Dr Rebecca Sims

Dr Rebecca Sims

Research Fellow, Division of Psychological Medicine and Clinical Neurosciences

School of Medicine

Email:
simsrc@cardiff.ac.uk
Telephone:
+44 (0)29 2068 8450
Location:
2.26, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ

Identifying Risk Genes for Common Alzheimer's disease

I use large scale genome-wide association and sequencing studies to identify genes that affect an individual's risk of developing late-onset Alzheimer’s disease.

I am a neurogeneticist with over ten years experience in neurodegeneration research. I have a particular interest in the generation of large-scale powerful datasets and data analysis. I have significant experience of International collaboration, maintaining networks and producing high quality publications. My recent work has included leading genome-wide association projects, such as exome chip array studies. My current work focuses on the translation of genetic findings to disease relevant induced pluripotent cell models, and utilizes Next Generation Sequencing (NGS) technology to identify novel risk loci for early-onset Alzheimer’s disease.

EMPLOYMENT

2016–ongoing CARDIFF UNIVERSITY, SCHOOL OF MEDICINE.

Tenured Fast Track Fellow

2012–Present  CARDIFF UNIVERSITY, SCHOOL OF MEDICINE.

Research Fellow.

Funded by Alzheimer’s Society Fellowship Award.

2010–2012      CARDIFF UNIVERSITY, SCHOOL OF MEDICINE.

Research Associate in the department of Psychological Medicine.

Funded via MRC Programme Grant.

FURTHER EDUCATION

2012-Present   CARDIFF UNIVERSITY, SCHOOL OF MEDICINE.

MSc Genetic Epidemiology and Bioinformatics

2005-2009      CARDIFF UNIVERSITY, SCHOOL OF MEDICINE.

PhD “The genetics of Alzheimer’s disease with psychosis.”

2001-2005      CARDIFF UNIVERSITY, SCHOOL OF BIOSCIENCES.

BSc Genetics  (2.1)

Honours and awards

CONFERENCE PRESENTATIONS

Alzheimer’s Society 2015 Oral presentation: Studying Alzheimer’s Genetics using Rare Variant Microarrays

AAIC 2015 Poster presentation: Powerful Study of Rare Variation in Alzheimer’s disease

BNA 2015 Oral presentation: Advances in Alzheimer’s Genetics

AAIC 2012 Poster presentation: Follow up of Alzheimer’s disease with psychosis genome-wide association studies

AAIC 2011 Poster presentation: No consistent evidence for association between mtDNA variants and Alzheimer disease

ESHG 2011 Poster presentation: Investigating Runs of Homozygosity in Alzheimer’s disease

ICAD 2010 Poster presentation: Mitochondrial Genome-Wide Association Study of Alzheimer’s disease

ICAD 2009 Poster presentation: Investigating psychosis candidate genes in Alzheimer’s disease with psychosis using genome-wide association (GWA) studies.

Wellcome Trust 2009 Oral and Poster presentation: Genome Wide Association Study for Alzheimer’s disease with Psychotic Symptoms

ASHG 2008 Poster presentation: Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) and association with Psychosis In Alzheimer’s disease

ICAD 2008 Poster presentation: Testing for association between Alzheimer’s disease with psychosis and variants identified as influencing risk of schizophrenia

Professional memberships

Member of the Genetics Society

My research identifies susceptibility genes for Alzheimer's disease. I have a particular interest in analysing rare frequency genetic variation and my recent work implicates immune cells, specifically microglia in disease development.

Funding

2015-2018     JOINT PROGRAMME FOR NEURODEGENERATIVE DISEASE

"A European AD DNA bank (EADB)" (UK-PI: 1,599,069€)

2016-2018     CENTRES OF EXCELLENCE IN NEURODEGENERATION

"Therapeutic targeting of impaired lysosomal flux in Alzheimer’s disease"   (Co-PI: £284,126)

2015               MOONDANCE FOUNDATION

“Moondance Centre for Young-onset Dementia” (Co-PI: £500,00)

2015               WELSH GOVERNMENT STRATEGIC AWARD

“Purchase of MassArray Genotyping Platform” (PI: £115,517)

2012-2016      ALZHEIMER’S SOCIETY RESEARCH FELLOWSHIP.

“Powerful Study of Rare Variants in Alzheimer’s disease” (PI: £200,000).

External profiles