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Dr Philip Pallmann

Dr Philip Pallmann

Deputy Director Research Design and Conduct Service and Research Fellow

Email
pallmannp@cardiff.ac.uk
Telephone
+44 (0)29 2068 7461
Campuses
505, 5th floor, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
Users
Available for postgraduate supervision

Overview

I am a Senior Research Fellow in the Centre for Trials Research where I work as a medical statistician on the design, conduct, analysis, and reporting of randomised controlled trials and other well-designed studies.

My background is in applied statistics, but I work across a wide range of clinical areas including infections, neurodegenerative diseases, and population health, as well as on the advancement of clinical trials methodology, in particular efficient design methods such as adaptive designs.

I am the Deputy Director of the Research Design and Conduct Service (RDCS) for South East Wales, which works with NHS and social care staff to develop high-quality funding applications for innovative research projects in health and social care.

I co-lead the Adaptive Designs Working Group of the MRC-NIHR Trials Methodology Research Partnership together with Sofía Villar.

I am an Associate Editor for the peer-reviewed journal Trials.

Biography

Education and qualifications

  • 2016: PhD Biostatistics, Leibniz Universität Hannover
  • 2012: MSc Plant Biotechnology, Leibniz Universität Hannover
  • 2010: BSc Plant Biotechnology, Leibniz Universität Hannover

Honours and awards

  • 2013: Bernd Streitberg Award of the International Biometric Society (German Region) for my MSc dissertation Two-sample tests and multiple contrast tests of several diversity indices
  • 2012: Second Prize for Best Student Oral Presentation at the 36th International Biometric Conference in Kobe, Japan

Professional memberships

  • Adaptive Designs Working Group, MRC-NIHR Trials Methodology Research Partnership
  • European Huntington's Disease Network

Academic positions

  • 2017 - present: Research Fellow & RDCS Deputy Director, Centre for Trials Research, Cardiff University
  • 2015 - 2017: Senior Research Associate, Department of Mathematics & Statistics, Lancaster University
  • 2012 - 2015: Research Associate, Institute of Biostatistics, Leibniz Universität Hannover
  • 2010 - 2012: Research Assistant, Institute of Biostatistics, Leibniz Universität Hannover
  • 2009 - 2010: Teaching Assistant, Institute of Plant Diseases and Plant Protection, Leibniz Universität Hannover

Speaking engagements

Invited speaker

  • x
  • x

Conference presentations

  • x
  • x

Committees and reviewing

External oversight committees

Reviewing

  • Associate Committee Member for NIHR (HTA)
  • Grant application reviewer for NIHR (HTA, EME, PHR, HS&DR), MRC (BMC DPFS, Better Methods Better Research), MRC-NIHR (Methodology Research Programme), UKRI (Future Leaders Fellowship), HCRW (PhD Health Studentship, Pathway to Portfolio) as well as internationally (DFG - German Science Foundation; NCN - Polish National Science Centre; ZonMW - Netherlands Organisation for Health Research and Development)
  • Final report reviewer for NIHR (HTA, PHR)
  • Associate Editor for Trials
  • Manuscript reviewer for journals including Statistics in Medicine, Journal of Statistical Software, Biometrical Journal, The American Statistician, Statistical Methods in Medical Research, Statistics, Journal of Applied Statistics, Journal of Biopharmaceutical Statistics, Communications in Statistics - Simulation and Computation, Journal of Statistical Computation and Simulation, Journal of Computational and Graphical Statistics, Statistica Neerlandica, Journal of Open Source Software, Applied Stochastic Models in Business and Industry, BMJ Open, PLOS One, Royal Society Open Science, PeerJ, Trials, Clinical Trials, Contemporary Clinical Trials, Frontiers in Neurology, Transfusion, Journal of Clinical Medicine, Nature Human Behaviour, The AAPS Journal, The British Student Doctor Journal, Future Internet, Environmental Science & Pollution Research, Pest Management Science (see my Publons profile)
  • Book proposal reviewer for Cambridge University Press
  • Abstract reviewer for ESPID 38th Annual Meeting 2020, ICTMC 2022

Publications

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

Summary of my research

I currently work on a number of trials (including BATCH, PRECISE, PRONTOTRIDENTFLAME, TAPERS, SaFE, SWIS, LISTEN, PLACEMENT and DocTIS) and observational studies (including DOMINO-HD, PEACH, Family VOICE and PERCEIVE).

I have been actively involved in the ACE Project to develop an official CONSORT extension for clinical trials with an adaptive design, the PANDA Project to create an educational online platform about adaptive designs, and the CAT Project to develop best practice costing guidance for CTUs supporting adaptive design trials.

I have (co-)authored and/or am the maintainer of a number of R packages that are freely available on CRAN, including MAMS (multi-arm multi-stage studies), BayesMAMS (Bayesian multi-arm multi-stage studies), jocre (joint confidence regions), modest (model-based dose-escalation trials), ANOM (analysis of means) and simboot (simultaneous inference for diversity indices).

Recently awarded grant funding

2022

  • NIHR HTA: Perineural local anaesthetic catheter after major lower limb amputation (PLACEMENT) (£1,635,918)

2021

  • NIHR Long COVID call: Long COVID personalised self-management support – co-design and evaluation (LISTEN) (£1,055,520)
  • NIHR HS&DR: Family group conferencing for children and families: evaluation of implementation, context and effectiveness (Family VOICE) (£1,194,736)

2020

  • NIHR HTA: Procalcitonin: evaluation of antibiotic use in COVID-19 hospitalised patients (PEACH) (£731,858)
  • HCRW RfPPB: PERCEIVE: prediction of risk and communication of outcome following major lower limb amputation – a collaborative study (£229,225)
  • DfE WWCSC: Social workers in schools scale-up (SWIS) (£385,597)
  • NIHR EME: MR-pro-adrenomedullin (MR-proADM) and ImmunoXpert evaluation of procalcitonin-guided anitbiotic duration in children with infection for stratification of effectiveness (PRECISE) (£385,450)

2019

  • HCRW CTU Infrastructure Funding: Centre for Trials Research 2020-23 (£2,470,489)
  • NIHR CTU Support Funding: Costing adaptive trials (CAT): developing best practice costing guidance for CTUs supporting adaptive trials (£55,629)
  • NIHR HTA: Procalcitonin and NEWS evaluation for timely identification of sepsis and optimal use of antibiotics in the emergency department (PRONTO) (£1,968,786)
  • NIHR PHR: Optimisation, feasibility testing and a pilot randomised trial of SaFE: a sexual health and healthy relationships intervention for further education (£510,815)
  • EU H2020: Decision on optimal combinatorial therapies in IMIDs using systems approaches (DocTIS) (€6,260,050)

2018

  • EU JPND Research: Multi-domain lifestyle targets for improving prognosis in Huntington's disease (DOMINO-HD) (€2,057,969)
  • NIHR CTU Support Funding: A practical adaptive and novel designs toolkit (PANDA) (£98,886)
  • HCRW RfPPB: Treating anxiety to prevent relapse in schizophrenia (TAPERS) – a feasibility trial (£229,865)

Supervision

Current supervision

A Markoulidakis

Andreas Markoulidakis

Research student

Past projects

  • Co-supervisor for Saif Abbas Chatoo – Antibiotic prescribing in hospitalised patients with COVID-19 as a function of inflammatory markers in wave 1 versus wave 2: a systematic review (Intercalated BSc Population Medicine, 2022)