Yr Athro Bing Song
Cyfarwyddwr Rhyngwladol, Athro, Cymrawd Ymchwil Prifysgol y Gymdeithas Frenhinol
Bywgraffiad
Education and Qualifications: July 1995, M.D., China Medical University, Shenyang, China. July 1998, M.Sc., Department of Ophthalmology, China Medical University, Shenyang, China. August 2004, Ph.D., School of Medical Sciences, University of Aberdeen, UK. Career to Date: 10/2009 $acirc; date, Chair, Cardiff Institute of Tissue Engineering and Repair, School of Dentistry, Cardiff University, UK. 10/2005 $acirc; date, Royal Society University Research Fellow, The Royal Society, UK. 10/2007 $acirc; 09/2009, Senior Lecturer, University of Aberdeen, UK. 03/2009 $acirc; 08/2009, Visiting faculty, University of California, Davis, USA. 10/2005 $acirc; 10/2010, Clinical specialist registrar, Aberdeen Royal Infirmary, NHS Grampian, UK. 12/2004 $acirc; 01/2005, Visiting faculty, Peter Devreotes lab, Department of Cell Biology, Johns Hopkins University, USA. 03/2003 $acirc; 06/2003, Visiting research fellow, Josef Penninger lab, University of Toronto, Canada. 04/1999 $acirc; 09/2005, Postdoc research fellow, Department of Biomedical Sciences, University of Aberdeen, UK. 01/1997 $acirc; 03/1999, Visiting scientist, Hamamatsu University School of Medicine, Japan. 1. General Medical Council Registered Medical Practitioner, GMC Registration No. 6149612, UK. 2. American Society for Cell Biology, USA. 3. The Society for Neuroscience, USA. 4. Chinese Society of Ophthalmology, China. Royal Society University Research Fellowship award (2005 $acirc; 2013).Career Profile
Memberships / External Activities
Awards
Cyhoeddiadau
2023
- Liu, Q. et al. 2023. Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation. Cell & Bioscience 13, article number: 4. (10.1186/s13578-023-00954-3)
2022
- Jiang, W. et al. 2022. MicroRNA-22 suppresses NLRP3/CASP1 inflammasome pathway-mediated proinflammatory cytokine production by targeting the HIF-1α and NLRP3 in human dental pulp fibroblasts. International Endodontic Journal 55(11), pp. 1225-1240. (10.1111/iej.13814)
- Liu, H., Zhang, Z., Zhou, S., Liu, X., Li, G., Song, B. and Xu, W. 2022. Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway. Cancer Gene Therapy 29, pp. 665-682. (10.1038/s41417-021-00328-2)
- Gao, Y. et al. 2022. Machine-learning based prediction and analysis of prognostic risk factors in patients with candidemia and bacteraemia: a 5-year analysis. PeerJ – the Journal of Life & Environmental Sciences 10, article number: e13594. (10.7717/peerj.13594)
- Li, Y. et al. 2022. Machine‑learning based prediction of prognostic risk factors in patients with invasive candidiasis infection and bacterial bloodstream infection: a singled centered retrospective study. BMC Infectious Diseases 22, article number: 150. (10.1186/s12879-022-07125-8)
2021
- Li, Y., Gao, Y., Niu, X., Tang, M., Li, J., Song, B. and Guan, X. 2021. LncRNA BASP1-AS1 interacts with YBX1 to regulate Notch transcription and drives the malignancy of melanoma. Cancer Science 112(11), pp. 4526-4542. (10.1111/cas.15140)
- Wang, D. et al. 2021. MicroRNA-223 negatively regulates LPS-induced inflammatory responses by targeting NLRP3 in human dental pulp fibroblasts. International Endodontic Journal 54(2), pp. 241-254. (10.1111/iej.13413)
- Song, B. et al. 2021. Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium. Cell and Bioscience 11, article number: 111. (10.1186/s13578-021-00580-x)
2020
- Jiang, L., Nishio Ayre, W., Melling, G. E., Song, B., Wei, X., Sloan, A. and Chen, X. 2020. Liposomes loaded with transforming growth factor β1 promote odontogenic differentiation of dental pulp stem cells. Journal of Dentistry 103, article number: 103501. (10.1016/j.jdent.2020.103501)
- Li, Y. et al. 2020. A 5-year review of invasive fungal infection at an academic medical center. Frontiers in Cellular and Infection Microbiology 10, article number: 553648. (10.3389/fcimb.2020.553648)
- Li, Y. et al. 2020. Identification of subtype-specific metastasis-related genetic signatures in sarcoma. Frontiers in Oncology 10, article number: 544956. (10.3389/fonc.2020.544956)
- Cheng, W. et al. 2020. Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway. Journal of Orthopaedic Translation 22, pp. 92-100. (10.1016/j.jot.2019.07.007)
- Gao, Y. et al. 2020. Identification and validation of prognostically relevant gene signature in melanoma. BioMed Research International, article number: 5323614. (10.1155/2020/5323614)
- Hu, Y. et al. 2020. Downregulation of hypoxia-inducible factor-1α by RNA interference alleviates the development of collagen-induced arthritis in rats. Molecular Therapy - Nucleic Acids 19, pp. 1330-1342. (10.1016/j.omtn.2020.01.014)
- Liu, P., Kong, L., Liang, K., Wu, Y., Jin, H., Song, B. and Tan, X. 2020. Identification of dissociation factors in pancreatic Cancer using a mass spectrometry-based proteomic approach. BMC Cancer 20(1), article number: 45. (10.1186/s12885-020-6522-3)
2019
- Liu, X., Liu, Y., Yu, S., Jiang, L., Song, B. and Chen, X. 2019. Potential immunomodulatory effects of SCAP on Treg conversion in tissue regeneration for regenerative endodontic treatment. International Endodontic Journal 52(12), pp. 1758-1767. (10.1111/iej.13197)
- Liu, P., Kong, L., Jin, H., Wu, Y., Tan, X. and Song, B. 2019. Differential secretome of pancreatic cancer cells in serum-containing conditioned medium reveals CCT8 as a new biomarker of pancreatic cancer invasion and metastasis. Cancer Cell International 19, article number: 262. (10.1186/s12935-019-0980-1)
- Jiang, W. et al. 2019. Wnt-GSK3ß/ß-catenin regulates the differentiation of dental pulp stem cells into bladder smooth muscle cells. Stem Cells International 2019, article number: 8907570. (10.1155/2019/8907570)
2018
- Ferguson, E. L. et al. 2018. Controlled release of Dextrin-conjugated growth factors to support growth and differentation of neural stem cells. Stem Cell Research 33, pp. 69-78. (10.1016/j.scr.2018.10.008)
- Li, Y., Gu, Y., Wang, H., Zhipeng, L., Song, B. and Yin, T. 2018. Electric pulses can influence galvanotaxis of Dictyostelium discoideum. BioMed Research International 2018, article number: 2534625. (10.1155/2018/2534625)
- Qiao, S. et al. 2018. An intelligent neural stem cell delivery system for neurodegenerative diseases treatment. Advanced Healthcare Materials 7(12), article number: 1800080. (10.1002/adhm.201800080)
- Hidalgo San Jose, L., Stephens, P., Song, B. and Barrow, D. 2018. Microfluidic encapsulation supports stem cell viability, proliferation and neuronal differentiation. Tissue Engineering Part C Methods 24(3), pp. 158-170. (10.1089/ten.TEC.2017.0368)
- Li, M. et al. 2018. Cdc42 is essential for the polarized movement and adhesion of human dental pulp stem cells. Archives of Oral Biology 85, pp. 104-112. (10.1016/j.archoralbio.2017.09.036)
- Liang, X. et al. 2018. Nanoparticles with CD44 targeting and ROS triggering properties as effective in vivo antigen delivery system. Molecular Pharmaceutics 15(2), pp. 508-518. (10.1021/acs.molpharmaceut.7b00890)
2017
- Mu, X. et al. 2017. Inhibition of Nkcc1 promotes axonal growth and motor recovery in ischemic rats. Neuroscience 365, pp. 83-93. (10.1016/j.neuroscience.2017.09.036)
- Gao, X. et al. 2017. High staphylococcus epidermidis colonization and impaired permeability barrier in facial seborrheic dermatitis. Chinese Medical Journal 130(14), pp. 1662-1669. (10.4103/0366-6999.209895)
- Yang, Y. et al. 2017. Heat increases the editing efficiency of human papillomavirus E2 gene by inducing upregulation of APOBEC3A and 3G. Journal of Investigative Dermatology 137(4), pp. 810-818. (10.1016/j.jid.2016.06.635)
2016
- Zhang, G. et al. 2016. Kindlin-1 regulates keratinocyte electrotaxis. Journal of Investigative Dermatology 136(11), pp. 2229-2239. (10.1016/j.jid.2016.05.129)
- Zhu, B., Nicholls, M., Gu, Y., Zhang, G., Zhao, C., Franklin, R. and Song, B. 2016. Electric signals regulate the directional migration of Oligodendrocyte Progenitor Cells (OPCs) via β1 Integrin. International Journal of Molecular Sciences 17(11), article number: 1948. (10.3390/ijms17111948)
- Li, P. et al. 2016. PLGA nano/micro particles encapsulated with pertussis toxoid (PTd) enhances Th1/Th17 immune response in a murine model. International Journal of Pharmaceutics 513(1-2), pp. 183-190. (10.1016/j.ijpharm.2016.08.059)
- Binley, K. E., Ng, W. S., Barde, Y., Song, B. and Morgan, J. E. 2016. Brain-derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells. European Journal of Neuroscience 44(3), pp. 2028-2039. (10.1111/ejn.13295)
- Zhang, G., Edmundson, M., Telezhkin, V., Gu, Y., Wei, X., Kemp, P. J. and Song, B. 2016. The role of Kv1.2 channel in electrotaxis cell migration. Journal of Cellular Physiology 231(6), pp. 1375-1384. (10.1002/jcp.25259)
- Young, F. I. et al. 2016. Clonal heterogeneity in the neuronal and glial differentiation of dental pulp stem/progenitor cells. Stem Cells International 2016, article number: 1290561. (10.1155/2016/1290561)
- Xue, Q. et al. 2016. miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a. Scientific Reports 6, article number: 26781. (10.1038/srep26781)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11(4), article number: e0152023. (10.1371/journal.pone.0152023)
- Zhu, B., Caldwell, M. and Song, B. 2016. Development of stem cell-based therapies for Parkinson's disease. International Journal of Neuroscience 126(11), pp. 955-962. (10.3109/00207454.2016.1148034)
- Zhang, Q. et al. 2016. Aldose reductase regulates microglia/macrophages polarization through the cAMP response element-binding protein after spinal cord injury in mice.. Molecular Neurobiology 53(1), pp. 662-676. (10.1007/s12035-014-9035-8)
- Song, B. et al. 2016. Bladder smooth muscle cells differentiation from dental pulp stem cells: future potential for bladder tissue engineering. Stem Cells International 2016, article number: 6979368. (10.1155/2016/6979368)
- Hughes, D. and Song, B. 2016. Dental and nondental stem cell based regeneration of the craniofacial region: a tissue based approach. Stem Cells International 2016, pp. 1-20., article number: 8307195. (10.1155/2016/8307195)
- Qian, L., Yun, L., Jiang, W., Yunzi, L., Lin, Z., Song, B. and Xinfeng, L. 2016. Inhibition of HSP90 promotes neural stem cell survival from oxidative stress through attenuating NF-κB/p65 activation. Oxidative Medicine and Cellular Longevity 2016, article number: 3507290.
2015
- Zhang, K. et al. 2015. Polarized macrophages have distinct roles in the differentiation and migration of embryonic spinal-cord-derived neural stem cells after grafting to injured sites of spinal cord. Molecular Therapy 23(6), pp. 1077-1091. (10.1038/mt.2015.46)
- Mehrban, N. et al. 2015. Functionalized α-helical peptide hydrogels for neural tissue engineering. ACS Biomaterials Science and Engineering 1(6), pp. 431-439. (10.1021/acsbiomaterials.5b00051)
- Haan, N., Zhu, B., Wang, J., Wei, X. and Song, B. 2015. Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury. Journal of Neuroinflammation 12, article number: 109. (10.1186/s12974-015-0327-3)
- Liu, J. et al. 2015. Electric signals regulate directional migration of ventral midbrain derived dopaminergic neural progenitor cells via Wnt/GSK3β signaling. Experimental Neurology 263, pp. 113-121. (10.1016/j.expneurol.2014.09.014)
- Xu, R., Sun, H., Williams, D. W., Jones, A. V., Al-Hussaini, A., Song, B. and Wei, X. 2015. IL-34 suppresses 'Candida albicans' induced TNFα production in M1 macrophages by downregulating expression of Dectin-1 and TLR2. Journal of Immunology Research 2015, article number: 328146. (10.1155/2015/328146)
2014
- Zhu, B., Zhao, C., Young, F., Franklin, R. J. M. and Song, B. 2014. Isolation and long-term expansion of functional, myelinating oligodendrocyte progenitor cells from neonatal rat brain. In: Schlaeger, T. et al. eds. Current Protocols in Stem Cell Biology., Vol. 31. Vol. 1. Wiley-Blackwell, pp. 300-308., (10.1002/9780470151808.sc02d17s31)
- Binley, K. E., Ng, W. S., Tribble, J. R., Song, B. and Morgan, J. E. 2014. Sholl analysis: A quantitative comparison of semi-automated methods. Journal of Neuroscience Methods 225, pp. 65-70. (10.1016/j.jneumeth.2014.01.017)
- Haan, N. and Song, B. 2014. Therapeutic application of electric fields in the injured nervous system. Advances in Wound Care 3(2), pp. 156-165. (10.1089/wound.2013.0450)
2013
- Young, F., Sloan, A. J. and Song, B. 2013. Dental pulp stem cells and their potential roles in central nervous system regeneration and repair. Journal of Neuroscience Research 91(11), pp. 1383-1393. (10.1002/jnr.23250)
- Zheng, X. F. et al. 2013. Lipopolysaccharide-induced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression. PLoS ONE 8(5), article number: e63967. (10.1371/journal.pone.0063967)
2012
- Meng, X., Li, W., Young, F., Gao, R., Chalmers, L., Zhao, M. and Song, B. 2012. Electric field-controlled directed migration of neural progenitor cells in 2D and 3D environments. Journal of Visualized Experiments(60), pp. 3453. (10.3791/3453)
2011
- Meng, X., Seton, H. C., Lu, L. T., Prior, I. A., Thanh, N. T. K. and Song, B. 2011. Magnetic CoPt nanoparticles as MRI contrast agent for transplanted neural stem cells detection. Nanoscale 3(3), pp. 977-984. (10.1039/c0nr00846j)
- Meng, X., Arocena, M., Penninger, J., Gage, F. H., Zhao, M. and Song, B. 2011. PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Experimental Neurology 227(1), pp. 210-217. (10.1016/j.expneurol.2010.11.002)
2010
- Arocena, M., Zhao, M., Collinson, J. M. and Song, B. 2010. A time-lapse and quantitative modelling analysis of neural stem cell motion in the absence of directional cues and in electric fields. Journal of Neuroscience Research 88(15), pp. 3267-3274. (10.1002/jnr.22502)
- Hardwicke, J., Song, B., Moseley, R. and Thomas, D. W. 2010. Investigation of the potential of polymer therapeutics in corneal re-epithelialisation. British Journal of Ophthalmology 94(12), pp. 1566-1570. (10.1136/bjo.2009.177295)
- Guo, A., Song, B., Reid, B., Gu, Y., Forrester, J. V., Jahoda, C. A. B. and Zhao, M. 2010. Effects of physiological electric fields on migration of human dermal fibroblasts. Journal of Investigative Dermatology 130(9), pp. 2320-2327. (10.1038/jid.2010.96)
- Lois, N., Reid, B., Song, B., Zhao, M., Forrester, J. and McCaig, C. 2010. Electric currents and lens regeneration in the rat. Experimental Eye Research 90(2), pp. 316-323. (10.1016/j.exer.2009.11.007)
2009
- McCaig, C. D., Song, B. and Rajnicek, A. M. 2009. Electrical dimensions in cell science. Journal of Cell Science 122(23), pp. 4267-4276. (10.1242/jcs.023564)
- Reid, B., Song, B. and Zhao, M. 2009. Electric currents in Xenopus tadpole tail regeneration. Developmental Biology 335(1), pp. 198-207. (10.1016/j.ydbio.2009.08.028)
2008
- Sun, H., Song, B., Dong, H., Reid, B., Player, M. A., Watson, J. and Zhao, M. 2008. Visualization of fast-moving cells in vivo using digital holographic video microscopy. Journal of biomedical optics 13(1), article number: 14007. (10.1117/1.2841050)
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