Dr Jonathan M. Tyrrell

2019

• Langley, G. W. et al. 2019. Profiling interactions of vaborbactam with metallo-β-lactamases. Bioorganic and Medicinal Chemistry Letters 29(15), pp. 1981-1984. (10.1016/j.bmcl.2019.05.031)
• Qamar, M. U., Walsh, T. R., Toleman, M. A., Tyrrell, J. M., Saleem, S., Aboklaish, A. and Jahan, S. 2019. Dissemination of genetically diverse NDM-1, -5, -7 producing-Gram-negative pathogens isolated from pediatric patients in Pakistan. Future Microbiology 14(8) (10.2217/fmb-2019-0012)
• Juhas, M. et al. 2019. In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii. Journal of Antimicrobial Chemotherapy 74(4), pp. 944-952. (10.1093/jac/dky546)
• Salimraj, R. et al. 2019. Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases. FEBS Journal 286(1), pp. 169-183. (10.1111/febs.14695)
• Tyrrell, J. M., Aboklaish, A. F., Walsh, T. R., Vaara, T. and Vaara, M. 2019. The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii. Peptides 112, pp. 149-153. (10.1016/j.peptides.2018.12.006)
• Yu, Y. et al. 2019. Novel partners with colistin to increase its in vivo therapeutic effectiveness and prevent the occurrence of colistin resistance in NDM- and MCR-co-producing Escherichia coli in a murine infection model. Journal of Antimicrobial Chemotherapy 74(14), pp. 87-95. (10.1093/jac/dky413)

2018

• Yang, Q. E., Agouri, S. R., Tyrrell, J. M. and Walsh, T. R. 2018. Heavy metal resistance genes are associated with blaNDM-1 and blaCTX-M-15-Enterobacteriaceae. Antimicrobial Agents and Chemotherapy 62(5), article number: e02642-17. (10.1128/AAC.02642-17)
• Carretto, E. et al. 2018. Clinical validation of sensitest colistin, a broth microdilution-based method to evaluate colistin MICs. Journal of Clinical Microbiology 56(4), article number: e01523-17. (10.1128/JCM.01523-17)
• Shen, Y. et al. 2018. Heterogeneous and flexible transmission of mcr-1 in hospital-associated escherichia coli. mBio 9(4), article number: e00943-18. (10.1128/mBio.00943-18)

2017

• Vaara, M., Vaara, T. and Tyrrell, J. M. 2017. Structure-activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity. Peptides 91, pp. 8-12. (10.1016/j.peptides.2017.03.002)
• Wang, Y. et al. 2017. Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1 -positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study. Lancet Infectious Diseases 17(4), pp. 390-399. (10.1016/S1473-3099(16)30527-8)
• Wang, Y. et al. 2017. Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production. Nature Microbiology 2, article number: 16260. (10.1038/nmicrobiol.2016.260)

2016

• Tyrrell, J. M., Wootton, M., Toleman, M. A., Howe, R. A., Woodward, M. and Walsh, T. R. 2016. Genetic & virulence profiling of ESBL-positive E. coli from nosocomial & veterinary sources. Veterinary Microbiology 186, pp. 37-43. (10.1016/j.vetmic.2016.02.007)

2011

• Davey, M. S., Tyrrell, J. M., Howe, R. A., Walsh, T. R., Moser, B., Toleman, M. A. H. and Eberl, M. 2011. A promising target for treatment of multidrug-resistant bacterial infections [Letter]. Antimicrobial Agents and Chemotherapy 55(7), pp. 3635-3636. (10.1128/AAC.00382-11)