Ewch i’r prif gynnwys
Dr Claudia Metzler-Baddeley

Dr Claudia Metzler-Baddeley

Reader, NIHR/HCRW Advanced Research Fellow

Yr Ysgol Seicoleg

+44 (0)29 2087 0705
Canolfan Ymchwil Delweddu'r Ymennydd Prifysgol Caerdydd, Heol Maendy, Caerdydd, CF24 4HQ
Ar gael fel goruchwyliwr ôl-raddedig


Research summary

I am a cognitive neuroscientist studying how ageing and neurodegeneration (Alzheimer's disease, Lewy body disease, Huntington's disease) affect the brain and cognition with a particular interest into the role of myelin and neuroglia in ageing and disease.

I also study the mechanisms underpinning brain plasticity, including myelin remodelling, and how they can be exploited to the benefit of people with brain disease such as Huntington's disease (HD).

I use quantitative multi-parametric MRI brain imaging based on diffusion weighted, magnetization transfer weighted and relaxometry techniques in combination with experimental-cognitive methods to address these questions.

I am the PI of the Cardiff Ageing and Risk of Dementia Study (CARDS) that aims to understand the risk factors and early warning signs for later life dementia and to develop and evaluate training interventions to promote successful ageing and prevention and delay of disease.


Undergraduate education

Psychology at Bonn University, Germany

Postgraduate education

D.Phil work on frontal attention deficits at Sussex University


Alzheimer’s Society and BRACE Research Fellow and  Lecturer, Cardiff University

Research Associate, Cardiff University

Neuropsychologist at the Research Institute for the Care of Older People (RICE) in Bath

Lectureship in Psychology at Manchester University and postdoctoral work at the Institute of Psychiatry, King’s College London

Anrhydeddau a Dyfarniadau

Awards/External Committees

Chartered Psychologist (CPsychol) and Associate Fellow of British Psychological Society (AFBPsS).

Member of Scientific Advisory Board, BRACE Alzheimer's charity

Member of UKRI BBSRC Ageing Across the Lifecourse Working Group

Member of editorial board for Scientific Reports (NPG)

Aelodaethau proffesiynol

Society for Neuroscience (SfN)

Cognitive Neuroscience Society (CNS)

Organisation of Human Brain Mapping (OHBM)

International Society for Magnetic Resonance in Medicine (ISMRM)























I contribute to undergraduate and postgraduate teaching and supervision.

I lecture on the BSc Psychology Year 1 modules Introduction to Psychology (PS1016) and Psychological Research (PS1014), the Year 3 module Memory Processes and Disorders (PS3208), as well as the MSc modules Clinical Neuroimaging Research (PST 508) and Topics in Psychology (PST720). I lead MSc diffusion MRI labs (PST513), undergraduate academic tutorials and cognitive labs. I supervise final year BSc and MSc dissertation projects.

Research topics and related papers

Adaptive cognitive and motor training

Brain plasticity

Healthy and pathological ageing

Neurodegenerative diseases (Alzheimer's disease, Lewy body disease, Huntington's disease)

Neuroglia models of ageing and neurodegeneration

Risk factors of dementia


Duckers, J et al (CoA) (2019) Cystic Fibrosis - Memory assessment and MRI screening. Health & Care Research Wales. £19,200  - currently on hold due to COVID-19.

Rosser, A, Busse, M & Metzler-Baddeley (2016) Exploring cognitive training as a non-pharmaceutical intervention for people with Huntington's disease. Jaque and Gloria Gossweiler Foundation. £94,714.

Metzler-Baddeley  C (PI) (2014) How do individual differences in midlife adiposity and APOE genotype as risk factors for dementia affect brain structure and cognition? A cross-sectional MRI study. Alzheimer’s Society and BRACE Fellowship. £305,161.

Metzler-Baddeley, C (PI), Jones, DK, Rosser AE. (2014) Effects of a novel intervention on white matter microstructure and cognition in Huntington’s disease. NISCHR and Welcome Trust ISSF project grant. £69,769.

Research group

Cognitive Neuroscience
Imaging Science

Research collaborators

  • Professor Derek Jones (Cardiff)
  • Professor David Linden (Cardiff)
  • Professor Anne Rosser (Cardiff)
  • Professor John Aggleton (Cardiff)
  • Dr Seralynne Vann (Cardiff)
  • Professor Monica Busse (Cardiff)
  • Dr John Evans (Cardiff)
  • Dr Rebecca Sims (Cardiff)
  • Dr Emma Kidd (Cardiff)
  • Fabrizio Fasano (Siemens)
  • Dr Elizabeth Coulthard (Bristol)
  • Dr Roland J Baddeley (Bristol)
  • Professor Karen Caeyenberghs (Deakin University, Australia)
  • Professor Michael O'Sullivan (University of Queensland, Australia)
  • Professor Fernando Maestu (University of Madrid, Spain)
  • Dr Michael Funke (University of Texas, USA)
  • Professor Derek Hamilton (University of New Mexico, USA)


  • Good evening Wales, BBC Radio Wales (11/12/2018)
  • ITV Wales (23/04/18).
  • BBC Wales  http://www.bbc.co.uk/news/uk-wales-36286847,
  • Guardian  - https://www.theguardian.com/science/2016/aug/04/brains-of-overweight-people-look-ten-years-older-than-those-of-lean-peers (4/08/16)
  • Panorama programme “Living with Dementia – Chris’ story broadcasted on BBC One (2/06/16).
  • Pint of Science Event Cardiff on brain plasticity (11/05/18)
  • BBC documentation on Terry Pratchett Living with Alzheimer’s Disease, broadcast February 2009.
  • BBC Radio 4 Memory Experience.


Current PhD students: Chiara Casella, Lauren Revie

Past projects

Co-supervision (50%) for Jilu P Mole - The white matter microstructure of the basal ganglia circuitry and its changes in Parkinson's disease, PhD Thesis, Cardiff University 2018.

Co-supervision (30%) for Kat Christiansen - An integrated analysis of the extended hippocampal system across species. PhD Thesis, Cardiff University 2017.


2008 - Consultation/Participation  in BBC documentation on Terry Pratchett Living with Alzheimer’s Disease, broadcast February 2009.

2006 - Consultation  for BBC Radio 4 Memory Experience.