Dr Joanna Martin
Research Associate, Division of Psychological Medicine and Clinical Neurosciences
- martinjm1@cardiff.ac.uk
- Adeilad Hadyn Ellis, Heol Maendy, Caerdydd, CF24 4HQ
Trosolwg
My main research interests concern investigating the genetic risks for neurodevelopmental disorders, including attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). I am currently being funded by the Wellcome Trust (2015-2019) to investigate a series of inter-related genetic hypotheses for the increased prevalence of neurodevelopmental disorders in boys compared to girls.
My Sir Henry Wellcome Postdoctoral Fellowship project is titled: "A genetic study examining sex differences in the prevalence of ADHD and other neurodevelopmental disorders". The project involves collaborations with Dr Ben Neale at the Broad Institute (Cambridge, USA), Prof Paul Lichtenstein at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet (Stockholm, Sweden), as well as Prof Anita Thapar at the MRC Centre for Neuropsychiatric Genetics and Genomics at Cardiff University. During this project, I will be analysing genetic data from the Psychiatric Genomics Consortium ADHD dataset and the Child and Adolescent Twin Study in Sweden.
I completed my PhD within the section of Child and Adolescent Psychiatry at the MRC Centre for Neuropsychiatric Genetics and Genomics in 2014. The title of my thesis was “Examining the Clinical and Genetic Overlap of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder Traits” and it can be downloaded freely.
Prior to my PhD, I obtained a BSc in Experimental Psychology from the University of Bristol and then worked as a Research Assistant at Cardiff University, collecting data and performing analyses as part of the Study of ADHD, Genes and Environment.
Cyhoeddiadau
2023
- Cortese, S. et al. 2023. Candidate diagnostic biomarkers for neurodevelopmental disorders in children and adolescents: a systematic review. World Psychiatry 22(1), pp. 129-149. (10.1002/wps.21037)
- Demontis, D. et al. 2023. Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains. Nature Genetics (10.1038/s41588-022-01285-8)
- Martin, J. et al. 2023. Investigating direct and indirect genetic effects in attention-deficit/hyperactivity disorder using parent-offspring trios. Biological Psychiatry 93(1), pp. 37-44. (10.1016/j.biopsych.2022.06.008)
2022
- Taylor, M., Ronald, A., Martin, J., Lundström, S., Hosang, G. and Lichtenstein, P. 2022. Examining the association between autistic traits in childhood and adolescent hypomania: a longitudinal twin study. Psychological Medicine 52(15), pp. 3606-3615. (10.1017/S0033291721000374)
- Vainieri, I. et al. 2022. Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments. Psychological Medicine 52(14), pp. 3150-3158. (10.1017/S0033291720005218)
- Mattheisen, M. et al. 2022. Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups. Nature Genetics 54, pp. 1470-1478. (10.1038/s41588-022-01171-3)
- Martini, M. et al. 2022. Sex differences in mental health problems and psychiatric hospitalization in autistic young adults. JAMA Psychiatry
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention-deficit hyperactivity disorder. In: Current Topics in Behavioral Neurosciences. Berlin, Heidelberg:, pp. 1-26., (10.1007/7854_2022_338)
- Garcia-Argibay, M. et al. 2022. The role of ADHD genetic risk in mid-to-late life somatic health conditions. Translational Psychiatry 12(1), article number: 152. (10.1038/s41398-022-01919-9)
- Martin, J. and Hadwin, J. 2022. The roles of sex and gender in child and adolescent mental health. JCPP Advances 2(1) (10.1002/jcv2.12059)
- Hosang, G. et al. 2022. Association of etiological factors for hypomanic symptoms, bipolar disorder, and other severe mental illnesses. JAMA Psychiatry 79(2), pp. 143-150. (10.1001/jamapsychiatry.2021.3654)
- Lewis, K., Martin, J., Gregory, A. M., Anney, R., Thapar, A. and Langley, K. 2022. Sleep disturbances in ADHD: Investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes. European Child and Adolescent Psychiatry (10.1007/s00787-021-01931-2)
- Langley, K., Martin, J. and Thapar, A. 2022. Genetics of attention deficit hyperactivity disorder. Springer Nature.
- Lynham, A. et al. 2022. DRAGON-Data: A platform and protocol for integrating genomic and phenotypic data across large psychiatric cohorts. BJPsych Open
2021
- Ghirardi, L. et al. 2021. Familial and genetic associations between autism spectrum disorder and other neurodevelopmental and psychiatric disorders. Journal of Child Psychology and Psychiatry 62(11), pp. 1274-1284. (10.1111/jcpp.13508)
- Brikell, I., Burton, C., Roth Mota, N. and Martin, J. 2021. Insights into attention-deficit/hyperactivity disorder from recent genetic studies. Psychological Medicine 51(13), pp. 2274-2286. (10.1017/S0033291721000982)
- Martin, J. et al. 2021. Sex differences in anxiety and depression in children with ADHD investigating genetic liability and comorbidity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 186(7), pp. 412-422. (10.1002/ajmg.b.32842)
- Martin, J. et al. 2021. Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression. PLoS ONE 16(9), article number: e0248254. (10.1371/journal.pone.0248254)
- Ip, H. F. et al. 2021. Genetic association study of childhood aggression across raters, instruments, and age. Translational Psychiatry 11(1), article number: 413. (10.1038/s41398-021-01480-x)
- Martin, J. et al. 2021. Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits. Biological Psychiatry 89(12), pp. 1127-1137. (10.1016/j.biopsych.2020.12.024)
- Powell, V., Martin, J., Thapar, A., Rice, F. and Anney, R. 2021. Investigating regions of shared genetic variation in attention deficit/hyperactivity disorder and major depressive disorder: a GWAS meta-analysis. Scientific Reports 11, article number: 7353. (10.1038/s41598-021-86802-1)
- Demontis, D. et al. 2021. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. Nature Communications 12(1), article number: 576. (10.1038/s41467-020-20443-2)
2020
- Powell, V. et al. 2020. What explains the link between childhood ADHD and adolescent depression? Investigating the role of peer relationships and academic attainment. European Child and Adolescent Psychiatry 29, pp. 1581-1591. (10.1007/s00787-019-01463-w)
- Vuijk, P. J. et al. 2020. Translating discoveries in Attention-Deficit/Hyperactivity Disorder genomics to an outpatient child and adolescent psychiatric cohort. Journal of the American Academy of Child and Adolescent Psychiatry 59(8), pp. 964-977. (10.1016/j.jaac.2019.08.004)
- Riglin, L. et al. 2020. Using genetics to examine a general liability to childhood psychopathology. Behavior Genetics 50, pp. 213-220. (10.1007/s10519-019-09985-4)
- Martin, J. et al. 2020. Investigating sex-specific effects of familial risk for ADHD and other neurodevelopmental disorders in the Swedish population. Bjpsych Open 6(4), article number: e65. (10.1192/bjo.2020.47)
- Martin, J. et al. 2020. A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder. Translational Psychiatry 10, article number: 135. (10.1038/s41398-020-0821-y)
2019
- Lee, P. H. et al. 2019. Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell 179(7), pp. 1469-1482.e11. (10.1016/j.cell.2019.11.020)
- Yao, S. et al. 2019. Associations between Attention-Deficit/Hyperactivity Disorder and various eating disorders: A Swedish nationwide population study using multiple genetically informative approaches. Biological Psychiatry 86(8), pp. 577-586. (10.1016/j.biopsych.2019.04.036)
- Mowlem, F. D., Rosenqvist, M. A., Martin, J., Lichtenstein, P., Asherson, P. and Larsson, H. 2019. Sex differences in predicting ADHD clinical diagnosis and pharmacological treatment. European Child and Adolescent Psychiatry 28(4), pp. 481-489. (10.1007/s00787-018-1211-3)
- Taylor, M. J., Martin, J., Lu, Y., Brikell, I., Lundstrom, S., Larsson, H. and Lichtenstein, P. 2019. Association of genetic risk factors for psychiatric disorders and traits of these disorders in a Swedish population twin sample. JAMA Psychiatry 76(3), pp. 280-289. (10.1001/jamapsychiatry.2018.3652)
- Grove, J. et al. 2019. Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics 51, pp. 431-444. (10.1038/s41588-019-0344-8)
- Demontis, D. et al. 2019. Discovery of the first genome-wide significant risk loci for attention-deficit/hyperactivity disorder. Nature Genetics 51, pp. 63-75. (10.1038/s41588-018-0269-7)
- Verhoef, E. et al. 2019. Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language. Translational Psychiatry 9, article number: 35. (10.1038/s41398-018-0324-2)
2018
- Martin, J., Tammimes, K., Karlsson, R., Lu, Y., Larsson, H., Lichtenstein, P. and Magnusson, P. K. 2018. Copy number variation and neuropsychiatric problems in females and males in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 180(6), pp. 341-350. (10.1002/ajmg.b.32685)
- Martin, J., Taylor, M. J. and Lichtenstein, P. 2018. Assessing the evidence for shared genetic risks across psychiatric disorders and traits. Psychological Medicine 48(11), pp. 1759-1774. (10.1017/S0033291717003440)
- Martin, J. et al. 2018. Sex-specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population. Journal of Child Psychology and Psychiatry 59(8), pp. 908-916. (10.1111/jcpp.12874)
- Guyatt, A. L. et al. 2018. Association of copy number variation across the genome with neuropsychiatric traits in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(5), pp. 489-502. (10.1002/ajmg.b.32637)
- Brikell, I. et al. 2018. The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology. Molecular Psychiatry (10.1038/s41380-018-0109-2)
- Martin, J. et al. 2018. A genetic investigation of sex bias in the prevalence of attention-deficit/hyperactivity disorder. Biological Psychiatry 83(12), pp. 1044-1053. (10.1016/j.biopsych.2017.11.026)
2017
- Riglin, L. et al. 2017. Investigating the genetic underpinnings of early-life irritability. Translational Psychiatry 7, article number: e1241. (10.1038/tp.2017.212)
- Stergiakouli, E. et al. 2017. Association between polygenic risk scores for attention-deficit hyperactivity disorder and educational and cognitive outcomes in the general population. International Journal of Epidemiology 46(2), pp. 421-428. (10.1093/ije/dyw216)
- Stergiakouli, E. et al. 2017. Shared genetic influences between dimensional ASD and ADHD symptoms during child and adolescent development. Molecular Autism 8, article number: 18. (10.1186/s13229-017-0131-2)
2016
- Thapar, A. et al. 2016. Psychiatric gene discoveries shape evidence on ADHD's biology. Molecular Psychiatry 21, pp. 1202-1207. (10.1038/mp.2015.163)
- Mooney, M. A. et al. 2016. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171(6), pp. 815-826. (10.1002/ajmg.b.32446)
- Martin, J. et al. 2016. Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study. American Journal of Epidemiology 183(12), pp. 1149-1158. (10.1093/aje/kww009)
- Robinson, E. B. et al. 2016. Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nature Genetics 48(5), pp. 552-555. (10.1038/ng.3529)
- Isles, A. R. et al. 2016. Parental origin of interstitial duplications at 15q11.2-q13.3 in schizophrenia and neurodevelopmental disorders. PLoS Genetics 12(5), article number: e1005993. (10.1371/journal.pgen.1005993)
- Aas, M. et al. 2016. Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014 [Conference Material]. Psychiatric Genetics 26(1), pp. 1-47. (10.1097/YPG.0000000000000112)
2015
- Niarchou, M., Martin, J., Thapar, A., Owen, M. J. and van den Bree, M. B. 2015. The clinical presentation of attention deficit-hyperactivity disorder (ADHD) in children with 22q11.2 deletion syndrome. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168(8), pp. 730-738. (10.1002/ajmg.b.32378)
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2015. Neurocognitive abilities in the general population and composite genetic risk scores for attention-deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry 56(6), pp. 648-656. (10.1111/jcpp.12336)
- Stergiakouli, E. et al. 2015. Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD. Journal of the American Academy of Child and Adolescent Psychiatry 54(4), pp. 322-327. (10.1016/j.jaac.2015.01.010)
- Martin, J., O'Donovan, M. C., Thapar, A., Langley, K. and Williams, N. 2015. The relative contribution of common and rare genetic variants to ADHD. Translational Psychiatry 5, article number: e506. (10.1038/tp.2015.5)
2014
- Martin, J., Hamshere, M. L., Stergiakouli, E., O'Donovan, M. C. and Thapar, A. 2014. Genetic risk for Attention Deficit/Hyperactivity Disorder contributes to neurodevelopmental traits in the general population. Biological Psychiatry 76(8), pp. 664-671. (10.1016/j.biopsych.2014.02.013)
- Martin, J. et al. 2014. Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants. Journal of the American Academy of Child and Adolescent Psychiatry 53(7), pp. 761-770.e26. (10.1016/j.jaac.2014.03.004)
- Cooper, M., Martin, J., Langley, K., Hamshere, M. L. and Thapar, A. 2014. Autistic traits in children with ADHD index clinical and cognitive problems. European Child & Adolescent Psychiatry 23(1), pp. 23-24. (10.1007/s00787-013-0398-6)
- Martin, J., Hamshere, M. L., O'Donovan, M. C., Rutter, M. and Thapar, A. 2014. Factor structure of autistic traits in children with ADHD. Journal of Autism and Developmental Disorders 44(1), pp. 204-215. (10.1007/s10803-013-1865-0)
- Martin, J. 2014. Examining the clinical and genetic overlap of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder traits. PhD Thesis, Cardiff University.
2013
- Ahuja, A., Martin, J., Langley, K. and Thapar, A. 2013. Intellectual disability in children with attention deficit hyperactivity disorder. The Journal of Pediatrics 163(3), pp. 890-895.e1. (10.1016/j.jpeds.2013.02.043)
- Hamshere, M. L. et al. 2013. Shared polygenic contribution between childhood attention-deficit hyperactivity disorder and adult schizophrenia. British Journal of Psychiatry 203(2), pp. 107-111. (10.1192/bjp.bp.112.117432)
- Hamshere, M. L. et al. 2013. High loading of polygenic risk for ADHD in children with comorbid aggression. American Journal of Psychiatry 170(8), pp. 909-916. (10.1176/appi.ajp.2013.12081129)
2011
- Langley, K. et al. 2011. Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants. British Journal of Psychiatry 199(5), pp. 398-403.
