![David Thomas BDS, FDRSCSEd, FDSRCSEng (ad eundem), PhD](https://profiles-cardiff.imgix.net/attachments/1685?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Professor David Thomas
BDS, FDRSCSEd, FDSRCSEng (ad eundem), PhD
Professor/Hon Consultant in Oral & Maxillofacial Surgery, Programme Director Implant Dentistry, Director Wales Integrated Academic Training programme in Dentistry, School of Dentistry, URI Innovation Lead,
Overview
Research Theme
Tissue Engineering & Reparative Dentistry
Research Groups
Microbial Effects on Tissue Function, and Tissue Repair and Remodelling
Repair and Regeneration in the Oral Mucosa
Our group$acirc; s research is focussed in defining the molecular and cellular control mechanisms involved in impaired human wound healing. From defining the genotypic and phenotypic changes in human fibroblasts associated with disease, we have highlighted the role of bacteria in modulating these processes. The group was instrumental in establishing CITER. Having obtained over £10M in external funding since our establishment of the Programme in 1993, we have worked to translate our understanding of the processes of impaired healing and particularly the role of bacterial pathogens in these processes. The group has welcomed inter-disciplinary research and the PhD and MD programme has seen general surgeons, plastic surgeons, dermatologists, physicians and dentists as postgraduate students.
This work led to a re-evaluation of how we diagnose and manage bacteria in chronic, non-healing wounds. This work is being translated to clinical practice via the development of new classes of agents (OligoG and polymer-drug conjugates) which offer the opportunity for new approaches to the management of human disease. We have developed and patented the use of the first oligosaccahride nanomedicines to treat multi-drug resistant gram-negative & biofilm-related infection in man (GB 0909556.3 GB 0909529.0 PCT/GB2010/001098 PCT/GB2010/001096 PCT/GB2010/001097); these agents have successfully completed Phase 1 clinical studies in humans.
Research interests
- Cellular and Molecular Control of human wound healing
- The role of bacteria in impaired wound healing
- The development of novel nanomedicines for application in anti-infective and wound healing applications
Selected Projects
US Department of Defence - $1.6M The development of new therapies to treat gram-negative MDR organisms in injured combat personnel
Wellcome Trust - UK £83,717 The goal of this project is to develop polymer therapeutic growth factor / polymer conjugates to direct cell migration and differentiation in human wound healing.
NHS / WAG - UK £1.4M Establishment of an integrated academic clinical training programme. The major goals of this project are the production of a cohort of clinicians with PhDs and clinical specialist training.
Algipharma - UK £266,000 Investigation of the in vitro antimicrobial acivity, and ability to overcome multi-drug resistance, of alginate oligosaccaharide nanomedicines.
UK Knowledge Transfer Partnership - UK £92,000 Development of in vitro models for testing of novel antimicrobial compounds in wound healing
UK Medical Research Council - £187,000 Development of reporter cell assays employing disease-specific fibroblast populations
UK Medical Research Council - UK £27,000 Bioresponsive polymer-peptide conjugates as novel antibacterial agents
This project has developed novel class of antimicrobial polymer-peptide conjugates for the treatment of human infections
Publication
2024
- Varache, M. et al. 2024. Dextrin conjugation to colistin inhibits its toxicity, cellular uptake and acute kidney injury in vivo. RSC Pharmaceutics (10.1039/D3PM00014A)
- Rizzo, S., Varache, M., Sayers, E. J., Jones, A. T., Tonks, A., Thomas, D. W. and Ferguson, E. L. 2024. Modification of the antibiotic, colistin, with dextrin causes enhanced cytotoxicity and triggers apoptosis in myeloid leukemia. International Journal of Nanomedicine
2023
- Pritchard, M. F. et al. 2023. Structure–activity relationships of low molecular weight alginate oligosaccharide therapy against Pseudomonas aeruginosa. Biomolecules 13(9), article number: 1366. (10.3390/biom13091366)
- Xue, W. et al. 2023. Defining in vitro topical antimicrobial and antibiofilm activity of epoxy-tigliane structures against oral pathogens. Journal of Oral Microbiology 15(1), article number: 2241326. (10.1080/20002297.2023.2241326)
- Lohana, P. et al. 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12(7), article number: 1374. (10.3390/antiox12071374)
- Mehreen, Z., Thomas, D., Adams, R., Farnell, D. and Claydon, N. 2023. A systematic review and meta-analysis of the clinical outcomes for adjunctive physical, chemical, and biological treatment of dental implants with peri-implantitis. Journal of Oral Implantology (10.1563/aaid-joi-d-21-00204)
- Powell, L. C. et al. 2023. Alginate oligosaccharides enhance the antifungal activity of nystatin against candidal biofilms. Frontiers in Cellular and Infection Microbiology 13, article number: 1122340. (10.3389/fcimb.2023.1122340)
2022
- Powell, L. C. et al. 2022. Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds. Science Translational Medicine 14(662) (10.1126/scitranslmed.abn3758)
- Saud, Z. et al. 2022. The SARS-CoV2 envelope differs from host cells, exposes pro-coagulant lipids, and is disrupted in vivo by oral rinses. Journal of Lipid Research 63(6), article number: 100208. (10.1016/j.jlr.2022.100208)
- Stokniene, J., Varache, M., Rye, P. D., Hill, K. E., Thomas, D. W. and Ferguson, E. L. 2022. Alginate oligosaccharides enhance diffusion and activity of colistin in a mucin-rich environment. Scientific Reports 12, article number: 4986. (10.1038/s41598-022-08927-1)
2021
- Chiron, E., Varache, M., Stokniene, J., Thomas, D. W. and Ferguson, E. L. 2021. A physicochemical assessment of the thermal stability of dextrin–colistin conjugates. Scientific Reports 11, article number: 10600. (10.1038/s41598-021-89946-2)
- Carey, E. C., Gardiner, A. T. C., Adams, R. J., Farnell, D. J. J., Claydon, N. C. and Thomas, D. W. 2021. The effects of age and sex on mandibular bone graft donor sites. Oral Surgery 14(1), pp. 52-58. (10.1111/ORS.12535)
- Oakley, J. L. et al. 2021. Phenotypic and genotypic adaptations in Pseudomonas aeruginosa biofilms following long-term exposure to an alginate oligomer therapy. mSphere 6(1), pp. e01216-20. (10.1128/mSphere.01216-20)
- Powell, L. C. et al. 2021. Quantifying the effects of antibiotic treatment on the extracellular polymer network of antimicrobial resistant and sensitive biofilms using multiple particle tracking. npj Biofilms and Microbiomes 7, article number: 13. (10.1038/s41522-020-00172-6)
- Jones, T. et al. 2021. The potential transmission of COVID-19 during routine dental surgery. Presented at: 8th UK–China International Particle Technology Forum 2021, Dali, Tunnan, China, 9-13 July 2021.
2020
- Stokniene, J. et al. 2020. Bi-functional alginate oligosaccharide–polymyxin conjugates for improved treatment of multidrug-resistant gram-negative bacterial infections. Pharmaceutics 12(11), article number: 1080. (10.3390/pharmaceutics12111080)
- Almershed, N., Adams, R., Mort, J., Farnell, D., Thomas, D. W. and Claydon, N. 2020. The use of non-surgical interventions in patients with periimplantitis; a systematic review and meta-analysis. Oral Surgery 14(2), pp. 178-190. (10.1111/ors.12548)
- O'Donnell, V. B. et al. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1(1), article number: zqaa002. (10.1093/function/zqaa002)
- Yang, Q. E. et al. 2020. Compensatory mutations modulate the competitiveness and dynamics of plasmid-mediated colistin resistance in Escherichia coli clones. ISME Journal 14, pp. 861-865. (10.1038/s41396-019-0578-6)
2019
- Varache, M., Powell, L. C., Aarstad, O. A., Williams, T. L., Wenzel, M. N., Thomas, D. W. and Ferguson, E. L. 2019. Polymer masked-unmasked protein therapy: Identification of the active species after amylase-activation of dextrin-colistin conjugates.. Molecular Pharmaceutics 16(7), pp. 3199-3207. (10.1021/acs.molpharmaceut.9b00393)
- Roberts, A., Powell, L., Pritchard, M., Thomas, D. and Jenkins, R. 2019. Anti-pseudomonad activity of manuka honey and antibiotics in a specialized ex vivo model simulating cystic fibrosis lung infection. Frontiers in Microbiology 10, pp. -., article number: 869. (10.3389/fmicb.2019.00869)
2018
- Ferguson, E. L. et al. 2018. Controlled release of Dextrin-conjugated growth factors to support growth and differentation of neural stem cells. Stem Cell Research 33, pp. 69-78. (10.1016/j.scr.2018.10.008)
- Al-Kadhim, K. A. H., Pritchard, M., Farnell, D., Thomas, D. W., Adams, R. and Claydon, N. 2018. Surgical therapy for peri-implantitis management: a systematic review and meta-analysis. Oral Surgery 11(3), pp. 200-212. (10.1111/ors.12344)
- Blaikie, P., Nishio Ayre, W., Thomas, D., Begum, T., Eaton, M., Harwood, C. and Crivelli, D. 2018. A smart surgical tool for optimal dental implant fixation. Presented at: 96th General Session of the IADR, London, UK, 25-28 Jul 2018.
- Powell, L. C. et al. 2018. Targeted disruption of the extracellular polymeric network of pseudomonas aeruginosa biofilms by alginate oligosaccharides. npj Biofilms and Microbiomes 4, article number: 13. (10.1038/s41522-018-0056-3)
- Adams, R., Hamid, L., Binney, A., Claydon, N., Farnell, D., Griffiths, B. and Thomas, D. 2018. A radiographic analysis of anatomical variation at the mandibular of intraoral bone harvesting. Oral Surgery 11(2), pp. 105-111. (10.1111/ors.12304)
- Jack, A. A. et al. 2018. Alginate Oligosaccharide-Induced Modification of the lasI-lasR and rhlI-rhlR Quorum Sensing Systems in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 62(5), article number: e02318-17. (10.1128/AAC.02318-17)
2017
- Yang, Q. et al. 2017. Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms. Nature Communications 8, article number: 2054. (10.1038/s41467-017-02149-0)
- Pritchard, M., Jack, A., Powell, L., Sadh, H., Hill, K. E., Thomas, D. W. and Rye, P. D. 2017. Alginate Oligosaccharides modify hyphal infiltration of Candida albicans in an in vitro model of invasive Human Candidosis. Journal of Applied Microbiology 123(3), pp. 625-636. (10.1111/jam.13516)
- Pritchard, M. F. et al. 2017. A low-molecular-weight alginate oligosaccharide disrupts pseudomonal microcolony formation and enhances antibiotic effectiveness. Antimicrobial Agents and Chemotherapy 61(9), article number: e00762-17. (10.1128/AAC.00762-17)
- Pritchard, M. F. et al. 2017. The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Scientific Reports 7, article number: 44731. (10.1038/srep44731)
- Jack, A. A. et al. 2017. The interaction of wood nanocellulose dressings and the wound pathogen P. aeruginosa. Carbohydrate Polymers 157, pp. 1955-1962. (10.1016/j.carbpol.2016.11.080)
2016
- Pritchard, M. F. et al. 2016. A new class of safe oligosaccharide polymer therapy to modify the mucus barrier of chronic respiratory disease. Molecular Pharmaceutics 13(3), pp. 863-872. (10.1021/acs.molpharmaceut.5b00794)
- Powell, L. C., Khan, S., Chinga-Carrasco, G., Wright, C. J., Hill, K. E. and Thomas, D. W. 2016. An investigation of Pseudomonas aeruginosa biofilm growth on novel nanocellulose fiber dressings. Carbohydrate Polymers 137, pp. 191-197. (10.1016/j.carbpol.2015.10.024)
- Roberts, J. L., Cattoz, B., Schweins, R., Beck, K., Thomas, D. W., Griffiths, P. C. and Ferguson, E. L. 2016. In vitro evaluation of the interaction of dextrin-colistin conjugates with bacterial lipopolysaccharide. Journal of Medicinal Chemistry 59(2), pp. 647-654. (10.1021/acs.jmedchem.5b01521)
2015
- Azzopardi, E. A., Ferguson, E. L. and Thomas, D. W. 2015. Development and validation of an in vitro pharmacokinetic/pharmacodynamic model to test the antibacterial efficacy of antibiotic polymer conjugates. Antimicrobial Agents and Chemotherapy 59(4), pp. 1837-1843. (10.1128/AAC.03708-14)
- Rees, A., Powell, L. C., Chinga-Carrasco, G., Gethin, D. T., Syverud, K., Hill, K. E. and Thomas, D. W. 2015. 3D bioprinting of carboxymethylated-periodate oxidized nanocellulose constructs for wound dressing applications. BioMedical Research International 2015, pp. 1-7., article number: 925757. (10.1155/2015/925757)
2014
- Ferguson, E. L., Azzopardi, E., Roberts, J. L., Walsh, T. R. and Thomas, D. W. 2014. Dextrin-Colistin conjugates as a model bioresponsive treatment for multidrug resistant bacterial infections. Molecular Pharmaceutics 11(12), pp. 4437-4447. (10.1021/mp500584u)
- Tondervik, A. et al. 2014. Alginate oligosaccharides inhibit fungal cell growth and potentiate the activity of anti-fungals against Candida and Aspergillus spp. PLoS ONE, article number: e112518. (10.1371/journal.pone.0112518)
- Peake, M. A. et al. 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22(3), pp. 399-405. (10.1111/wrr.12170)
- Powell, L. C. et al. 2014. A nanoscale characterization of the interaction of a novel alginate oligomer with the cell surface and motility of pseudomonas aeruginosa. American Journal of Respiratory Cell and Molecular Biology 50(3), pp. 483-492. (10.1165/rcmb.2013-0287OC)
- Azzopardi, E. A., Ferguson, E. L. and Thomas, D. W. 2014. A novel class of bioreponsive nanomedicines for localised reinstatement of bioactivity and specific targeting [Abstract]. The Lancet 383, pp. S9. (10.1016/S0140-6736(14)60272-5)
- McInnes, R. L. et al. 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22(1), pp. 58-69. (10.1111/wrr.12133)
2013
- Roberts, J. L. et al. 2013. An in vitro study of alginate oligomer therapies on oral biofilms. Journal of Dentistry 41(10), pp. 892-899. (10.1016/j.jdent.2013.07.011)
- Daw, A. E. et al. 2013. Differential cellular and microbial responses to nano-/micron-scale titanium surface roughness induced by hydrogen peroxide treatment. Journal of Biomaterials Applications 28(1), pp. 144-160. (10.1177/0885328212441495)
- Azzopardi, E. A., Ferguson, E. L. and Thomas, D. W. 2013. Colistin past and future: A bibliographic analysis. Journal of Critical Care 28(2), pp. 219.e13-219.e19. (10.1016/j.jcrc.2012.04.008)
- Azzopardi, E. A., Ferguson, E. L. and Thomas, D. W. 2013. The enhanced permeability retention effect: a new paradigm for drug targeting in infection. Journal of Antimicrobial Chemotherapy 68(2), pp. 257-274. (10.1093/jac/dks379)
- Powell, L. C. et al. 2013. The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms. Biofouling 29(4), pp. 413-421. (10.1080/08927014.2013.777954)
- Azzopardi, E. A., Camilleri, L., Moseley, R., Thomas, D. W. and Ferguson, E. L. 2013. Statistical characterization of succinoylated dextrin degradation behavior in human α-amylase. Journal of Carbohydrate Chemistry 32(7), pp. 438-449. (10.1080/07328303.2013.831434)
2012
- Hooper, S. J., Percival, S. L., Hill, K. E., Thomas, D. W., Hayes, A. J. and Williams, D. W. 2012. The visualisation and speed of kill of wound isolates on a silver alginate dressing. International Wound Journal 9(6), pp. 633-642. (10.1111/j.1742-481X.2012.00927.x)
- Khan, S. et al. 2012. Overcoming drug resistance with alginate oligosaccharides able to potentiate the action of selected antibiotics. Antimicrobial Agents and Chemotherapy 56(10), pp. 5134-5141. (10.1128/AAC.00525-12)
- Percival, S. L., Hill, K. E., Williams, D. W., Hooper, S. J., Thomas, D. W. and Costerton, J. W. 2012. A review of the scientific evidence for biofilms in wounds. Wound Repair and Regeneration 20(5), pp. 647-657. (10.1111/j.1524-475X.2012.00836.x)
- Wildeboer, D. et al. 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31(9), pp. 2183-2189. (10.1007/s10096-012-1553-6)
- Wagstaffe, S. J., Hill, K. E., Williams, D. W., Randle, B. J., Thomas, D. W., Stephens, P. and Riley, D. J. 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84(14), pp. 5876-5884. (10.1021/ac203403d)
- Hooper, S. J., Williams, D. W., Thomas, D. W., Hill, K. E. and Percival, S. L. 2012. An in vitro comparison of two silver- containing antimicrobial wound dressings. Ostomy Wound Management 58(1), pp. 16-22.
2011
- Ferguson, E. L., Roberts, J. L., Moseley, R., Griffiths, P. C. and Thomas, D. W. 2011. Evaluation of the physical and biological properties of hyaluronan and hyaluronan fragments. International Journal of Pharmaceutics 420(1), pp. 84-92. (10.1016/j.ijpharm.2011.08.031)
- Hardwicke, J., Hart, J., Bell, A., Duncan, R., Thomas, D. W. and Moseley, R. 2011. The effect of dextrin-rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse. Journal of Controlled Release 152(3), pp. 411-417. (10.1016/j.jconrel.2011.03.016)
- Percival, S. L., Hill, K. E., Malic, S., Thomas, D. W. and Williams, D. W. 2011. Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms. Wound Repair and Regeneration 19(1), pp. 1-9. (10.1111/j.1524-475X.2010.00651.x)
- Malic, S., Hill, K. E., Playle, R. A., Thomas, D. W. and Williams, D. W. 2011. In vitro interaction of chronic wound bacteria in biofilms. Journal of Wound Care 20(12), pp. 569-577.
2010
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
- Ferguson, E. L., Alshame, A. M. J. and Thomas, D. W. 2010. Evaluation of hyaluronic acid-protein conjugates for polymer masked-unmasked protein therapy. International Journal of Pharmaceutics 402(1-2), pp. 95-102. (10.1016/j.ijpharm.2010.09.029)
- Pukstad, B. . S. et al. 2010. Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers. Journal of Dermatological Science 59(2), pp. 115-122. (10.1016/j.jdermsci.2010.05.003)
- Hardwicke, J., Moseley, R., Stephens, P., Harding, K. G., Duncan, R. and Thomas, D. W. 2010. Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7(3), pp. 699-707. (10.1021/mp9002656)
- Davies, L. C. et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19(6), pp. 819-830. (10.1089/scd.2009.0089)
- Simpson, R. M. L., Wells, A., Thomas, D. W., Stephens, P., Steadman, R. and Phillips, A. O. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176(3), pp. 1215-1228. (10.2353/ajpath.2010.090802)
- Hardwicke, J., Song, B., Moseley, R. and Thomas, D. W. 2010. Investigation of the potential of polymer therapeutics in corneal re-epithelialisation. British Journal of Ophthalmology 94(12), pp. 1566-1570. (10.1136/bjo.2009.177295)
- Hill, K. E., Malic, S., McKee, R., Rennison, T., Harding, K. G., Williams, D. W. and Thomas, D. W. 2010. An in vitro model of chronic wound biofilms to test wound dressings and assess antimicrobial susceptibilities. Journal of Antimicrobial Chemotherapy 65(6), pp. 1195-1206. (10.1093/jac/dkq105)
2009
- Simpson, R. M. L., Meran, S., Thomas, D. W., Stephens, P., Bowen, T., Steadman, R. and Phillips, A. O. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175(5), pp. 1915-1928. (10.2353/ajpath.2009.090045)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
- Iversen, A. et al. 2009. A proviral role for CpG in cytomegalovirus infection. Journal of Immunology 182(9), pp. 5672-5681. (10.4049/jimmunol.0801268)
- Simpson, R. M., Stephens, P., Thomas, D., Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90(2), pp. A128-A129.
- Cook, H., Stephens, P., Davies, K. J., Harding, K. G. and Thomas, D. W. 2009. Phenotypic differences in wound healing responses are reflected by differences in ECM reorganisation and MMP-2 activation. Journal of Gastroenterology and Hepatology 24, pp. A88-A88. (10.1046/j.1365-2613.2000.0145k.x)
- Malic, S., Hill, K. E., Hayes, A. J., Percival, S. L., Thomas, D. W. and Williams, D. W. 2009. Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH). Microbiology-Sgm 155, pp. 2603-2611. (10.1099/mic.0.028712-0)
- Roberts, J., Drage, N., Davies, J. and Thomas, D. W. 2009. Effective dose from cone beam CT examinations in dentistry. British Journal of Radiology 82(973), pp. 35-40. (10.1259/bjr/31419627)
2008
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Hardwicke, J., Ferguson, E. L., Moseley, R., Stephens, P., Thomas, D. W. and Duncan, R. 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130(3), pp. 275-283. (10.1016/j.jconrel.2008.07.023)
- Meran, S., Thomas, D. W., Stephens, P., Enoch, S., Martin, J., Steadman, R. and Phillips, A. O. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283(10), pp. 6530-6545. (10.1074/jbc.M704819200)
- Enoch, S., Moseley, R., Stephens, P. and Thomas, D. W. 2008. The oral mucosa: A model of wound healing with reduced scarring. Oral Surgery 1, pp. 11-21. (10.1111/j.1752-248x.2007.00005.x)
- Peake, M. A., Giles, P. J., Wall, I. B., Enoch, S., Kipling, D. G., Thomas, D. W. and Stephens, P. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16(6), pp. A71. (10.1111/j.1524-475X.2008.00424.x)
- Nagassa, M. E., Daw, A. E., Rowe, W. G., Carley, A. F., Thomas, D. W. and Moseley, R. 2008. Optimisation of the hydrogen peroxide pre-treatment of titanium: surface characterisation and protein adsorption. Clinical Oral Implants Research 19(12), pp. 1317-1326. (10.1111/j.1600-0501.2008.01611.x)
- Hardwicke, J., Schmaljohann, D., Boyce, D. and Thomas, D. W. 2008. Epidermal growth factor therapy and wound healing - past, present and future. Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 6(3), pp. 172-177. (10.1016/S1479-666X(08)80114-X)
- Meran, S., Steadman, R., Phillips, A. O., Thomas, D. W. and Stephens, P. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16(2), pp. A12. (10.1111/j.1524-475X.2008.00371.x)
2007
- Meran, S., Thomas, D. W., Stephens, P., Martin, J., Bowen, T., Phillips, A. O. and Steadman, R. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282(35), pp. 25687-25697. (10.1074/jbc.M700773200)
- Malic, S., Hill, K. E., Ralphs, J. R., Hayes, A. J., Thomas, D. W., Potts, A. J. C. and Williams, D. W. 2007. Characterisation of Candida albicans infection of an in vitro oral epithelial model using confocal laser scanning microscopy. Oral Microbiology And Immunolology 22(3), pp. 188-194. (10.1111/j.1399-302X.2007.00344.x)
- Davies, C. E., Hill, K. E., Newcombe, R. G., Stephens, P., Wilson, M., Harding, K. G. and Thomas, D. W. 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15(1), pp. 17-22. (10.1111/j.1524-475X.2006.00180.x)
- Andersen, A., Hill, K. E., Stephens, P., Thomas, D. W., Jorgensen, B. and Krogfelt, K. A. 2007. Bacterial profiling using skin grafting, standard culture and molecular bacteriological methods. Journal of Wound Care 16(4), pp. 171-175.
2006
- Seager, J. M., Howell-Jones, R. S., Dunstan, F. D. J., Lewis, M. A. O., Richmond, S. and Thomas, D. W. 2006. A randomised controlled trial of clinical outreach education to rationalise antibiotic prescribing for acute dental pain in the primary care setting. British Dental Journal 201(4), pp. 217-222. (10.1038/sj.bdj.4813879)
- Howell-Jones, R., Price, P. E., Howard, A. J. and Thomas, D. W. 2006. Antibiotic prescribing for chronic skin wounds in primary care. Wound Repair and Regeneration 14(4), pp. 387-393. (10.1111/j.1743-6109.2006.00144.x)
- Tebble, N., Adams, R., Thomas, D. W. and Price, P. E. 2006. Anxiety and self-consciousness in patients with facial lacerations one week and six months later. British Journal of Oral & Maxillofacial Surgery 44(6), pp. 520-525. (10.1016/j.bjoms.2005.10.010)
2005
- Howell-Jones, R. S., Wilson, M., Hill, K. E., Howard, A. J., Price, P. E. and Thomas, D. W. 2005. A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. Journal of Antimicrobial Chemotherapy 55(2), pp. 143-149. (10.1093/jac/dkh513)
2004
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
- Davies, C. E., Hill, K. E., Wilson, M., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42(8), pp. 3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
- Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117(15), pp. 3389-3403. (10.1242/jcs.01188)
- Enoch, S., Price, P. E., Harding, K. G., Thomas, D. W. and Stephens, P. 2004. Identifying the molecular and genetic basis for non-healing wounds, scarless healing and scarring: study of human fibroblasts. British Journal of Surgery 91(S1), pp. 82-82.
- Moseley, R., Stewart, J. E., Stephens, P., Waddington, R. J. and Thomas, D. W. 2004. Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?. British Journal of Dermatology 150(3), pp. 401-413. (10.1111/j.1365-2133.2004.05845.x)
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
2003
- Hill, K. E., Davies, C. E., Wilson, M., Stephens, P., Harding, K. G. and Thomas, D. W. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52(4), pp. 365-369. (10.1099/jmm.0.05030-0)
- Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148(3), pp. 456-466. (10.1046/j.1365-2133.2003.05232.x)
- Stephens, P. et al. 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283(1), pp. 22-35. (10.1016/S0014-4827(02)00021-6)
- White, P., Thomas, D. W., Fong, S., Stelnicki, E., Meijlink, F., Largman, C. and Stephens, P. 2003. Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. Journal Of Investigative Dermatology 120(1), pp. 135-144. (10.1046/j.1523-1747.2003.12015.x)
2002
- Hill, K. E. et al. 2002. Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51(11), pp. 949-957.
- Wall, I. B., Davies, C. E., Hill, K. E., Wilson, M. J., Stephens, P., Harding, K. G. and Thomas, D. W. 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10(6), pp. 346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
- Wall, S. J., Bevan, D., Thomas, D. W., Harding, K. G., Edwards, D. R. and Murphy, G. 2002. Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse. Journal of Investigative Dermatology 119(1), pp. 91-98. (10.1046/j.1523-1747.2002.01779.x)
- Stephens, P. and Thomas, D. W. 2002. The cellular proliferative phase of the wound repair process. Journal of Wound Care 11(7), pp. 253-261. (10.12968/jowc.2002.11.7.26421)
- Wall, S. J., Bevan, D., Thomas, D. W., Harding, K. G., Edwards, D. R. and Murphy, G. 2002. Differential expression of matrix matalloproteinases during impaired wound healing of the diabetes mouse. Journal of Investigative Dermatology 119(1), pp. 91-98. (10.1046/j.1523-1747.2002.01779.x)
2001
- Davies, C. E., Wilson, M. J., Hill, K. E., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9(5), pp. 332-340. (10.1046/j.1524-475x.2001.00332.x)
- Thomas, D. W., Baboolal, K., Subramanian, N. and Newcombe, R. G. 2001. Cyclosporin A-induced gingival overgrowth is unrelated to allograft function in renal transplant recipients. Journal of clinical periodontology 28(7), pp. 706-709. (10.1034/j.1600-051x.2001.028007706.x)
- Hill, C. M., Balkenohl, M., Thomas, D. W., Walker, R. V., Mathe, H. and Murray, G. 2001. Pregabalin in patients with postoperative dental pain. European Journal of Pain 5(2), pp. 119-124. (10.1053/eujp.2001.0235)
- Stephens, P. et al. 2001. Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity. British Journal Of Dermatology 144(2), pp. 229-237. (10.1046/j.1365-2133.2001.04006.x)
- Stephens, P., Hiscox, S. E., Cook, H., Jiang, W. G., Zhiquiang, W. and Thomas, D. W. 2001. Phenotypic variation in the production of bioactive hepatocyte growth factor/scatter factor by oral mucosal and skin fibroblasts. Wound Repair and Regeneration 9(1), pp. 34-43. (10.1046/j.1524-475x.2001.00034.x)
2000
- Cook, H., Stephens, P., Davies, K. J., Thomas, D. W. and Harding, K. G. 2000. Defective Extracellular Matrix Reorganization by Chronic Wound Fibroblasts is Associated with Alterations in TIMP-1, TIMP-2, and MMP-2 Activity. Journal of Investigative Dermatology 115(2), pp. 225-233. (10.1046/j.1523-1747.2000.00044.x)
- Thomas, D. W., Hill, C. M., Lewis, M. A. O., Stephens, P., Walker, R. and Von Der Weth, A. 2000. Randomized clinical trial of the effect of semi-occlusive dressings on the microflora and clinical outcome of acute facial wounds. Wound Repair and Regeneration 8(4), pp. 258-263. (10.1046/j.1524-475x.2000.00258.x)
1998
- Stephens, M., Lim, K., Stephens, P., Lim, S. H. and Thomas, D. W. 1998. Molecular characterisation of tumour infiltrating lymphocytes in oral squamous cell carcinoma. Cancer Immunology, Immunotherapy 46(1), pp. 34-40. (10.1007/s002620050457)
1997
- Lim, S. H., Stephens, P., Cao, Q., Coleman, S. L. and Thomas, D. 1997. Molecular analysis of T cell receptor beta variability in a patient with orofacial granulomatosis. Gut 40(5), pp. 683-686. (10.1136/gut.40.5.683)
- Thomas, D. W., Stephens, P., Stephens, M., Patten, D. W. and Lim, S. H. 1997. T-cell receptor Vbeta usage by lesional lymphocytes in oral lichen planus. Journal of Oral Pathology & Medicine 26(3), pp. 105-109. (10.1111/j.1600-0714.1997.tb00031.x)
- al-Khateeb, T., Stephens, P., Shepherd, J. and Thomas, D. 1997. An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model. Journal of Periodontology 68(11), pp. 1063-1069. (10.1902/jop.1997.68.11.1063)
1996
- Stephens, P., Davies, K. J., Al-Khateeb, T., Shepherd, J. P. and Thomas, D. W. 1996. A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction. Journal of Dental Research 75(6), pp. 1358-1364. (10.1177/00220345960750060601)
- Stephens, P., Al-Khateeb, T., Davies, K. J., Shepherd, J. P. and Thomas, D. W. 1996. An investigation of the interaction between alcohol and fibroblasts in wound healing. International Journal of Oral and Maxillofacial Surgery 25(2), pp. 161-164. (10.1016/S0901-5027(96)80065-8)
Cynadleddau
- Jones, T. et al. 2021. The potential transmission of COVID-19 during routine dental surgery. Presented at: 8th UK–China International Particle Technology Forum 2021, Dali, Tunnan, China, 9-13 July 2021.
- Blaikie, P., Nishio Ayre, W., Thomas, D., Begum, T., Eaton, M., Harwood, C. and Crivelli, D. 2018. A smart surgical tool for optimal dental implant fixation. Presented at: 96th General Session of the IADR, London, UK, 25-28 Jul 2018.
Erthyglau
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- Roberts, J., Drage, N., Davies, J. and Thomas, D. W. 2009. Effective dose from cone beam CT examinations in dentistry. British Journal of Radiology 82(973), pp. 35-40. (10.1259/bjr/31419627)
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Hardwicke, J., Ferguson, E. L., Moseley, R., Stephens, P., Thomas, D. W. and Duncan, R. 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130(3), pp. 275-283. (10.1016/j.jconrel.2008.07.023)
- Meran, S., Thomas, D. W., Stephens, P., Enoch, S., Martin, J., Steadman, R. and Phillips, A. O. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283(10), pp. 6530-6545. (10.1074/jbc.M704819200)
- Enoch, S., Moseley, R., Stephens, P. and Thomas, D. W. 2008. The oral mucosa: A model of wound healing with reduced scarring. Oral Surgery 1, pp. 11-21. (10.1111/j.1752-248x.2007.00005.x)
- Peake, M. A., Giles, P. J., Wall, I. B., Enoch, S., Kipling, D. G., Thomas, D. W. and Stephens, P. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16(6), pp. A71. (10.1111/j.1524-475X.2008.00424.x)
- Nagassa, M. E., Daw, A. E., Rowe, W. G., Carley, A. F., Thomas, D. W. and Moseley, R. 2008. Optimisation of the hydrogen peroxide pre-treatment of titanium: surface characterisation and protein adsorption. Clinical Oral Implants Research 19(12), pp. 1317-1326. (10.1111/j.1600-0501.2008.01611.x)
- Hardwicke, J., Schmaljohann, D., Boyce, D. and Thomas, D. W. 2008. Epidermal growth factor therapy and wound healing - past, present and future. Surgeon-Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 6(3), pp. 172-177. (10.1016/S1479-666X(08)80114-X)
- Meran, S., Steadman, R., Phillips, A. O., Thomas, D. W. and Stephens, P. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16(2), pp. A12. (10.1111/j.1524-475X.2008.00371.x)
- Meran, S., Thomas, D. W., Stephens, P., Martin, J., Bowen, T., Phillips, A. O. and Steadman, R. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282(35), pp. 25687-25697. (10.1074/jbc.M700773200)
- Malic, S., Hill, K. E., Ralphs, J. R., Hayes, A. J., Thomas, D. W., Potts, A. J. C. and Williams, D. W. 2007. Characterisation of Candida albicans infection of an in vitro oral epithelial model using confocal laser scanning microscopy. Oral Microbiology And Immunolology 22(3), pp. 188-194. (10.1111/j.1399-302X.2007.00344.x)
- Davies, C. E., Hill, K. E., Newcombe, R. G., Stephens, P., Wilson, M., Harding, K. G. and Thomas, D. W. 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15(1), pp. 17-22. (10.1111/j.1524-475X.2006.00180.x)
- Andersen, A., Hill, K. E., Stephens, P., Thomas, D. W., Jorgensen, B. and Krogfelt, K. A. 2007. Bacterial profiling using skin grafting, standard culture and molecular bacteriological methods. Journal of Wound Care 16(4), pp. 171-175.
- Seager, J. M., Howell-Jones, R. S., Dunstan, F. D. J., Lewis, M. A. O., Richmond, S. and Thomas, D. W. 2006. A randomised controlled trial of clinical outreach education to rationalise antibiotic prescribing for acute dental pain in the primary care setting. British Dental Journal 201(4), pp. 217-222. (10.1038/sj.bdj.4813879)
- Howell-Jones, R., Price, P. E., Howard, A. J. and Thomas, D. W. 2006. Antibiotic prescribing for chronic skin wounds in primary care. Wound Repair and Regeneration 14(4), pp. 387-393. (10.1111/j.1743-6109.2006.00144.x)
- Tebble, N., Adams, R., Thomas, D. W. and Price, P. E. 2006. Anxiety and self-consciousness in patients with facial lacerations one week and six months later. British Journal of Oral & Maxillofacial Surgery 44(6), pp. 520-525. (10.1016/j.bjoms.2005.10.010)
- Howell-Jones, R. S., Wilson, M., Hill, K. E., Howard, A. J., Price, P. E. and Thomas, D. W. 2005. A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. Journal of Antimicrobial Chemotherapy 55(2), pp. 143-149. (10.1093/jac/dkh513)
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
- Davies, C. E., Hill, K. E., Wilson, M., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42(8), pp. 3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
- Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117(15), pp. 3389-3403. (10.1242/jcs.01188)
- Enoch, S., Price, P. E., Harding, K. G., Thomas, D. W. and Stephens, P. 2004. Identifying the molecular and genetic basis for non-healing wounds, scarless healing and scarring: study of human fibroblasts. British Journal of Surgery 91(S1), pp. 82-82.
- Moseley, R., Stewart, J. E., Stephens, P., Waddington, R. J. and Thomas, D. W. 2004. Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?. British Journal of Dermatology 150(3), pp. 401-413. (10.1111/j.1365-2133.2004.05845.x)
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
- Hill, K. E., Davies, C. E., Wilson, M., Stephens, P., Harding, K. G. and Thomas, D. W. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52(4), pp. 365-369. (10.1099/jmm.0.05030-0)
- Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148(3), pp. 456-466. (10.1046/j.1365-2133.2003.05232.x)
- Stephens, P. et al. 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283(1), pp. 22-35. (10.1016/S0014-4827(02)00021-6)
- White, P., Thomas, D. W., Fong, S., Stelnicki, E., Meijlink, F., Largman, C. and Stephens, P. 2003. Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. Journal Of Investigative Dermatology 120(1), pp. 135-144. (10.1046/j.1523-1747.2003.12015.x)
- Hill, K. E. et al. 2002. Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51(11), pp. 949-957.
- Wall, I. B., Davies, C. E., Hill, K. E., Wilson, M. J., Stephens, P., Harding, K. G. and Thomas, D. W. 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10(6), pp. 346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
- Wall, S. J., Bevan, D., Thomas, D. W., Harding, K. G., Edwards, D. R. and Murphy, G. 2002. Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse. Journal of Investigative Dermatology 119(1), pp. 91-98. (10.1046/j.1523-1747.2002.01779.x)
- Stephens, P. and Thomas, D. W. 2002. The cellular proliferative phase of the wound repair process. Journal of Wound Care 11(7), pp. 253-261. (10.12968/jowc.2002.11.7.26421)
- Wall, S. J., Bevan, D., Thomas, D. W., Harding, K. G., Edwards, D. R. and Murphy, G. 2002. Differential expression of matrix matalloproteinases during impaired wound healing of the diabetes mouse. Journal of Investigative Dermatology 119(1), pp. 91-98. (10.1046/j.1523-1747.2002.01779.x)
- Davies, C. E., Wilson, M. J., Hill, K. E., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9(5), pp. 332-340. (10.1046/j.1524-475x.2001.00332.x)
- Thomas, D. W., Baboolal, K., Subramanian, N. and Newcombe, R. G. 2001. Cyclosporin A-induced gingival overgrowth is unrelated to allograft function in renal transplant recipients. Journal of clinical periodontology 28(7), pp. 706-709. (10.1034/j.1600-051x.2001.028007706.x)
- Hill, C. M., Balkenohl, M., Thomas, D. W., Walker, R. V., Mathe, H. and Murray, G. 2001. Pregabalin in patients with postoperative dental pain. European Journal of Pain 5(2), pp. 119-124. (10.1053/eujp.2001.0235)
- Stephens, P. et al. 2001. Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity. British Journal Of Dermatology 144(2), pp. 229-237. (10.1046/j.1365-2133.2001.04006.x)
- Stephens, P., Hiscox, S. E., Cook, H., Jiang, W. G., Zhiquiang, W. and Thomas, D. W. 2001. Phenotypic variation in the production of bioactive hepatocyte growth factor/scatter factor by oral mucosal and skin fibroblasts. Wound Repair and Regeneration 9(1), pp. 34-43. (10.1046/j.1524-475x.2001.00034.x)
- Cook, H., Stephens, P., Davies, K. J., Thomas, D. W. and Harding, K. G. 2000. Defective Extracellular Matrix Reorganization by Chronic Wound Fibroblasts is Associated with Alterations in TIMP-1, TIMP-2, and MMP-2 Activity. Journal of Investigative Dermatology 115(2), pp. 225-233. (10.1046/j.1523-1747.2000.00044.x)
- Thomas, D. W., Hill, C. M., Lewis, M. A. O., Stephens, P., Walker, R. and Von Der Weth, A. 2000. Randomized clinical trial of the effect of semi-occlusive dressings on the microflora and clinical outcome of acute facial wounds. Wound Repair and Regeneration 8(4), pp. 258-263. (10.1046/j.1524-475x.2000.00258.x)
- Stephens, M., Lim, K., Stephens, P., Lim, S. H. and Thomas, D. W. 1998. Molecular characterisation of tumour infiltrating lymphocytes in oral squamous cell carcinoma. Cancer Immunology, Immunotherapy 46(1), pp. 34-40. (10.1007/s002620050457)
- Lim, S. H., Stephens, P., Cao, Q., Coleman, S. L. and Thomas, D. 1997. Molecular analysis of T cell receptor beta variability in a patient with orofacial granulomatosis. Gut 40(5), pp. 683-686. (10.1136/gut.40.5.683)
- Thomas, D. W., Stephens, P., Stephens, M., Patten, D. W. and Lim, S. H. 1997. T-cell receptor Vbeta usage by lesional lymphocytes in oral lichen planus. Journal of Oral Pathology & Medicine 26(3), pp. 105-109. (10.1111/j.1600-0714.1997.tb00031.x)
- al-Khateeb, T., Stephens, P., Shepherd, J. and Thomas, D. 1997. An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model. Journal of Periodontology 68(11), pp. 1063-1069. (10.1902/jop.1997.68.11.1063)
- Stephens, P., Davies, K. J., Al-Khateeb, T., Shepherd, J. P. and Thomas, D. W. 1996. A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction. Journal of Dental Research 75(6), pp. 1358-1364. (10.1177/00220345960750060601)
- Stephens, P., Al-Khateeb, T., Davies, K. J., Shepherd, J. P. and Thomas, D. W. 1996. An investigation of the interaction between alcohol and fibroblasts in wound healing. International Journal of Oral and Maxillofacial Surgery 25(2), pp. 161-164. (10.1016/S0901-5027(96)80065-8)
Teaching
Clinically, in our postgraduate training Programme in Implantology, 15 years ago I established, with my colleague Rob Adams, the Implantology educational Programme at Cardiff. Starting with "short" (3-day) CPD courses, we developed structured training courses (in bone- and soft-tissue grafting) and then a full-time Masters Programme in 2008. In 2012, we launched a part-time Diploma/Masters programme in Implantology to allow practitioners to undertake these qualifications and to date we have trained >100 individuals. The group has now grown with 3 Lecturers (Rob, Adrian Binney and Nick Claydon) and in 2014 will welcome 10 students to the Programme. In 2014 the UK's first postgraduate programme in the management of peri-implantitis. My main clinical interest is in implantology and bone- and soft-tissue grafting to replace missing tissues as part of implant therapy.
Biography
Since returning to Cardiff following a Wellcome Clinical Research Fellowship at Bristol, I started my research group as a full-time Registrar/Lecturer in Oral & Maxillofacial Surgery it numbers over 10 individuals and have been fortunate to attract over £15M in funding. Working on a variety of projects in wound healing and nanomedicines, clinical utility is key to our group's activities; we have obtained numerous international and national patents in the UK, EU, US and Australia (including a family of patents on the OligoG alginates). We have, with our industrial collaborators Algipharma AS and the support of funding agencies (Norwegian Research Council, MRC, Wellcome, EU) polymer therapies at all stages of development, from in-vitro screening to Phase 2b multi-centre trials. This work has moved forward latterly in collaboration with researchers in Trondheim and Swansea University with the support of US Dept of Defence, the US Cystic Fibrosis Foundation and a €3M EU Eurostars Programme (www.eurostars-eureka.eu) to our collaborators.
Honours and awards
King James IV Professor RCS (2013-2014)
Professional memberships
SSA
Academic positions
2013-2014 King James IV Professor, Royal College of Surgeons of Edinburgh
2013- STC Royal College Representative, NHS Education for Scotland
2012-2013 Scientific Consultant, US Department of Defence
2012 Invited expert, European Commission Brussels; Nanomedicine for Biohorizons 2020
2008-2012 Integrated Academic Training Programme Director, Dentistry (Wales)
2008-2012 Elected President, Academic Association British Oral & Maxillofacial Surgeons
2007-2010 Elected Secretary, European Tissue Repair Society
2010 Elected European Science Foundation Nanomedicine Conference Organising Committee
2006-2010 Vice Dean Research (School of Dentistry)
2004- 2010 Clinical Executive Manager Cardiff Institute of Tissue Engineering & Repair
2002-Present Professor /Honorary Consultant in Oral & Maxillofacial Surgery (Cardiff University)
1992 - 1996 Lecturer / Honorary Senior Registrar in Oral & Maxillofacial Surgery (Cardiff)
1989 - 1992 Wellcome Clinical Research Fellow (Bristol)
