Ewch i’r prif gynnwys
Yr Athro Andrea Brancale

Yr Athro Andrea Brancale

Reader

Ysgol Fferylliaeth a Gwyddorau Fferyllol

I graduated in Medicinal Chemistry at the University of Rome "La Sapienza" in 1996, and moved to Cardiff in 1997. I completed my PhD at Cardiff University in 2001 under the supervision of Professor McGuigan working on a novel class on anti-VZV (Varicella Zoster Virus) nucleosides. 

Following a two year post-doctoral position under the supervision of Professor McGuigan, I was appointed lecturer in Medicinal Chemistry in 2002 and promoted to senior lecturer in 2011.

Qualifications

PhD in Medicinal Chemistry. The Welsh School of Pharmacy, Cardiff, 2001

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  • PH1122  The role of the pharmacist in professional practice
  • PH1125  Chemical and biological properties of drug molecules
  • PH2112  Principles of drug design
  • PH3101  Optimisation of drug design
  • PH3202  Research methodology
  • PH4116  Pharmacy research or scholarship project
  • PH4117  Pharmaceutical sciences, pharmacy practice and the population
  • PH3110  Optimisation of pharmaceutical care
  • Laboratory classes; Molecular Modelling workshops using MOE (Chemical Computing Group); Research Projects

Research interests

  • Computer-aided design and synthesis of novel antiviral agents 
  • Design and optimisation of novel anti-tubulin agents 
  • Molecular modeling software development

My group research is focused on the use of computer-aided techniques in the design and discovery of novel anti-viral and anti-cancer compounds. Some representative projects are described below.

Development of a haptic-driven molecular modeling environment

The development of many modelling software packages is often oriented toward limiting the human intervention, considered to be the bottleneck of the process. The user carries out preparation of the input and analysis of the output, leaving the rest of the discovery process to the computer. Indeed, the use of these methodologies has led to many successes, but it would be fair to ask us if a process that relies mostly on computer pseudo-knowledge whilst, marginalizing researcher knowledge, could be really considered a rational approach. 

We are developing a novel immersive molecular modelling simulator where the user uses a haptic device to probe a biological target and its interactions with a potential drug, feeling the forces and molecular interactions on his/her hand while having complete three dimensional visual feedback.

Key expertise

  • Computer-aided Drug Design methodologies (De Novo drug design, Virtual screening, homology modelling)
  • Organic synthetic chemistry
  • Analytical spectroscopy (NMR, mass spectrometry)

Experience

Before being appointed as lecturer, my research experiences were mainly in the design and synthesis of novel antiviral nucleosides and nucleotides. When I started my academic appointment I focused my scientific interest in the use of computer-based techniques to understand biological problems and design novel potential drugs, in particular in the antiviral and anticancer research fields. In my research project I apply several different structure-based methodologies, like molecular docking, homology modelling and molecular dynamics. More recently, I have made a strategic decision to expand my research in the molecular modelling software developing area.

I am the Chemistry Editor of Antiviral Chemistry and Chemotherapy

PhD students

  • Bordoni, Cinzia
  • Cima, Cecilia
  • Ginacotti, Gilda

Proffiliau allanol