Ewch i’r prif gynnwys
Dr David Miller

Dr David Miller

Research Fellow in Chemical Biology

Yr Ysgol Cemeg

Email:
millerdj@cardiff.ac.uk
Telephone:
+44 (0)29 2087 4068
Fax:
+44 (0)29 2087 4030

Links

Research Group: Biological and Organic Chemistry

Research Interests

I am interested in the use of synthetic organic chemistry as applied to the solution of biological problems and vice versa.  The understanding of how Nature$acirc; s macromolecules such as proteins and DNA work and interact with one another can often be probed by use of small organic molecules.  Such molecules are often not available from the natural pool and so the synthetic chemist is central to solving such problems.  Similarly, synthetic chemistry although well capable of preparing the most complex and intricate of molecules can often only do so at great expense of time and resources. Natural systems, if harnessed correctly offer the opportunity to construct molecules of such complexity much more quickly and efficiently.

For more information, click on the 'Research' tab above.

Teaching

CH3113 Chemical Biology I: Cells and the Molecules of Life

CH3216 Chemical Biology II: Introduction to Enzyme and Nucleic Acid Chemistry

CH3408 Modern Catalytic Processes

CHT214 Biocatalysis I: Modern Approaches to Biocatalysis

CHT215 Key Skills in Catalysis

CHT223 Biocatalysis II: Industrial Applications of Biocatalysis

CHT224 Medicinal Chemistry

BI1215 Chemistry 2

PhD, Southampton University (under Prof. T. D. H. Bugg). Postdoctoral research Fellow, University of St. Andrews 1997-1998. Post doctoral research fellow, Birmingham University 1998-2005. Post doctoral research fellow, Cardiff University 2005-2007. Appointed research fellow, 2007.

2019

2018

2016

2015

2014

2013

2012

2009

2008

2007

2006

2004

2003

1998

I am interested in the use of synthetic organic chemistry as applied to the solution of biological problems and vice versa.  The understanding of how Nature$acirc; s macromolecules such as proteins and DNA work and interact with one another can often be probed by use of small organic molecules.  Such molecules are often not available from the natural pool and so the synthetic chemist is central to solving such problems.  Similarly, synthetic chemistry although well capable of preparing the most complex and intricate of molecules can often only do so at great expense of time and resources. Natural systems, if harnessed correctly offer the opportunity to construct molecules of such complexity much more quickly and efficiently.

Inositol monophoshphatase.

Inositol monophosphatase is an enzyme that is involved in a crucial signal transduction pathway within our cells that has been implicated as a target for drugs that treat bipolar disorders.  We are interested in the study of the mechanism of action of this enzyme and in the discovery of new inhibitors that may ultimately lead to better treatments for this debilitating condition.

Diagram showing the natural substrate inositol-1-phosphate bound at the active site of IMPase.

mu-Calpain

Calpains are cysteine proteases that are activated by calcium ions.  mu-Calpain is a member of this family of enzymes that appears to have a key role in cell-membrane expansion and hence motility of white blood cells (neutrophils).  Development of potent and selective mu-calpain inhibitors may lead to a treatment for a variety of autoimmune diseases such as osteoarthritis.

Mercaptoacrylate PD150606 bound to domain VI of calpain.

Biosynthesis of terpenoids

Terpenes are the largest and most diverse group of natural products but originate from only a tiny group of prenyl diphosphate precursors.  Diversity is generated in nature by the structurally similar terpene cyclases that form many different products from each prenyl diphosphate.  By a combination of chemical synthesis, enzymology and molecular biology we seek to understand how such diversity can be created by enzymes that share a common fold.

Diagram showing the sesquiterpene precursor farnesyl diphosphate and some of the downstream sesquiterpene products.