Dr Claudia Metzler-Baddeley
Senior Lecturer in Cognitive Neuroscience
- metzler-baddeleyc@cardiff.ac.uk
- +44 (0)29 2087 0705
- Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ
- Ar gael fel goruchwyliwr ôl-raddedig
Research summary
My research looks at how networks of cortical and subcortical brain areas implement cognitive-behavioural control processes. I employ quantitative multi-parametric MRI brain imaging techniques in combination with experimental-cognitive techniques to study both clinical and non-clinical populations. My research focuses on:
- Cognitive and behavioural training
- Healthy and pathological ageing
- Lifestyle and genetic risk of dementia
- Neurodegenerative disease (Alzheimer’s disease, Lewy body disease and Huntington’s disease)
- Neuroglia models of ageing and neurodegeneration
My research aims to understand the risk factors and early warning signs for later life dementia and to develop and evaluate training interventions to promote successful ageing and prevention and delay of disease.
Undergraduate education
Psychology at Bonn University, Germany
Postgraduate education
D.Phil work on frontal attention deficits at Sussex University
Employment
Alzheimer’s Society and BRACE Research Fellow and Lecturer, Cardiff University
Research Associate, Cardiff University
Neuropsychologist at the Research Institute for the Care of Older People (RICE) in Bath
Lectureship in Psychology at Manchester University and postdoctoral work at the Institute of Psychiatry, King’s College London
Anrhydeddau a Dyfarniadau
Awards/External Committees
2011 - Associate Fellow of British Psychological Society (AFBPsS).
2011 - Specialist Review Panel member of the Alzheimer’s Society.
2020
- Coad, B.et al. 2020. Precommissural and postcommissural fornix microstructure in healthy aging and cognition. Brain and Neuroscience Advances 4, pp. 1-12. (10.1177/2398212819899316)
- Mole, J. P.et al. 2020. Genetic risk of dementia modifies the impact of obesity on limbic white matter and spatial navigation behavior in cognitively healthy adults. BioRxiv, pp. -.
- Casella, C.et al. 2020. Drumming motor sequence training induces myelin remodelling in Huntington?s disease: a longitudinal diffusion MRI and quantitative magnetization transfer study. BioRxiv
- Revie, L.et al. 2020. A review of the perceptual and attentional-executive characteristics of dementia with Lewy bodies relative to Alzheimer's and Parkinson's disease. PsyArXiv
- Casella, C.et al. 2020. A critical review of white matter changes in Huntington’s disease.. Movement Disorders
2019
- Bourbon Teles, J.et al. 2019. Myelin breakdown in human Huntington's disease: multi-modal evidence from diffusion MRI and quantitative magnetization transfer. Neuroscience 403, pp. 79-92. (10.1016/j.neuroscience.2017.05.042)
- Metzler-Baddeley, C.et al. 2019. Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure. NeuroImage 189, pp. 793-803. (10.1016/j.neuroimage.2019.02.007)
- Metzler-Baddeley, C.et al. 2019. Fornix white matter glia damage causes hippocampal gray matter damage during age-dependent limbic decline. Scientific Reports 9, pp. -., article number: 1060. (10.1038/s41598-018-37658-5)
- Hartopp, N.et al. 2019. A key role for subiculum-fornix connectivity in recollection in older age. Frontiers in Systems Neuroscience 12, article number: 70. (10.3389/fnsys.2018.00070)
2018
- Furby, H.et al. 2018. Using 3T MRI to explore myelin break-down in pre-symptomatic huntington’s disease. Journal of Neurology, Neurosurgery and Psychiatry 89(S1), pp. A37-A38., article number: E06. (10.1136/jnnp-2018-EHDN.100)
- Bubb, E., Metzler-Baddeley, C. and Aggleton, J. 2018. The cingulum bundle: anatomy, function, and dysfunction. Neuroscience and Biobehavioral Reviews 92, pp. 104-127. (10.1016/j.neubiorev.2018.05.008)
- Yhnell, E.et al. 2018. Exploring computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD): protocol for a randomised feasibility study. Pilot and Feasibility Studies 4, article number: 45. (10.1186/s40814-018-0237-0)
- Caeyenberghs, K.et al. 2018. Evidence for training-dependent structural neuroplasticity in brain-injured patients: A critical review. Neurorehabilitation and Neural Repair 32(2), pp. 99-114. (10.1177/1545968317753076)
2017
- Gan, C. L.et al. 2017. Association of imaging abnormalities of the subcallosal septal area with Alzheimer's disease and mild cognitive impairment. Clinical Radiology 72(11), pp. 915-922. (10.1016/j.crad.2017.04.021)
- Metzler-Baddeley, C.et al. 2017. Dynamics of white matter plasticity underlying working memory training: Multi-modal evidence from diffusion MRI and relaxometry. Journal of Cognitive Neuroscience 29(9), pp. 1509-1520. (10.1162/jocn_a_01127)
2016
- Christiansen, K.et al. 2016. Topographic separation of fornical fibers associated with the anterior and posterior hippocampus in the human brain: an MRI-diffusion study. Brain and Behavior 7(1) (10.1002/brb3.604)
- Rok, B.et al. 2016. Global efficiency of structural networks mediates cognitive control in Mild Cognitive Impairment. Frontiers in Aging Neuroscience 8, article number: 292. (10.3389/fnagi.2016.00292)
- Mole, J. P.et al. 2016. Increased fractional anisotropy in the motor tracts of Parkinson's disease suggests compensatory neuroplasticity or selective neurodegeneration. European Radiology 26(10), pp. 3327-3335. (10.1007/s00330-015-4178-1)
- Metzler-Baddeley, C.et al. 2016. Longitudinal data on cortical thickness before and after working memory training. Data in Brief 7, pp. 1143-1147. (10.1016/j.dib.2016.03.090)
- Christiansen, K.et al. 2016. The status of the precommissural and postcommissural fornix in normal ageing and mild cognitive impairment: an MRI tractography study. NeuroImage 130, pp. 35-47. (10.1016/j.neuroimage.2015.12.055)
- Metzler-Baddeley, C.et al. 2016. Task complexity and location specific changes of cortical thickness in executive and salience networks after working memory training. NeuroImage 130, pp. 48-62. (10.1016/j.neuroimage.2016.01.007)
- Caeyenberghs, K.et al. 2016. Dynamics of the human structural connectome underlying working memory training. Journal of Neuroscience 36(14), pp. 4056-4066. (10.1523/JNEUROSCI.1973-15.2016)
2015
- Kehoe, E. G.et al. 2015. Fornix white matter is correlated with resting state functional connectivity of the thalamus and hippocampus in healthy aging but not in mild cognitive impairment- a preliminary study. Frontiers in Aging Neuroscience 7, article number: 10. (10.3389/fnagi.2015.00010)
- Ray, N. J.et al. 2015. Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment. Journal of Neuroscience 35(2), pp. 739-747. (10.1523/JNEUROSCI.3617-14.2015)
- Gomez, P. A.et al. 2015. Joint reconstruction of multi-contrast MRI for Multiple Sclerosis lesion segmentation. Bildverarbeitung fuer die Medizin 2015, pp. 155-160. (10.1007/978-3-662-46224-9_28)
2014
- Berlot, R.et al. 2014. CSF contamination contributes to apparent microstructural alterations in mild cognitive impairment. NeuroImage 92, pp. 27-35. (10.1016/j.neuroimage.2014.01.031)
- Metzler-Baddeley, C.et al. 2014. Improved executive function and callosal white matter microstructure after rhythmn exercise in Huntington's disease. Journal of Huntington's Disease 3(3), pp. 273-283. (10.3233/JHD-140113)
2013
- Metzler-Baddeley, C.et al. 2013. Individual differences in fornix microstructure and body mass index. PLoS ONE 8(3), article number: e59849. (10.1371/journal.pone.0059849)
2012
- Metzler-Baddeley, C.et al. 2012. Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. Journal of Neuroscience 32(49), pp. 17612-17619. (10.1523/JNEUROSCI.3299-12.2012)
- Metzler-Baddeley, C.et al. 2012. Temporal association tracts and the breakdown of episodic memory in mild cognitive impairment. Neurology 79(23), pp. 2233-2240. (10.1212/WNL.0b013e31827689e8)
- Metzler-Baddeley, C.et al. 2012. How and how not to correct for CSF-contamination in diffusion MRI. Neuroimage 59(2), pp. 1394-1403. (10.1016/j.neuroimage.2011.08.043)
2011
- Metzler-Baddeley, C.et al. 2011. Frontotemporal connections in episodic memory and aging: A diffusion MRI tractography study. The Journal of Neuroscience 31(37), pp. 13236-13245. (10.1523/JNEUROSCI.2317-11.2011)
- Metzler-Baddeley, C.et al. 2011. The fornix in ageing and memory decline: a diffusion MRI tractography study. Journal of Neurology 258(S1), pp. 18-18. (10.1007/s00415-011-6026-9)
2010
- Laffan, A. J.et al. 2010. Making errorless learning more active: Self-generation in an error free learning context is superior to standard errorless learning of face-name associations in people with Alzheimer's disease. Neuropsychological Rehabilitation 20(2), pp. 197-211. (10.1080/09602010903202432)
- Metzler-Baddeley, C. and Jones, R. W. 2010. Brief Communication: Cognitive Rehabilitation of Executive Functioning in a Case of Craniopharyngioma. Applied Neuropsychology 17(4), pp. 299-304. (10.1080/09084282.2010.523394)
- Metzler-Baddeley, C.et al. 2010. Visual impairments in dementia with Lewy bodies and posterior cortical atrophy.. Neuropsychology 24(1), pp. 35-48. (10.1037/a0016834)
2009
- Metzler-Baddeley, C. and Baddeley, R. J. 2009. Does adaptive training work?. Applied Cognitive Psychology 23(2), pp. 254-266. (10.1002/acp.1454)
- Metzler-Baddeley, C.et al. 2009. Visual impairment in posterior cortical atrophy and dementia with lewy bodies [Abstract]. Alzheimer's and Dementia 5(4), pp. P458. (10.1016/j.jalz.2009.04.862)
2008
- Metzler-Baddeley, C., Salter, A. and Jones, R. W. 2008. The significance of dyslexia screening for the assessment of dementia in older people. International Journal of Geriatric Psychiatry 23(7), pp. 766-768. (10.1002/gps.1957)
2007
- Metzler-Baddeley, C. 2007. A Review of Cognitive Impairments in Dementia with Lewy Bodies Relative to Alzheimer's Disease and Parkinson's Disease with Dementia. Cortex 43(5), pp. 583-600. (10.1016/S0010-9452(08)70489-1)
2005
- Metzler-Baddeley, C. and Snowden, J. S. 2005. Brief Report: Errorless versus Errorful Learning as a Memory Rehabilitation Approach in Alzheimer's Disease. Journal of Clinical and Experimental Neuropsychology 27(8), pp. 1070-1079. (10.1080/13803390490919164)
2001
- Metzler-Baddeley, C. 2001. Effects of left frontal lesions on the selection of context-appropriate meanings. Neuropsychology 15(3), pp. 315-328. (10.1037/0894-4105.15.3.315)
- Metzler-Baddeley, C. 2001. Location negative priming may be abolished in older age. Zeitschrift für Gerontopsychologie & -psychiatrie 14(4), pp. 187-202. (10.1024//1011-6877.14.4.187)
2000
- Metzler-Baddeley, C. and Parkin, A. J. 2000. Reversed negative priming following frontal lobe lesions. Neuropsychologia 38(4), pp. 363-379. (10.1016/S0028-3932(99)00097-4)
1996
- Parkin, A. J.et al. 1996. Pathological false alarm rates following damage to the left frontal cortex. Brain and Cognition 32(1), pp. 14-27. (10.1006/brcg.1996.0055)
I lecture on the Year 3 module Memory Processes and Disorders (PS3208), the Year 1 module Psychological Research (PS1014), and the MSc module Clinical Neuroimaging Research (PST 508). I run MSc diffusion MRI labs (PST513) as well as Year 2 undergraduate academic tutorials and cognitive labs. I supervise final year undergraduate and MSc student projects.
Research topics and related papers
Cognitive Neuroscience of ageing and neurodegeneration
Neuroglia models of ageing and neurodegeneration
Risk factors of disease
Brain plasticity
Funding
Duckers, J et al (CoA) (2019) Cystic Fibrosis - Memory assessment and MRI screening. Health & Care Research Wales. £19,200 for 12 months.
Rosser, A, Busse, M & Metzler-Baddeley (2016) Exploring cognitive training as a non-pharmaceutical intervention for people with Huntington's disease. Jaque and Gloria Gossweiler Foundation. £94,714 for 30 months.
Metzler-Baddeley C (PI) (2014) How do individual differences in midlife adiposity and APOE genotype as risk factors for dementia affect brain structure and cognition? A cross-sectional MRI study. Alzheimer’s Society and BRACE Fellowship. £305,161 for 36 months.
Metzler-Baddeley, C (PI), Jones, DK, Rosser AE. (2014) Effects of a novel intervention on white matter microstructure and cognition in Huntington’s disease. NISCHR and Welcome Trust ISSF project grant. £69,769 for 12 months.
Research group
CUBRIC
Cognitive Neuroscience
Imaging Science
Research collaborators
- Professor Derek Jones (Cardiff)
- Professor David Linden (Cardiff)
- Professor Anne Rosser (Cardiff)
- Professor John Aggleton (Cardiff)
- Dr Seralynne Vann (Cardiff)
- Dr Mike O’Sullivan (London)
- Dr Elizabeth Coulthard (Bristol)
- Dr Roland J Baddeley (Bristol)
- Professor Karen Caeyenberghs (Gent)
Media
2008 - Consultation/Participation in BBC documentation on Terry Pratchett Living with Alzheimer’s Disease, broadcast February 2009.
2006 - Consultation for BBC Radio 4 Memory Experience.
Current PhD students: Chiara Casella, Lauren Revie
Prosiectau ymchwil ôl-raddedig
Co-supervision (50%) for Jilu P Mole - The white matter microstructure of the basal ganglia circuitry and its changes in Parkinson's disease, PhD Thesis, Cardiff University 2018.
Co-supervision (30%) for Kat Christiansen - An integrated analysis of the extended hippocampal system across species. PhD Thesis, Cardiff University 2017.
Media
2008 - Consultation/Participation in BBC documentation on Terry Pratchett Living with Alzheimer’s Disease, broadcast February 2009.
2006 - Consultation for BBC Radio 4 Memory Experience.
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