Overview
I provide analysis support and teaching for data-driven research within the Systems Immunity Research Institute and the College of Biomedical and Life Sciences. My projects include: ‘omic analysis, analysis coaching, data clinics, establishing research networks and infrastructure.
Publications
2021
- Jones, R. E.et al. 2021. Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer's disease. Scientific Reports 11(1), article number: 14935. (10.1038/s41598-021-94324-z)
- Hrastelj, J.et al. 2021. CSF-resident CD4+ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis. Brain Communications (10.1093/braincomms/fcab155)
- Takala, R.et al. 2021. Anti-inflammatory and immunoregulatory effects of pinolenic acid in rheumatoid arthritis. Rheumatology (10.1093/rheumatology/keab467)
- Khalid, U.et al. 2021. Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules. Scientific Reports 11(1), article number: 9862. (10.1038/s41598-021-89195-3)
- Sands, K.et al. 2021. Characterization of antimicrobial resistant Gram-negative bacteria that cause neonatal sepsis in seven low and middle-income countries. Nature Microbiology 6, pp. 512–523. (10.1038/s41564-021-00870-7)
- Crittenden, S.et al. 2021. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science Advances 7(7), article number: eabd7954. (10.1126/sciadv.abd7954)
- Ponsford, M. J.et al. 2021. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology (10.1136/jclinpath-2020-207157)
- Tyrrell, V. J.et al. 2021. Lipidomic and transcriptional analysis of the Linoleoyl-omega-Hydroxyceramide biosynthetic pathway in human psoriatic lesions. Journal of Lipid Research 62, article number: 100094. (10.1016/j.jlr.2021.100094)
2020
- Pires, A.et al. 2020. Immune remodelling of the extracellular matrix drives loss of cancer stem cells and tumor rejection. Cancer Immunology Research 8(12), pp. 1520 - 1531. (10.1158/2326-6066.CIR-20-0070)
- Greenshields-Watson, A.et al. 2020. CD4 + T cells recognize conserved influenza A epitopes through shared patterns of V-Gene usage and complementary biochemical features. Cell Reports 32(2), article number: 107885. (10.1016/j.celrep.2020.107885)
- Meckelmann, S. W.et al. 2020. Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274. Circulation: Genomic and Precision Medicine 13(3), pp. 149-164., article number: e002806. (10.1161/CIRCGEN.119.002806)
- Scurr, M. J.et al. 2020. Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. Clinical Cancer Research (10.1158/1078-0432.CCR-19-3087)
2019
- Thompson, A.et al. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15(6), article number: e1007850. (10.1371/journal.ppat.1007850)
- Twohig, J. P.et al. 2019. Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. Nature Immunology 20, pp. 458-470. (10.1038/s41590-019-0350-0)
- Allen-Redpath, K.et al. 2019. Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity. Proceedings of the National Academy of Sciences 116(16), pp. 8038-8047. (10.1073/pnas.1814409116)
- Liu, Z.et al. 2019. Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p. Cell Death and Disease 10, article number: 55. (10.1038/s41419-018-1287-1)
- Lear, B.et al. 2019. De novo transcriptome analysis of peduncle necking in cut Rosa hybrida cultivar 'H30'. Acta Horticulturae 1263, pp. 351-358.
2018
- Kentala, H.et al. 2018. OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism. Cellular and Molecular Life Sciences 75(21), pp. 4041-4057.
- McCully, M. L.et al. 2018. CCR8 expression defines tissue-resident memory T cells in human skin. Journal of Immunology 200(5), pp. 1639-1650. (10.4049/jimmunol.1701377)
- McNamara, G. I.et al. 2018. Loss of offspring Peg3 reduces neonatal ultrasonic vocalizations and increases maternal anxiety in wild-type mothers. Human Molecular Genetics 27(3), pp. 440-450. (10.1093/hmg/ddx412)
- Kentala, H.et al. 2018. Analysis of ORP2 knockout hepatocytes uncovers a novel function in actin cytoskeletal regulation. FASEB Journal (10.1096/fj.201700604R)
2017
- Dovey, O. M.et al. 2017. Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia. Blood 130(17), pp. 1911-1922. (10.1182/blood-2017-01-760595)
- Fisher, C., Andrews, R. and Skarnes, W. 2017. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Nucleic Acids Research (10.1093/nar/gkx811)
- Liao, C.et al. 2017. Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes. Kidney International 91(5), pp. 1088-1103. (10.1016/j.kint.2016.10.030)