Ewch i’r prif gynnwys
Dr Natalie Connor-Robson

Dr Natalie Connor-Robson

Research Fellow, Dementia Research Institute

Yr Ysgol Meddygaeth

Email
connor-robsonnl@cardiff.ac.uk
Campuses
Adeilad Hadyn Ellis, Heol Maendy, Caerdydd, CF24 4HQ
Users
Ar gael fel goruchwyliwr ôl-raddedig

Trosolwg

Understanding the molecular mechanisms of Alzheimer's Disease

Alzheimer’s disease has huge personal and economic costs and as yet there are no effective treatments. It is important to understand the earliest pathogenic mechanisms that occur on a cellular level in order to design better treatment options. My research focuses on the role of the endocytic pathway in neurodegeneration and on understanding how common genetic changes alter cellular function in sporadic Alzheimer's Disease. I use iPSC-derived neurons and microglia to study this.

Research Goals

  1. Study the role of endocytic dysfunction in neurodegenerative diseases
  2. Identify pathogenic cellular mechanisms caused by polygenic risk in Alzheimer's Disease
  3. Investigate potential new therapeutic strategies

Bywgraffiad

I received my BSc in Biomedical Sciences from Cardiff University before completing my PhD  on the role of the synuclein family in health and disease. In 2014 I joined the Oxford Parkinson’s Disease Centre at the University of Oxford as a Career Development Fellow in the group of Prof. Richard Wade-Martins. During this time, I worked on understanding the earliest cellular pathogenic events to occur in Parkinson’s Disease using both rodent models and iPSC-derived dopaminergic neurons. My work highlighted the extensive roles of LRRK2 mutations in the endocytic and autophagic pathways as well as examining the role of GBA in Parkinson’s.

In 2021 I was awarded an ARUK Research Fellowship and joined the UKDRI as an Emerging Leader.

Cyhoeddiadau

2021

2020

2019

2018

2016

2015

2013

2012

2011