![Phil Stephens BSc (Hons) PhD](https://profiles-cardiff.imgix.net/attachments/1684?w=200&h=200&auto=format&crop=faces&fit=crop&q=90")
Yr Athro Phil Stephens
(e/fe)
BSc (Hons) PhD
Dirprwy Bennaeth yr Ysgol, Cyfarwyddwr Materion Rhyngwladol, Athro Bioleg Celloedd
- StephensP@caerdydd.ac.uk
- +44 29207 42529
- Ysbyty Deintyddol y Brifysgol, Ystafell 5F.06 Swyddfa Ymchwil Ôl-raddedig, Parc y Mynydd Bychan, Caerdydd, CF14 4XY
- Sylwebydd y cyfryngau
- Ar gael fel goruchwyliwr ôl-raddedig
Trosolwyg
Cyfarwyddwr Materion Rhyngwladol, Athro Bioleg Celloedd, Trwydded Ymchwil HTA Dynodwyd Arweinydd Unigol ac Academaidd ar gyfer Banc Bio Prifysgol Caerdydd.
Grŵp ymchwil
Grŵp Therapïau Uwch
Cyhoeddiad
2023
- Wang, Z., Knight, R., Stephens, P., Ongkosuwito, E. M., Wagener, F. A. D. T. G. and Von den Hoff, J. W. 2023. Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing. Stem Cell Research and Therapy 14(1), article number: 203. (10.1186/s13287-023-03423-3)
- Lohana, P. et al. 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12(7), article number: 1374. (10.3390/antiox12071374)
2022
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11(8), pp. 861-875. (10.1093/stcltm/szac037)
2021
- Brown, H., Clayton, A. and Stephens, P. 2021. The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges. Wound Repair and Regeneration 29(6), pp. 864-880. (10.1111/wrr.12949)
- Stephens, N. and Stephens, P. 2021. Interdisciplinary projects as an expert-network: analysing team work across biological and physical sciences. Science and Technology Studies 34(4), pp. 56-73. (10.23987/sts.87339)
2020
- Yang, Y., Knight, R., Stephens, P. and Zhang, Y. 2020. Three-dimensional culture of oral progenitor cells: effects on small extracellular vesicles production and proliferative function. Journal of Oral Pathology and Medicine 49(4), pp. 342-349. (10.1111/jop.12981)
2018
- Masia, F., Glen, A., Stephens, P., Langbein, W. and Borri, P. 2018. Label-free quantitative chemical imaging and classification analysis of adipogenesis using mouse embryonic stem cells. Journal of Biophotonics 11(7), article number: e201700219. (10.1002/jbio.201700219)
- Caley, M., Wall, I., Peake, M., Kipling, D., Giles, P., Thomas, D. and Stephens, P. 2018. Development and characterisation of a human chronic skin wound cell line - towards an alternative for animal experimentation. International Journal of Molecular Sciences 19(4), article number: 1001. (10.3390/ijms19041001)
- Hidalgo San Jose, L., Stephens, P., Song, B. and Barrow, D. 2018. Microfluidic encapsulation supports stem cell viability, proliferation and neuronal differentiation. Tissue Engineering Part C Methods 24(3), pp. 158-170. (10.1089/ten.TEC.2017.0368)
2016
- Locke, M., Davies, L. C. and Stephens, P. 2016. Oral mucosal progenitor cell clones resist In Vitro myogenic differentiation. Archives of Oral Biology 70, pp. 100-110. (10.1016/j.archoralbio.2016.06.013)
- Howard-Jones, R. A., Cheung, O. K. Y., Glen, A., Allen, N. D. and Stephens, P. 2016. Integration-free reprogramming of lamina propria progenitor cells. Journal of Dental Research 95(8), pp. 882-888. (10.1177/0022034516637579)
- Perkins, B. L. et al. 2016. The life science exchange: A case study of a sectoral and sub-sectoral knowledge exchange programme. Health Research Policy and Systems 14, article number: 32. (10.1186/s12961-016-0105-4)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11(4), article number: e0152023. (10.1371/journal.pone.0152023)
2015
- Roper, J. A. et al. 2015. Ultrasonic stimulation of mouse skin reverses the healing delays in diabetes and aging by activation of Rac1. Journal of Investigative Dermatology 135(11), pp. 2842-2851. (10.1038/jid.2015.224)
- Board-Davies, E., Moses, R., Sloan, A. J., Stephens, P. and Davies, L. C. 2015. Oral mucosal lamina propria-progenitor cells exert antibacterial properties via the secretion of osteoprotegerin and haptoglobin. Stem Cells Translational Medicine 4(11), pp. 1283-1293. (10.5966/sctm.2015-0043)
2014
- Stephens, P. and Davies, L. C. 2014. Oral mucosal progenitor cells. In: Vishwakarma, A. et al. eds. Stem Cell Biology and Tissue Engineering in Dental Sciences. Academic Press, pp. 297-306., (10.1016/B978-0-12-397157-9.00025-4)
- Peake, M. A. et al. 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22(3), pp. 399-405. (10.1111/wrr.12170)
- McInnes, R. L. et al. 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22(1), pp. 58-69. (10.1111/wrr.12133)
2013
- Masia, F., Glen, A., Stephens, P., Borri, P. and Langbein, W. W. 2013. Quantitative chemical imaging and unsupervised analysis using hyperspectral coherent anti-Stokes Raman scattering microscopy. Analytical Chemistry 85(22), pp. 10820-10828. (10.1021/ac402303g)
- Stephens, P., Caley, M. and Peake, M. 2013. Alternatives for animal wound model systems. In: Gourdie, R. G. and Myers, T. A. eds. Wound Regeneration and Repair., Vol. 1037. Methods in Molecular Biology Springer, pp. 177-201., (10.1007/978-1-62703-505-7_10)
2012
- Wildeboer, D. et al. 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31(9), pp. 2183-2189. (10.1007/s10096-012-1553-6)
- Wagstaffe, S. J., Hill, K. E., Williams, D. W., Randle, B. J., Thomas, D. W., Stephens, P. and Riley, D. J. 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84(14), pp. 5876-5884. (10.1021/ac203403d)
- Davies, L. C. et al. 2012. Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner. Stem Cells and Development 21(9), pp. 1478-1487. (10.1089/scd.2011.0434)
2011
- Stephens, P. 2011. Dysfunctional wound healing in chronic wounds. In: Farrar, D. ed. Advanced Wound Repair Therapies. Woodhead Publishing, pp. 3-38., (10.1533/9780857093301.1.3)
2010
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
- Hardwicke, J., Moseley, R., Stephens, P., Harding, K. G., Duncan, R. and Thomas, D. W. 2010. Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7(3), pp. 699-707. (10.1021/mp9002656)
- Davies, L. C. et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19(6), pp. 819-830. (10.1089/scd.2009.0089)
- Simpson, R. M. L., Wells, A., Thomas, D. W., Stephens, P., Steadman, R. and Phillips, A. O. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176(3), pp. 1215-1228. (10.2353/ajpath.2010.090802)
- Stephens, P. 2010. Development of a cell-based diabetic wound assay. ATLA Alternatives to Laboratory Animals 38(SUPPL.), pp. 45-48.
2009
- Simpson, R. M. L., Meran, S., Thomas, D. W., Stephens, P., Bowen, T., Steadman, R. and Phillips, A. O. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175(5), pp. 1915-1928. (10.2353/ajpath.2009.090045)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
- Iversen, A. et al. 2009. A proviral role for CpG in cytomegalovirus infection. Journal of Immunology 182(9), pp. 5672-5681. (10.4049/jimmunol.0801268)
- Simpson, R. M., Stephens, P., Thomas, D., Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90(2), pp. A128-A129.
- Cook, H., Stephens, P., Davies, K. J., Harding, K. G. and Thomas, D. W. 2009. Phenotypic differences in wound healing responses are reflected by differences in ECM reorganisation and MMP-2 activation. Journal of Gastroenterology and Hepatology 24, pp. A88-A88. (10.1046/j.1365-2613.2000.0145k.x)
- Enoch, S. and Stephens, P. 2009. Scarless healing: Oral mucosa as a scientific model. Wounds UK 5(1), pp. 42-48.
2008
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Hardwicke, J., Ferguson, E. L., Moseley, R., Stephens, P., Thomas, D. W. and Duncan, R. 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130(3), pp. 275-283. (10.1016/j.jconrel.2008.07.023)
- Meran, S., Thomas, D. W., Stephens, P., Enoch, S., Martin, J., Steadman, R. and Phillips, A. O. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283(10), pp. 6530-6545. (10.1074/jbc.M704819200)
- Enoch, S., Moseley, R., Stephens, P. and Thomas, D. W. 2008. The oral mucosa: A model of wound healing with reduced scarring. Oral Surgery 1, pp. 11-21. (10.1111/j.1752-248x.2007.00005.x)
- Peake, M. A., Giles, P. J., Wall, I. B., Enoch, S., Kipling, D. G., Thomas, D. W. and Stephens, P. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16(6), pp. A71. (10.1111/j.1524-475X.2008.00424.x)
- Mantripragada, K. K. et al. 2008. Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals. Genes Chromosomes and Cancer 47(3), pp. 238-246. (10.1002/gcc.20525)
- Meran, S., Steadman, R., Phillips, A. O., Thomas, D. W. and Stephens, P. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16(2), pp. A12. (10.1111/j.1524-475X.2008.00371.x)
2007
- Lygoe, K. A., Wall, I., Stephens, P. and Lewis, M. P. 2007. Role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation. Biology of the Cell 99(11), pp. 601-614. (10.1042/BC20070008)
- Meran, S., Thomas, D. W., Stephens, P., Martin, J., Bowen, T., Phillips, A. O. and Steadman, R. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282(35), pp. 25687-25697. (10.1074/jbc.M700773200)
- Davies, C. E., Hill, K. E., Newcombe, R. G., Stephens, P., Wilson, M., Harding, K. G. and Thomas, D. W. 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15(1), pp. 17-22. (10.1111/j.1524-475X.2006.00180.x)
- Stephens, P. and Genever, P. 2007. Non-epithelial oral mucosal progenitor cell populations. Oral Diseases 13(1), pp. 1-10. (10.1111/j.1601-0825.2006.01314.x)
- Andersen, A., Hill, K. E., Stephens, P., Thomas, D. W., Jorgensen, B. and Krogfelt, K. A. 2007. Bacterial profiling using skin grafting, standard culture and molecular bacteriological methods. Journal of Wound Care 16(4), pp. 171-175.
2004
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
- Davies, C. E., Hill, K. E., Wilson, M., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42(8), pp. 3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
- Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117(15), pp. 3389-3403. (10.1242/jcs.01188)
- Enoch, S., Price, P. E., Harding, K. G., Thomas, D. W. and Stephens, P. 2004. Identifying the molecular and genetic basis for non-healing wounds, scarless healing and scarring: study of human fibroblasts. British Journal of Surgery 91(S1), pp. 82-82.
- Moseley, R., Stewart, J. E., Stephens, P., Waddington, R. J. and Thomas, D. W. 2004. Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?. British Journal of Dermatology 150(3), pp. 401-413. (10.1111/j.1365-2133.2004.05845.x)
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
2003
- Hill, K. E., Davies, C. E., Wilson, M., Stephens, P., Harding, K. G. and Thomas, D. W. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52(4), pp. 365-369. (10.1099/jmm.0.05030-0)
- Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148(3), pp. 456-466. (10.1046/j.1365-2133.2003.05232.x)
- Stephens, P. et al. 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283(1), pp. 22-35. (10.1016/S0014-4827(02)00021-6)
- White, P., Thomas, D. W., Fong, S., Stelnicki, E., Meijlink, F., Largman, C. and Stephens, P. 2003. Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. Journal Of Investigative Dermatology 120(1), pp. 135-144. (10.1046/j.1523-1747.2003.12015.x)
2002
- Hill, K. E. et al. 2002. Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51(11), pp. 949-957.
- Wall, I. B., Davies, C. E., Hill, K. E., Wilson, M. J., Stephens, P., Harding, K. G. and Thomas, D. W. 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10(6), pp. 346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
- Stephens, P. and Thomas, D. W. 2002. The cellular proliferative phase of the wound repair process. Journal of Wound Care 11(7), pp. 253-261. (10.12968/jowc.2002.11.7.26421)
2001
- Davies, C. E., Wilson, M. J., Hill, K. E., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9(5), pp. 332-340. (10.1046/j.1524-475x.2001.00332.x)
- Stephens, P. et al. 2001. Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity. British Journal Of Dermatology 144(2), pp. 229-237. (10.1046/j.1365-2133.2001.04006.x)
- Stephens, P., Hiscox, S. E., Cook, H., Jiang, W. G., Zhiquiang, W. and Thomas, D. W. 2001. Phenotypic variation in the production of bioactive hepatocyte growth factor/scatter factor by oral mucosal and skin fibroblasts. Wound Repair and Regeneration 9(1), pp. 34-43. (10.1046/j.1524-475x.2001.00034.x)
2000
- Cook, H., Stephens, P., Davies, K. J., Thomas, D. W. and Harding, K. G. 2000. Defective Extracellular Matrix Reorganization by Chronic Wound Fibroblasts is Associated with Alterations in TIMP-1, TIMP-2, and MMP-2 Activity. Journal of Investigative Dermatology 115(2), pp. 225-233. (10.1046/j.1523-1747.2000.00044.x)
- Thomas, D. W., Hill, C. M., Lewis, M. A. O., Stephens, P., Walker, R. and Von Der Weth, A. 2000. Randomized clinical trial of the effect of semi-occlusive dressings on the microflora and clinical outcome of acute facial wounds. Wound Repair and Regeneration 8(4), pp. 258-263. (10.1046/j.1524-475x.2000.00258.x)
1998
- Stephens, M., Lim, K., Stephens, P., Lim, S. H. and Thomas, D. W. 1998. Molecular characterisation of tumour infiltrating lymphocytes in oral squamous cell carcinoma. Cancer Immunology, Immunotherapy 46(1), pp. 34-40. (10.1007/s002620050457)
1997
- Lim, S. H., Stephens, P., Cao, Q., Coleman, S. L. and Thomas, D. 1997. Molecular analysis of T cell receptor beta variability in a patient with orofacial granulomatosis. Gut 40(5), pp. 683-686. (10.1136/gut.40.5.683)
- Thomas, D. W., Stephens, P., Stephens, M., Patten, D. W. and Lim, S. H. 1997. T-cell receptor Vbeta usage by lesional lymphocytes in oral lichen planus. Journal of Oral Pathology & Medicine 26(3), pp. 105-109. (10.1111/j.1600-0714.1997.tb00031.x)
- al-Khateeb, T., Stephens, P., Shepherd, J. and Thomas, D. 1997. An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model. Journal of Periodontology 68(11), pp. 1063-1069. (10.1902/jop.1997.68.11.1063)
- Stephens, P., Genever, P. G., Wood, E. J. and Raxworthy, M. J. 1997. Integrin receptor involvement in actin cable formation in an in vitro model of events associated with wound contraction. The International Journal of Biochemistry & Cell Biology 29(1), pp. 121-128. (10.1016/S1357-2725(96)00123-9)
1996
- Stephens, P., Davies, K. J., Al-Khateeb, T., Shepherd, J. P. and Thomas, D. W. 1996. A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction. Journal of Dental Research 75(6), pp. 1358-1364. (10.1177/00220345960750060601)
- Stephens, P., Al-Khateeb, T., Davies, K. J., Shepherd, J. P. and Thomas, D. W. 1996. An investigation of the interaction between alcohol and fibroblasts in wound healing. International Journal of Oral and Maxillofacial Surgery 25(2), pp. 161-164. (10.1016/S0901-5027(96)80065-8)
- Lim, S. H., Thomas, D. W., Coleman, S. L. and Stephens, P. 1996. T cell receptor Vβ repertoire of tumour-infiltrating lymphocytes in oral squamous-cell carcinoma. Cancer Immunology, Immunotherapy 42(1), pp. 69-70. (10.1007/s002620050253)
Articles
- Wang, Z., Knight, R., Stephens, P., Ongkosuwito, E. M., Wagener, F. A. D. T. G. and Von den Hoff, J. W. 2023. Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing. Stem Cell Research and Therapy 14(1), article number: 203. (10.1186/s13287-023-03423-3)
- Lohana, P. et al. 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12(7), article number: 1374. (10.3390/antiox12071374)
- Knight, R. et al. 2022. Oral progenitor cell line-derived small extracellular vesicles as a treatment for preferential wound healing outcome. Stem Cells Translational Medicine 11(8), pp. 861-875. (10.1093/stcltm/szac037)
- Brown, H., Clayton, A. and Stephens, P. 2021. The role of bacterial extracellular vesicles in chronic wound infections: current knowledge and future challenges. Wound Repair and Regeneration 29(6), pp. 864-880. (10.1111/wrr.12949)
- Stephens, N. and Stephens, P. 2021. Interdisciplinary projects as an expert-network: analysing team work across biological and physical sciences. Science and Technology Studies 34(4), pp. 56-73. (10.23987/sts.87339)
- Yang, Y., Knight, R., Stephens, P. and Zhang, Y. 2020. Three-dimensional culture of oral progenitor cells: effects on small extracellular vesicles production and proliferative function. Journal of Oral Pathology and Medicine 49(4), pp. 342-349. (10.1111/jop.12981)
- Masia, F., Glen, A., Stephens, P., Langbein, W. and Borri, P. 2018. Label-free quantitative chemical imaging and classification analysis of adipogenesis using mouse embryonic stem cells. Journal of Biophotonics 11(7), article number: e201700219. (10.1002/jbio.201700219)
- Caley, M., Wall, I., Peake, M., Kipling, D., Giles, P., Thomas, D. and Stephens, P. 2018. Development and characterisation of a human chronic skin wound cell line - towards an alternative for animal experimentation. International Journal of Molecular Sciences 19(4), article number: 1001. (10.3390/ijms19041001)
- Hidalgo San Jose, L., Stephens, P., Song, B. and Barrow, D. 2018. Microfluidic encapsulation supports stem cell viability, proliferation and neuronal differentiation. Tissue Engineering Part C Methods 24(3), pp. 158-170. (10.1089/ten.TEC.2017.0368)
- Locke, M., Davies, L. C. and Stephens, P. 2016. Oral mucosal progenitor cell clones resist In Vitro myogenic differentiation. Archives of Oral Biology 70, pp. 100-110. (10.1016/j.archoralbio.2016.06.013)
- Howard-Jones, R. A., Cheung, O. K. Y., Glen, A., Allen, N. D. and Stephens, P. 2016. Integration-free reprogramming of lamina propria progenitor cells. Journal of Dental Research 95(8), pp. 882-888. (10.1177/0022034516637579)
- Perkins, B. L. et al. 2016. The life science exchange: A case study of a sectoral and sub-sectoral knowledge exchange programme. Health Research Policy and Systems 14, article number: 32. (10.1186/s12961-016-0105-4)
- Morgan, A. J. L. et al. 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11(4), article number: e0152023. (10.1371/journal.pone.0152023)
- Roper, J. A. et al. 2015. Ultrasonic stimulation of mouse skin reverses the healing delays in diabetes and aging by activation of Rac1. Journal of Investigative Dermatology 135(11), pp. 2842-2851. (10.1038/jid.2015.224)
- Board-Davies, E., Moses, R., Sloan, A. J., Stephens, P. and Davies, L. C. 2015. Oral mucosal lamina propria-progenitor cells exert antibacterial properties via the secretion of osteoprotegerin and haptoglobin. Stem Cells Translational Medicine 4(11), pp. 1283-1293. (10.5966/sctm.2015-0043)
- Peake, M. A. et al. 2014. Identification of a transcriptional signature for the wound healing continuum. Wound Repair and Regeneration 22(3), pp. 399-405. (10.1111/wrr.12170)
- McInnes, R. L. et al. 2014. Contrasting host immuno-inflammatory responses to bacterial challenge within venous and diabetic ulcers. Wound Repair and Regeneration 22(1), pp. 58-69. (10.1111/wrr.12133)
- Masia, F., Glen, A., Stephens, P., Borri, P. and Langbein, W. W. 2013. Quantitative chemical imaging and unsupervised analysis using hyperspectral coherent anti-Stokes Raman scattering microscopy. Analytical Chemistry 85(22), pp. 10820-10828. (10.1021/ac402303g)
- Wildeboer, D. et al. 2012. Specific protease activity indicates the degree of Pseudomonas aeruginosa infection in chronic infected wounds. European Journal of Clinical Microbiology & Infectious Diseases 31(9), pp. 2183-2189. (10.1007/s10096-012-1553-6)
- Wagstaffe, S. J., Hill, K. E., Williams, D. W., Randle, B. J., Thomas, D. W., Stephens, P. and Riley, D. J. 2012. Bispecific antibody-mediated detection of the staphylococcus aureus thermonuclease. Analytical Chemistry 84(14), pp. 5876-5884. (10.1021/ac203403d)
- Davies, L. C. et al. 2012. Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner. Stem Cells and Development 21(9), pp. 1478-1487. (10.1089/scd.2011.0434)
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
- Hardwicke, J., Moseley, R., Stephens, P., Harding, K. G., Duncan, R. and Thomas, D. W. 2010. Bioresponsive dextrin-rhEGF conjugates: in vitro evaluation in models relevant to its proposed use as a treatment for chronic wounds. Molecular Pharmaceutics 7(3), pp. 699-707. (10.1021/mp9002656)
- Davies, L. C. et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19(6), pp. 819-830. (10.1089/scd.2009.0089)
- Simpson, R. M. L., Wells, A., Thomas, D. W., Stephens, P., Steadman, R. and Phillips, A. O. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176(3), pp. 1215-1228. (10.2353/ajpath.2010.090802)
- Stephens, P. 2010. Development of a cell-based diabetic wound assay. ATLA Alternatives to Laboratory Animals 38(SUPPL.), pp. 45-48.
- Simpson, R. M. L., Meran, S., Thomas, D. W., Stephens, P., Bowen, T., Steadman, R. and Phillips, A. O. 2009. Age-related changes in pericellular hyaluronan organization leads to impaired dermal fibroblast to myofibroblast differentiation. American Journal of Pathology 175(5), pp. 1915-1928. (10.2353/ajpath.2009.090045)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
- Iversen, A. et al. 2009. A proviral role for CpG in cytomegalovirus infection. Journal of Immunology 182(9), pp. 5672-5681. (10.4049/jimmunol.0801268)
- Simpson, R. M., Stephens, P., Thomas, D., Webber, J. P., Meran, S., Steadman, R. and Phillips, A. O. 2009. Age related changes in pericellular hyaluronan leads to impaired dermal fibroblast to myofibroblast differentiation. International Journal of Experimental Pathology 90(2), pp. A128-A129.
- Cook, H., Stephens, P., Davies, K. J., Harding, K. G. and Thomas, D. W. 2009. Phenotypic differences in wound healing responses are reflected by differences in ECM reorganisation and MMP-2 activation. Journal of Gastroenterology and Hepatology 24, pp. A88-A88. (10.1046/j.1365-2613.2000.0145k.x)
- Enoch, S. and Stephens, P. 2009. Scarless healing: Oral mucosa as a scientific model. Wounds UK 5(1), pp. 42-48.
- Wall, I. B. et al. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. Journal of Investigative Dermatology 128(10), pp. 2526-2540. (10.1038/jid.2008.114)
- Hardwicke, J., Ferguson, E. L., Moseley, R., Stephens, P., Thomas, D. W. and Duncan, R. 2008. Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. Journal of Controlled Release 130(3), pp. 275-283. (10.1016/j.jconrel.2008.07.023)
- Meran, S., Thomas, D. W., Stephens, P., Enoch, S., Martin, J., Steadman, R. and Phillips, A. O. 2008. Hyaluronan facilitates transforming growth factor-β1-mediated fibroblast proliferation. Journal of Biological Chemistry 283(10), pp. 6530-6545. (10.1074/jbc.M704819200)
- Enoch, S., Moseley, R., Stephens, P. and Thomas, D. W. 2008. The oral mucosa: A model of wound healing with reduced scarring. Oral Surgery 1, pp. 11-21. (10.1111/j.1752-248x.2007.00005.x)
- Peake, M. A., Giles, P. J., Wall, I. B., Enoch, S., Kipling, D. G., Thomas, D. W. and Stephens, P. 2008. Identifying a Gene signature for the wound healing continuum [Abstract]. Wound Repair and Regeneration 16(6), pp. A71. (10.1111/j.1524-475X.2008.00424.x)
- Mantripragada, K. K. et al. 2008. Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals. Genes Chromosomes and Cancer 47(3), pp. 238-246. (10.1002/gcc.20525)
- Meran, S., Steadman, R., Phillips, A. O., Thomas, D. W. and Stephens, P. 2008. Hyaluronan facilitates TGF beta 1 mediated myofibroblastic differentiation [Abstract]. Wound Repair and Regeneration 16(2), pp. A12. (10.1111/j.1524-475X.2008.00371.x)
- Lygoe, K. A., Wall, I., Stephens, P. and Lewis, M. P. 2007. Role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation. Biology of the Cell 99(11), pp. 601-614. (10.1042/BC20070008)
- Meran, S., Thomas, D. W., Stephens, P., Martin, J., Bowen, T., Phillips, A. O. and Steadman, R. 2007. Involvement of hyaluronan in regulation of fibroblast phenotype. The Journal of Biological Chemistry 282(35), pp. 25687-25697. (10.1074/jbc.M700773200)
- Davies, C. E., Hill, K. E., Newcombe, R. G., Stephens, P., Wilson, M., Harding, K. G. and Thomas, D. W. 2007. A prospective study of the microbiology of chronic venous leg ulcers to re-evaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 15(1), pp. 17-22. (10.1111/j.1524-475X.2006.00180.x)
- Stephens, P. and Genever, P. 2007. Non-epithelial oral mucosal progenitor cell populations. Oral Diseases 13(1), pp. 1-10. (10.1111/j.1601-0825.2006.01314.x)
- Andersen, A., Hill, K. E., Stephens, P., Thomas, D. W., Jorgensen, B. and Krogfelt, K. A. 2007. Bacterial profiling using skin grafting, standard culture and molecular bacteriological methods. Journal of Wound Care 16(4), pp. 171-175.
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
- Davies, C. E., Hill, K. E., Wilson, M., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2004. Use of 16S ribosomal DNA PCR and denaturing gradient gel electrophoresis for analysis of the microfloras of healing and non-healing chronic venous leg ulcers. Journal of Clinical Microbiology 42(8), pp. 3549-3557. (10.1128/JCM.42.8.3549-3557.2004)
- Stephens, P. et al. 2004. Crosslinking and G-protein functions of transglutaminase 2 contribute differentially to fibroblast wound healing responses. Journal of cell science 117(15), pp. 3389-3403. (10.1242/jcs.01188)
- Enoch, S., Price, P. E., Harding, K. G., Thomas, D. W. and Stephens, P. 2004. Identifying the molecular and genetic basis for non-healing wounds, scarless healing and scarring: study of human fibroblasts. British Journal of Surgery 91(S1), pp. 82-82.
- Moseley, R., Stewart, J. E., Stephens, P., Waddington, R. J. and Thomas, D. W. 2004. Extracellular matrix metabolites as potential biomarkers of disease activity in wound fluid: lessons learned from other inflammatory diseases?. British Journal of Dermatology 150(3), pp. 401-413. (10.1111/j.1365-2133.2004.05845.x)
- Moseley, R., Hilton, J. R., Waddington, R. J., Harding, K. G., Stephens, P. and Thomas, D. W. 2004. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair and Regeneration 12(4), pp. 419-429. (10.1111/j.1067-1927.2004.12406.x)
- Hill, K. E., Davies, C. E., Wilson, M., Stephens, P., Harding, K. G. and Thomas, D. W. 2003. Molecular analysis of the microflora in chronic venous leg ulceration. Journal of Medical Microbiology 52(4), pp. 365-369. (10.1099/jmm.0.05030-0)
- Stephens, P. et al. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. British Journal Of Dermatology 148(3), pp. 456-466. (10.1046/j.1365-2133.2003.05232.x)
- Stephens, P. et al. 2003. An analysis of replicative senescence in dermal fibroblasts derived from chronic leg wounds predicts that telomerase therapy would fail to reverse their disease-specific cellular and proteolytic phenotype. Experimental Cell Research 283(1), pp. 22-35. (10.1016/S0014-4827(02)00021-6)
- White, P., Thomas, D. W., Fong, S., Stelnicki, E., Meijlink, F., Largman, C. and Stephens, P. 2003. Deletion of the homeobox gene PRX-2 affects fetal but not adult fibroblast wound healing responses. Journal Of Investigative Dermatology 120(1), pp. 135-144. (10.1046/j.1523-1747.2003.12015.x)
- Hill, K. E. et al. 2002. Heterogeneity within the gram-positive anaerobic cocci demonstrated by analysis of 16S-23S intergenic ribosomal RNA polymorphisms. Journal of Medical Microbiology 51(11), pp. 949-957.
- Wall, I. B., Davies, C. E., Hill, K. E., Wilson, M. J., Stephens, P., Harding, K. G. and Thomas, D. W. 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair and Regeneration 10(6), pp. 346-353. (10.1046/j.1524-475X.2002.t01-1-10602.x)
- Stephens, P. and Thomas, D. W. 2002. The cellular proliferative phase of the wound repair process. Journal of Wound Care 11(7), pp. 253-261. (10.12968/jowc.2002.11.7.26421)
- Davies, C. E., Wilson, M. J., Hill, K. E., Stephens, P., Hill, C. M., Harding, K. G. and Thomas, D. W. 2001. Use of molecular techniques to study microbial diversity in the skin: Chronic wounds reevaluated. Wound Repair and Regeneration 9(5), pp. 332-340. (10.1046/j.1524-475x.2001.00332.x)
- Stephens, P. et al. 2001. Skin and oral fibroblasts exhibit phenotypic differences in extracellular matrix reorganization and matrix metalloproteinase activity. British Journal Of Dermatology 144(2), pp. 229-237. (10.1046/j.1365-2133.2001.04006.x)
- Stephens, P., Hiscox, S. E., Cook, H., Jiang, W. G., Zhiquiang, W. and Thomas, D. W. 2001. Phenotypic variation in the production of bioactive hepatocyte growth factor/scatter factor by oral mucosal and skin fibroblasts. Wound Repair and Regeneration 9(1), pp. 34-43. (10.1046/j.1524-475x.2001.00034.x)
- Cook, H., Stephens, P., Davies, K. J., Thomas, D. W. and Harding, K. G. 2000. Defective Extracellular Matrix Reorganization by Chronic Wound Fibroblasts is Associated with Alterations in TIMP-1, TIMP-2, and MMP-2 Activity. Journal of Investigative Dermatology 115(2), pp. 225-233. (10.1046/j.1523-1747.2000.00044.x)
- Thomas, D. W., Hill, C. M., Lewis, M. A. O., Stephens, P., Walker, R. and Von Der Weth, A. 2000. Randomized clinical trial of the effect of semi-occlusive dressings on the microflora and clinical outcome of acute facial wounds. Wound Repair and Regeneration 8(4), pp. 258-263. (10.1046/j.1524-475x.2000.00258.x)
- Stephens, M., Lim, K., Stephens, P., Lim, S. H. and Thomas, D. W. 1998. Molecular characterisation of tumour infiltrating lymphocytes in oral squamous cell carcinoma. Cancer Immunology, Immunotherapy 46(1), pp. 34-40. (10.1007/s002620050457)
- Lim, S. H., Stephens, P., Cao, Q., Coleman, S. L. and Thomas, D. 1997. Molecular analysis of T cell receptor beta variability in a patient with orofacial granulomatosis. Gut 40(5), pp. 683-686. (10.1136/gut.40.5.683)
- Thomas, D. W., Stephens, P., Stephens, M., Patten, D. W. and Lim, S. H. 1997. T-cell receptor Vbeta usage by lesional lymphocytes in oral lichen planus. Journal of Oral Pathology & Medicine 26(3), pp. 105-109. (10.1111/j.1600-0714.1997.tb00031.x)
- al-Khateeb, T., Stephens, P., Shepherd, J. and Thomas, D. 1997. An investigation of preferential fibroblast wound repopulation using a novel in vitro wound model. Journal of Periodontology 68(11), pp. 1063-1069. (10.1902/jop.1997.68.11.1063)
- Stephens, P., Genever, P. G., Wood, E. J. and Raxworthy, M. J. 1997. Integrin receptor involvement in actin cable formation in an in vitro model of events associated with wound contraction. The International Journal of Biochemistry & Cell Biology 29(1), pp. 121-128. (10.1016/S1357-2725(96)00123-9)
- Stephens, P., Davies, K. J., Al-Khateeb, T., Shepherd, J. P. and Thomas, D. W. 1996. A comparison of the ability of intra-oral and extra-oral fibroblasts to stimulate extracellular matrix reorganization in a model of wound contraction. Journal of Dental Research 75(6), pp. 1358-1364. (10.1177/00220345960750060601)
- Stephens, P., Al-Khateeb, T., Davies, K. J., Shepherd, J. P. and Thomas, D. W. 1996. An investigation of the interaction between alcohol and fibroblasts in wound healing. International Journal of Oral and Maxillofacial Surgery 25(2), pp. 161-164. (10.1016/S0901-5027(96)80065-8)
- Lim, S. H., Thomas, D. W., Coleman, S. L. and Stephens, P. 1996. T cell receptor Vβ repertoire of tumour-infiltrating lymphocytes in oral squamous-cell carcinoma. Cancer Immunology, Immunotherapy 42(1), pp. 69-70. (10.1007/s002620050253)
Book sections
- Stephens, P. and Davies, L. C. 2014. Oral mucosal progenitor cells. In: Vishwakarma, A. et al. eds. Stem Cell Biology and Tissue Engineering in Dental Sciences. Academic Press, pp. 297-306., (10.1016/B978-0-12-397157-9.00025-4)
- Stephens, P., Caley, M. and Peake, M. 2013. Alternatives for animal wound model systems. In: Gourdie, R. G. and Myers, T. A. eds. Wound Regeneration and Repair., Vol. 1037. Methods in Molecular Biology Springer, pp. 177-201., (10.1007/978-1-62703-505-7_10)
- Stephens, P. 2011. Dysfunctional wound healing in chronic wounds. In: Farrar, D. ed. Advanced Wound Repair Therapies. Woodhead Publishing, pp. 3-38., (10.1533/9780857093301.1.3)
- Davies, L. C. et al. 2012. Oral mucosal progenitor cells are potently immunosuppressive in a dose-independent manner. Stem Cells and Development 21(9), pp. 1478-1487. (10.1089/scd.2011.0434)
- Enoch, S. et al. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. Journal of Dental Research 89(12), pp. 1407-1413. (10.1177/0022034510377796)
- Davies, L. C. et al. 2010. A multipotent neural crest derived progenitor cell population is resident within the oral mucosa lamina propria. Stem Cells and Development 19(6), pp. 819-830. (10.1089/scd.2009.0089)
- Simpson, R. M. L., Wells, A., Thomas, D. W., Stephens, P., Steadman, R. and Phillips, A. O. 2010. Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling. American Journal of Pathology 176(3), pp. 1215-1228. (10.2353/ajpath.2010.090802)
- Enoch, S. et al. 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88(10), pp. 916-921. (10.1177/0022034509342979)
Ymchwil
Celloedd Propria-Progenitor Mucosal Llafar ar gyfer atgyweirio meinwe:
Mae clwyfau yn y geg yn gwella'n dda iawn o'u cymharu â chlwyfau croen arferol gan eu bod yn dangos ychydig neu ddim creithiau o gwbl. Rydym wedi bod yn ymchwilio i'r celloedd o feinweoedd meddal yn y geg ac wedi dangos eu bod yn wahanol i gelloedd croen ac mewn gwirionedd yn debycach i gelloedd y ffetws. Awgrymodd hyn y gall y celloedd o'r geg fod yn debycach i fôn-gelloedd mewn gwirionedd. Mae ein gwaith diweddar wedi nodi cell mor debyg i fôn-gelloedd yn y geg a all wneud gwahanol fathau o feinweoedd, yn gryf wrth is-reoleiddio'r system imiwnedd ac mae ganddynt eiddo gwrth-bacteriol. Felly, gall celloedd o'r fath fod yn ddefnyddiol i (a) helpu i atgyweirio/adfywio meinwe sydd wedi'i difrodi neu wedi'i heintio, (b) helpu i is-reoleiddio'r system imiwnedd yn ystod trawsblannu neu ar ôl i unigolion ddioddef o glefydau awtoimiwn a (c) bod yn ddefnyddiol wrth frwydro yn erbyn heintiau / canser. Yn bwysig, oherwydd bod meinwe sy'n cynnwys y celloedd llafar yn hawdd ei gyrchu a'i wella heb graith, gallai hyn fod y ffynhonnell ffafriol ar gyfer bôn-gelloedd ar gyfer therapi cleifion yn y dyfodol (patentau a ddyfarnwyd ac a ffeiliwyd; a ariennir gan yr MRC).
Gwella clwyfau cronig:
Rydym wedi bod â diddordeb hirdymor yn y sbectrwm o ymatebion clwyfau, gan gynnwys y rhai nad ydynt yn gwella (wlserau gwythiennol cronig, wlserau traed diabetig). Rydym eisoes wedi dangos, trwy ein dadansoddiadau in vitro , fod ymatebion moleciwlaidd a cellog ffibroblastau o glwyfau cronig yn gamweithredol. Mae hyn yn cynnwys ein harsylwadau bod ffibroblastau clwyfau cronig yn dangos senescence cynamserol sy'n effeithio ar eu gallu i yrru gwaith atgyweirio'r clwyf sy'n ddyledus i ddiffyg cynhyrchu sawl chemocinau allweddol. Rydym bellach yn datblygu'r straeniau cronig hyn yn llinellau celloedd clwyfau cronig wedi'u nodweddu'n dda a allai fod â'r potensial i gymryd lle rhywfaint o arbrofi anifeiliaid ar gyfer cyn-sgrinio deunyddiau yn y dyfodol a allai gael effeithiau buddiol i ddioddefwyr clwyfau cronig.
Olrhain bôn-gelloedd:
Un o'r prif rwystrau i gyfieithu mewn perthynas ag olrhain llinach/tynged bôn-gelloedd yw'r gallu i ddelweddu celloedd o fewn meinweoedd 3D mewn amser real. Yn draddodiadol, ceisiwyd defnyddio technegau delweddu golau sy'n seiliedig ar fflworoleuedd gyda galluoedd adrannol 3D megis confocal laser-sganio neu ficrosgopeg aml-ffoton i ddarparu delweddu meintiol, amser real o gelloedd. Fodd bynnag, mae dull o'r fath yn gyfyngedig oherwydd ffotoblethu ac effeithiau ffotowenwynig y label fflworochrome / moiety a ddefnyddir. Felly, rydym yn gweithio ar draws disgyblaethau (Ffiseg a Chemeg) i ddatblygu dulliau delweddu newydd, annistrywiol (PET ac MRI) i olrhain bôn-gelloedd a'u hepil mewn amser real mewn cleifion (a ariennir gan yr EPSRC ac Ymddiriedolaeth Wellcome).
Biobanking:
Trwy fy rôl fel Unigolyn Dynodedig HTA ym Mhrifysgol Caerdydd, rwyf ar hyn o bryd yn sefydlu Banc Bio Prifysgol Caerdydd i gydlynu mynediad ymchwil i samplau a data meinwe dynol ar draws ac allan gyda'r Brifysgol.
Cydweithio:
- Steve Paisey/Ian Fallis/Angelo Amoroso (Prifysgol Caerdydd, y DU) – Dulliau newydd ar gyfer olrhain bôn-gelloedd
- Aled Clayton/Helen Brown (Prifysgol Caerdydd, y DU) – Celloedd cynhenid llafar fel asiantau gwrth-bacteriol
- Rob Knight (UCLA, UDA) - Exosomau progenitor llafar fel asiant gwrth-greithio
- Hans von den Hoff (Canolfan Feddygol Prifysgol Radboud, Yr Iseldiroedd - Exosomau progenitor llafar fel asiant gwrth-greithio
Dyfarniadau
- Phil Stephens: Gwobr Teilyngdod Urdd Lifrai Cymru (2012)
- Rachel Howard-Jones: Gwobr Poster (Diwrnod Ymchwil Ôl-raddedig Prifysgol Caerdydd, 2009); Gwobr Llafar (Diwrnod Ymchwil Ôl-raddedig Prifysgol Caerdydd, 2011); Gwobr Uwch Colgate Cymdeithas Ymchwil Llafar a Deintyddol Prydain (2012); Gwobr Poster Cymdeithas Peirianneg Cell Meinwe (2014)
- Adam Glen: Gwobr Cyflwyniad Llafar y Gymdeithas Peirianneg Cell Meinwe (2013)
- Emma Board Davies: Gwobr Cyflwyniad Llafar (Cyfarfod Gwyddonol Blynyddol CITER, 2014)
- Lorena Hidalgo San Jose: Gwobr Cyflwyniad Llafar (Cyfarfod Gwyddonol Blynyddol CITER, 2015)
Peirianneg meinwe ac arbenigedd atgyweirio
- Bioleg celloedd progenitor llafar (datblygu / rheoli llinol, immunosuppression)
- Bioleg ffibroblast/matrics allgellog
- Datblygu systemau in vitro i ddisodli anifeiliaid mewn arbrofi
- Delweddu celloedd byw
- Bioassays gwella clwyfau
- Mynediad at ddeunydd clinigol o ffynonellau moesegol at ddibenion ymchwil
Addysgu
BDS Deintyddol (Ecosystemau Llafar)
MSc Peirianneg Meinwe a Meddygaeth Adfywiol
MSc Bioleg Llafar
MSc Mewnblanoleg
Bywgraffiad
Ar hyn o bryd mae'r Athro Phil Stephens yn Athro Bioleg Cell ac yn Gyfarwyddwr Materion Rhyngwladol yn yr Ysgol Deintyddiaeth, Coleg y Gwyddorau Biofeddygol a Bywyd, Prifysgol Caerdydd. Symudodd i Brifysgol Caerdydd yn 1994 fel Ymchwilydd Ôl-Ddoethurol ar ôl ennill gradd anrhydedd dosbarth cyntaf a PhD o Brifysgol Leeds. Wedi hynny sefydlodd y Grŵp Bioleg Clwyfau gyda chydweithiwr clinigol. Mae ei ddiddordebau ymchwil yn y meysydd celloedd progenitor llafar, gwella clwyfau gwahaniaethol, heneiddio, peirianneg meinwe, systemau model amnewid anifeiliaid a delweddu cellog. O fewn y meysydd hyn mae wedi rheoli prosiectau ymchwil (Cyngor Ymchwil, Elusen a Diwydiant) sy'n dod i gyfanswm o dros £4.5 miliwn, a gyhoeddwyd yn eang, ffeilio patentau ac mae ei grŵp wedi ennill llawer o wobrau Cenedlaethol a Rhyngwladol. Yn allanol, mae'n gweithio'n agos gyda sefydliadau fel y Ganolfan Genedlaethol ar gyfer y Disodli, Mireinio a Lleihau Anifeiliaid mewn Ymchwil ac yn adolygu ceisiadau grant a llawysgrifau ar gyfer nifer o gyllidwyr/cylchgronau cenedlaethol a rhyngwladol. Ef hefyd yw Arweinydd Academaidd Banc Bio Prifysgol Caerdydd sy'n cyflenwi biosamplau dynol ar gyfer ymchwil sy'n canolbwyntio ar wella iechyd pobl.
Aelodaethau proffesiynol
- Cymdeithas Ymchwil Llafar a Deintyddol Prydain
- Cymdeithas Atgyweirio Meinwe Ewropeaidd
- Aelod o Sefydliad Peirianneg ac Atgyweirio Meinwe Caerdydd.
Safleoedd academaidd blaenorol
2008 - Athro Bioleg Celloedd, Grŵp Bioleg Adfywiol, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2013 - cyflwyno trwydded ymchwil HTA Unigol Dynodedig.
2015 - yn cyflwyno Arweinydd Academaidd ar gyfer Banc Bio Prifysgol Caerdydd
2022- Cyfarwyddwr Materion Rhyngwladol presennol, Ysgol Deintyddiaeth, Prifysgol Caerdydd
2016 - 2022 Deon Rhyngwladol, Coleg y Gwyddorau Biofeddygol a Bywyd, Prifysgol Caerdydd
2017 - 2019 Llywydd Cymdeithas Atgyweirio Meinwe Ewrop
2015 - 2016 Arweinydd Thema Ymchwil ar gyfer Biosystemau Integreiddiol, Coleg y Gwyddorau Biofeddygol a Bywyd (BLS), Prifysgol Caerdydd
2010 - 2015 Is-Ddeon (Ymchwil), Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2010 - 2015 Pennaeth Sefydliad Peirianneg a Thrwsio Meinwe Caerdydd (CITER)
2008 - 2010 Pennaeth Peirianneg Meinwe a Deintyddiaeth Ddibynadwy, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2004 - 2008 Darllenydd mewn Bioleg Celloedd, Grŵp Bioleg Clwyfau, Adran Deintyddiaeth, Meddygaeth a Patholeg, Ysgol Deintyddiaeth, Prifysgol Caerdydd, Caerdydd
2002 - 2004 Uwch Ddarlithydd mewn Bioleg Celloedd, Adran Llawfeddygaeth y Llafar, Meddygaeth a Patholeg, Ysgol Ddeintyddol, UWCM, Caerdydd
1998 - 2002 Darlithydd mewn Bioleg Celloedd, Dept. Llawfeddygaeth lafar, Meddygaeth a Patholeg, Ysgol Ddeintyddol, UWCM, Caerdydd
Rhagfyr - Rhagfyr 1997 Secondiad i'r Labordai Hematopoiesis Moleciwlaidd yr Athro Corey Largman, UCSF, San Francisco, UDA i ymchwilio i rôl genynnau homeobox newydd mewn iacháu clwyfau di-ofn
1994 - 1998 Cymrawd Ymchwil Ôl-ddoethurol, Adran Llawfeddygaeth Lafar, Meddygaeth a Phatholeg, Ysgol Ddeintyddol, UWCM, Caerdydd
Meysydd goruchwyliaeth
- Celloedd progenitor llafar fesiglau allgellog bach fel asiantau gwrth-greithio a gwrthficrobaidd
- Datblygu asiantau olrhain celloedd tymor hir (PET, MRI)
Themâu ymchwil
Arbenigeddau
- Bioleg Celloedd
- Meddygaeth adfywiol
- Celloedd bonyn
- Peirianneg meinwe