp. 401-402. (10.1053/j.gastro.2011.12.024)
- Claesson, M. J. et al. 2012. Gut microbiota composition correlates with diet and health in the elderly. Nature 488(7410), pp. 178-184. (10.1038/nature11319)
- Morris, L., Evans, J. and Marchesi, J. R. 2012. A robust plate assay for detection of extracellular microbial protease activity in metagenomic screens and pure cultures. Journal of Microbiological Methods 91(1), pp. 144-146. (10.1016/j.mimet.2012.08.006)
- Baker, P. W., Dobson, A. D. W. and Marchesi, J. R. 2012. In situ extraction of RNA from marine-derived fungi associated with the marine sponge, Haliclona simulans. Mycological Progress 11(4), pp. 953-956. (10.1007/s11557-011-0796-4)
- Holmes, E., Li, J., Marchesi, J. R. and Nicholson, J. K. 2012. Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk. Cell Metabolism 16(5), pp. 559-564. (10.1016/j.cmet.2012.10.007)
2011
- Marchesi, J. R. 2011. Human distal gut microbiome. Environmental Microbiology 13(12), pp. 3088-3102. (10.1111/j.1462-2920.2011.02574.x)
- Twomey, K., Alvarez de Eulate, E., Marchesi, J. R., Kolida, S., Gibson, G., Arrigan, D. W. M. and Ogurtsov, V. I. 2011. Characterization of the electrochemical behavior of gastrointestinal fluids using a multielectrode sensor probe. IEEE Transactions on Biomedical Engineering 58(9), pp. 2521-2527. (10.1109/TBME.2011.2158543)
- Brown, R. C., Marchesi, J. R. and Morby, A. P. 2011. Functional characterisation of Lp_2714, an EAL-domain protein from Lactobacillus plantarum. Biochemical and Biophysical Research Communications 411(1), pp. 132-136. (10.1016/j.bbrc.2011.06.112)
- Marchesi, J. R., Dutilh, B., Hall, N., Peters, W., Roelofs, R., Boleij, A. and Tjalsma, H. 2011. Towards the human colorectal cancer microbiome. PLoS ONE 6(5), article number: e20447. (10.1371/journal.pone.0020447)
- Claesson, M. J. et al. 2011. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proceedings of the National Academy of Sciences of the United States of America 108(S1), pp. 4586-4591. (10.1073/pnas.1000097107)
- Li, J. V. et al. 2011. Metabolic surgery profoundly influences gut microbial-host metabolic cross-talk. Gut 60(9), pp. 1214-1223. (10.1136/gut.2010.234708)
- Marchesi, J. R. 2011. Shifting from a gene-centric to metabolite-centric strategy to determine the core gut microbiome. Bioengineered Bugs 2(6), pp. 309-314. (10.4161/bbug.2.6.17235)
2010
- Baker, P. W., Kennedy, J., Morrissey, J., O'Gara, F., Dobson, A. D. W. and Marchesi, J. R. 2010. Endoglucanase activities and growth of marine-derived fungi isolated from the sponge Haliclona simulans. Journal of Applied Microbiology 108(5), pp. 1668 -1675. (10.1111/j.1365-2672.2009.04563.x)
- Friswell, M. K., Roberts, C. L., Winstanley, C., Marchesi, J. . R., Rhodes, J. M. and Campbell, B. J. 2010. Increased mucosa-associated diffusely adherent E coli in Crohn's and colon cancer: possible role in pathogenesis [Abstract]. Gut 59(S1), pp. A110. (10.1136/gut.2009.208983h)
- Jones, B., Sun, F. and Marchesi, J. R. 2010. Comparative metagenomic analysis of plasmid encoded functions in the human gut microbiome. BMC Genomics 11(1), article number: 46. (10.1186/1471-2164-11-46)
- Codling, C., O'Mahony, L., Shanahan, F., Quigley, E. M. M. and Marchesi, J. . R. 2010. A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome. Digestive Diseases and Sciences 55(2), pp. 392-397. (10.1007/s10620-009-0934-x)
- Marchesi, J. R. 2010. Prokaryotic and Eukaryotic Diversity of the Human Gut. Advances in Applied Microbiology 72, pp. 43-62. (10.1016/S0065-2164(10)72002-5)
2009
- Scanlan, P., Shanahan, F. and Marchesi, J. R. 2009. Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals. FEMS Microbiology Ecology 69(2), pp. 213-221. (10.1111/j.1574-6941.2009.00709.x)
- Forbes, C., O'Leary, N., Dobson, A. and Marchesi, J. R. 2009. The contribution of ‘omic’-based approaches to the study of enhanced biological phosphorus removal microbiology. FEMS Microbiology Ecology 69(1), pp. 1-15. (10.1111/j.1574-6941.2009.00698.x)
- Claesson, M. J. et al. 2009. Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLoS ONE 4(8), article number: e6669. (10.1371/journal.pone.0006669)
- O'Mahony, S. M. et al. 2009. Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses. Biological Psychiatry 65(3), pp. 263-267. (10.1016/j.biopsych.2008.06.026)
- Kennedy, J. et al. 2009. Isolation and analysis of bacteria with antimicrobial activities from the marine sponge haliclona simulans collected from irish waters. Marine Biotechnology 11(3), pp. 384-396. (10.1007/s10126-008-9154-1)
- Turroni, F. et al. 2009. Microbiomic analysis of the bifidobacterial population in the human distal gut. ISME Journal 3(6), pp. 745-751. (10.1038/ismej.2009.19)
- Baker, P. W., Kennedy, J., Dobson, A. D. W. and Marchesi, J. R. 2009. Phylogenetic diversity and antimicrobial activities of fungi associated with haliclona simulans isolated from irish coastal waters. Marine Biotechnology 11(4), pp. 540-547. (10.1007/s10126-008-9169-7)
- Twomey, K. and Marchesi, J. R. 2009. Swallowable capsule technology: current perspectives and future directions. Endoscopy 41(4), pp. 357-362. (10.1055/s-0028-1119640)
2008
- Marchesi, J. R. and Prosser, J. 2008. Gut microbiology: the black box and beyond [Editorial]. FEMS Microbiology Ecology 66(3), pp. 485-486. (10.1111/j.1574-6941.2008.00607.x)
- Kennedy, J., Codling, C., Jones, B., Dobson, A. and Marchesi, J. R. 2008. Diversity of microbes associated with the marine sponge, Haliclona simulans, isolated from Irish waters and identification of polyketide synthase genes from the sponge metagenome. Environmental Microbiology 10(7), pp. 1888-1902. (10.1111/j.1462-2920.2008.01614.x)
- Scanlan, P. et al. 2008. Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis. Environmental Microbiology 10(3), pp. 789-798. (10.1111/j.1462-2920.2007.01503.x)
- Scanlan, P. et al. 2008. Culture-independent analysis of the gut microbiota in colorectal cancer and polyposis. Corrects article in Vol 10 (3) pages 789-798. Environmental Microbiology 10(5), pp. 1382. (10.1111/j.1462-2920.2008.01622.x)
- Jones, B. V., Begley, M., Hill, C., Gahan, C. G. and Marchesi, J. R. 2008. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proceedings of the National Academy of Sciences of the United States of America 105(36), pp. 13580-13585. (10.1073/pnas.0804437105)
- Scanlan, P. D., Shanahan, F. and Marchesi, J. R. 2008. Human methanogen diversity and incidence in healthy and diseased colonic groups using mcrA gene analysis. BMC Microbiology 8 :79 (10.1186/1471-2180-8-79)
- Kennedy, J., Marchesi, J. R. and Dobson, A. D. 2008. Marine metagenomics: strategies for the discovery of novel enzymes with biotechnological applications from marine environments. Microbial Cell Factories 7:27 (10.1186/1475-2859-7-27)
- Scanlan, P. D. and Marchesi, J. R. 2008. Micro-eukaryotic diversity of the human distal gut microbiota: qualitative assessment using culture-dependent and -independent analysis of faeces. ISME Journal 2(12), pp. 1183-1193. (10.1038/ismej.2008.76)
- Yap, I. K. et al. 2008. Metabonomic and microbiological analysis of the dynamic effect of vancomycin-induced gut microbiota modification in the mouse. Journal of Proteome Research 7(9), pp. 3718-28. (10.1021/pr700864x)
- Saric, J. et al. 2008. Species variation in the fecal metabolome gives insight into differential gastrointestinal function. Journal of Proteome Research 7(1), pp. 352-360. (10.1021/pr070340k)
- Scanlan, P. D. and Marchesi, J. R. 2008. Application of TRACA to the human intestinal microbiota: insights into tetracycline resistant genes of the mobile metagenome using PCR based screen [Abstract]. FEBS Journal 275(S1), pp. 284. (10.1111/j.1742-4658.2008.06448.x)
- Ferreira, M. I. M., Marchesi, J. R. and Janssen, D. B. 2008. Degradation of 4-fluorophenol by Arthrobacter sp. strain IF1. Applied Microbiology and Biotechnology 78(4), pp. 709-717. (10.1007/s00253-008-1343-3)
2007
- Jones, B. V., Sun, F. and Marchesi, J. R. 2007. Using skimmed milk agar to functionally screen a gut metagenomic library for proteases may lead to false positives. Letters In Applied Microbiology 45(4), pp. 418-420. (10.1111/j.1472-765X.2007.02202.x)
- Scanlan, P. D., Shanahan, F., O'Mahony, C. and Marchesi, J. R. 2007. Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease [Erratum]. Journal of Clinical Microbiology 45(5), pp. 1671. (10.1128/JCM.00398-07)
- Kennedy, J., Marchesi, J. R. and Dobson, A. D. W. 2007. Metagenomic approaches to exploit the biotechnological potential of the microbial consortia of marine sponges. Applied Microbiology and Biotechnology 75(1), pp. 11-20. (10.1007/s00253-007-0875-2)
- Moriarty, J., Marchesi, J. R. and Metcalfe, A. 2007. Bounds on the distribution of the number of gaps when circles and lines are covered by fragments: Theory and practical application to genomic and metagenomic projects. BMC Bioinformatics 8, article number: 70. (10.1186/1471-2105-8-70)
- Jones, B. V. and Marchesi, J. R. 2007. Accessing the mobile metagenome of the human gut microbiota. Molecular Biosystems 3(11), pp. 749-758. (10.1039/b705657e)
- Marchesi, J. R. and Shanahan, F. 2007. The normal intestinal microbiota. Current Opinion in Infectious Diseases 20(5), pp. 508-513. (10.1097/QCO.0b013e3282a56a99)
- Marchesi, J. R. et al. 2007. Rapid and noninvasive metabonomic characterization of inflammatory bowel disease. Journal of Proteome Research 6(2), pp. 546-551. (10.1021/pr060470d)
- Jones, B. V. and Marchesi, J. R. 2007. Transposon-aided capture (TRACA) of plasmids resident in the human gut mobile metagenome. Nature Methods 4(1), pp. 55-61. (10.1038/nmeth964)
2006
- Scanlan, P. D., Shanahan, F., O'Mahony, C. and Marchesi, J. R. 2006. Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease. Journal of Clinical Microbiology 44(11), pp. 3980-3988. (10.1128/JCM.00312-06)
- Kerr, L. M. and Marchesi, J. R. 2006. Isolation of novel bacteria able to degrade α-halocarboxylic acids by enrichment from environmental samples. Chemosphere 64(5), pp. 848-855. (10.1016/j.chemosphere.2005.10.042)
2005
- O'Connor, K. E., O'Leary, N. P., Marchesi, J. R., Dobson, A. D. W. and Duetz, W. 2005. Isolation and characterization of a diverse group of phenylacetic acid degrading microorganisms from pristine soil. Chemosphere 61(7), pp. 965-973. (10.1016/j.chemosphere.2005.03.017)
2003
- Marchesi, J. R. 2003. A microplate fluorimetric assay for measuring dehalogenase activity. Journal of Microbiological Methods 55(1), pp. 325-329. (10.1016/S0167-7012(03)00132-5)
- Marchesi, J. R. and Weightman, A. J. 2003. Comparing the Dehalogenase Gene Pool in Cultivated -Halocarboxylic Acid-Degrading Bacteria with the Environmental Metagene Pool. Applied and Environmental Microbiology 69(8), pp. 4375-4382. (10.1128/AEM.69.8.4375-4382.2003)
- Marchesi, J. R. and Weightman, A. J. 2003. Diversity of alpha-halocarboxylic acid dehalogenases in bacteria isolated from a pristine soil after enrichment and selection on the herbicide 2,2-dichloropropionic acid (Dalapon). Environmental Microbiology 5(1), pp. 48-54. (10.1046/j.1462-2920.2003.00384.x)
2001
- Marchesi, J. R., Weightman, A. J., Cragg, B. A., Parkes, R. J. and Fry, J. C. 2001. Methanogen and bacterial diversity and distribution in deep gas hydrate sediments from the Cascadia Margin as revealed by 16S rRNA molecular analysis. FEMS Microbiology Ecology 34(3), pp. 221-228. (10.1111/j.1574-6941.2001.tb00773.x)
2000
- Poelarends, G. J. et al. 2000. Haloalkane-Utilizing Rhodococcus Strains Isolated from Geographically Distinct Locations Possess a Highly Conserved Gene Cluster Encoding Haloalkane Catabolism. Journal of Bacteriology 182(10), pp. 2725-2731. (10.1128/JB.182.10.2725-2731.2000)
1999
- Hill, K. E., Marchesi, J. R. and Weightman, A. J. 1999. Investigation of two evolutionarily unrelated halocarboxylic acid dehalogenase gene families. Journal of Bacteriology 181(9), pp. 2535-2547. (10.1128/JB.181.8.2535-2547.1999)
1997
- Ashelford, K. E. et al. 1997. Using microcosms to study gene transfer in aquatic habitats. FEMS Microbiology Ecology 23(2), pp. 81-94. (10.1111/j.1574-6941.1997.tb00393.x)
- Bale, S. J., Goodman, K., Rochelle, P. A., Marchesi, J. R., Fry, J. C., Weightman, A. J. and Parkes, R. J. 1997. Desulfovibrio profundus sp. nov., a novel barophilic sulfate-reducing bacterium from deep sediment layers in the Japan Sea. International Journal of Systematic Bacteriology 47(2), pp. 515-521. (10.1099/00207713-47-2-515)
1996
- Hill, K. E., Marchesi, J. R. and Fry, J. C. 1996. Conjugation in the epilithon. In: Akkermans, A. D. L., Van Elsas, J. D. and de Bruijn, F. J. eds. Molecular Microbial Ecology Manual. Kluwer Academic Publishers, Dortrecht, The Netherlands, pp. 125-152., (10.1007/978-94-009-0215-2_9)
The main focus of the research in my group is to determine the role gut microbes play in host development, health and disease. We have been using a variety of molecular approached to investigate both the culturable and unculturable fractions of the gut microbiota, including microbiomics (16S rRNA gene clone libraries, DGGE), functional metagenomics and metabonomics.
Additionally we are also exploring the potential of the gut associated microbes to provide novel bioactive and biocatalytic agents which can be used to treat disorders of the gut and the host, for example, Clostridium difficile associated diseases, inflammatory bowel disease and colorectal cancer.