Ewch i’r prif gynnwys
Dr Alex White

Dr Alex White

Lecturer and Examinations Officer

Ysgol Fferylliaeth a Gwyddorau Fferyllol

Email
whiteaw@cardiff.ac.uk
Telephone
+44 (0)29 2087 6308
Campuses
Adeilad Redwood , Rhodfa'r Brenin Edward VII, Caerdydd, CF10 3NB

Major interests concern the design and synthesis of novel anti-cancer agents. This involves synthetic organic chemistry, molecular modelling, purification methods and spectroscopy, particularly high field NMR, and close collaboration with biochemists. Particularly of interest is the development of natural product lead compounds as clinically useful chemotherapeutic agents.

Career profile 

Graduated from the University of Newcastle upon Tyne and awarded a PhD in anti-cancer drug design from the same University. Held a faculty research position at the Arizona State University Cancer Research Institute under Professor Bob Pettit studying the anti-cancer constituents of marine organisms. Returned to the UK as a research associate at the Northern Institute of Cancer Research (1998-2000) and joined the staff of the School of Pharmacy and Pharmaceutical Sciences in 2000.

2019

2013

2012

2011

2010

2008

2004

2002

2000

Convenor of undergraduate examinations

  • PH1121  Molecule to patient
  • PH1122  The role of the pharmacist in professional practice
  • PH1123  Structure and function of cells and microbes
  • PH1124  Human body systems
  • PH1125  Chemical and biological properties of drug molecules
  • PH2110  Clinical & professional pharmacy
  • PH2112  Principles of drug design
  • PH2113  Diseases and drugs I
  • PH3101  Optimisation of drug design
  • PH3110  Optimisation of pharmaceutical care
  • PH3202  Research methodology
  • PH4116  Pharmacy research or scholarship project
  • PH4117  Pharmaceutical sciences, pharmacy practice and the population
  • PH4118  Pharmaceutical sciences, pharmacy practice and the patient

Research interests

Major interests concern the design and synthesis of novel anti-cancer agents. This involves synthetic organic chemistry, molecular modelling, purification methods and spectroscopy, particularly high field NMR, and close collaboration with biochemists. Particularly of interest is the development of natural product lead compounds as clinically useful chemotherapeutic agents.

Anti-cancer drug design

Structure-based drug design against various targets of interest including the DNA damage response, the EGFR-IGFR1 signalling pathway and the cell cycle. Several novel lead compounds have been identified that are currently undergoing further development. 

Novel treatments for psoriasis

We have successfully developed a novel co-drug for the treatment of psoriasis with improved therapeutic and topical delivery properties compared to current treatments for the disease. 

Natural Products Research

We have been investigating natural products from Welsh marine organisms and have identified anti-cancer activity in extracts from Welsh sponges. Currently involved in isolation and characterisation of discrete biologically active molecules.

Goruchwyliaeth gyfredol

Benjamin Dummer

Research student