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Dr Georgina Menzies

Dr Georgina Menzies

Lecturer

School of Biosciences

Email
menziesg@cardiff.ac.uk
Telephone
+44 29206 88463
Campuses
Sir Martin Evans Building, Museum Avenue, Cardiff, CF10 3AX
Users
Available for postgraduate supervision

Overview

Structural and functional investigations using molecular modelling and molecular simulations

My main research interests involve studying DNA repair pathways, in particular, the protein and DNA structures using molecular modelling techniques. I also collaborate with a number of other researchers and research groups to provide structural and functional information for their biological structure of interest. This ranges from drugs to anti-bodies and proteins.

Most of my research involves techniques including molecular dynamics, coarse grain modelling and mathematical modelling. I use these models resulting from these studies to elucidate information as to how structural changes may be affecting the function of the biological system. A large part of this is data analysis. All model systems produce 'large data' sets and I utilise multivariate analysis tools to decipher patterns and correlate this back to biological answers.

I have always been interested in how structure relates to function and am always interested in studying something new.

Biography

April 2020 -
present
LecturerCardiff University School of Biosciences
June 2018 -
April 2020
Ser Cymru II FellowDementia Research Institute at Cardiff University
December 2016 - June 2018Post-Doctoral Research AssociateCardiff University. MRC Centre for Neuropsychiatric Genetics & Genomics
July 2014 - December 2016Post-Doctoral Research AssistantSwansea University - Tailored OligoG Project - funded by Norwegian Research Council
January 2015 -
January 2016
Developer

MutAIT project (http://mutait.org/home.html)

June 2012 -
June 2014
Research Assistant

Swansea University - Celtic Alliance for NanoHealth Project - funded by INTERREG IVA Ireland Wales Program

After gaining my BSc(Hons) in Forensic Science from the University of Glamorgan I studied for a MSc in Molecular Modelling from Cardiff University. My PhD focused on the structure of DNA in cancer hotspot sites but I also worked on projects studying spectroscopy as a form of early diagnostic.

Honours and awards

CLIRSPC attendance and travel bursary for SPEC2016

SDMF seed corn grant 2015 (£2,500)

UKEMS conference attendance bursary for EEMS 2014 and UKEMS 2013

EuroTox bursary for conference fees 2014

Professional memberships

ARUK Wales Network

Royal Society of Chemistry (RSC)

United Kingdom Environmental Mutagenesis Society (UKEMS)

Molecular Graphics and Modelling Society (MGMS)

The International Society for Clinical Spectroscopy (CLIRSPEC)

Speaking engagements

Oral Presentations:

  • DRI-NI ECR Event - 2019 - Molecular dynamic simulations support a structural change causing the in vitro observed differences in binding between TREM2 and suggested ligands when Alzheimer’s disease mutations are present.
  • AD/PD - 2019 - Molecular dynamics simulations of Alzheimer's variants, R47H and R62H, in TREM2 provide evidence for structural alterations which could be causing known functional changes.
  • DPUK – AAIC 2017 - the DPUK genetics platform.
  • DPUK-EMIF – 2017, Manchester UK – the DPUK genetics platform.
  • CLIRSPEC 2015 - Fourier transform infrared for noninvasive optical diagnosis of oral, oropharyngeal, and laryngeal cancer.
  • GE and Swansea University 2014, GE Cardiff – FTIR for detection of changes in respiratory disease.
  • NanoScience Event 2014, Liberty Stadium – two talks, 1. FTIR in nano, 2. Big Data.
  • Dentist CPD course 2014, Swansea University - Head and Neck Cancer, Detection of biological changes by FTIR.
  • CAN Event 2014, Dublin Aviva Stadium – The CAN project so far and how we can work with you.
  • Four Projects, One Goal 2013, Swansea University - How Supercomputing has changed my world...
  • HPC Wales Workshop 2012, Glamorgan University - A Molecular Modelling Study into the Structural and Curvature Differences in DNA.

Poster Presentations:

  • AAIC 2018, Chicago, MOLECULAR DYNAMIC MODELLING OF TWO TREM2 MUTATIONS REVEAL KEY STRUCTURAL SIMILARITIES AND PROBABLE FUNCTIONAL IMPACT IN ALZHEIMER’S DISEASE.
  • AAIC 2017, London, Molecular dynamic modelling of a novel PLCG2 variant reveals key protein structural differences.
  • SPEC2016, Montreal - Evaluation of a handheld ATR-FTIR spectrometer to determine lung cancer specific diagnostic metabolic changes in sputum.
  • 1st Student Symposium on Computational Biology and Life Sciences 2014, Glamorgan – The possible use of Molecular Dynamics to improve understanding of mucin structure in Cystic Fibrosis.
  • EuroTox 2014, Edinburgh International Conference Centre - Molecular Dynamics modelling of local 3D structural differences in genes when carcinogens are bound at mutation hotspots – The link between structural change and mutation hotspot status.
  • EEMS 2014, Lancaster University - Methylation may play an important role in structural change and consequential mutation status in cancer genes.
  • UKEMS 2013, Bristol University - Molecular dynamical modelling of local 3D structural differences in TP53 when a number of different carcinogens are bound at mutation hotspots *POSTER PRIZE*.
  • Conversazione 2012, Swansea University – Evaluation of FTIR Spectroscopy of mucus samples for the differentiation of Head and Neck Cancer subtypes.
  • MGMS Computational Chemical Biology Meeting 2012, Manchester- Molecular Dynamics Modelling of Local 3D structural differences in genes when carcinogens are bound at mutation hotspots.

Committees and reviewing

ECR Representative (ARUK Network & DNA repair theme, Dementia Research Institute)

Dementia Research Institute executive committee member 2018 - present

Alzheimer’s Research UK (ARUK) South Wales Network ECR Rep.

Organiser - ARUK Afternoon Tea and Talks, open day, 2019 Hadyn Ellis Building

Organiser - ARUK Cheese and Wine Research Evening, 2019 Hadyn Ellis Building

Co-organiser - ARUK open day 2018, Hadyn Ellis Building

Publications

2020

2019

2018

2017

2016

2015

2014

Teaching

I am involved in the development of new masters level modules as well as the supervision of undergraduate and postgraduate students.

Current teaching contributions:

  • BI3255 - Synthetic Biology and Protein Engineering.
  • CM2203 - Informatics.
  • BI3008 - Advanced Research Techniques

Supervision

  • Development of Molecular Modelling platforms for DNA strucural analysis
  • Molecular Dynamics simulations of CRISPR systems
  • Molecular Dyanamics simulations of protein mutations
  • Simulations and analysis of DNA strucutre in relation to repair pathways
Current supervision:
  • 25% Elisa Salis; IN VIVO MODELLING OF HUMAN MICROGLIAL ALTERATIONS ASSOCIATED WITH ALZHEIMER'S DISEASE AND POLYGENIC RISK
  • 50% Antione Mangin; Optimizing Cas9 delivery as a gene editing treatment in expanded CAG/CTG repeats.

External profiles

Research links