Dr Philip Pallmann
Deputy Director Research Design and Conduct Service and Senior Research Fellow
- pallmannp@cardiff.ac.uk
- +44 (0)29 2068 7461
- 505, 5th floor, Neuadd Meirionnydd, University Hospital of Wales, Heath Park, Cardiff, CF14 4YS
- Available for postgraduate supervision
Overview
I am a Senior Research Fellow in the Centre for Trials Research where I work as a medical statistician on the design, conduct, analysis, and reporting of randomised controlled trials and other well-designed studies.
My background is in applied statistics, but I work across a wide range of clinical areas including infections, neurodegenerative diseases, and population health, as well as on the advancement of clinical trials methodology, in particular efficient design methods such as adaptive designs.
I am the Deputy Director of the Research Design and Conduct Service (RDCS) for South East Wales, which works with NHS and social care staff to develop high-quality funding applications for innovative research projects in health and social care.
I co-lead the Adaptive Designs Working Group of the MRC-NIHR Trials Methodology Research Partnership together with Sofía Villar.
I am a member of the MRC-NIHR Efficacy and Mechanism Evaluation (EME) funding committee.
I am an Associate Editor for the peer-reviewed journal Trials.
Biography
Education and qualifications
- 2016: PhD Biostatistics, Leibniz Universität Hannover
- 2012: MSc Plant Biotechnology, Leibniz Universität Hannover
- 2010: BSc Plant Biotechnology, Leibniz Universität Hannover
Honours and awards
- 2013: Bernd Streitberg Award of the International Biometric Society (German Region) for my MSc dissertation Two-sample tests and multiple contrast tests of several diversity indices
2012: Second Prize for Best Student Oral Presentation at the 36th International Biometric Conference in Kobe, Japan
Professional memberships
- Co-lead of the Adaptive Designs Working Group, MRC-NIHR Trials Methodology Research Partnership (previously: MRC Network of Hubs for Trials Methodology Research)
- Member of the European Huntington's Disease Network
Academic positions
- 2022 - present: Senior Research Fellow & RDCS Deputy Director, Centre for Trials Research, Cardiff University
- 2017 - 2022: Research Fellow & RDCS Deputy Director, Centre for Trials Research, Cardiff University
- 2015 - 2017: Senior Research Associate, Department of Mathematics & Statistics, Lancaster University
- 2012 - 2015: Research Associate, Institute of Biostatistics, Leibniz Universität Hannover
- 2010 - 2012: Research Assistant, Institute of Biostatistics, Leibniz Universität Hannover
- 2009 - 2010: Teaching Assistant, Institute of Plant Diseases and Plant Protection, Leibniz Universität Hannover
Speaking engagements
Invited speaker
- x
- x
Conference presentations (selected)
- Trial designs with co-primary superiority and non-inferiority endpoints: methodological discussion points and practical guidance. ICTMC, Harrogate, UK. 5 October 2022. Co-authors: Simon Schoenbuchner, Abin Thomas, David Gillespie.
- Simultaneous confidence regions for multi-parameter bioequivalence. 62nd Biometrisches Kolloquium & DAGStat, Göttingen, Germany. 18 March 2016. Co-author: Thomas Jaki.
- Multiple contrast tests with longitudinal data. International Conference on Simultaneous Inference, Hannover, Germany. 25 September 2013.
- Establishing bioequivalence in AB/BA cross-over trials using the ratio of AUCs estimated from sparse sampling designs. 59th Biometrisches Kolloquium & DAGStat, Freiburg, Germany. 19 March 2013. Co-authors: Thomas Jaki, Martin J Wolfsegger.
- Comparing biodiversity by simultaneously testing a user-defined selection of diversity indices. 36th International Biometric Conference, Kobe, Japan. 30 August 2012.
- Comparing biodiversity by simultaneously testing a user-defined selection of diversity indices. 58th Biometrisches Kolloquium, Berlin, Germany. 14 March 2012.
Conference posters (selected)
- Efficient model-based dose escalation at your fingertips: a simple software tool to design and evaluate phase I cancer trials. NCRI Cancer Conference, Liverpool, UK. 6 November 2017. Co-authors: Fang Wan, Christina Yap, Adrian P Mander, Graham M Wheeler, Sally Clive, Thomas Jaki, Lisa V Hampson.
- Designing multi-arm multi-stage trials with the R package 'MAMS'. PSI Conference, Berlin, Germany. 23 May 2016. Co-authors: Thomas Jaki, Dominic Magirr.
- Analysis of means with the R package 'ANOM'. 62nd Biometrisches Kolloquium & DAGStat, Göttingen, Germany. 16 March 2016. Co-author: Ludwig A Hothorn.
- Simultaneous small-sample inference in longitudinal settings using multiple contrasts. 60th Biometrisches Kolloquium, Bremen, Germany. 12 March 2014.
Committees and reviewing
External oversight committees
- Independent Trial Steering Committee member: NOTACS, TIP2, MODULATE, INTERACT, TREADON (currently); TIP, PLAN-A, AML18/19/LI1 (previously)
- Independent Data Monitoring Committee/Data Safety Monitoring Board member: ABC Sepsis, TRICEPS, ECRAID-Prime (currently); CANTOP-RCT (previously)
Funding committees
- Funding committee member for MRC-NIHR EME (since 2022)
- Associate funding committee member for NIHR HTA (2021-2022)
Editorial duties
- Associate Editor for Trials
- Review Editor for Frontiers in Psychology
Reviewing
- Grant application reviewer for NIHR (HTA, EME, PHR, HS&DR), MRC (BMC DPFS, Better Methods Better Research), MRC-NIHR (Methodology Research Programme), UKRI (Future Leaders Fellowship), HCRW (PhD Health Studentship, Pathway to Portfolio) as well as internationally (DFG - German Science Foundation; NCN - Polish National Science Centre; ZonMW - Netherlands Organisation for Health Research and Development)
- Final report reviewer for NIHR (HTA, PHR)
- Abstract reviewer for ESPID 38th Annual Meeting 2020, ICTMC 2022
- Book proposal reviewer for Cambridge University Press
- Manuscript reviewer for journals including Statistics in Medicine, Journal of Statistical Software, Biometrical Journal, The American Statistician, Statistical Methods in Medical Research, Statistical Papers, Statistics, Journal of Applied Statistics, Journal of Biopharmaceutical Statistics, Communications in Statistics - Simulation and Computation, Journal of Statistical Computation and Simulation, Journal of Computational and Graphical Statistics, Statistica Neerlandica, Journal of Clinical Epidemiology, Journal of Open Source Software, Applied Stochastic Models in Business and Industry, BMJ Open, PLOS One, Royal Society Open Science, PeerJ, Trials, Clinical Trials, Contemporary Clinical Trials, Journal of Infection, Frontiers in Neurology, Transfusion, Journal of Clinical Medicine, Nature Reviews Drug Discovery, Nature Human Behaviour, The AAPS Journal, The British Student Doctor Journal, Future Internet, Environmental Science & Pollution Research, Pest Management Science (see my Publons profile)
Publications
2023
- Potter, C. et al. 2023. Effectiveness and cost-effectiveness of a personalised self-management intervention for living with long covid: protocol for the listen randomised controlled trial. Trials 24, article number: 75. (10.1186/s13063-023-07090-w)
- Robertson, D. S., Choodari-Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. and Jaki, T. 2023. Point estimation for adaptive trial designs II: practical considerations and guidance. Statistics in Medicine
2022
- Lenihan, R. A. F. et al. 2022. Mid-regional pro-adrenomedullin in combination with pediatric early warning scores for risk stratification of febrile children presenting to the emergency department: secondary analysis of a nonprespecified United Kingdom cohort study. Pediatric Critical Care Medicine 23(12), pp. 980-989. (10.1097/PCC.0000000000003075)
- Gwilym, B. L. et al. 2022. Short-term risk prediction after major lower limb amputation: PERCEIVE study. BJS Open 109(12), pp. 1300-1311. (10.1093/bjs/znac309)
- Llewelyn, M. J., West, R. M., Carrol, E. D., Pallmann, P. and Sandoe, J. A. T. 2022. Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data - authors' response. Journal of Antimicrobial Chemotherapy 77(11), pp. 3211-3212., article number: dkac315. (10.1093/jac/dkac315)
- Kumwenda, M. et al. 2022. Identifying critically ill children at risk of dying during hospital admission in Malawi: prognostic accuracy of a modified qSOFA score for low-resource settings. Presented at: 11th World Congress on Pediatric Intensive and Critical Care, Virtual, 12-16 July 2022, Vol. 23. Vol. OP044., (10.1097/01.pcc.0000899856.14238.94)
- Robertson, D. S., Choodari‐Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. and Jaki, T. 2022. Point estimation for adaptive trial designs I: A methodological review. Statistics in Medicine (10.1002/sim.9605)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients (PEACH): protocol for a retrospective observational study. Methods and Protocols 5(6), article number: 95. (10.3390/mps5060095)
- Metzler-Baddeley, C., Busse, M. E., Drew, C. J., Pallmann, P., Jones, D. K. and Rosser, A. 2022. HD-DRUM – a novel computerised drumming training for movement and cognitive abilities in people with Huntington’s disease – app development and protocol of a randomised controlled feasibility study. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September 2022, Vol. 93. Vol. S1. pp. A100-A101., (10.1136/jnnp-2022-ehdn.267)
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2022. Covariate balancing & weighting web app (COBWEB): an online tool simplifying robust causal inference in observational studies. Journal of Neurology, Neurosurgery and Psychiatry 93(S1), article number: A44. (10.1136/jnnp-2022-ehdn.114)
- Markoulidakis, A., Busse, M., Doheny, E., Drew, C., Kirby, N. and Pallmann, P. 2022. Lifestyle index for individuals with HD (LifeHD): an aggregated measure that characterises the lifestyle habits of individuals with HD. Presented at: EHDN 2022 Plenary Meeting, Bologna, Italy, 16-18 September, Vol. 93. Vol. S1., (10.1136/jnnp-2022-ehdn.111)
- Love, S. B. et al. 2022. Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units. Trials 23, article number: 757. (10.1186/s13063-022-06680-4)
- Westlake, D. et al. 2022. Evaluating a school-based intervention through routine local authority data and national school data: challenges and opportunities. Presented at: International Population Data Linkage Conference 2022, 7 - 9 September 2022, Vol. 7. Vol. 3., (10.23889/ijpds.v7i3.1886)
- Wason, J. M. S. et al. 2022. Practical guidance for planning resources required to support publicly‑funded adaptive clinical trials. BMC Medicine 20, article number: 254. (10.1186/s12916-022-02445-7)
- Morgan-Jones, P. et al. 2022. Monitoring and managing lifestyle behaviours using wearable activity trackers: a mixed methods study of views from the Huntington's disease community. JMIR Formative Research 6(6), article number: e36870. (10.2196/36870)
- Chatoo, S. A., Thomas-Jones, E., Pallmann, P. and Euden, J. 2022. Antibiotic prescribing in hospitalized patients with COVID-19 as a function of inflammatory markers in wave 1 versus wave 2: a systematic review. Presented at: BSAC Spring Conference 2022, 10 - 11 May 2022, Vol. 4. Vol. S.2., (10.1093/jacamr/dlac053.012)
- Euden, J. et al. 2022. PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label, randomised controlled trial. BMJ Open 12(6), article number: e063424. (10.1136/bmjopen-2022-063424)
- Westlake, D. et al. 2022. The SWIS trial: protocol of a pragmatic cluster randomised controlled trial of school based social work. PLoS ONE 17(6), article number: e0265354. (10.1371/journal.pone.0265354)
- Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse, M., Godley, M. D. and Griffin, B. A. 2022. A tutorial comparing different covariate balancing methods with an application evaluating the causal effects of substance use treatment programs for adolescents. Health Services and Outcomes Research Methodology (10.1007/s10742-022-00280-0)
- Llewelyn, M. J. et al. 2022. Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series analysis of organization-level data. Journal of Antimicrobial Chemotherapy 77(4), pp. 1189-1196. (10.1093/jac/dkac017)
- Euden, J. et al. 2022. Procalcitonin evaluation of antibiotic use in COVID-19 hospitalized patients during the first wave of COVID-19: the PEACH study. Presented at: Infection 2021: BSAC Winter Conference, Virtual, 9-10 December 2021, Vol. 4. Vol. 1., (10.1093/jacamr/dlac004.013)
- Waldron, C. et al. 2022. Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): protocol for a randomised controlled trial. BMJ Open 12(1), article number: e047490. (10.1136/bmjopen-2020-047490)
- Milosevic, S. et al. 2022. PrEdiction of Risk and Communication of outcomE followIng major lower limb amputation: a collaboratiVE study (PERCEIVE)—protocol for the PERCEIVE qualitative study. BMJ Open 12(1), article number: e053159. (10.1136/bmjopen-2021-053159)
- Powell, E., James, D., Collis, R., Collins, P., Pallmann, P. and Bell, S. 2022. Introduction of standardized, cumulative quantitative measurement of blood loss into routine maternity care. Journal of Maternal-Fetal and Neonatal Medicine 35(8), pp. 1491-1497. (10.1080/14767058.2020.1759534)
- Dimairo, M. et al. 2022. PANDA: a practical adaptive and novel designs and analysis toolkit. [Online]. University of Sheffield. Available at: https://panda.shef.ac.uk/
2021
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2021. CoBWeb: a user-friendly web application to estimate causal treatment effects from observational data using multiple algorithms. [Online]. Cornell University. Available at: https://arxiv.org/abs/2112.05035
- Gwilym, B. L. et al. 2021. The PERCEIVE quantitative study: PrEdiction of Risk and Communication of outcome following major lower-limb amputation: protocol for a collaboratiVE study. BJS Open 5(6), article number: zrab118. (10.1093/bjsopen/zrab118)
- Richards, O. et al. 2021. Procalcitonin increase is associated with the development of critical care-acquired infections in COVID-19 ARDS. Antibiotics 10(11), article number: 1425. (10.3390/antibiotics10111425)
- Wilson, N. et al. 2021. Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project. BMC Medicine 19, article number: 251. (10.1186/s12916-021-02124-z)
- Preece, R. et al. 2021. A systematic review and narrative synthesis of risk prediction tools used to estimate mortality, morbidity, and other outcomes following major lower limb amputation. European Journal of Vascular and Endovascular Surgery 62(1), pp. 127-135. (10.1016/j.ejvs.2021.02.038)
- Romaine, S. T. et al. 2021. Performance of seven different paediatric early warning scores to predict critical care admission in febrile children presenting to the emergency department: a retrospective cohort study. BMJ Open 11(5), article number: e044091. (10.1136/bmjopen-2020-044091)
- Robertson, D. S., Choodari-Oskooei, B., Dimairo, M., Flight, L., Pallmann, P. and Jaki, T. 2021. Point estimation for adaptive trial designs. [Online]. Cornell University. Available at: https://arxiv.org/abs/2105.08836
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study. BMC Pregnancy and Childbirth 21, article number: 377. (10.1186/s12884-021-03853-y)
- Powell, N. et al. 2021. Use of procalcitonin during the first wave of COVID-19 in the acute NHS hospitals: a retrospective observational study. Antibiotics 10(5), article number: 516. (10.3390/antibiotics10050516)
- Gwilym, B. et al. 2021. PERCEIVE: PrEdiction of Risk and Communication of outcome following major lower limb amputation - a collaboratIVE study. Presented at: National Research Collaborative Meeting 2020 (NRCM 2020), Virtual, 19 November - 10 December 2020, Vol. 5. Vol. Supple. Wiley, (10.1093/bjsopen/zrab032.089)
- Bell, S. F. et al. 2021. Reduction in massive postpartum haemorrhage and red blood cell transfusion during a national quality improvement project, Obstetric Bleeding Strategy for Wales, OBS Cymru: an observational study. SSRN: Available at: http://doi.org/10.2139/ssrn.3746928
- Wheeler, M., Powell, E. and Pallmann, P. 2021. Use of high-fidelity simulation training for radiology healthcare professionals in the management of acute medical emergencies. British Journal of Radiology 94(1117), article number: 20200520. (10.1259/bjr.20200520)
- Drew, C. et al. 2021. Protocol for an open label, phase I trial within a cohort of fetal cell transplants in people with Huntington’s disease. Brain Communications 3(1), article number: fcaa230. (10.1093/braincomms/fcaa230)
- Markoulidakis, A., Holmans, P., Pallmann, P., Busse, M. and Griffin, B. A. 2021. How balance and sample size impact bias in the estimation of causal treatment effects: a simulation study. [Online]. Cornell University. Available at: https://arxiv.org/abs/2107.09009
2020
- Burnett, T., Mozgunov, P., Pallmann, P., Villar, S. S., Wheeler, G. M. and Jaki, T. 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. BMC Medicine 18, article number: 352. (10.1186/s12916-020-01808-2)
- Romaine, S. T. et al. 2020. Accuracy of a modified qSOFA score for predicting critical care admission in febrile children. Pediatrics 146(4), article number: e20200782. (10.1542/peds.2020-0782)
- Dimairo, M. et al. 2020. The Adaptive designs CONSORT Extension (ACE) Statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ 369, article number: m115. (10.1136/bmj.m115)
- Dimairo, M. et al. 2020. The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials 21, article number: 528. (10.1186/s13063-020-04334-x)
- Parkes, M., Lunt, M., Pallmann, P. and Felson, D. 2020. Futility of the treatment, rather than futility of the trial, as the primary focus of interim analyses in clinical trials. Presented at: Society for Clinical Trials (SCT) 40th Annual Meeting, New Orleans, LA, US, 19-22 May 2019, Vol. 17. Vol. 1_Supp. SAGE Publications (UK and US) pp. 62., (10.1177/1740774520907457)
- Pallmann, P. et al. 2020. Designing and evaluating dose-escalation studies made easy: the MoDEsT web app. Clinical Trials 17(2), pp. 147-156. (10.1177/1740774519890146)
- Burnett, T., Mozgunov, P., Pallmann, P., Villar, S. S., Wheeler, G. M. and Jaki, T. 2020. Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs. [Online]. arXiv. Available at: https://arxiv.org/abs/2006.12811
- Markoulidakis, A., Taiyari, K., Holmans, P., Pallmann, P., Busse-Morris, M. and Griffin, B. A. 2020. A tutorial comparing different covariate balancing methods with an application evaluating the causal effect of exercise on the progression of Huntington’s disease. [Online]. arXiv. Available at: https://arxiv.org/abs/2010.09563
2019
- Dimairo, M. et al. 2019. Introducing the Adaptive designs CONSORT Extension (ACE) Statement to improve reporting of randomised trials that use an adaptive design (P-7). Presented at: 5th International Clinical Trials Methodology Conference (ICTMC 2019), Brighton, UK, 6-9 October 2019. BioMed Central pp. -., (10.1186/s13063-019-3688-6)
- Hornbacher, J., Rumlow, A., Pallmann, P., Turcios, A. E., Riemenschneider, A. and Papenbrock, J. 2019. The levels of sulfur-containing metabolites in Brassica napus are not influenced by the circadian clock but diurnally. Journal of Plant Biology 62(5), pp. 359-373. (10.1007/s12374-019-0143-x)
- Drew, C. J. G. et al. 2019. A protocol for a randomised controlled, double-blind feasibility trial investigating fluoxetine treatment in improving memory and learning impairments in patients with mesial temporal lobe epilepsy: Fluoxetine, Learning and Memory in Epilepsy (FLAME trial). Pilot and Feasibility Studies 5(1), article number: 87. (10.1186/s40814-019-0474-x)
- Jansen, J. O., Pallmann, P., MacLennan, G. and Campbell, M. K. 2019. Bayesian clinical trial designs another option for trauma trials? Erratum. Journal of Trauma and Acute Care Surgery 86(4), pp. 760. (10.1097/TA.0000000000002236)
- Jaki, T., Pallmann, P. and Magirr, D. 2019. The R package MAMS for designing multi-arm multi-stage clinical trials. Journal of Statistical Software 88(4)
2018
- Dimairo, M. et al. 2018. Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design. BMC Medicine 16(1), article number: 210. (10.1186/s12916-018-1196-2)
- Pallmann, P., Ritz, C. and Hothorn, L. A. 2018. Simultaneous small-sample comparisons in longitudinal or multi-endpoint trials using multiple marginal models. Statistics in Medicine 37(9), pp. 1562-1576. (10.1002/sim.7610)
- Pallmann, P. et al. 2018. Adaptive designs in clinical trials: why use them, and how to run and report them. BMC Medicine 16, article number: 29. (10.1186/s12916-018-1017-7)
2017
- Pallmann, P. and Jaki, T. 2017. Simultaneous confidence regions for multivariate bioequivalence. Statistics in Medicine 36(29), pp. 4585-4603. (10.1002/sim.7446)
- Pallmann, P., Pretorius, M. and Ritz, C. 2017. Simultaneous comparisons of treatments at multiple time points: Combined marginal models versus joint modeling. Statistical Methods in Medical Research 26(6), pp. 2633-2648. (10.1177/0962280215603743)
- Jansen, J. O., Pallmann, P., MacLennan, G. and Campbell, M. K. 2017. Bayesian clinical trial designs: Another option for trauma trials?. Journal of Trauma and Acute Care Surgery 83(4), pp. 736-741. (10.1097/TA.0000000000001638)
- Parkes, M., Lunt, M., Pallmann, P. and Felson, D. T. 2017. The two-stage treatment selection (TSTS) design: a novel approach to treatment selection in clinical trials. Trials 18(S1), pp. 166., article number: P440. (10.1186/s13063-017-1902-y)
- Otieno, J. A., Pallmann, P. and Poehling, H. 2017. Additive and synergistic interactions amongst Orius laevigatus (Heteroptera: Anthocoridae), entomopathogens and azadirachtin for controlling western flower thrips (Thysanoptera: Thripidae). BioControl 62(1), pp. 85-95. (10.1007/s10526-016-9767-7)
- Pallmann, P. 2017. Sample size determination in clinical trials with multiple endpoints. T. Sozu, R. Sugimoto, T. Hamasaki, and S. R. Evans (2015). New York, NY: Springer. 95 pages, ISBN: 978-3-319-22004-8. Biometrical Journal 59(1), pp. 218. (10.1002/bimj.201600135)
2016
- Rumlow, A., Keunen, E., Klein, J., Pallmann, P., Riemenschneider, A., Cuypers, A. and Papenbrock, J. 2016. Quantitative expression analysis in brassica napus by northern blot analysis and reverse transcription-quantitative PCR in a complex experimental setting. PLoS ONE 11(9), article number: e0163679. (10.1371/journal.pone.0163679)
- Pallmann, P. and Hothorn, L. A. 2016. Boxplots for grouped and clustered data in toxicology. Archives of Toxicology 90(7), pp. 1631-1638. (10.1007/s00204-015-1608-4)
- Otieno, J. A., Pallmann, P. and Poehling, H. -. 2016. The combined effect of soil-applied azadirachtin with entomopathogens for integrated management of western flower thrips. Journal of Applied Entomology 140(3), pp. 174-186. (10.1111/jen.12242)
- Pallmann, P. and Hothorn, L. A. 2016. Analysis of means: a generalized approach using R. Journal of Applied Statistics 43(8), pp. 1541-1560. (10.1080/02664763.2015.1117584)
- Pallmann, P. and Schaarschmidt, F. 2016. Common pitfalls when testing additivity of treatment mixtures with chi-square analyses. Journal of Applied Entomology 140(1-2), pp. 135-141. (10.1111/jen.12258)
2015
- Pallmann, P. 2015. Simultaneous Statistical Inference: With Applications in the Life Sciences. T.Dickhaus (2014). Heidelberg: Springer. 180 pages, ISBN: 978-3-642-45181-2.. Biometrical Journal 57(6), pp. 1151-1152. (10.1002/bimj.201500129)
- Pallmann, P. 2015. Analyzing baseball data with R [book review]. Journal of the Royal Statistical Society Series A (Statistics in Society) 178(4), pp. 1099-1099. (10.1111/rssa.3_12138)
- Karanja, J., Poehling, H. and Pallmann, P. 2015. Efficacy and dose response of soil-applied neem formulations in substrates with different amounts of organic matter, in the control of whiteflies, aleyrodes proletella and trialeurodes vaporariorum (hemiptera: aleyrodidae). Journal of Economic Entomology 108(3), pp. 1182-1190. (10.1093/jee/tov047)
- Weese, A., Pallmann, P., Papenbrock, J. and Riemenschneider, A. 2015. Brassica napus L. cultivars show a broad variability in their morphology, physiology and metabolite levels in response to sulfur limitations and to pathogen attack. Frontiers in Plant Science 6, article number: 9. (10.3389/fpls.2015.00009)
2014
- Pallmann, P., Hothorn, L. A. and Djira, G. D. 2014. A Levene-type test of homogeneity of several variances against ordered alternatives. Computational Statistics 29, pp. 1593-1608. (10.1007/s00180-014-0508-z)
- Pallmann, P. 2014. Applied meta-analysis with R. Journal of Applied Statistics 42(4), pp. 914-915. (10.1080/02664763.2014.989464)
2013
- Jaki, T., Pallmann, P. and Wolfsegger, M. J. 2013. Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs. Statistics in Medicine 32(30), pp. 5469-5483. (10.1002/sim.5886)
- Jaki, T., Pallmann, P. and Wolfsegger, M. J. 2013. Authors' reply to Comments on 'Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs'. Statistics in Medicine 32(30), pp. 5487-5488. (10.1002/sim.6000)
2012
- Pallmann, P., Schaarschmidt, F., Hothorn, L. A., Fischer, C., Nacke, H., Priesnitz, K. U. and Schork, N. J. 2012. Assessing group differences in biodiversity by simultaneously testing a user-defined selection of diversity indices. Molecular Ecology Resources 12(6), pp. 1068-1078. (10.1111/1755-0998.12004)
Summary of my research
I currently work on a number of trials (including BATCH, PRECISE, PRONTO, TRIDENT, FLAME, TAPERS, SaFE, SWIS, LISTEN, PLACEMENT, TIPTOE, OBS UK and DocTIS) and observational studies (including DOMINO-HD, PEACH, Family VOICE and PERCEIVE). I am the chief investigator for PROTECT.
I have been actively involved in the ACE Project to develop an official CONSORT extension for clinical trials with an adaptive design, the PANDA Project to create an educational online platform about adaptive designs, and the CAT Project to develop best practice costing guidance for CTUs supporting adaptive design trials.
I have (co-)authored and/or am the maintainer of a number of R packages that are freely available on CRAN, including MAMS (multi-arm multi-stage studies), BayesMAMS (Bayesian multi-arm multi-stage studies), jocre (joint confidence regions), modest (model-based dose-escalation trials), ANOM (analysis of means) and simboot (simultaneous inference for diversity indices).
Recently awarded grant funding
2023
- NIHR HTA: Platform randomised evaluation of clinical outcomes using novel technologies to optimise antimicrobial therapy (PROTECT) (£204,987)
2022
- NIHR HSDR: Clinical and cost-effectiveness of a maternity quality improvement programme to reduce excess bleeding and need for transfusion after childbirth: the obstetric bleeding study UK (OBS UK) stepped wedge cluster randomised trial (£x,xxx,xxx)
- NIHR HTA: Multi-domain self-management in older people with osteoarthritis and multi-morbidities (TIPTOE) (£1,711,355)
- NIHR HTA: Perineural local anaesthetic catheter after major lower limb amputation (PLACEMENT) (£1,635,918)
2021
- NIHR Long COVID call: Long COVID personalised self-management support – co-design and evaluation (LISTEN) (£1,055,520)
- NIHR HS&DR: Family group conferencing for children and families: evaluation of implementation, context and effectiveness (Family VOICE) (£1,194,736)
2020
- NIHR HTA: Procalcitonin: evaluation of antibiotic use in COVID-19 hospitalised patients (PEACH) (£731,858)
- HCRW RfPPB: PERCEIVE: prediction of risk and communication of outcome following major lower limb amputation – a collaborative study (£229,225)
- DfE WWCSC: Social workers in schools scale-up (SWIS) (£385,597)
- NIHR EME: MR-pro-adrenomedullin (MR-proADM) and ImmunoXpert evaluation of procalcitonin-guided anitbiotic duration in children with infection for stratification of effectiveness (PRECISE) (£385,450)
2019
- HCRW CTU Infrastructure Funding: Centre for Trials Research 2020-23 (£2,470,489)
- NIHR CTU Support Funding: Costing adaptive trials (CAT): developing best practice costing guidance for CTUs supporting adaptive trials (£55,629)
- NIHR HTA: Procalcitonin and NEWS evaluation for timely identification of sepsis and optimal use of antibiotics in the emergency department (PRONTO) (£1,968,786)
- NIHR PHR: Optimisation, feasibility testing and a pilot randomised trial of SaFE: a sexual health and healthy relationships intervention for further education (£510,815)
- EU H2020: Decision on optimal combinatorial therapies in IMIDs using systems approaches (DocTIS) (€6,260,050)
2018
- EU JPND Research: Multi-domain lifestyle targets for improving prognosis in Huntington's disease (DOMINO-HD) (€2,057,969)
- NIHR CTU Support Funding: A practical adaptive and novel designs toolkit (PANDA) (£98,886)
- HCRW RfPPB: Treating anxiety to prevent relapse in schizophrenia (TAPERS) – a feasibility trial (£229,865)
Supervision
Current supervision
Past projects
- Co-supervisor for William Blake – Applying causal inference techniques to estimate the impact of lifestyle variables on the severity of Huntington's disease (MSc, 2022, with Andreas Markoulidakis and Monica Busse)
- Co-supervisor for Saif Abbas Chatoo – Antibiotic prescribing in hospitalised patients with COVID-19 as a function of inflammatory markers in wave 1 versus wave 2: a systematic review (Intercalated BSc Population Medicine, 2022, with Joanne Euden and Emma Thomas-Jones)